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Volumn 133, Issue 3, 2013, Pages 601-607

γ-secretase mutations in hidradenitis suppurativa: New insights into disease pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR;

EID: 84873703164     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.372     Document Type: Article
Times cited : (135)

References (58)
  • 1
    • 0029115555 scopus 로고
    • The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
    • Alzheimer's Disease Collaborative Group
    • Alzheimer's Disease Collaborative Group (1995) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 11: 219-22
    • (1995) Nat Genet , vol.11 , pp. 219-222
  • 2
    • 0028823908 scopus 로고
    • Immunohistochemical localization of IL-1 alpha-, IL-1 beta-, IL-6-and TNF-alphalike immunoreactivities in human apocrine glands
    • Ahmed AA, Nordlind K, Schultzberg M et al. (1995) Immunohistochemical localization of IL-1 alpha-, IL-1 beta-, IL-6-and TNF-alphalike immunoreactivities in human apocrine glands. Arch Dermatol Res 287: 764-6
    • (1995) Arch Dermatol Res , vol.287 , pp. 764-766
    • Ahmed, A.A.1    Nordlind, K.2    Schultzberg, M.3
  • 3
    • 61849173997 scopus 로고    scopus 로고
    • Hidradenitis suppurativa: A comprehensive review
    • Alikhan A, Lynch PJ, Eisen DB (2009) Hidradenitis suppurativa: a comprehensive review. J Am Acad Dermatol 60: 539-61
    • (2009) J Am Acad Dermatol , vol.60 , pp. 539-561
    • Alikhan, A.1    Lynch, P.J.2    Eisen, D.B.3
  • 4
    • 76449085569 scopus 로고    scopus 로고
    • Gammasecretases: From cell biology to therapeutic strategies
    • Bergmans BA, De Strooper B (2010) Gammasecretases: from cell biology to therapeutic strategies. Lancet Neurol 9: 215-26
    • (2010) Lancet Neurol , vol.9 , pp. 215-226
    • Bergmans, B.A.1    De Strooper, B.2
  • 5
    • 0029907640 scopus 로고    scopus 로고
    • Hidradenitis suppurativa or acne inversa. A clinicopathological study of early lesions
    • Boer J, Weltevreden EF (1996) Hidradenitis suppurativa or acne inversa. A clinicopathological study of early lesions. Br J Dermatol 135: 721-5
    • (1996) Br J Dermatol , vol.135 , pp. 721-725
    • Boer, J.1    Weltevreden, E.F.2
  • 6
    • 0346732290 scopus 로고    scopus 로고
    • Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain
    • Capell A, Kaether C, Edbauer D et al. (2003) Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. J Biol Chem 278: 52519-23
    • (2003) J Biol Chem , vol.278 , pp. 52519-52523
    • Capell, A.1    Kaether, C.2    Edbauer, D.3
  • 7
    • 50649119079 scopus 로고    scopus 로고
    • Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
    • Chavez-Gutierrez L, Tolia A, Maes E et al. (2008) Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. J Biol Chem 283: 20096-105
    • (2008) J Biol Chem , vol.283 , pp. 20096-20105
    • Chavez-Gutierrez, L.1    Tolia, A.2    Maes, E.3
  • 8
    • 0034896955 scopus 로고    scopus 로고
    • Nicastrin binds to membrane-tethered Notch
    • Chen F, Yu G, Arawaka S et al. (2001) Nicastrin binds to membrane-tethered Notch. Nat Cell Biol 3: 751-4
    • (2001) Nat Cell Biol , vol.3 , pp. 751-754
    • Chen, F.1    Yu, G.2    Arawaka, S.3
  • 9
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
    • Citron M, Westaway D, Xia W et al. (1997) Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med 3: 67-72
    • (1997) Nat Med , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3
  • 10
    • 0002067473 scopus 로고
    • Pregnancy and apocrine gland diseases: Hidradenitis, Fox-Fordyce disease
