메뉴 건너뛰기




Volumn 20, Issue 23, 2014, Pages 7104-7122

Production and pathogenicity of hepatitis C virus core gene products

Author keywords

Core protein; Hepatitis C virus; Hepatocellular carcinoma; Insulin resistance; Interferon; Steatosis

Indexed keywords

ARF PROTEIN; BETA INTERFERON; CORE PROTEIN; DEAD BOX PROTEIN; FOCAL ADHESION KINASE; INSULIN; INTERFERON; JANUS KINASE; MICRORNA; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDASE; STAT PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ANTIVIRUS AGENT; VIRULENCE FACTOR;

EID: 84902653396     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i23.7104     Document Type: Review
Times cited : (27)

References (198)
  • 1
    • 34848881072 scopus 로고    scopus 로고
    • Sequence diversity of hepatitis C virus: Implications for immune control and therapy
    • [PMID: 17828811]
    • Timm J, Roggendorf M. Sequence diversity of hepatitis C virus: implications for immune control and therapy. World J Gastroenterol 2007; 13: 4808-4817 [PMID: 17828811]
    • (2007) World J Gastroenterol , vol.13 , pp. 4808-4817
    • Timm, J.1    Roggendorf, M.2
  • 2
    • 0033458046 scopus 로고    scopus 로고
    • Natural history of hepatitis C
    • [PMID: 10622555]
    • Alberti A, Chemello L, Benvegnù L. Natural history of hepatitis C. J Hepatol 1999; 31 Suppl 1: 17-24 [PMID: 10622555]
    • (1999) J Hepatol , vol.31 , Issue.SUPPL. 1 , pp. 17-24
    • Alberti, A.1    Chemello, L.2    Benvegnù, L.3
  • 3
    • 0036828783 scopus 로고    scopus 로고
    • Course and outcome of hepatitis C
    • [PMID: 12407573]
    • Hoofnagle JH. Course and outcome of hepatitis C. Hepatology 2002; 36: S21-S29 [PMID: 12407573]
    • (2002) Hepatology , vol.36
    • Hoofnagle, J.H.1
  • 4
    • 33646250428 scopus 로고    scopus 로고
    • The natural history of hepatitis C virus (HCV) infection
    • [PMID: 16614742]
    • Chen SL, Morgan TR. The natural history of hepatitis C virus (HCV) infection. Int J Med Sci 2006; 3: 47-52 [PMID: 16614742]
    • (2006) Int J Med Sci , vol.3 , pp. 47-52
    • Chen, S.L.1    Morgan, T.R.2
  • 6
    • 84880222037 scopus 로고    scopus 로고
    • Virus C hepatitis and type 2 diabetes: A cohort study in southern Italy
    • [PMID: 23567360 DOI: 10.1038/ajg.2013.90]
    • Montenegro L, De Michina A, Misciagna G, Guerra V, Di Leo A. Virus C hepatitis and type 2 diabetes: a cohort study in southern Italy. Am J Gastroenterol 2013; 108: 1108-1111 [PMID: 23567360 DOI: 10.1038/ajg.2013.90]
    • (2013) Am J Gastroenterol , vol.108 , pp. 1108-1111
    • Montenegro, L.1    De Michina, A.2    Misciagna, G.3    Guerra, V.4    Di Leo, A.5
  • 7
    • 1442281992 scopus 로고    scopus 로고
    • Structural biology of hepatitis C virus
    • [PMID: 14752815 DOI: 10.1002/hep.20032]
    • Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM. Structural biology of hepatitis C virus. Hepatology 2004; 39: 5-19 [PMID: 14752815 DOI: 10.1002/hep.20032]
    • (2004) Hepatology , vol.39 , pp. 5-19
    • Penin, F.1    Dubuisson, J.2    Rey, F.A.3    Moradpour, D.4    Pawlotsky, J.M.5
  • 8
    • 34547094367 scopus 로고    scopus 로고
    • Hepatitis C Virus
    • In: Knipe DM, Ha PM, editors. 5th ed. Philadelphia: Lippincott Williams and Wilkins
    • Lemon SM, Walker CM, Alter MJ, Yi M. Hepatitis C Virus. In: Knipe DM, Ha PM, editors. Fields' Virology. 5th ed. Philadelphia: Lippincott Williams and Wilkins, 2007: 1253-1304
    • (2007) Fields' Virology , pp. 1253-1304
    • Lemon, S.M.1    Walker, C.M.2    Alter, M.J.3    Yi, M.4
  • 11
    • 78650766355 scopus 로고    scopus 로고
    • Hepatitis C virus: How genetic variability affects pathobiology of disease
    • [PMID: 21199518 DOI: 10.1111/j.1440-1746.2010.06550.x]
    • Chayama K, Hayes CN. Hepatitis C virus: How genetic variability affects pathobiology of disease. J Gastroenterol Hepatol 2011; 26 Suppl 1: 83-95 [PMID: 21199518 DOI: 10.1111/j.1440-1746.2010.06550.x]
    • (2011) J Gastroenterol Hepatol , vol.26 , Issue.SUPPL. 1 , pp. 83-95
    • Chayama, K.1    Hayes, C.N.2
  • 12
    • 0028945033 scopus 로고
    • Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes
    • [PMID: 7597443 DOI: 10.1055/ s-2007-1007262]
    • Bukh J, Miller RH, Purcell RH. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis 1995; 15: 41-63 [PMID: 7597443 DOI: 10.1055/ s-2007-1007262]
    • (1995) Semin Liver Dis , vol.15 , pp. 41-63
    • Bukh, J.1    Miller, R.H.2    Purcell, R.H.3
  • 13
    • 7444256169 scopus 로고    scopus 로고
    • Genetic diversity and evolution of hepatitis C virus--15 years on
    • [PMID: 15483230]
    • Simmonds P. Genetic diversity and evolution of hepatitis C virus--15 years on. J Gen Virol 2004; 85: 3173-3188 [PMID: 15483230]
    • (2004) J Gen Virol , vol.85 , pp. 3173-3188
    • Simmonds, P.1
  • 14
    • 0028233530 scopus 로고
    • Biosynthesis and biochemical properties of the hepatitis C virus core protein
    • [PMID: 8189501]
    • Santolini E, Migliaccio G, La Monica N. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol 1994; 68: 3631-3641 [PMID: 8189501]
    • (1994) J Virol , vol.68 , pp. 3631-3641
    • Santolini, E.1    Migliaccio, G.2    La Monica, N.3
  • 15
    • 50149086906 scopus 로고    scopus 로고
    • Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
    • [PMID: 18562515 DOI: 10.1128/JVI.00306-08]
    • Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y. Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation. J Virol 2008; 82: 8349-8361 [PMID: 18562515 DOI: 10.1128/JVI.00306-08]
    • (2008) J Virol , vol.82 , pp. 8349-8361
    • Okamoto, K.1    Mori, Y.2    Komoda, Y.3    Okamoto, T.4    Okochi, M.5    Takeda, M.6    Suzuki, T.7    Moriishi, K.8    Matsuura, Y.9
  • 16
    • 33847116605 scopus 로고    scopus 로고
    • Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase
    • [PMID: 17237979 DOI: 10.1007/ s11373-006-9127-1]
    • Ma HC, Ku YY, Hsieh YC, Lo SY. Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase. J Biomed Sci 2007; 14: 31-41 [PMID: 17237979 DOI: 10.1007/ s11373-006-9127-1]
    • (2007) J Biomed Sci , vol.14 , pp. 31-41
    • Ma, H.C.1    Ku, Y.Y.2    Hsieh, Y.C.3    Lo, S.Y.4
  • 17
    • 6344265564 scopus 로고    scopus 로고
    • Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells
    • [PMID: 15479818]
    • Ogino T, Fukuda H, Imajoh-Ohmi S, Kohara M, Nomoto A. Membrane binding properties and terminal residues of the mature hepatitis C virus capsid protein in insect cells. J Virol 2004; 78: 11766-11777 [PMID: 15479818]
    • (2004) J Virol , vol.78 , pp. 11766-11777
    • Ogino, T.1    Fukuda, H.2    Imajoh-Ohmi, S.3    Kohara, M.4    Nomoto, A.5
  • 18
    • 0343035762 scopus 로고    scopus 로고
    • Evaluation of hepatitis C virus envelope proteins expressed in E. coli and insect cells for use as tools for antibody screening
    • [PMID: 9210602]
    • Hüssy P, Faust H, Wagner JC, Schmid G, Mous J, Jacobsen H. Evaluation of hepatitis C virus envelope proteins expressed in E. coli and insect cells for use as tools for antibody screening. J Hepatol 1997; 26: 1179-1186 [PMID: 9210602]
    • (1997) J Hepatol , vol.26 , pp. 1179-1186
    • Hüssy, P.1    Faust, H.2    Wagner, J.C.3    Schmid, G.4    Mous, J.5    Jacobsen, H.6
  • 19
    • 75449084143 scopus 로고    scopus 로고
    • Genetic analysis of the carboxy-terminal region of the hepatitis C virus core protein
    • [PMID: 20007277 DOI: 10.1128/JVI.02043-09]
    • Kopp M, Murray CL, Jones CT, Rice CM. Genetic analysis of the carboxy-terminal region of the hepatitis C virus core protein. J Virol 2010; 84: 1666-1673 [PMID: 20007277 DOI: 10.1128/JVI.02043-09]
    • (2010) J Virol , vol.84 , pp. 1666-1673
    • Kopp, M.1    Murray, C.L.2    Jones, C.T.3    Rice, C.M.4
  • 20
    • 0033373404 scopus 로고    scopus 로고
    • Hepatitis C virus genotypes and quasispecies
    • [PMID: 10653451]
    • Davis GL. Hepatitis C virus genotypes and quasispecies. Am J Med 1999; 107: 21S-26S [PMID: 10653451]
    • (1999) Am J Med , vol.107
    • Davis, G.L.1
  • 21
    • 0028218513 scopus 로고
    • Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS-5 regions
    • [PMID: 8176367]
    • Simmonds P, Smith DB, McOmish F, Yap PL, Kolberg J, Urdea MS, Holmes EC. Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS-5 regions. J Gen Virol 1994; 75 (Pt 5): 1053-1061 [PMID: 8176367]
    • (1994) J Gen Virol , vol.75 , Issue.PART 5 , pp. 1053-1061
    • Simmonds, P.1    Smith, D.B.2    McOmish, F.3    Yap, P.L.4    Kolberg, J.5    Urdea, M.S.6    Holmes, E.C.7
  • 22
    • 84857586532 scopus 로고    scopus 로고
    • Direct binding of a hepatitis C virus inhibitor to the viral capsid protein
    • [PMID: 22389688 DOI: 10.1371/journal.pone.0032207]
    • Kota S, Takahashi V, Ni F, Snyder JK, Strosberg AD. Direct binding of a hepatitis C virus inhibitor to the viral capsid protein. PLoS One 2012; 7: e32207 [PMID: 22389688 DOI: 10.1371/journal.pone.0032207]
    • (2012) PLoS One , vol.7
    • Kota, S.1    Takahashi, V.2    Ni, F.3    Snyder, J.K.4    Strosberg, A.D.5
  • 23
    • 77649199607 scopus 로고    scopus 로고
    • Cellular lipid droplets and hepatitis C virus life cycle
    • [PMID: 20190392]
    • Fukasawa M. Cellular lipid droplets and hepatitis C virus life cycle. Biol Pharm Bull 2010; 33: 355-359 [PMID: 20190392]
    • (2010) Biol Pharm Bull , vol.33 , pp. 355-359
    • Fukasawa, M.1
  • 24
    • 43049117108 scopus 로고    scopus 로고
