HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment

Journal of Hepatology

Volumn 59, Issue 6, 2013, Pages 1160-1168

  Benzoubir, Nassima ^a,b   Lejamtel, Charlène ^a,b   Battaglia, Serena ^a,b   Testoni, Barbara ^c,d   Benassi, Barbara ^d   Gondeau, Claire ^e,f   Perrin Cocon, Laure ^g,h   Desterke, Christophe ⁱ   Thiers, Valérie ^a,b,k   Samuel, Didier ^a,b   Levrero, Massimo ^c,d   Bréchot, Christian ^a,b,j   Bourgeade, Marie Françoise ^a,b  

^a HÔPITAL PAUL BROUSSE   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^e INSERM   (France)

^f UNIV MONTPELLIER   (France)

^g CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^h UNIVERSITÉ DE LYON   (France)

ⁱ SFR André Lwolf   (France)

^j Fondation Merieux   (France)

^k INSTITUT PASTEUR   (France)

more..

Author keywords

Active TGF beta; HCV core; Paracrine effect; Stellate cell activation

Indexed keywords

CORE PROTEIN; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL ACTIVATION; CELL INTERACTION; CONTROLLED STUDY; GENE EXPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HEPATOMA CELL; IN VIVO STUDY; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL;

ACTIVE TGF-BETA; CNT; CT; ECM; EMT; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; HCC; HCV; HCV CORE; HCV CORE FROM NON-TUMOR NODULE; HCV CORE FROM TUMOR NODULE; HEPATIC STELLATE CELL; HEPATITIS C VIRUS; HEPATOCELLULAR CARCINOMA; HSC; PARACRINE EFFECT; SMA; SMOOTH MUSCLE ACTIN; STELLATE CELL ACTIVATION; TGF-Β; TRANSFORMING GROWTH FACTOR BETA; TROMBOSPONDIN; TSP;

ANIMALS; HEPACIVIRUS; HEPATOCYTES; HUMANS; MICE; MICE, TRANSGENIC; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 84888013892     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.07.036     Document Type: Article

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