    • Cornbleet T (1952) Pregnancy and apocrine gland diseases: hidradenitis, Fox-Fordyce disease. AMA Arch Derm Syphilol 65: 12-9
    • (1952) AMA Arch Derm Syphilol , vol.65 , pp. 12-19
    • Cornbleet, T.1
  • 11
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
    • Duff K, Eckman C, Zehr C et al. (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383: 710-3
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1    Eckman, C.2    Zehr, C.3
  • 12
    • 34548574739 scopus 로고    scopus 로고
    • Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture
    • Estrach S, Legg J, Watt FM (2007) Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci 120: 2944-52
    • (2007) J Cell Sci , vol.120 , pp. 2944-2952
    • Estrach, S.1    Legg, J.2    Watt, F.M.3
  • 13
    • 0021932833 scopus 로고
    • A family study of hidradenitis suppurativa
    • Fitzsimmons JS, Guilbert PR (1985) A family study of hidradenitis suppurativa. J Med Genet 22: 367-73
    • (1985) J Med Genet , vol.22 , pp. 367-373
    • Fitzsimmons, J.S.1    Guilbert, P.R.2
  • 14
    • 33745580349 scopus 로고    scopus 로고
    • Inversa acne (hidradenitis suppurativa): A case report and identification of the locus at chromosome 1p21.1-1q25.3
    • Gao M, Wang PG, Cui Y et al. (2006) Inversa acne (hidradenitis suppurativa): a case report and identification of the locus at chromosome 1p21.1-1q25.3. J Invest Dermatol 126: 1302-6
    • (2006) J Invest Dermatol , vol.126 , pp. 1302-1306
    • Gao, M.1    Wang, P.G.2    Cui, Y.3
  • 15
    • 66149127297 scopus 로고    scopus 로고
    • Mutant presenilin 1 increases the expression and activity of BACE1
    • Giliberto L, Borghi R, Piccini A et al. (2009) Mutant presenilin 1 increases the expression and activity of BACE1. J Biol Chem 284: 9027-38
    • (2009) J Biol Chem , vol.284 , pp. 9027-9038
    • Giliberto, L.1    Borghi, R.2    Piccini, A.3
  • 16
    • 0024227184 scopus 로고
    • Endocrine basis for the clinical presentation of hidradenitis suppurativa
    • Harrison BJ, Read GF, Hughes LE (1988) Endocrine basis for the clinical presentation of hidradenitis suppurativa. Br J Surg 75: 972-5
    • (1988) Br J Surg , vol.75 , pp. 972-975
    • Harrison, B.J.1    Read, G.F.2    Hughes, L.E.3
  • 17
    • 0030761094 scopus 로고    scopus 로고
    • The presenilins and Alzheimer's disease
    • Hutton M, Hardy J (1997) The presenilins and Alzheimer's disease. Hum Mol Genet 6: 1639-46
    • (1997) Hum Mol Genet , vol.6 , pp. 1639-1646
    • Hutton, M.1    Hardy, J.2
  • 18
    • 0029777345 scopus 로고    scopus 로고
    • The prevalence of hidradenitis suppurativa and its potential precursor lesions
    • Jemec GB, Heidenheim M, Nielsen NH (1996) The prevalence of hidradenitis suppurativa and its potential precursor lesions. J Am Acad Dermatol 35: 191-4
    • (1996) J Am Acad Dermatol , vol.35 , pp. 191-194
    • Jemec, G.B.1    Heidenheim, M.2    Nielsen, N.H.3
  • 19
    • 78449272415 scopus 로고    scopus 로고
    • Genetics. Gammasecretase and human disease
    • Kelleher RJ 3rd, Shen J (2010) Genetics. Gammasecretase and human disease. Science 330: 1055-6
    • (2010) Science , vol.330 , pp. 1055-1056
    • Kelleher Iii., R.J.1    Shen, J.2
  • 20
    • 12544255206 scopus 로고    scopus 로고
    • A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1
    • Kim SH, Sisodia SS (2005) A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1. J Biol Chem 280: 1992-2001
    • (2005) J Biol Chem , vol.280 , pp. 1992-2001
    • Kim, S.H.1    Sisodia, S.S.2
  • 21
    • 33947166199 scopus 로고    scopus 로고
    • Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases
    • Lefort K, Mandinova A, Ostano P et al. (2007) Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev 21: 562-77
    • (2007) Genes Dev , vol.21 , pp. 562-577
    • Lefort, K.1    Mandinova, A.2    Ostano, P.3
  • 22
    • 79960652604 scopus 로고    scopus 로고
    • Two novel mutations of the nicastrin gene in Chinese patients with acne inversa
    • Li CR, Jiang MJ, Shen DB et al. (2011) Two novel mutations of the nicastrin gene in Chinese patients with acne inversa. Br J Dermatol 165: 415-8
    • (2011) Br J Dermatol , vol.165 , pp. 415-418
    • Li, C.R.1    Jiang, M.J.2    Shen, D.B.3
  • 23
    • 36148993580 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase
    • Li T, Wen H, Brayton C et al. (2007) Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem 282: 32264-73
    • (2007) J Biol Chem , vol.282 , pp. 32264-32273
    • Li, T.1    Wen, H.2    Brayton, C.3
  • 24
    • 79958806209 scopus 로고    scopus 로고
    • Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa
    • Liu Y, Gao M, Lv YM et al. (2011) Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa). J Invest Dermatol 131: 1570-2
    • (2011) J Invest Dermatol , vol.131 , pp. 1570-1572
    • Liu, Y.1    Gao, M.2    Lv, Y.M.3
  • 25
    • 80755174519 scopus 로고    scopus 로고
    • Squamous cell carcinoma complicating chronic suppurative hydradenitis
    • Losanoff JE, Sochaki P, Khoury N et al. (2011) Squamous cell carcinoma complicating chronic suppurative hydradenitis. Am Surg 77: 1449-53
    • (2011) Am Surg , vol.77 , pp. 1449-1453
    • Losanoff, J.E.1    Sochaki, P.2    Khoury, N.3
  • 26
    • 0034192461 scopus 로고    scopus 로고
    • Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters
    • Lowell S, Jones P, Le Roux I et al. (2000) Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol 10: 491-500
    • (2000) Curr Biol , vol.10 , pp. 491-500
    • Lowell, S.1    Jones, P.2    Le Roux, I.3
  • 27
    • 71949126504 scopus 로고    scopus 로고
    • Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: Is there a basis for treatment with anti-tumour necrosis factor-alpha agents?
    • Matusiak L, Bieniek A, Szepietowski JC (2009) Increased serum tumour necrosis factor-alpha in hidradenitis suppurativa patients: is there a basis for treatment with anti-tumour necrosis factor-alpha agents?. Acta Derm Venereol 89: 601-3
    • (2009) Acta Derm Venereol , vol.89 , pp. 601-603
    • Matusiak, L.1    Bieniek, A.2    Szepietowski, J.C.3
  • 28
    • 77749291969 scopus 로고    scopus 로고
    • Hidradenitis suppurativa markedly decreases quality of life and professional activity
    • 708.e1
    • Matusiak L, Bieniek A, Szepietowski JC (2010) Hidradenitis suppurativa markedly decreases quality of life and professional activity. J Am Acad Dermatol 62: 706-8. 708.e1
    • (2010) J Am Acad Dermatol , vol.62 , pp. 706-708
    • Matusiak, L.1    Bieniek, A.2    Szepietowski, J.C.3
  • 29
    • 84861187217 scopus 로고    scopus 로고
    • Nicastrin mutations in French families with hidradenitis suppurativa
    • Miskinyte S, Nassif A, Merabtene F et al. (2012) Nicastrin mutations in French families with hidradenitis suppurativa. J Invest Dermatol 132: 1728-30
    • (2012) J Invest Dermatol , vol.132 , pp. 1728-1730
    • Miskinyte, S.1    Nassif, A.2    Merabtene, F.3
  • 30
    • 84873706591 scopus 로고    scopus 로고
    • Pathogenesis and pharmacotherapy of hidradenitis suppurativa
    • Nazary M, der Zee HV, Prens E et al. (2011) Pathogenesis and pharmacotherapy of hidradenitis suppurativa. Eur J Pharmacol 132: 1728-30
    • (2011) Eur J Pharmacol , vol.132 , pp. 1728-1730