    • Hepatitis C virus core protein: Its coordinate roles with PA28gamma in metabolic abnormality and carcinogenicity in the liver
    • [PMID: 18321762 DOI: 10.1016/ j.biocel.2008.01.027]
    • Mori Y, Moriishi K, Matsuura Y. Hepatitis C virus core protein: its coordinate roles with PA28gamma in metabolic abnormality and carcinogenicity in the liver. Int J Biochem Cell Biol 2008; 40: 1437-1442 [PMID: 18321762 DOI: 10.1016/ j.biocel.2008.01.027]
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1437-1442
    • Mori, Y.1    Moriishi, K.2    Matsuura, Y.3
  • 27
    • 0028840840 scopus 로고
    • Differential subcellular localization of hepatitis C virus core gene products
    • [PMID: 7491770]
    • Lo SY, Masiarz F, Hwang SB, Lai MM, Ou JH. Differential subcellular localization of hepatitis C virus core gene products. Virology 1995; 213: 455-461 [PMID: 7491770]
    • (1995) Virology , vol.213 , pp. 455-461
    • Lo, S.Y.1    Masiarz, F.2    Hwang, S.B.3    Lai, M.M.4    Ou, J.H.5
  • 29
    • 0028038280 scopus 로고
    • Sequence analysis of the core gene of 14 hepatitis C virus genotypes
    • [PMID: 8058787]
    • Bukh J, Purcell RH, Miller RH. Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci USA 1994; 91: 8239-8243 [PMID: 8058787]
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8239-8243
    • Bukh, J.1    Purcell, R.H.2    Miller, R.H.3
  • 30
    • 0035050164 scopus 로고    scopus 로고
    • Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame
    • [PMID: 11350035]
    • Walewski JL, Keller TR, Stump DD, Branch AD. Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame. RNA 2001; 7: 710-721 [PMID: 11350035]
    • (2001) RNA , vol.7 , pp. 710-721
    • Walewski, J.L.1    Keller, T.R.2    Stump, D.D.3    Branch, A.D.4
  • 31
    • 0028309691 scopus 로고
    • Comparative studies of the core gene products of two different hepatitis C virus isolates: Two alternative forms determined by a single amino acid substitution
    • [PMID: 8116235]
    • Lo SY, Selby M, Tong M, Ou JH. Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution. Virology 1994; 199: 124-131 [PMID: 8116235]
    • (1994) Virology , vol.199 , pp. 124-131
    • Lo, S.Y.1    Selby, M.2    Tong, M.3    Ou, J.H.4
  • 32
    • 0035898608 scopus 로고    scopus 로고
    • Synthesis of a novel hepatitis C virus protein by ribosomal frameshift
    • [PMID: 11447125 DOI: 10.1093/emboj/20.14.3840]
    • Xu Z, Choi J, Yen TS, Lu W, Strohecker A, Govindarajan S, Chien D, Selby MJ, Ou J. Synthesis of a novel hepatitis C virus protein by ribosomal frameshift. EMBO J 2001; 20: 3840-3848 [PMID: 11447125 DOI: 10.1093/emboj/20.14.3840]
    • (2001) EMBO J , vol.20 , pp. 3840-3848
    • Xu, Z.1    Choi, J.2    Yen, T.S.3    Lu, W.4    Strohecker, A.5    Govindarajan, S.6    Chien, D.7    Selby, M.J.8    Ou, J.9
  • 33
    • 0037124073 scopus 로고    scopus 로고
    • Alternate translation occurs within the core coding region of the hepatitis C viral genome
    • [PMID: 11884417 DOI: 10.1074/jbc.M201722200]
    • Varaklioti A, Vassilaki N, Georgopoulou U, Mavromara P. Alternate translation occurs within the core coding region of the hepatitis C viral genome. J Biol Chem 2002; 277: 17713-17721 [PMID: 11884417 DOI: 10.1074/jbc.M201722200]
    • (2002) J Biol Chem , vol.277 , pp. 17713-17721
    • Varaklioti, A.1    Vassilaki, N.2    Georgopoulou, U.3    Mavromara, P.4
  • 34
    • 14644415892 scopus 로고    scopus 로고
    • The hepatitis C virus alternate reading frame (ARF) and its family of novel products: The alternate reading frame protein/F-protein, the double-frameshift protein, and others
    • [PMID: 15732002 DOI: 10.1055/s-2005-864786]
    • Branch AD, Stump DD, Gutierrez JA, Eng F, Walewski JL. The hepatitis C virus alternate reading frame (ARF) and its family of novel products: the alternate reading frame protein/F-protein, the double-frameshift protein, and others. Semin Liver Dis 2005; 25: 105-117 [PMID: 15732002 DOI: 10.1055/s-2005-864786]
    • (2005) Semin Liver Dis , vol.25 , pp. 105-117
    • Branch, A.D.1    Stump, D.D.2    Gutierrez, J.A.3    Eng, F.4    Walewski, J.L.5
  • 35
    • 0242413008 scopus 로고    scopus 로고
    • Unusual multiple recoding events leading to alternative forms of hepatitis C virus core protein from genotype 1b
    • [PMID: 12952944 DOI: 10.1074/jbc. M307174200]
    • Boulant S, Becchi M, Penin F, Lavergne JP. Unusual multiple recoding events leading to alternative forms of hepatitis C virus core protein from genotype 1b. J Biol Chem 2003; 278: 45785-45792 [PMID: 12952944 DOI: 10.1074/jbc. M307174200]
    • (2003) J Biol Chem , vol.278 , pp. 45785-45792
    • Boulant, S.1    Becchi, M.2    Penin, F.3    Lavergne, J.P.4
  • 36
    • 14844348002 scopus 로고    scopus 로고
    • Translation of the F protein of hepatitis C virus is initiated at a non-AUG codon in a +1 reading frame relative to the polyprotein
    • [PMID: 15755749]
    • Baril M, Brakier-Gingras L. Translation of the F protein of hepatitis C virus is initiated at a non-AUG codon in a +1 reading frame relative to the polyprotein. Nucleic Acids Res 2005; 33: 1474-1486 [PMID: 15755749]
    • (2005) Nucleic Acids Res , vol.33 , pp. 1474-1486
    • Baril, M.1    Brakier-Gingras, L.2
  • 37
    • 41049108222 scopus 로고    scopus 로고
    • Expression studies of the HCV-1a core+1 open reading frame in mammalian cells
    • [PMID: 18243391 DOI: 10.1016/ j.virusres.2007.10.019]
    • Vassilaki N, Boleti H, Mavromara P. Expression studies of the HCV-1a core+1 open reading frame in mammalian cells. Virus Res 2008; 133: 123-135 [PMID: 18243391 DOI: 10.1016/ j.virusres.2007.10.019]
    • (2008) Virus Res , vol.133 , pp. 123-135
    • Vassilaki, N.1    Boleti, H.2    Mavromara, P.3
  • 38
    • 78650582619 scopus 로고    scopus 로고
    • Internal translation initiation stimulates expression of the ARF/core+1 open reading frame of HCV genotype 1b
    • [PMID: 20959129 DOI: 10.1016/j.virusres.2010.10.007]
    • Boumlic A, Vassilaki N, Dalagiorgou G, Kochlios E, Kakkanas A, Georgopoulou U, Markoulatos P, Orfanoudakis G, Mavromara P. Internal translation initiation stimulates expression of the ARF/core+1 open reading frame of HCV genotype 1b. Virus Res 2011; 155: 213-220 [PMID: 20959129 DOI: 10.1016/j.virusres.2010.10.007]
    • (2011) Virus Res , vol.155 , pp. 213-220
    • Boumlic, A.1    Vassilaki, N.2    Dalagiorgou, G.3    Kochlios, E.4    Kakkanas, A.5    Georgopoulou, U.6    Markoulatos, P.7    Orfanoudakis, G.8    Mavromara, P.9
  • 39
    • 44349122400 scopus 로고    scopus 로고
    • The major form of hepatitis C virus alternate reading frame protein is suppressed by core protein expression
    • [PMID: 18400784 DOI: 10.1093/nar/ gkn111]
    • Wolf M, Dimitrova M, Baumert TF, Schuster C. The major form of hepatitis C virus alternate reading frame protein is suppressed by core protein expression. Nucleic Acids Res 2008; 36: 3054-3064 [PMID: 18400784 DOI: 10.1093/nar/ gkn111]
    • (2008) Nucleic Acids Res , vol.36 , pp. 3054-3064
    • Wolf, M.1    Dimitrova, M.2    Baumert, T.F.3    Schuster, C.4
  • 40
    • 69249215471 scopus 로고    scopus 로고
    • The HCV ARFP/F/core+1 protein: Production and functional analysis of an unconventional viral product
    • [PMID: 19548320 DOI: 10.1002/iub.201]
    • Vassilaki N, Mavromara P. The HCV ARFP/F/core+1 protein: production and functional analysis of an unconventional viral product. IUBMB Life 2009; 61: 739-752 [PMID: 19548320 DOI: 10.1002/iub.201]
    • (2009) IUBMB Life , vol.61 , pp. 739-752
    • Vassilaki, N.1    Mavromara, P.2
  • 41
    • 34547795201 scopus 로고    scopus 로고
    • Expression studies of the core+1 protein of the hepatitis C virus 1a in mammalian cells. The influence of the core protein and proteasomes on the intracellular levels of core+1
    • [PMID: 17651444]
    • Vassilaki N, Boleti H, Mavromara P. Expression studies of the core+1 protein of the hepatitis C virus 1a in mammalian cells. The influence of the core protein and proteasomes on the intracellular levels of core+1. FEBS J 2007; 274: 4057-4074 [PMID: 17651444]
    • (2007) FEBS J , vol.274 , pp. 4057-4074
    • Vassilaki, N.1    Boleti, H.2    Mavromara, P.3
  • 42
    • 0037223688 scopus 로고    scopus 로고
    • Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum
    • [PMID: 12502871]
    • Xu Z, Choi J, Lu W, Ou JH. Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum. J Virol 2003; 77: 1578-1583 [PMID: 12502871]
    • (2003) J Virol , vol.77 , pp. 1578-1583
    • Xu, Z.1    Choi, J.2    Lu, W.3    Ou, J.H.4
  • 43
    • 58149517677 scopus 로고    scopus 로고
    • Ubiquitin-independent degradation of hepatitis C virus F protein
    • [PMID: 18971267 DOI: 10.1128/JVI.00832-08]
    • Yuksek K, Chen WL, Chien D, Ou JH. Ubiquitin-independent degradation of hepatitis C virus F protein. J Virol 2009; 83: 612-621 [PMID: 18971267 DOI: 10.1128/JVI.00832-08]
    • (2009) J Virol , vol.83 , pp. 612-621
    • Yuksek, K.1    Chen, W.L.2    Chien, D.3    Ou, J.H.4
  • 45
    • 34250634419 scopus 로고    scopus 로고
    • New animal models for hepatitis C viral infection and pathogenesis studies
    • [PMID: 17552025]
    • Kremsdorf D, Brezillon N. New animal models for hepatitis C viral infection and pathogenesis studies. World J Gastroenterol 2007; 13: 2427-2435 [PMID: 17552025]
    • (2007) World J Gastroenterol , vol.13 , pp. 2427-2435
    • Kremsdorf, D.1    Brezillon, N.2
  • 46
    • 84855338121 scopus 로고    scopus 로고
    • Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species
