Streamlining chemical probe discovery: Libraries of "fully functionalized" small molecules for phenotypic screening

Angewandte Chemie - International Edition

Volumn 52, Issue 5, 2013, Pages 1368-1370

  Oeljeklaus, Julian ^a   Kaschani, Farnusch ^a   Kaiser, Markus ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

chemical biology; compound library; phenotype; photo affinity labeling; target identification

Indexed keywords

CHEMICAL BIOLOGY; CHEMICAL PROBES; COMPOUND LIBRARIES; FUNCTIONALIZED; PHENOTYPE; PHENOTYPIC SCREENING; SMALL MOLECULES; TARGET IDENTIFICATION;

MOLECULES; PROBES;

CROSSLINKING;

BENZOPHENONE; BENZOPHENONE DERIVATIVE; EPOXIDE HYDROLASE; MT ND1 PROTEIN, HUMAN; MT-ND1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ARTICLE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR LIBRARY; OXIDATIVE PHOSPHORYLATION; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

BENZOPHENONES; CELL LINE, TUMOR; EPOXIDE HYDROLASES; HUMANS; NADH DEHYDROGENASE; OXIDATIVE PHOSPHORYLATION; SMALL MOLECULE LIBRARIES; ULTRAVIOLET RAYS;

EID: 84872852493     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201207306     Document Type: Article

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