    • Nazary, M.1    Der Zee, H.V.2    Prens, E.3
  • 31
    • 16844364135 scopus 로고    scopus 로고
    • Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
    • Niimura M, Isoo N, Takasugi N et al. (2005) Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. J Biol Chem 280: 12967-75
    • (2005) J Biol Chem , vol.280 , pp. 12967-12975
    • Niimura, M.1    Isoo, N.2    Takasugi, N.3
  • 32
    • 84876953082 scopus 로고    scopus 로고
    • A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa
    • e-pub ahead of print 27 July 2012
    • Nomura Y, Nomura T, Sakai K et al. (2012) A novel splice site mutation in NCSTN underlies a Japanese family with hidradenitis suppurativa. Br J Dermatol; e-pub ahead of print 27 July 2012
    • Br J Dermatol , vol.2012
    • Nomura, Y.1    Nomura, T.2    Sakai, K.3
  • 33
    • 79953707599 scopus 로고    scopus 로고
    • Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype
    • Ostergaard P, Simpson MA, Brice G et al. (2011) Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. J Med Genet 48: 251-5
    • (2011) J Med Genet , vol.48 , pp. 251-255
    • Ostergaard, P.1    Simpson, M.A.2    Brice, G.3
  • 34
    • 0034775446 scopus 로고    scopus 로고
    • P300 acts as a transcriptional coactivator for mammalian Notch-1
    • Oswald F, Tauber B, Dobner T et al. (2001) p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol 21: 7761-74
    • (2001) Mol Cell Biol , vol.21 , pp. 7761-7774
    • Oswald, F.1    Tauber, B.2    Dobner, T.3
  • 35
    • 7744240345 scopus 로고    scopus 로고
    • Gammasecretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    • Pan Y, Lin MH, Tian X et al. (2004) Gammasecretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell 7: 731-43
    • (2004) Dev Cell , vol.7 , pp. 731-743
    • Pan, Y.1    Lin, M.H.2    Tian, X.3
  • 36
    • 77956419098 scopus 로고    scopus 로고
    • Review: Gamma-secretase inhibitors for the treatment of Alzheimer's disease: The current state
    • Panza F, Frisardi V, Imbimbo BP et al. (2010) Review: gamma-secretase inhibitors for the treatment of Alzheimer's disease: the current state. CNS Neurosci Ther 16: 272-84
    • (2010) CNS Neurosci Ther , vol.16 , pp. 272-284
    • Panza, F.1    Frisardi, V.2    Imbimbo, B.P.3
  • 37
    • 84856060315 scopus 로고    scopus 로고
    • Mutant presenilin 2 increases beta-secretase activity through reactive oxygen speciesdependent activation of extracellular signalregulated kinase
    • Park MH, Choi DY, Jin HW et al. (2012) Mutant presenilin 2 increases beta-secretase activity through reactive oxygen speciesdependent activation of extracellular signalregulated kinase. J Neuropathol Exp Neurol 71: 130-9
    • (2012) J Neuropathol Exp Neurol , vol.71 , pp. 130-139
    • Park, M.H.1    Choi, D.Y.2    Jin, H.W.3
  • 38
    • 79958816937 scopus 로고    scopus 로고
    • PSENEN and NCSTN mutations in familial hidradenitis suppurativa (acne inversa
    • Pink AE, Simpson MA, Brice GW et al. (2011) PSENEN and NCSTN mutations in familial hidradenitis suppurativa (acne inversa). J Invest Dermatol 131: 1568-70
    • (2011) J Invest Dermatol , vol.131 , pp. 1568-1570
    • Pink, A.E.1    Simpson, M.A.2    Brice, G.W.3
  • 39
    • 84866375243 scopus 로고    scopus 로고
    • Mutations in the gamma-secretase genes NCSTN, PSENEN, and PSEN1 Underlie rare forms of hidradenitis suppurativa (acne inversa)
    • Pink AE, Simpson MA, Desai N et al. (2012) Mutations in the gamma-secretase genes NCSTN, PSENEN, and PSEN1 Underlie rare forms of hidradenitis suppurativa (acne inversa). J Invest Dermatol.