    • [PMID: 22212930 DOI: 10.1159/000333253]
    • Fujinaga H, Tsutsumi T, Yotsuyanagi H, Moriya K, Koike K. Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species. Oncology 2011; 81 Suppl 1: 11-17 [PMID: 22212930 DOI: 10.1159/000333253]
    • (2011) Oncology , vol.81 , Issue.SUPPL. 1 , pp. 11-17
    • Fujinaga, H.1    Tsutsumi, T.2    Yotsuyanagi, H.3    Moriya, K.4    Koike, K.5
  • 47
    • 34547449770 scopus 로고    scopus 로고
    • Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: Studies in vitro and in conditionally transgenic mice
    • [PMID: 17659694]
    • Chang ML, Chen JC, Yeh CT, Sheen IS, Tai DI, Chang MY, Chiu CT, Lin DY, Bissell DM. Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice. World J Gastroenterol 2007; 13: 3472-3477 [PMID: 17659694]
    • (2007) World J Gastroenterol , vol.13 , pp. 3472-3477
    • Chang, M.L.1    Chen, J.C.2    Yeh, C.T.3    Sheen, I.S.4    Tai, D.I.5    Chang, M.Y.6    Chiu, C.T.7    Lin, D.Y.8    Bissell, D.M.9
  • 49
    • 33846849610 scopus 로고    scopus 로고
    • Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein
    • [PMID: 17135326]
    • Miyamoto H, Moriishi K, Moriya K, Murata S, Tanaka K, Suzuki T, Miyamura T, Koike K, Matsuura Y. Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein. J Virol 2007; 81: 1727-1735 [PMID: 17135326]
    • (2007) J Virol , vol.81 , pp. 1727-1735
    • Miyamoto, H.1    Moriishi, K.2    Moriya, K.3    Murata, S.4    Tanaka, K.5    Suzuki, T.6    Miyamura, T.7    Koike, K.8    Matsuura, Y.9
  • 51
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance
    • [PMID: 14988838]
    • Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, Moriya K, Koike K. Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004; 126: 840-848 [PMID: 14988838]
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3    Tsutsumi, T.4    Tsukamoto, K.5    Kimura, S.6    Moriya, K.7    Koike, K.8
  • 52
    • 69549138347 scopus 로고    scopus 로고
    • Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation
    • [PMID: 19664232 DOI: 10.1186/1755-8794-2-51]
    • Chang ML, Yeh CT, Lin DY, Ho YP, Hsu CM, Bissell DM. Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation. BMC Med Genomics 2009; 2: 51 [PMID: 19664232 DOI: 10.1186/1755-8794-2-51]
    • (2009) BMC Med Genomics , vol.2 , pp. 51
    • Chang, M.L.1    Yeh, C.T.2    Lin, D.Y.3    Ho, Y.P.4    Hsu, C.M.5    Bissell, D.M.6
  • 54
    • 78149449552 scopus 로고    scopus 로고
    • Network based analysis of hepatitis C virus core and NS4B protein interactions
    • [PMID: 20953506 DOI: 10.1039/c0mb00103a]
    • Tripathi LP, Kataoka C, Taguwa S, Moriishi K, Mori Y, Matsuura Y, Mizuguchi K. Network based analysis of hepatitis C virus core and NS4B protein interactions. Mol Biosyst 2010; 6: 2539-2553 [PMID: 20953506 DOI: 10.1039/c0mb00103a]
    • (2010) Mol Biosyst , vol.6 , pp. 2539-2553
    • Tripathi, L.P.1    Kataoka, C.2    Taguwa, S.3    Moriishi, K.4    Mori, Y.5    Matsuura, Y.6    Mizuguchi, K.7
  • 55
    • 84859487519 scopus 로고    scopus 로고
    • Fuzziness in the core of the human pathogenic viruses HCV and HIV
    • [PMID: 22399323 DOI: 10.1007/978-1-461 4-0659-4_9]
    • Ivanyi-Nagy R, Darlix JL. Fuzziness in the core of the human pathogenic viruses HCV and HIV. Adv Exp Med Biol 2012; 725: 142-158 [PMID: 22399323 DOI: 10.1007/978-1-461 4-0659-4_9]
    • (2012) Adv Exp Med Biol , vol.725 , pp. 142-158
    • Ivanyi-Nagy, R.1    Darlix, J.L.2
  • 56
    • 79952126737 scopus 로고    scopus 로고
    • Oncogenic potential of hepatitis C virus proteins
    • [PMID: 21994721 DOI: 10.3390/v2092108]
    • Banerjee A, Ray RB, Ray R. Oncogenic potential of hepatitis C virus proteins. Viruses 2010; 2: 2108-2133 [PMID: 21994721 DOI: 10.3390/v2092108]
    • (2010) Viruses , vol.2 , pp. 2108-2133
    • Banerjee, A.1    Ray, R.B.2    Ray, R.3
  • 57
    • 17844372967 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates hepatocyte growth: Correlation with upregulation of wnt-1 expression
    • [PMID: 15841445 DOI: 10.1002/hep.20668]
    • Fukutomi T, Zhou Y, Kawai S, Eguchi H, Wands JR, Li J. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology 2005; 41: 1096-1105 [PMID: 15841445 DOI: 10.1002/hep.20668]
    • (2005) Hepatology , vol.41 , pp. 1096-1105
    • Fukutomi, T.1    Zhou, Y.2    Kawai, S.3    Eguchi, H.4    Wands, J.R.5    Li, J.6
  • 58
    • 84878199095 scopus 로고    scopus 로고
    • Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice
    • [PMID: 23628415 DOI: 10.1016/ j.bbrc.2013.04.059]
    • Hu WT, Li HC, Lee SK, Ma HC, Yang CH, Chen HL, Lo SY. Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice. Biochem Biophys Res Commun 2013; 435: 147-152 [PMID: 23628415 DOI: 10.1016/ j.bbrc.2013.04.059]
    • (2013) Biochem Biophys Res Commun , vol.435 , pp. 147-152
    • Hu, W.T.1    Li, H.C.2    Lee, S.K.3    Ma, H.C.4    Yang, C.H.5    Chen, H.L.6    Lo, S.Y.7
  • 59
    • 33646887378 scopus 로고    scopus 로고
    • Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes
    • [PMID: 16545852]
    • Basu A, Meyer K, Lai KK, Saito K, Di Bisceglie AM, Grosso LE, Ray RB, Ray R. Microarray analyses and molecular profiling of Stat3 signaling pathway induced by hepatitis C virus core protein in human hepatocytes. Virology 2006; 349: 347-358 [PMID: 16545852]
    • (2006) Virology , vol.349 , pp. 347-358
    • Basu, A.1    Meyer, K.2    Lai, K.K.3    Saito, K.4    Di Bisceglie, A.M.5    Grosso, L.E.6    Ray, R.B.7    Ray, R.8
  • 60
    • 64749092296 scopus 로고    scopus 로고
    • Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins
    • [PMID: 18803589 DOI: 10.1111/j.1478-3231.2008.01866.x]
    • Pazienza V, Clément S, Pugnale P, Conzelmann S, Pascarella S, Mangia A, Negro F. Gene expression profile of Huh-7 cells expressing hepatitis C virus genotype 1b or 3a core proteins. Liver Int 2009; 29: 661-669 [PMID: 18803589 DOI: 10.1111/j.1478-3231.2008.01866.x]
    • (2009) Liver Int , vol.29 , pp. 661-669
    • Pazienza, V.1    Clément, S.2    Pugnale, P.3    Conzelmann, S.4    Pascarella, S.5    Mangia, A.6    Negro, F.7
  • 62
    • 34547752462 scopus 로고    scopus 로고
    • Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins
    • [PMID: 17404395]
    • Budhu A, Chen Y, Kim JW, Forgues M, Valerie K, Harris CC, Wang XW. Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins. Carcinogenesis 2007; 28: 1552-1560 [PMID: 17404395]
    • (2007) Carcinogenesis , vol.28 , pp. 1552-1560
    • Budhu, A.1    Chen, Y.2    Kim, J.W.3    Forgues, M.4    Valerie, K.5    Harris, C.C.6    Wang, X.W.7
  • 63
    • 17644368895 scopus 로고    scopus 로고
    • Effect of heptitis C virus core protein on cellular gene expression: Specific inhibition of cyclooxygenase 2
    • [PMID: 15809909]
    • Jhaveri R, Kundu P, Shapiro AM, Venkatesan A, Dasgupta A. Effect of heptitis C virus core protein on cellular gene expression: specific inhibition of cyclooxygenase 2. J Infect Dis 2005; 191: 1498-1506 [PMID: 15809909]
    • (2005) J Infect Dis , vol.191 , pp. 1498-1506
    • Jhaveri, R.1    Kundu, P.2    Shapiro, A.M.3    Venkatesan, A.4    Dasgupta, A.5
  • 64
    • 33746467483 scopus 로고    scopus 로고
    • Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes
    • [PMID: 16838065 DOI: 10.2119/2006-00020.Wu]
    • Wu CG, Budhu A, Chen S, Zhou X, Popescu NC, Valerie K, Wang XW. Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes. Mol Med 2006; 12: 47-53 [PMID: 16838065 DOI: 10.2119/2006-00020.Wu]
    • (2006) Mol Med , vol.12 , pp. 47-53
    • Wu, C.G.1    Budhu, A.2    Chen, S.3    Zhou, X.4    Popescu, N.C.5    Valerie, K.6    Wang, X.W.7
  • 66
    • 32944477003 scopus 로고    scopus 로고
    • Cellular response to gene expression profiles of different hepatitis C virus core proteins in the Huh-7 cell line with microarray analysis
    • [PMID: 16193983]
    • Dou J, Liu P, Zhang X. Cellular response to gene expression profiles of different hepatitis C virus core proteins in the Huh-7 cell line with microarray analysis. J Nanosci Nanotechnol 2005; 5: 1230-1235 [PMID: 16193983]
    • (2005) J Nanosci Nanotechnol , vol.5 , pp. 1230-1235
    • Dou, J.1    Liu, P.2    Zhang, X.3
  • 67
    • 34249862369 scopus 로고    scopus 로고
    • Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV
    • [PMID: 16893504]
    • Dou J, Liu P, Wang J, Zhang X. Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV. Cell Mol Immunol 2006; 3: 227-233 [PMID: 16893504]
    • (2006) Cell Mol Immunol , vol.3 , pp. 227-233
    • Dou, J.1    Liu, P.2    Wang, J.3    Zhang, X.4
  • 68
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • [PMID: 19167326 DOI: 10.1016/j.cell.2009.01.002]
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233 [PMID: 19167326 DOI: 10.1016/j.cell.2009.01.002]
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 69
    • 84875340222 scopus 로고    scopus 로고
    • The effects of hepatitis C virus core protein on the expression of miR-122 in vitro
    • [PMID: 23537271 DOI: 10.1186/1743-422X-10-98]
    • Li S, Xing X, Yang Q, Xu H, He J, Chen Z, Zhu H. The effects of hepatitis C virus core protein on the expression of miR-122 in vitro. Virol J 2013; 10: 98 [PMID: 23537271 DOI: 10.1186/1743-422X-10-98]
    • (2013) Virol J , vol.10 , pp. 98
    • Li, S.1    Xing, X.2    Yang, Q.3    Xu, H.4    He, J.5    Chen, Z.6    Zhu, H.7
  • 70
    • 84866602061 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3
