Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition

Oncogene

Volumn 33, Issue 22, 2014, Pages 2826-2835

  Quan, H ^a   Zhou, F ^a   Nie, D ^a   Chen, Q ^a   Cai, X ^a   Shan, X ^a   Zhou, Z ^a   Chen, K ^a   Huang, A ^a   Li, S ^a   Tang, N ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

epigenetic silencing; hepatitis C virus; methylation; SFRP1; Wnt b catenin signaling pathway

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BETA CATENIN; CORE PROTEIN; CYCLIN D1; DNA METHYLTRANSFERASE 1; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; MYC PROTEIN; SECRETED FRIZZLED RELATED PROTEIN 1; TRICHOSTATIN A; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER MODEL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; CONTROLLED STUDY; CPG ISLAND; DEACETYLATION; DNA METHYLATION; DOWN REGULATION; EPIGENETIC REPRESSION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE SILENCING; HEPATITIS C VIRUS; HEPATOMA CELL; HEPG2 CELL LINE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TUMOR XENOGRAFT; VIRUS CARCINOGENESIS; WNT SIGNALING PATHWAY;

HEPATITIS C VIRUS;

ACETYLATION; ANIMALS; AZACITIDINE; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; EPIGENESIS, GENETIC; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HISTONES; HUMANS; HYDROXAMIC ACIDS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MEMBRANE PROTEINS; PROMOTER REGIONS, GENETIC; TUMOR BURDEN; VIRAL CORE PROTEINS; WNT PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84901831717     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.225     Document Type: Article

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