    • (2012) J Invest Dermatol
    • Pink, A.E.1    Simpson, M.A.2    Desai, N.3
  • 40
    • 21344463310 scopus 로고    scopus 로고
    • Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments
    • Prokop S, Haass C, Steiner H (2005) Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. J Neurochem 94: 57-62
    • (2005) J Neurochem , vol.94 , pp. 57-62
    • Prokop, S.1    Haass, C.2    Steiner, H.3
  • 41
    • 33747891694 scopus 로고    scopus 로고
    • Impaired notch signaling promotes de novo squamous cell carcinoma formation
    • Proweller A, Tu L, Lepore JJ et al. (2006) Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res 66: 7438-44
    • (2006) Cancer Res , vol.66 , pp. 7438-7444
    • Proweller, A.1    Tu, L.2    Lepore, J.J.3
  • 42
    • 34247569879 scopus 로고    scopus 로고
    • Functional consequences of NOD2/CARD15 mutations in Crohn disease
    • Quaglietta L, te Velde A, Staiano A et al. (2007) Functional consequences of NOD2/CARD15 mutations in Crohn disease. J Pediatr Gastroenterol Nutr 44: 529-39
    • (2007) J Pediatr Gastroenterol Nutr , vol.44 , pp. 529-539
    • Quaglietta, L.1    Te Velde, A.2    Staiano, A.3
  • 43
    • 80054976611 scopus 로고    scopus 로고
    • Dissociation between the processivity and total activity of gamma-secretase: Implications for the mechanism of Alzheimer's disease-causing presenilin mutations
    • Quintero-Monzon O, Martin MM, Fernandez MA et al. (2011) Dissociation between the processivity and total activity of gamma-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations. Biochemistry 50: 9023-35
    • (2011) Biochemistry , vol.50 , pp. 9023-9035
    • Quintero-Monzon, O.1    Martin, M.M.2    Fernandez, M.A.3
  • 44
    • 51349113269 scopus 로고    scopus 로고
    • Prevalence and factors associated with hidradenitis suppurativa: Results from two case-control studies
    • Revuz JE, Canoui-Poitrine F, Wolkenstein P et al. (2008) Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies. J Am Acad Dermatol 59: 596-601
    • (2008) J Am Acad Dermatol , vol.59 , pp. 596-601
    • Revuz, J.E.1    Canoui-Poitrine, F.2    Wolkenstein, P.3
  • 45
    • 0038607071 scopus 로고    scopus 로고
    • Gamma-secretase activity is associated with a conformational change of nicastrin
    • Shirotani K, Edbauer D, Capell A et al. (2003) Gamma-secretase activity is associated with a conformational change of nicastrin. J Biol Chem 278: 16474-7
    • (2003) J Biol Chem , vol.278 , pp. 16474-16477
    • Shirotani, K.1    Edbauer, D.2    Capell, A.3
  • 46
    • 0033536072 scopus 로고    scopus 로고
    • Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
    • Song W, Nadeau P, Yuan M et al. (1999) Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Nat Acad Sci USA 96: 6959-63
    • (1999) Proc Nat Acad Sci USA , vol.96 , pp. 6959-6963
    • Song, W.1    Nadeau, P.2    Yuan, M.3
  • 47
    • 63649118865 scopus 로고    scopus 로고
    • Structure and function of gamma-secretase
    • Tolia A, De Strooper B (2009) Structure and function of gamma-secretase. Semin Cell Dev Biol 20: 211-8
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 211-218
    • Tolia, A.1    De Strooper, B.2
  • 48
    • 79957608446 scopus 로고    scopus 로고
    • Elevated levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10 in hidradenitis suppurativa skin: A rationale for targeting TNF-alpha and IL-1beta
    • van der Zee HH, de Ruiter L, van den Broecke DG et al. (2011) Elevated levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-alpha and IL-1beta. Br J Dermatol 164: 1292-8
    • (2011) Br J Dermatol , vol.164 , pp. 1292-1298
    • Van Der Zee, H.H.1    De Ruiter, L.2    Van Den Broecke, D.G.3
  • 49
    • 72749089411 scopus 로고    scopus 로고
    • Hidradenitis suppurativa and inflammatory bowel disease: Are they associated? Results of a pilot study