    • [PMID: 22819820 DOI: 10.1016/j.febslet.2012.06.049]
    • Zeng B, Li Z, Chen R, Guo N, Zhou J, Zhou Q, Lin Q, Cheng D, Liao Q, Zheng L, Gong Y. Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3. FEBS Lett 2012; 586: 3271-3278 [PMID: 22819820 DOI: 10.1016/j.febslet.2012.06.049]
    • (2012) FEBS Lett , vol.586 , pp. 3271-3278
    • Zeng, B.1    Li, Z.2    Chen, R.3    Guo, N.4    Zhou, J.5    Zhou, Q.6    Lin, Q.7    Cheng, D.8    Liao, Q.9    Zheng, L.10    Gong, Y.11
  • 71
    • 84875991033 scopus 로고    scopus 로고
    • Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells
    • [PMID: 23577194 DOI: 10.1371/ journal.pone.0061089]
    • Shiu TY, Huang SM, Shih YL, Chu HC, Chang WK, Hsieh TY. Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells. PLoS One 2013; 8: e61089 [PMID: 23577194 DOI: 10.1371/ journal.pone.0061089]
    • (2013) PLoS One , vol.8
    • Shiu, T.Y.1    Huang, S.M.2    Shih, Y.L.3    Chu, H.C.4    Chang, W.K.5    Hsieh, T.Y.6
  • 72
    • 84864337139 scopus 로고    scopus 로고
    • Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection
    • [PMID: 22846613 DOI: 10.1186/1479-5876-10-151]
    • Bala S, Tilahun Y, Taha O, Alao H, Kodys K, Catalano D, Szabo G. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. J Transl Med 2012; 10: 151 [PMID: 22846613 DOI: 10.1186/1479-5876-10-151]
    • (2012) J Transl Med , vol.10 , pp. 151
    • Bala, S.1    Tilahun, Y.2    Taha, O.3    Alao, H.4    Kodys, K.5    Catalano, D.6    Szabo, G.7
  • 74
    • 84863539854 scopus 로고    scopus 로고
    • Differentially expressed microRNAs in Huh-7 cells expressing HCV core genotypes 3a or 1b: Potential functions and downstream pathways
    • [PMID: 22580575 DOI: 10.3892/ijmm.2012.991]
    • Gu Y, Xu Y, Jiang L, Cao X, Liu F, Li H, Zhang L, Li Z, Li J, Ye J, Li Q. Differentially expressed microRNAs in Huh-7 cells expressing HCV core genotypes 3a or 1b: potential functions and downstream pathways. Int J Mol Med 2012; 30: 374-382 [PMID: 22580575 DOI: 10.3892/ijmm.2012.991]
    • (2012) Int J Mol Med , vol.30 , pp. 374-382
    • Gu, Y.1    Xu, Y.2    Jiang, L.3    Cao, X.4    Liu, F.5    Li, H.6    Zhang, L.7    Li, Z.8    Li, J.9    Ye, J.10    Li, Q.11
  • 75
    • 34848842182 scopus 로고    scopus 로고
    • Hepatitis C virus infection and apoptosis
    • [PMID: 17828818]
    • Fischer R, Baumert T, Blum HE. Hepatitis C virus infection and apoptosis. World J Gastroenterol 2007; 13: 4865-4872 [PMID: 17828818]
    • (2007) World J Gastroenterol , vol.13 , pp. 4865-4872
    • Fischer, R.1    Baumert, T.2    Blum, H.E.3
  • 76
    • 84857640803 scopus 로고    scopus 로고
    • Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC
    • [PMID: 22266242 DOI: 10.1016/ j.meegid.2012.01.006]
    • Jahan S, Ashfaq UA, Khaliq S, Samreen B, Afzal N. Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC. Infect Genet Evol 2012; 12: 236-239 [PMID: 22266242 DOI: 10.1016/ j.meegid.2012.01.006]
    • (2012) Infect Genet Evol , vol.12 , pp. 236-239
    • Jahan, S.1    Ashfaq, U.A.2    Khaliq, S.3    Samreen, B.4    Afzal, N.5
  • 77
    • 0031550806 scopus 로고    scopus 로고
    • Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein
    • [PMID: 9123879]
    • Ruggieri A, Harada T, Matsuura Y, Miyamura T. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology 1997; 229: 68-76 [PMID: 9123879]
    • (1997) Virology , vol.229 , pp. 68-76
    • Ruggieri, A.1    Harada, T.2    Matsuura, Y.3    Miyamura, T.4
  • 79
    • 0031892177 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein
    • [PMID: 9442069]
    • Ray RB, Meyer K, Steele R, Shrivastava A, Aggarwal BB, Ray R. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein. J Biol Chem 1998; 273: 2256-2259 [PMID: 9442069]
    • (1998) J Biol Chem , vol.273 , pp. 2256-2259
    • Ray, R.B.1    Meyer, K.2    Steele, R.3    Shrivastava, A.4    Aggarwal, B.B.5    Ray, R.6
  • 80
    • 0031957325 scopus 로고    scopus 로고
    • Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
    • [PMID: 9557650]
    • Zhu N, Khoshnan A, Schneider R, Matsumoto M, Dennert G, Ware C, Lai MM. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol 1998; 72: 3691-3697 [PMID: 9557650]
    • (1998) J Virol , vol.72 , pp. 3691-3697
    • Zhu, N.1    Khoshnan, A.2    Schneider, R.3    Matsumoto, M.4    Dennert, G.5    Ware, C.6    Lai, M.M.7
  • 81
    • 33646166625 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein
    • [PMID: 16611896]
    • Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R. Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein. J Virol 2006; 80: 4372-4379 [PMID: 16611896]
    • (2006) J Virol , vol.80 , pp. 4372-4379
    • Saito, K.1    Meyer, K.2    Warner, R.3    Basu, A.4    Ray, R.B.5    Ray, R.6
  • 82
    • 81555237181 scopus 로고    scopus 로고
    • Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line
    • [PMID: 22108100 DOI: 10.1186/1743-422X-8-522]
    • Jahan S, Khaliq S, Siddiqi MH, Ijaz B, Ahmad W, Ashfaq UA, Hassan S. Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line. Virol J 2011; 8: 522 [PMID: 22108100 DOI: 10.1186/1743-422X-8-522]
    • (2011) Virol J , vol.8 , pp. 522
    • Jahan, S.1    Khaliq, S.2    Siddiqi, M.H.3    Ijaz, B.4    Ahmad, W.5    Ashfaq, U.A.6    Hassan, S.7
  • 83
    • 0037399329 scopus 로고    scopus 로고
    • The hepatitis C virus persistence: How to evade the immune system?
    • [PMID: 12734407]
    • Pavio N, Lai MM. The hepatitis C virus persistence: how to evade the immune system? J Biosci 2003; 28: 287-304 [PMID: 12734407]
    • (2003) J Biosci , vol.28 , pp. 287-304
    • Pavio, N.1    Lai, M.M.2
  • 84
    • 79953105820 scopus 로고    scopus 로고
    • Sequence variability of HCV Core region: Important predictors of HCV induced pathogenesis and viral production
    • [PMID: 21292033 DOI: 10.1016/ j.meegid.2011.01.017]
    • Khaliq S, Jahan S, Pervaiz A. Sequence variability of HCV Core region: important predictors of HCV induced pathogenesis and viral production. Infect Genet Evol 2011; 11: 543-556 [PMID: 21292033 DOI: 10.1016/ j.meegid.2011.01.017]
    • (2011) Infect Genet Evol , vol.11 , pp. 543-556
    • Khaliq, S.1    Jahan, S.2    Pervaiz, A.3
  • 85
    • 84879992779 scopus 로고    scopus 로고
    • Mutations in the STAT1-interacting domain of the hepatitis C virus core protein modulate the response to antiviral therapy
    • [PMID: 23799612 DOI: 10.3892/mmr.2013.1541]
    • Anjum S, Afzal MS, Ahmad T, Aslam B, Waheed Y, Shafi T, Qadri I. Mutations in the STAT1-interacting domain of the hepatitis C virus core protein modulate the response to antiviral therapy. Mol Med Rep 2013; 8: 487-492 [PMID: 23799612 DOI: 10.3892/mmr.2013.1541]
    • (2013) Mol Med Rep , vol.8 , pp. 487-492
    • Anjum, S.1    Afzal, M.S.2    Ahmad, T.3    Aslam, B.4    Waheed, Y.5    Shafi, T.6    Qadri, I.7
  • 86
    • 33748488244 scopus 로고    scopus 로고
    • Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain
    • [PMID: 16940534]
    • Lin W, Kim SS, Yeung E, Kamegaya Y, Blackard JT, Kim KA, Holtzman MJ, Chung RT. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J Virol 2006; 80: 9226-9235 [PMID: 16940534]
    • (2006) J Virol , vol.80 , pp. 9226-9235
    • Lin, W.1    Kim, S.S.2    Yeung, E.3    Kamegaya, Y.4    Blackard, J.T.5    Kim, K.A.6    Holtzman, M.J.7    Chung, R.T.8
  • 87
    • 84870341699 scopus 로고    scopus 로고
    • Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1
    • [PMID: 23122814 DOI: 10.1016/ j.bbrc.2012.10.079]
    • Inoue K, Tsukiyama-Kohara K, Matsuda C, Yoneyama M, Fujita T, Kuge S, Yoshiba M, Kohara M. Impairment of interferon regulatory factor-3 activation by hepatitis C virus core protein basic amino acid region 1. Biochem Biophys Res Commun 2012; 428: 494-499 [PMID: 23122814 DOI: 10.1016/ j.bbrc.2012.10.079]
    • (2012) Biochem Biophys Res Commun , vol.428 , pp. 494-499
    • Inoue, K.1    Tsukiyama-Kohara, K.2    Matsuda, C.3    Yoneyama, M.4    Fujita, T.5    Kuge, S.6    Yoshiba, M.7    Kohara, M.8
  • 88
    • 84860327274 scopus 로고    scopus 로고
    • Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants
    • [PMID: 22616990 DOI: 10.1016/j.febslet.2012.03.062]
    • Kang JI, Kwon YC, Ahn BY. Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants. FEBS Lett 2012; 586: 1272-1278 [PMID: 22616990 DOI: 10.1016/j.febslet.2012.03.062]
    • (2012) FEBS Lett , vol.586 , pp. 1272-1278
    • Kang, J.I.1    Kwon, Y.C.2    Ahn, B.Y.3
  • 89
    • 78650127763 scopus 로고    scopus 로고
    • Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction
    • [PMID: 21170385 DOI: 10.1371/journal.pone.0014258]
    • Oshiumi H, Ikeda M, Matsumoto M, Watanabe A, Takeuchi O, Akira S, Kato N, Shimotohno K, Seya T. Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS One 2010; 5: e14258 [PMID: 21170385 DOI: 10.1371/journal.pone.0014258]
    • (2010) PLoS One , vol.5
    • Oshiumi, H.1    Ikeda, M.2    Matsumoto, M.3    Watanabe, A.4    Takeuchi, O.5    Akira, S.6    Kato, N.7    Shimotohno, K.8    Seya, T.9
  • 90
    • 83455235444 scopus 로고    scopus 로고
    • The effects of hepatitis C virus core protein on functional responses in the NK cell line YTS
    • [PMID: 21916918 DOI: 10.1111/j.1365-3083.2011.02624. x]
    • Dominguez-Villar M, Garcia-Cozar FJ, Chambers BJ. The effects of hepatitis C virus core protein on functional responses in the NK cell line YTS. Scand J Immunol 2012; 75: 54-60 [PMID: 21916918 DOI: 10.1111/j.1365-3083.2011.02624. x]