    • van der Zee HH, van der Woude CJ, Florencia EF et al. (2010) Hidradenitis suppurativa and inflammatory bowel disease: are they associated? Results of a pilot study. Br J Dermatol 162: 195-7
    • (2010) Br J Dermatol , vol.162 , pp. 195-197
    • Van Der Zee, H.H.1    Van Der Woude, C.J.2    Florencia, E.F.3
  • 50
    • 84863886830 scopus 로고    scopus 로고
    • Comparing treatment outcome of infliximab and adalimumab in patients with severe hidradenitis suppurativa
    • van Rappard DC, Leenarts MF, Meijerink-van't Oost L et al. (2011) Comparing treatment outcome of infliximab and adalimumab in patients with severe hidradenitis suppurativa. J Dermatolog Treat 3: 284-9
    • (2011) J Dermatolog Treat , vol.3 , pp. 284-289
    • Van Rappard, D.C.1    Leenarts, M.F.2    Meijerink-Van't Oost, L.3
  • 51
    • 84871442684 scopus 로고    scopus 로고
    • The off-label treatment of severe hidradenitis suppurativa with TNF-alpha inhibitors: A systematic review
    • e-pub ahead of print 12 April 2012
    • van Rappard DC, Limpens J, Mekkes JR (2012) The off-label treatment of severe hidradenitis suppurativa with TNF-alpha inhibitors: a systematic review. J Dermatolog Treat; e-pub ahead of print 12 April 2012
    • (2012) J Dermatolog Treat
    • Van Rappard, D.C.1    Limpens, J.2    Mekkes, J.R.3
  • 52
    • 0034078738 scopus 로고    scopus 로고
    • The clinical genetics of hidradenitis suppurativa revisited
    • Von Der Werth JM, Williams HC, Raeburn JA (2000) The clinical genetics of hidradenitis suppurativa revisited. Br J Dermatol 142: 947-53
    • (2000) Br J Dermatol , vol.142 , pp. 947-953
    • Von Der Werth, J.M.1    Williams, H.C.2    Raeburn, J.A.3
  • 53
    • 78449287185 scopus 로고    scopus 로고
    • Gammasecretase gene mutations in familial acne inversa
    • Wang B, Yang W, Wen W et al. (2010) Gammasecretase gene mutations in familial acne inversa. Science 330: 1065
    • (2010) Science , vol.330 , pp. 1065
    • Wang, B.1    Yang, W.2    Wen, W.3
  • 54
    • 41549166020 scopus 로고    scopus 로고
    • Epidermal Notch signalling: Differentiation, cancer and adhesion
    • Watt FM, Estrach S, Ambler CA (2008) Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol 20: 171-9
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 171-179
    • Watt, F.M.1    Estrach, S.2    Ambler, C.A.3
  • 55
    • 67651119978 scopus 로고    scopus 로고
    • Lymph nodes in hidradenitis suppurativa
    • Wortsman X, Revuz J, Jemec GB (2009) Lymph nodes in hidradenitis suppurativa. Dermatology 219: 22-4
    • (2009) Dermatology , vol.219 , pp. 22-24
    • Wortsman, X.1    Revuz, J.2    Jemec, G.B.3
  • 56
    • 0035845481 scopus 로고    scopus 로고
    • Loss of presenilin 1 is associated with enhanced betacatenin signaling and skin tumorigenesis
    • Xia X, Qian S, Soriano S et al. (2001) Loss of presenilin 1 is associated with enhanced betacatenin signaling and skin tumorigenesis. Proc Nat Acad Sci Usa 98: 10863-8
    • (2001) Proc Nat Acad Sci Usa , vol.98 , pp. 10863-10868
    • Xia, X.1    Qian, S.2    Soriano, S.3
  • 57
    • 0025367937 scopus 로고
    • Hidradenitis suppurativa: A disease of follicular epithelium, rather than apocrine glands
    • Yu CC, Cook MG (1990) Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands. Br J Dermatol 122: 763-9
    • (1990) Br J Dermatol , vol.122 , pp. 763-769
    • Yu, C.C.1    Cook, M.G.2
  • 58
    • 84888206173 scopus 로고    scopus 로고
    • Two novel mutations of the NCSTN gene in Chinese familial acne inverse
    • e-pub ahead of print 13 July 2012
    • Zhang C, Wang L, Chen L et al. (2012) Two novel mutations of the NCSTN gene in Chinese familial acne inverse. J Eur Acad Dermatol Venereol; e-pub ahead of print 13 July 2012
    • J Eur Acad Dermatol Venereol , vol.2012
    • Zhang, C.1    Wang, L.2    Chen, L.3


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