    • (2012) Scand J Immunol , vol.75 , pp. 54-60
    • Dominguez-Villar, M.1    Garcia-Cozar, F.J.2    Chambers, B.J.3
  • 91
    • 84862514366 scopus 로고    scopus 로고
    • Interaction of Hepatitis C virus proteins with pattern recognition receptors
    • [PMID: 22726246 DOI: 10.1186/1743-422X-9-126]
    • Imran M, Waheed Y, Manzoor S, Bilal M, Ashraf W, Ali M, Ashraf M. Interaction of Hepatitis C virus proteins with pattern recognition receptors. Virol J 2012; 9: 126 [PMID: 22726246 DOI: 10.1186/1743-422X-9-126]
    • (2012) Virol J , vol.9 , pp. 126
    • Imran, M.1    Waheed, Y.2    Manzoor, S.3    Bilal, M.4    Ashraf, W.5    Ali, M.6    Ashraf, M.7
  • 92
    • 84880258824 scopus 로고    scopus 로고
    • Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles
    • [PMID: 23658447 DOI: 10.1128/ JVI.00917-13]
    • Mazumdar B, Kim H, Meyer K, Bose SK, Di Bisceglie AM, Ray RB, Diamond MS, Atkinson JP, Ray R. Hepatitis C virus infection upregulates CD55 expression on the hepatocyte surface and promotes association with virus particles. J Virol 2013; 87: 7902-7910 [PMID: 23658447 DOI: 10.1128/ JVI.00917-13]
    • (2013) J Virol , vol.87 , pp. 7902-7910
    • Mazumdar, B.1    Kim, H.2    Meyer, K.3    Bose, S.K.4    Di Bisceglie, A.M.5    Ray, R.B.6    Diamond, M.S.7    Atkinson, J.P.8    Ray, R.9
  • 93
    • 84877351660 scopus 로고    scopus 로고
    • Hepatitis C virus suppresses C9 complement synthesis and impairs membrane attack complex function
    • [PMID: 23487461 DOI: 10.1128/JVI.00174-13]
    • Kim H, Meyer K, Di Bisceglie AM, Ray R. Hepatitis C virus suppresses C9 complement synthesis and impairs membrane attack complex function. J Virol 2013; 87: 5858-5867 [PMID: 23487461 DOI: 10.1128/JVI.00174-13]
    • (2013) J Virol , vol.87 , pp. 5858-5867
    • Kim, H.1    Meyer, K.2    Di Bisceglie, A.M.3    Ray, R.4
  • 94
    • 0036720777 scopus 로고    scopus 로고
    • Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model
    • [PMID: 12186917]
    • Soguero C, Joo M, Chianese-Bullock KA, Nguyen DT, Tung K, Hahn YS. Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J Virol 2002; 76: 9345-9354 [PMID: 12186917]
    • (2002) J Virol , vol.76 , pp. 9345-9354
    • Soguero, C.1    Joo, M.2    Chianese-Bullock, K.A.3    Nguyen, D.T.4    Tung, K.5    Hahn, Y.S.6
  • 95
    • 77957747850 scopus 로고    scopus 로고
    • Programmed death-1 affects suppressor of cytokine signaling-1 expression in T cells during hepatitis C infection
    • [PMID: 20883163 DOI: 10.1089/vim.2010.0010]
    • Frazier AD, Zhang CL, Ni L, Ma CJ, Zhang Y, Wu XY, Atia AN, Yao ZQ, Moorman JP. Programmed death-1 affects suppressor of cytokine signaling-1 expression in T cells during hepatitis C infection. Viral Immunol 2010; 23: 487-495 [PMID: 20883163 DOI: 10.1089/vim.2010.0010]
    • (2010) Viral Immunol , vol.23 , pp. 487-495
    • Frazier, A.D.1    Zhang, C.L.2    Ni, L.3    Ma, C.J.4    Zhang, Y.5    Wu, X.Y.6    Atia, A.N.7    Yao, Z.Q.8    Moorman, J.P.9
  • 96
    • 79952761607 scopus 로고    scopus 로고
    • Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection
    • [PMID: 21263070 DOI: 10.4049/jimmunol.1002006]
    • Zhang Y, Ma CJ, Ni L, Zhang CL, Wu XY, Kumaraguru U, Li CF, Moorman JP, Yao ZQ. Cross-talk between programmed death-1 and suppressor of cytokine signaling-1 in inhibition of IL-12 production by monocytes/macrophages in hepatitis C virus infection. J Immunol 2011; 186: 3093-3103 [PMID: 21263070 DOI: 10.4049/jimmunol.1002006]
    • (2011) J Immunol , vol.186 , pp. 3093-3103
    • Zhang, Y.1    Ma, C.J.2    Ni, L.3    Zhang, C.L.4    Wu, X.Y.5    Kumaraguru, U.6    Li, C.F.7    Moorman, J.P.8    Yao, Z.Q.9
  • 97
    • 79957569297 scopus 로고    scopus 로고
    • Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection
    • [PMID: 21637332 DOI: 10.1371/journal.pone.0019664]
    • Zhang Y, Ma CJ, Wang JM, Ji XJ, Wu XY, Jia ZS, Moorman JP, Yao ZQ. Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection. PLoS One 2011; 6: e19664 [PMID: 21637332 DOI: 10.1371/journal.pone.0019664]
    • (2011) PLoS One , vol.6
    • Zhang, Y.1    Ma, C.J.2    Wang, J.M.3    Ji, X.J.4    Wu, X.Y.5    Jia, Z.S.6    Moorman, J.P.7    Yao, Z.Q.8
  • 98
    • 79953178933 scopus 로고    scopus 로고
    • Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway
    • [PMID: 21282107 DOI: 10.1074/jbc. M110.217653]
    • Tacke RS, Tosello-Trampont A, Nguyen V, Mullins DW, Hahn YS. Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. J Biol Chem 2011; 286: 10847-10855 [PMID: 21282107 DOI: 10.1074/jbc. M110.217653]
    • (2011) J Biol Chem , vol.286 , pp. 10847-10855
    • Tacke, R.S.1    Tosello-Trampont, A.2    Nguyen, V.3    Mullins, D.W.4    Hahn, Y.S.5
  • 99
    • 84866184701 scopus 로고    scopus 로고
    • Hepatitis C virus-mediated inhibition of cathepsin S increases invariant-chain expression on hepatocyte surface
    • [PMID: 22761382 DOI: 10.1128/JVI.00388-12]
    • Kim H, Mazumdar B, Bose SK, Meyer K, Di Bisceglie AM, Hoft DF, Ray R. Hepatitis C virus-mediated inhibition of cathepsin S increases invariant-chain expression on hepatocyte surface. J Virol 2012; 86: 9919-9928 [PMID: 22761382 DOI: 10.1128/JVI.00388-12]
    • (2012) J Virol , vol.86 , pp. 9919-9928
    • Kim, H.1    Mazumdar, B.2    Bose, S.K.3    Meyer, K.4    Di Bisceglie, A.M.5    Hoft, D.F.6    Ray, R.7
  • 100
    • 84860227446 scopus 로고    scopus 로고
    • Upregulation of FOXP3 and induction of suppressive function in CD4+ Jurkat T-cells expressing hepatitis C virus core protein
    • [PMID: 22214248 DOI: 10.1042/CS20110631]
    • Dominguez-Villar M, Fernandez-Ponce C, Munoz-Suano A, Gomez E, Rodríguez-Iglesias M, Garcia-Cozar F. Upregulation of FOXP3 and induction of suppressive function in CD4+ Jurkat T-cells expressing hepatitis C virus core protein. Clin Sci (Lond) 2012; 123: 15-27 [PMID: 22214248 DOI: 10.1042/CS20110631]
    • (2012) Clin Sci (Lond) , vol.123 , pp. 15-27
    • Dominguez-Villar, M.1    Fernandez-Ponce, C.2    Munoz-Suano, A.3    Gomez, E.4    Rodríguez-Iglesias, M.5    Garcia-Cozar, F.6
  • 103
    • 33645819203 scopus 로고    scopus 로고
    • Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus
    • [PMID: 16603728]
    • Choi J, Ou JH. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 2006; 290: G847-G851 [PMID: 16603728]
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Choi, J.1    Ou, J.H.2
  • 104
    • 27844604269 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
    • [PMID: 16150732]
    • Korenaga M, Wang T, Li Y, Showalter LA, Chan T, Sun J, Weinman SA. Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production. J Biol Chem 2005; 280: 37481-37488 [PMID: 16150732]
    • (2005) J Biol Chem , vol.280 , pp. 37481-37488
    • Korenaga, M.1    Wang, T.2    Li, Y.3    Showalter, L.A.4    Chan, T.5    Sun, J.6    Weinman, S.A.7
  • 105
    • 84896844772 scopus 로고    scopus 로고
    • Interactions Between Hepatitis C Virus and Mitochondria: Impact on Pathogenesis and Innate Immunity
    • [PMID: 23956955 DOI: 10.1007/s40139-013-0024-9]
    • Wang T, Weinman SA. Interactions Between Hepatitis C Virus and Mitochondria: Impact on Pathogenesis and Innate Immunity. Curr Pathobiol Rep 2013; 1: 179-187 [PMID: 23956955 DOI: 10.1007/s40139-013-0024-9]
    • (2013) Curr Pathobiol Rep , vol.1 , pp. 179-187
    • Wang, T.1    Weinman, S.A.2
  • 106
    • 79953220445 scopus 로고    scopus 로고
    • Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins
    • [PMID: 21216956 DOI: 10.1074/jbc. M110.186684]
    • Carvajal-Yepes M, Himmelsbach K, Schaedler S, Ploen D, Krause J, Ludwig L, Weiss T, Klingel K, Hildt E. Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins. J Biol Chem 2011; 286: 8941-8951 [PMID: 21216956 DOI: 10.1074/jbc. M110.186684]
    • (2011) J Biol Chem , vol.286 , pp. 8941-8951
    • Carvajal-Yepes, M.1    Himmelsbach, K.2    Schaedler, S.3    Ploen, D.4    Krause, J.5    Ludwig, L.6    Weiss, T.7    Klingel, K.8    Hildt, E.9
  • 107
    • 0036236226 scopus 로고    scopus 로고
    • Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cells
    • [PMID: 11981774]
    • Li K, Prow T, Lemon SM, Beard MR. Cellular response to conditional expression of hepatitis C virus core protein in Huh7 cultured human hepatoma cells. Hepatology 2002; 35: 1237-1246 [PMID: 11981774]
    • (2002) Hepatology , vol.35 , pp. 1237-1246
    • Li, K.1    Prow, T.2    Lemon, S.M.3    Beard, M.R.4
  • 108
    • 80052750522 scopus 로고    scopus 로고
    • Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells
    • [PMID: 21931870 DOI: 10.1371/journal. pone.0024957]
    • Ivanov AV, Smirnova OA, Ivanova ON, Masalova OV, Kochetkov SN, Isaguliants MG. Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells. PLoS One 2011; 6: e24957 [PMID: 21931870 DOI: 10.1371/journal. pone.0024957]
    • (2011) PLoS One , vol.6
    • Ivanov, A.V.1    Smirnova, O.A.2    Ivanova, O.N.3    Masalova, O.V.4    Kochetkov, S.N.5    Isaguliants, M.G.6
  • 110
    • 0028876341 scopus 로고
    • Hepatitis C: A multifaceted disease. Review of extrahepatic manifestations
    • [PMID: 7677303]
    • Gumber SC, Chopra S. Hepatitis C: a multifaceted disease. Review of extrahepatic manifestations. Ann Intern Med 1995; 123: 615-620 [PMID: 7677303]
    • (1995) Ann Intern Med , vol.123 , pp. 615-620
    • Gumber, S.C.1    Chopra, S.2
  • 112
    • 73449102141 scopus 로고    scopus 로고
    • Steatosis and insulin resistance in hepatitis C: A way out for the virus?
    • [PMID: 19859993]
    • Del Campo JA, Romero-Gómez M. Steatosis and insulin resistance in hepatitis C: a way out for the virus? World J Gastroenterol 2009; 15: 5014-5019 [PMID: 19859993]
    • (2009) World J Gastroenterol , vol.15 , pp. 5014-5019
    • Del Campo, J.A.1    Romero-Gómez, M.2
  • 113
    • 59449099132 scopus 로고    scopus 로고
    • Hepatitis C, insulin resistance and diabetes: Clinical and pathogenic data
    • [PMID: 19187069 DOI: 10.1111/j.1478-3231.2008.01952. x]
    • Serfaty L, Capeau J. Hepatitis C, insulin resistance and diabetes: clinical and pathogenic data. Liver Int 2009; 29 Suppl 2: 13-25 [PMID: 19187069 DOI: 10.1111/j.1478-3231.2008.01952. x]
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 2 , pp. 13-25
    • Serfaty, L.1    Capeau, J.2
  • 115
    • 40149089262 scopus 로고    scopus 로고
    • Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance
    • [PMID: 18160431]
    • Banerjee S, Saito K, Ait-Goughoulte M, Meyer K, Ray RB, Ray R. Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. J Virol 2008; 82: 2606-2612 [PMID: 18160431]
    • (2008) J Virol , vol.82 , pp. 2606-2612
    • Banerjee, S.1    Saito, K.2    Ait-Goughoulte, M.3    Meyer, K.4    Ray, R.B.5    Ray, R.6
  • 116
    • 34248671715 scopus 로고    scopus 로고
    • The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    • [PMID: 17465001 DOI: 10.1002/ hep.21634]
    • Pazienza V, Clément S, Pugnale P, Conzelman S, Foti M, Mangia A, Negro F. The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms. Hepatology 2007; 45: 1164-1171 [PMID: 17465001 DOI: 10.1002/ hep.21634]
    • (2007) Hepatology , vol.45 , pp. 1164-1171
    • Pazienza, V.1    Clément, S.2    Pugnale, P.3    Conzelman, S.4    Foti, M.5    Mangia, A.6    Negro, F.7
  • 117
    • 77954168704 scopus 로고    scopus 로고
    • Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells
    • [PMID: 20357037 DOI: 10.1099/ vir.0.020644-0]
    • Pazienza V, Vinciguerra M, Andriulli A, Mangia A. Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells. J Gen Virol 2010; 91: 1678-1686 [PMID: 20357037 DOI: 10.1099/ vir.0.020644-0]
    • (2010) J Gen Virol , vol.91 , pp. 1678-1686
    • Pazienza, V.1    Vinciguerra, M.2    Andriulli, A.3    Mangia, A.4
  • 118
    • 24644513922 scopus 로고    scopus 로고
    • Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans
    • [PMID: 16127460 DOI: 10.1172/ JCI23853]
    • Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB. Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest 2005; 115: 2462-2471 [PMID: 16127460 DOI: 10.1172/ JCI23853]
    • (2005) J Clin Invest , vol.115 , pp. 2462-2471
    • Banks, A.S.1    Li, J.2    McKeag, L.3    Hribal, M.L.4    Kashiwada, M.5    Accili, D.6    Rothman, P.B.7
  • 119
    • 36349030379 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy
    • [PMID: 17668875 DOI: 10.1002/hep.21782]
    • Persico M, Capasso M, Persico E, Svelto M, Russo R, Spano D, Crocè L, La Mura V, Moschella F, Masutti F, Torella R, Tiribelli C, Iolascon A. Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus-related chronic hepatitis: Insulin resistance and response to antiviral therapy. Hepatology 2007; 46: 1009-1015 [PMID: 17668875 DOI: 10.1002/hep.21782]
    • (2007) Hepatology , vol.46 , pp. 1009-1015
    • Persico, M.1    Capasso, M.2    Persico, E.3    Svelto, M.4    Russo, R.5    Spano, D.6    Crocè, L.7    La Mura, V.8    Moschella, F.9    Masutti, F.10    Torella, R.11    Tiribelli, C.12    Iolascon, A.13
  • 121
    • 79954583080 scopus 로고    scopus 로고
    • Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: Comparison between different genotypes and core protein sequence analysis
    • [PMID: 21503913 DOI: 10.1002/ jmv.22072]
    • Pascarella S, Clément S, Guilloux K, Conzelmann S, Penin F, Negro F. Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: comparison between different genotypes and core protein sequence analysis. J Med Virol 2011; 83: 1005-1015 [PMID: 21503913 DOI: 10.1002/ jmv.22072]
    • (2011) J Med Virol , vol.83 , pp. 1005-1015
    • Pascarella, S.1    Clément, S.2    Guilloux, K.3    Conzelmann, S.4    Penin, F.5    Negro, F.6
  • 122
    • 66449096358 scopus 로고    scopus 로고
    • Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus
    • [PMID: 19382270 DOI: 10.1002/ jmv.21473]
    • Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Saitoh S, Arase Y, Ikeda K, Kumada H. Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus. J Med Virol 2009; 81: 1032-1039 [PMID: 19382270 DOI: 10.1002/ jmv.21473]
    • (2009) J Med Virol , vol.81 , pp. 1032-1039
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3    Kawamura, Y.4    Yatsuji, H.5    Sezaki, H.6    Suzuki, Y.7    Hosaka, T.8    Kobayashi, M.9    Kobayashi, M.10    Saitoh, S.11    Arase, Y.12    Ikeda, K.13    Kumada, H.14
  • 124
    • 59349094958 scopus 로고    scopus 로고
    • Hepatitis C virus, steatosis and lipid abnormalities: Clinical and pathogenic data
    • [PMID: 19187070 DOI: 10.1111/ j.1478-3231.2008.01950.x]
    • Negro F, Sanyal AJ. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int 2009; 29 Suppl 2: 26-37 [PMID: 19187070 DOI: 10.1111/ j.1478-3231.2008.01950.x]
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 2 , pp. 26-37
    • Negro, F.1    Sanyal, A.J.2
  • 125
    • 77952567110 scopus 로고    scopus 로고
    • Hepatitis C virus-induced steatosis: An overview
    • [PMID: 20460926 DOI: 10.1159/000282105]
    • Negro F. Hepatitis C virus-induced steatosis: an overview. Dig Dis 2010; 28: 294-299 [PMID: 20460926 DOI: 10.1159/000282105]
    • (2010) Dig Dis , vol.28 , pp. 294-299
    • Negro, F.1
  • 126
    • 38449108483 scopus 로고    scopus 로고
    • Hepatitis C virus core protein, lipid droplets and steatosis
    • [PMID: 18086178]
    • Roingeard P, Hourioux C. Hepatitis C virus core protein, lipid droplets and steatosis. J Viral Hepat 2008; 15: 157-164 [PMID: 18086178]
    • (2008) J Viral Hepat , vol.15 , pp. 157-164
    • Roingeard, P.1    Hourioux, C.2
  • 128
    • 78149410401 scopus 로고    scopus 로고
    • Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis
    • [PMID: 20842391 DOI: 10.1007/s00705-010-0797-7]
    • Khan M, Jahan S, Khaliq S, Ijaz B, Ahmad W, Samreen B, Hassan S. Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis. Arch Virol 2010; 155: 1735-1753 [PMID: 20842391 DOI: 10.1007/s00705-010-0797-7]
    • (2010) Arch Virol , vol.155 , pp. 1735-1753
    • Khan, M.1    Jahan, S.2    Khaliq, S.3    Ijaz, B.4    Ahmad, W.5    Samreen, B.6    Hassan, S.7
  • 129
    • 18244365866 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis
    • [PMID: 11818366 DOI: 10.1096/ fj.01-0396com]
    • Perlemuter G, Sabile A, Letteron P, Vona G, Topilco A, Chrétien Y, Koike K, Pessayre D, Chapman J, Barba G, Bréchot C. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J 2002; 16: 185-194 [PMID: 11818366 DOI: 10.1096/ fj.01-0396com]
    • (2002) FASEB J , vol.16 , pp. 185-194
    • Perlemuter, G.1    Sabile, A.2    Letteron, P.3    Vona, G.4    Topilco, A.5    Chrétien, Y.6    Koike, K.7    Pessayre, D.8    Chapman, J.9    Barba, G.10    Bréchot, C.11
  • 130
    • 77952737082 scopus 로고    scopus 로고
    • Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway
    • [PMID: 20130133 DOI: 10.1099/vir.0.017418-0]
    • Jackel-Cram C, Qiao L, Xiang Z, Brownlie R, Zhou Y, Babiuk L, Liu Q. Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway. J Gen Virol 2010; 91: 1388-1395 [PMID: 20130133 DOI: 10.1099/vir.0.017418-0]
    • (2010) J Gen Virol , vol.91 , pp. 1388-1395
    • Jackel-Cram, C.1    Qiao, L.2    Xiang, Z.3    Brownlie, R.4    Zhou, Y.5    Babiuk, L.6    Liu, Q.7
  • 131
    • 34547097746 scopus 로고    scopus 로고
    • Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress
    • [PMID: 17507484]
    • Waris G, Felmlee DJ, Negro F, Siddiqui A. Hepatitis C virus induces proteolytic cleavage of sterol regulatory element binding proteins and stimulates their phosphorylation via oxidative stress. J Virol 2007; 81: 8122-8130 [PMID: 17507484]
    • (2007) J Virol , vol.81 , pp. 8122-8130
    • Waris, G.1    Felmlee, D.J.2    Negro, F.3    Siddiqui, A.4
  • 133
    • 84864475305 scopus 로고    scopus 로고
    • Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication
    • [PMID: 22641099 DOI: 10.1038/labinvest. 2012.88]
    • García-Mediavilla MV, Pisonero-Vaquero S, Lima-Cabello E, Benedicto I, Majano PL, Jorquera F, González-Gallego J, Sánchez-Campos S. Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication. Lab Invest 2012; 92: 1191-1202 [PMID: 22641099 DOI: 10.1038/labinvest. 2012.88]
    • (2012) Lab Invest , vol.92 , pp. 1191-1202
    • García-Mediavilla, M.V.1    Pisonero-Vaquero, S.2    Lima-Cabello, E.3    Benedicto, I.4    Majano, P.L.5    Jorquera, F.6    González-Gallego, J.7    Sánchez-Campos, S.8
  • 135
    • 31644451456 scopus 로고    scopus 로고
    • Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A
    • [PMID: 16437683]
    • Cheng Y, Dharancy S, Malapel M, Desreumaux P. Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA transferase 1A. World J Gastroenterol 2005; 11: 7591-7596 [PMID: 16437683]
    • (2005) World J Gastroenterol , vol.11 , pp. 7591-7596
    • Cheng, Y.1    Dharancy, S.2    Malapel, M.3    Desreumaux, P.4
  • 136
    • 23044450214 scopus 로고    scopus 로고
    • Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver
    • [PMID: 16047488]
    • Yamaguchi A, Tazuma S, Nishioka T, Ohishi W, Hyogo H, Nomura S, Chayama K. Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver. Dig Dis Sci 2005; 50: 1361-1371 [PMID: 16047488]
    • (2005) Dig Dis Sci , vol.50 , pp. 1361-1371
    • Yamaguchi, A.1    Tazuma, S.2    Nishioka, T.3    Ohishi, W.4    Hyogo, H.5    Nomura, S.6    Chayama, K.7
  • 139
    • 38849184816 scopus 로고    scopus 로고
    • PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    • [PMID: 18188449 DOI: 10.1172/JCI33594]
    • Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T. PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J Clin Invest 2008; 118: 683-694 [PMID: 18188449 DOI: 10.1172/JCI33594]
    • (2008) J Clin Invest , vol.118 , pp. 683-694
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Gonzalez, F.J.5    Aoyama, T.6
  • 140
    • 58849166220 scopus 로고    scopus 로고
    • Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection
    • [PMID: 19148799 DOI: 10.1007/s00535-008-2276-4]
    • Koike K. Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection. J Gastroenterol 2009; 44 Suppl 19: 82-88 [PMID: 19148799 DOI: 10.1007/s00535-008-2276-4]
    • (2009) J Gastroenterol , vol.44 , Issue.SUPPL. 19 , pp. 82-88
    • Koike, K.1
  • 141
    • 84877673791 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPK signaling pathway
    • [PMID: 23510538 DOI: 10.1016/j.ijid.2013.01.027]
    • Yu JW, Sun LJ, Liu W, Zhao YH, Kang P, Yan BZ. Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1-AMPK signaling pathway. Int J Infect Dis 2013; 17: e539-e545 [PMID: 23510538 DOI: 10.1016/j.ijid.2013.01.027]
    • (2013) Int J Infect Dis , vol.17
    • Yu, J.W.1    Sun, L.J.2    Liu, W.3    Zhao, Y.H.4    Kang, P.5    Yan, B.Z.6
  • 142
    • 78149359508 scopus 로고    scopus 로고
    • Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
    • [PMID: 20935628 DOI: 10.1038/ nm.2238]
    • Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M. Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nat Med 2010; 16: 1295-1298 [PMID: 20935628 DOI: 10.1038/ nm.2238]
    • (2010) Nat Med , vol.16 , pp. 1295-1298
    • Herker, E.1    Harris, C.2    Hernandez, C.3    Carpentier, A.4    Kaehlcke, K.5    Rosenberg, A.R.6    Farese, R.V.7    Ott, M.8
  • 143
    • 82755163055 scopus 로고    scopus 로고
    • Hepatitis C virus core protein decreases lipid droplet turnover: A mechanism for core-induced steatosis
    • [PMID: 21984835 DOI: 10.1074/jbc.M111.285148]
    • Harris C, Herker E, Farese RV, Ott M. Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis. J Biol Chem 2011; 286: 42615-42625 [PMID: 21984835 DOI: 10.1074/jbc.M111.285148]
    • (2011) J Biol Chem , vol.286 , pp. 42615-42625
    • Harris, C.1    Herker, E.2    Farese, R.V.3    Ott, M.4
  • 144
    • 84862888834 scopus 로고    scopus 로고
    • HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration
    • [PMID: 22421894 DOI: 10.1038/oby.2012.45]
    • Chang ML, Yeh HC, Tsou YK, Wang CJ, Cheng HY, Sung CM, Ho YP, Chen TH, Yeh CT. HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Obesity (Silver Spring) 2012; 20: 1474-1480 [PMID: 22421894 DOI: 10.1038/oby.2012.45]
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 1474-1480
    • Chang, M.L.1    Yeh, H.C.2    Tsou, Y.K.3    Wang, C.J.4    Cheng, H.Y.5    Sung, C.M.6    Ho, Y.P.7    Chen, T.H.8    Yeh, C.T.9
  • 146
    • 34548130208 scopus 로고    scopus 로고
    • The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model
    • [PMID: 17213339]
    • Hourioux C, Patient R, Morin A, Blanchard E, Moreau A, Trassard S, Giraudeau B, Roingeard P. The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut 2007; 56: 1302-1308 [PMID: 17213339]
    • (2007) Gut , vol.56 , pp. 1302-1308
    • Hourioux, C.1    Patient, R.2    Morin, A.3    Blanchard, E.4    Moreau, A.5    Trassard, S.6    Giraudeau, B.7    Roingeard, P.8
  • 147
    • 34247636649 scopus 로고    scopus 로고
    • Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: Genotype-3a core has a stronger effect than genotype-1b core
    • [PMID: 17188392]
    • Jackel-Cram C, Babiuk LA, Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol 2007; 46: 999-1008 [PMID: 17188392]
    • (2007) J Hepatol , vol.46 , pp. 999-1008
    • Jackel-Cram, C.1    Babiuk, L.A.2    Liu, Q.3
  • 148
    • 79954527881 scopus 로고    scopus 로고
    • Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non-cirrhotic patients without overt diabetes
    • [PMID: 21054524 DOI: 10.1111/j.1440-1746.2010.06568.x]
    • Sumida Y, Kanemasa K, Hara T, Inada Y, Sakai K, Imai S, Yoshida N, Yasui K, Itoh Y, Okanoue T, Yoshikawa T. Impact of amino acid substitutions in hepatitis C virus genotype 1b core region on liver steatosis and glucose tolerance in non-cirrhotic patients without overt diabetes. J Gastroenterol Hepatol 2011; 26: 836-842 [PMID: 21054524 DOI: 10.1111/j.1440-1746.2010.06568.x]
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 836-842
    • Sumida, Y.1    Kanemasa, K.2    Hara, T.3    Inada, Y.4    Sakai, K.5    Imai, S.6    Yoshida, N.7    Yasui, K.8    Itoh, Y.9    Okanoue, T.10    Yoshikawa, T.11
  • 149
    • 77950605678 scopus 로고    scopus 로고
    • Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C
    • [PMID: 19951380 DOI: 10.1111/j.1478-3231.2009.02164.x]
    • Tachi Y, Katano Y, Honda T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Samejima Y, Goto H. Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C. Liver Int 2010; 30: 554-559 [PMID: 19951380 DOI: 10.1111/j.1478-3231.2009.02164.x]
    • (2010) Liver Int , vol.30 , pp. 554-559
    • Tachi, Y.1    Katano, Y.2    Honda, T.3    Hayashi, K.4    Ishigami, M.5    Itoh, A.6    Hirooka, Y.7    Nakano, I.8    Samejima, Y.9    Goto, H.10
  • 150
    • 39149138470 scopus 로고    scopus 로고
    • Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation
    • [PMID: 18177246 DOI: 10.1086/524846]
    • Jhaveri R, McHutchison J, Patel K, Qiang G, Diehl AM. Specific polymorphisms in hepatitis C virus genotype 3 core protein associated with intracellular lipid accumulation. J Infect Dis 2008; 197: 283-291 [PMID: 18177246 DOI: 10.1086/524846]
    • (2008) J Infect Dis , vol.197 , pp. 283-291
    • Jhaveri, R.1    McHutchison, J.2    Patel, K.3    Qiang, G.4    Diehl, A.M.5
  • 151
    • 56349107309 scopus 로고    scopus 로고
    • Hepatic fibrosis--overview
    • [PMID: 18662740 DOI: 10.1016/j.tox.2008.06.013]
    • Friedman SL. Hepatic fibrosis--overview. Toxicology 2008; 254: 120-129 [PMID: 18662740 DOI: 10.1016/j.tox.2008.06.013]
    • (2008) Toxicology , vol.254 , pp. 120-129
    • Friedman, S.L.1
  • 152
    • 33845642594 scopus 로고    scopus 로고
    • Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells
    • [PMID: 17133487 DOI: 10.1002/ hep.21427]
    • Nieto N. Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells. Hepatology 2006; 44: 1487-1501 [PMID: 17133487 DOI: 10.1002/ hep.21427]
    • (2006) Hepatology , vol.44 , pp. 1487-1501
    • Nieto, N.1
  • 153
    • 0344012537 scopus 로고    scopus 로고
    • Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription
    • [PMID: 14635011 DOI: 10.1002/jmv.10545]
    • Taniguchi H, Kato N, Otsuka M, Goto T, Yoshida H, Shiratori Y, Omata M. Hepatitis C virus core protein upregulates transforming growth factor-beta 1 transcription. J Med Virol 2004; 72: 52-59 [PMID: 14635011 DOI: 10.1002/jmv.10545]
    • (2004) J Med Virol , vol.72 , pp. 52-59
    • Taniguchi, H.1    Kato, N.2    Otsuka, M.3    Goto, T.4    Yoshida, H.5    Shiratori, Y.6    Omata, M.7
  • 157
    • 0028010903 scopus 로고
    • Buoyant density of hepatitis C virus recovered from infected hosts: Two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation
    • [PMID: 8294087]
    • Kanto T, Hayashi N, Takehara T, Hagiwara H, Mita E, Naito M, Kasahara A, Fusamoto H, Kamada T. Buoyant density of hepatitis C virus recovered from infected hosts: two different features in sucrose equilibrium density-gradient centrifugation related to degree of liver inflammation. Hepatology 1994; 19: 296-302 [PMID: 8294087]
    • (1994) Hepatology , vol.19 , pp. 296-302
    • Kanto, T.1    Hayashi, N.2    Takehara, T.3    Hagiwara, H.4    Mita, E.5    Naito, M.6    Kasahara, A.7    Fusamoto, H.8    Kamada, T.9
  • 158
    • 84872799752 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor
    • [PMID: 22961938 DOI: 10.1002/jcb.24392]
    • Wu CF, Lin YL, Huang YT. Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor. J Cell Biochem 2013; 114: 541-550 [PMID: 22961938 DOI: 10.1002/jcb.24392]
    • (2013) J Cell Biochem , vol.114 , pp. 541-550
    • Wu, C.F.1    Lin, Y.L.2    Huang, Y.T.3
  • 160
    • 84860683318 scopus 로고    scopus 로고
    • Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxiainducible factor-1α axis under hypoxic conditions
    • [PMID: 22221855 DOI: 10.1111/j.1872-034X.2011.00953.x]
    • Abe M, Koga H, Yoshida T, Masuda H, Iwamoto H, Sakata M, Hanada S, Nakamura T, Taniguchi E, Kawaguchi T, Yano H, Torimura T, Ueno T, Sata M. Hepatitis C virus core protein upregulates the expression of vascular endothelial growth factor via the nuclear factor-κB/hypoxiainducible factor-1α axis under hypoxic conditions. Hepatol Res 2012; 42: 591-600 [PMID: 22221855 DOI: 10.1111/j.1872-034X.2011.00953.x]
    • (2012) Hepatol Res , vol.42 , pp. 591-600
    • Abe, M.1    Koga, H.2    Yoshida, T.3    Masuda, H.4    Iwamoto, H.5    Sakata, M.6    Hanada, S.7    Nakamura, T.8    Taniguchi, E.9    Kawaguchi, T.10    Yano, H.11    Torimura, T.12    Ueno, T.13    Sata, M.14
  • 163
    • 26444492154 scopus 로고    scopus 로고
    • Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: Lessons from animal model studies
    • [PMID: 16234061]
    • Koike K. Molecular basis of hepatitis C virus-associated hepatocarcinogenesis: lessons from animal model studies. Clin Gastroenterol Hepatol 2005; 3: S132-S135 [PMID: 16234061]
    • (2005) Clin Gastroenterol Hepatol , vol.3
    • Koike, K.1
  • 165
    • 0034713462 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
    • [PMID: 10814584 DOI: 10.1006/ viro.2000.0295]
    • Ray RB, Meyer K, Ray R. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 2000; 271: 197-204 [PMID: 10814584 DOI: 10.1006/ viro.2000.0295]
    • (2000) Virology , vol.271 , pp. 197-204
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 166
    • 84862799636 scopus 로고    scopus 로고
    • Hepatitis C virus Core protein overcomes stress-induced premature senescence by downregulating p16 expression via DNA methylation
    • [PMID: 22326283 DOI: 10.1016/ j.canlet.2012.01.044]
    • Lim JS, Park SH, Jang KL. Hepatitis C virus Core protein overcomes stress-induced premature senescence by downregulating p16 expression via DNA methylation. Cancer Lett 2012; 321: 154-161 [PMID: 22326283 DOI: 10.1016/ j.canlet.2012.01.044]
    • (2012) Cancer Lett , vol.321 , pp. 154-161
    • Lim, J.S.1    Park, S.H.2    Jang, K.L.3
  • 167
    • 66149084790 scopus 로고    scopus 로고
    • Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways
    • [PMID: 19235829 DOI: 10.1002/hep.22849]
    • Hassan M, Selimovic D, Ghozlan H, Abdel-kader O. Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways. Hepatology 2009; 49: 1469-1482 [PMID: 19235829 DOI: 10.1002/hep.22849]
    • (2009) Hepatology , vol.49 , pp. 1469-1482
    • Hassan, M.1    Selimovic, D.2    Ghozlan, H.3    Abdel-kader, O.4
  • 168
    • 84864283714 scopus 로고    scopus 로고
    • Liver cancerderived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition
    • [PMID: 19190755 DOI: 10.1371/journal.pone.0004355]
    • Battaglia S, Benzoubir N, Nobilet S, Charneau P, Samuel D, Zignego AL, Atfi A, Bréchot C, Bourgeade MF. Liver cancerderived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. PLoS One 2009; 4: e4355 [PMID: 19190755 DOI: 10.1371/journal.pone.0004355]
    • (2009) PLoS One , vol.4
    • Battaglia, S.1    Benzoubir, N.2    Nobilet, S.3    Charneau, P.4    Samuel, D.5    Zignego, A.L.6    Atfi, A.7    Bréchot, C.8    Bourgeade, M.F.9
  • 169
    • 84901831717 scopus 로고    scopus 로고
    • Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition
    • [PMID: 23770846 DOI: 10.1038/onc.2013.225]
    • Quan H, Zhou F, Nie D, Chen Q, Cai X, Shan X, Zhou Z, Chen K, Huang A, Li S, Tang N. Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition. Oncogene 2014; 33: 2826-2835 [PMID: 23770846 DOI: 10.1038/onc.2013.225]
    • (2014) Oncogene , vol.33 , pp. 2826-2835
    • Quan, H.1    Zhou, F.2    Nie, D.3    Chen, Q.4    Cai, X.5    Shan, X.6    Zhou, Z.7    Chen, K.8    Huang, A.9    Li, S.10    Tang, N.11
  • 170
    • 79956313428 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer
    • [PMID: 21470566 DOI: 10.1016/ j.virusres.2011.03.025]
    • Feng X, Xiu B, Xu L, Yang X, He J, Leong D, He F, Zhang H. Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer. Virus Res 2011; 158: 146-153 [PMID: 21470566 DOI: 10.1016/ j.virusres.2011.03.025]
    • (2011) Virus Res , vol.158 , pp. 146-153
    • Feng, X.1    Xiu, B.2    Xu, L.3    Yang, X.4    He, J.5    Leong, D.6    He, F.7    Zhang, H.8
  • 171
    • 79953249749 scopus 로고    scopus 로고
    • Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis
    • [PMID: 21457561 DOI: 10.1186/1743-422X-8-155]
    • Jahan S, Khaliq S, Ijaz B, Ahmad W, Hassan S. Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis. Virol J 2011; 8: 155 [PMID: 21457561 DOI: 10.1186/1743-422X-8-155]
    • (2011) Virol J , vol.8 , pp. 155
    • Jahan, S.1    Khaliq, S.2    Ijaz, B.3    Ahmad, W.4    Hassan, S.5
  • 172
    • 0035129174 scopus 로고    scopus 로고
    • Comparative sequence analysis of the core-and NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue
    • [PMID: 11170049]
    • Rüster B, Zeuzem S, Krump-Konvalinkova V, Berg T, Jonas S, Severin K, Roth WK. Comparative sequence analysis of the core-and NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue. J Med Virol 2001; 63: 128-134 [PMID: 11170049]
    • (2001) J Med Virol , vol.63 , pp. 128-134
    • Rüster, B.1    Zeuzem, S.2    Krump-Konvalinkova, V.3    Berg, T.4    Jonas, S.5    Severin, K.6    Roth, W.K.7
  • 173
    • 0036594910 scopus 로고    scopus 로고
    • Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: The core protein-encoding region
    • [PMID: 12108585]
    • Alam SS, Nakamura T, Naganuma A, Nozaki A, Nouso K, Shimomura H, Kato N. Hepatitis C virus quasispecies in cancerous and noncancerous hepatic lesions: the core protein-encoding region. Acta Med Okayama 2002; 56: 141-147 [PMID: 12108585]
    • (2002) Acta Med Okayama , vol.56 , pp. 141-147
    • Alam, S.S.1    Nakamura, T.2    Naganuma, A.3    Nozaki, A.4    Nouso, K.5    Shimomura, H.6    Kato, N.7
  • 174
    • 0036790144 scopus 로고    scopus 로고
    • Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma
    • [PMID: 12354856]
    • Ogata S, Nagano-Fujii M, Ku Y, Yoon S, Hotta H. Comparative sequence analysis of the core protein and its frameshift product, the F protein, of hepatitis C virus subtype 1b strains obtained from patients with and without hepatocellular carcinoma. J Clin Microbiol 2002; 40: 3625-3630 [PMID: 12354856]
    • (2002) J Clin Microbiol , vol.40 , pp. 3625-3630
    • Ogata, S.1    Nagano-Fujii, M.2    Ku, Y.3    Yoon, S.4    Hotta, H.5
  • 175
    • 65649143507 scopus 로고    scopus 로고
    • Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma
    • [PMID: 19383824 DOI: 10.1158/1078-0432. CCR-08-2418]
    • Fishman SL, Factor SH, Balestrieri C, Fan X, Dibisceglie AM, Desai SM, Benson G, Branch AD. Mutations in the hepatitis C virus core gene are associated with advanced liver disease and hepatocellular carcinoma. Clin Cancer Res 2009; 15: 3205-3213 [PMID: 19383824 DOI: 10.1158/1078-0432. CCR-08-2418]
    • (2009) Clin Cancer Res , vol.15 , pp. 3205-3213
    • Fishman, S.L.1    Factor, S.H.2    Balestrieri, C.3    Fan, X.4    Dibisceglie, A.M.5    Desai, S.M.6    Benson, G.7    Branch, A.D.8
  • 177
    • 70649083892 scopus 로고    scopus 로고
    • Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma
    • [PMID: 20175782 DOI: 10.1111/ j.1349-7006.2009.01338.x]
    • Hu Z, Muroyama R, Kowatari N, Chang J, Omata M, Kato N. Characteristic mutations in hepatitis C virus core gene related to the occurrence of hepatocellular carcinoma. Cancer Sci 2009; 100: 2465-2468 [PMID: 20175782 DOI: 10.1111/ j.1349-7006.2009.01338.x]
    • (2009) Cancer Sci , vol.100 , pp. 2465-2468
    • Hu, Z.1    Muroyama, R.2    Kowatari, N.3    Chang, J.4    Omata, M.5    Kato, N.6
  • 179
    • 79955431726 scopus 로고    scopus 로고
    • Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells
    • [PMID: 21450690 DOI: 10.1093/ abbs/gmr021]
    • Guo N, Chen R, Li Z, Liu Y, Cheng D, Zhou Q, Zhou J, Lin Q. Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells. Acta Biochim Biophys Sin (Shanghai) 2011; 43: 354-361 [PMID: 21450690 DOI: 10.1093/ abbs/gmr021]
    • (2011) Acta Biochim Biophys Sin (Shanghai) , vol.43 , pp. 354-361
    • Guo, N.1    Chen, R.2    Li, Z.3    Liu, Y.4    Cheng, D.5    Zhou, Q.6    Zhou, J.7    Lin, Q.8
  • 181
    • 84888308190 scopus 로고    scopus 로고
    • HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages
    • [PMID: 23774506]
    • Khan KA, Abbas W, Varin A, Kumar A, Di Martino V, Dichamp I, Herbein G. HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages. J Innate Immun 2013; 5: 639-656 [PMID: 23774506]
    • (2013) J Innate Immun , vol.5 , pp. 639-656
    • Khan, K.A.1    Abbas, W.2    Varin, A.3    Kumar, A.4    Di Martino, V.5    Dichamp, I.6    Herbein, G.7
  • 182
    • 77958458743 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity
    • [PMID: 20877724 DOI: 10.1371/ journal.pone.0012856]
    • Vivithanaporn P, Maingat F, Lin LT, Na H, Richardson CD, Agrawal B, Cohen EA, Jhamandas JH, Power C. Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity. PLoS One 2010; 5: e12856 [PMID: 20877724 DOI: 10.1371/ journal.pone.0012856]
    • (2010) PLoS One , vol.5
    • Vivithanaporn, P.1    Maingat, F.2    Lin, L.T.3    Na, H.4    Richardson, C.D.5    Agrawal, B.6    Cohen, E.A.7    Jhamandas, J.H.8    Power, C.9
  • 183
    • 0032579547 scopus 로고    scopus 로고
    • A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma
    • [PMID: 9455792]
    • Donato F, Boffetta P, Puoti M. A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma. Int J Cancer 1998; 75: 347-354 [PMID: 9455792]
    • (1998) Int J Cancer , vol.75 , pp. 347-354
    • Donato, F.1    Boffetta, P.2    Puoti, M.3
  • 185
    • 0032189258 scopus 로고    scopus 로고
    • Signal sequences: More than just greasy peptides
    • [PMID: 9789330]
    • Martoglio B, Dobberstein B. Signal sequences: more than just greasy peptides. Trends Cell Biol 1998; 8: 410-415 [PMID: 9789330]
    • (1998) Trends Cell Biol , vol.8 , pp. 410-415
    • Martoglio, B.1    Dobberstein, B.2
  • 186
    • 0346788899 scopus 로고    scopus 로고
    • Intramembrane proteolysis and post-targeting functions of signal peptides
    • [PMID: 14641034]
    • Martoglio B. Intramembrane proteolysis and post-targeting functions of signal peptides. Biochem Soc Trans 2003; 31: 1243-1247 [PMID: 14641034]
    • (2003) Biochem Soc Trans , vol.31 , pp. 1243-1247
    • Martoglio, B.1
  • 187
    • 0028783818 scopus 로고
    • Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein
    • [PMID: 7595234]
    • Hombach J, Pircher H, Tonegawa S, Zinkernagel RM. Strictly transporter of antigen presentation (TAP)-dependent presentation of an immunodominant cytotoxic T lymphocyte epitope in the signal sequence of a virus protein. J Exp Med 1995; 182: 1615-1619 [PMID: 7595234]
    • (1995) J Exp Med , vol.182 , pp. 1615-1619
    • Hombach, J.1    Pircher, H.2    Tonegawa, S.3    Zinkernagel, R.M.4
  • 189
    • 78650119643 scopus 로고    scopus 로고
    • Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection
    • [PMID: 21151917 DOI: 10.1371/journal.pone.0014237]
    • Gao DY, Jin GD, Yao BL, Zhang DH, Gu LL, Lu ZM, Gong Q, Lone YC, Deng Q, Zhang XX. Characterization of the specific CD4+ T cell response against the F protein during chronic hepatitis C virus infection. PLoS One 2010; 5: e14237 [PMID: 21151917 DOI: 10.1371/journal.pone.0014237]
    • (2010) PLoS One , vol.5
    • Gao, D.Y.1    Jin, G.D.2    Yao, B.L.3    Zhang, D.H.4    Gu, L.L.5    Lu, Z.M.6    Gong, Q.7    Lone, Y.C.8    Deng, Q.9    Zhang, X.X.10
  • 190
    • 56449110274 scopus 로고    scopus 로고
    • Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication
    • [PMID: 18799568 DOI: 10.1128/JVI.01640-08]
    • Vassilaki N, Friebe P, Meuleman P, Kallis S, Kaul A, Paranhos-Baccalà G, Leroux-Roels G, Mavromara P, Bartenschlager R. Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication. J Virol 2008; 82: 11503-11515 [PMID: 18799568 DOI: 10.1128/JVI.01640-08]
    • (2008) J Virol , vol.82 , pp. 11503-11515
    • Vassilaki, N.1    Friebe, P.2    Meuleman, P.3    Kallis, S.4    Kaul, A.5    Paranhos-Baccalà, G.6    Leroux-Roels, G.7    Mavromara, P.8    Bartenschlager, R.9
  • 191
    • 0036064441 scopus 로고    scopus 로고
    • Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation
    • [PMID: 12135786]
    • Ray RB, Steele R, Basu A, Meyer K, Majumder M, Ghosh AK, Ray R. Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation. Virus Res 2002; 87: 21-29 [PMID: 12135786]
    • (2002) Virus Res , vol.87 , pp. 21-29
    • Ray, R.B.1    Steele, R.2    Basu, A.3    Meyer, K.4    Majumder, M.5    Ghosh, A.K.6    Ray, R.7
  • 192
    • 4043094150 scopus 로고    scopus 로고
    • Functional properties of a 16 kDa protein translated from an alternative open reading frame of the core-encoding genomic region of hepatitis C virus
    • [PMID: 15269371 DOI: 10.1099/vir.0.80028-0]
    • Basu A, Steele R, Ray R, Ray RB. Functional properties of a 16 kDa protein translated from an alternative open reading frame of the core-encoding genomic region of hepatitis C virus. J Gen Virol 2004; 85: 2299-2306 [PMID: 15269371 DOI: 10.1099/vir.0.80028-0]
    • (2004) J Gen Virol , vol.85 , pp. 2299-2306
    • Basu, A.1    Steele, R.2    Ray, R.3    Ray, R.B.4
  • 193
    • 44949127124 scopus 로고    scopus 로고
    • Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc
    • [PMID: 18398700 DOI: 10.1007/s11373-008-9248-9]
    • Ma HC, Lin TW, Li H, Iguchi-Ariga SM, Ariga H, Chuang YL, Ou JH, Lo SY. Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc. J Biomed Sci 2008; 15: 417-425 [PMID: 18398700 DOI: 10.1007/s11373-008-9248-9]
    • (2008) J Biomed Sci , vol.15 , pp. 417-425
    • Ma, H.C.1    Lin, T.W.2    Li, H.3    Iguchi-Ariga, S.M.4    Ariga, H.5    Chuang, Y.L.6    Ou, J.H.7    Lo, S.Y.8
  • 194
    • 0034020036 scopus 로고    scopus 로고
    • Amino acid substitutions in codons 9-11 of hepatitis C virus core protein lead to the synthesis of a short core protein product
    • [PMID: 10735543]
    • Yeh CT, Lo SY, Dai DI, Tang JH, Chu CM, Liaw YF. Amino acid substitutions in codons 9-11 of hepatitis C virus core protein lead to the synthesis of a short core protein product. J Gastroenterol Hepatol 2000; 15: 182-191 [PMID: 10735543]
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 182-191
    • Yeh, C.T.1    Lo, S.Y.2    Dai, D.I.3    Tang, J.H.4    Chu, C.M.5    Liaw, Y.F.6
  • 196
    • 84879142325 scopus 로고    scopus 로고
    • Hepatitis C virus core+1/ ARF protein decreases hepcidin transcription through an AP1 binding site
    • [PMID: 23580428 DOI: 10.1099/vir.0.050328-0]
    • Kotta-Loizou I, Vassilaki N, Pissas G, Kakkanas A, Bakiri L, Bartenschlager R, Mavromara P. Hepatitis C virus core+1/ ARF protein decreases hepcidin transcription through an AP1 binding site. J Gen Virol 2013; 94: 1528-1534 [PMID: 23580428 DOI: 10.1099/vir.0.050328-0]
    • (2013) J Gen Virol , vol.94 , pp. 1528-1534
    • Kotta-Loizou, I.1    Vassilaki, N.2    Pissas, G.3    Kakkanas, A.4    Bakiri, L.5    Bartenschlager, R.6    Mavromara, P.7
  • 198
    • 33746731000 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization
    • [PMID: 16876117 DOI: 10.1016/j.bbrc.2006.07.062]
    • Tsao ML, Chao CH, Yeh CT. Interaction of hepatitis C virus F protein with prefoldin 2 perturbs tubulin cytoskeleton organization. Biochem Biophys Res Commun 2006; 348: 271-277 [PMID: 16876117 DOI: 10.1016/j.bbrc.2006.07.062]
    • (2006) Biochem Biophys Res Commun , vol.348 , pp. 271-277
    • Tsao, M.L.1    Chao, C.H.2    Yeh, C.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.