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Volumn 45, Issue 1, 2014, Pages 459-469

Orostachys japonicus induces apoptosis and cell cycle arrest through the mitochondria-dependent apoptotic pathway in AGS human gastric cancer cells

Author keywords

AGS human gastric cancer cells apoptosis; Cell cycle arrest; MAPKs; Orostachys japonicus

Indexed keywords

ACETIC ACID ETHYL ESTER; CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; OROSTACHYS JAPONICUS EXTRACT; PLANT EXTRACT; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT;

EID: 84902583274     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2404     Document Type: Article
Times cited : (23)

References (51)
  • 1
    • 0032704372 scopus 로고    scopus 로고
    • Perspectives on cancer chemoprevention research and drug development
    • Kelloff GJ: Perspectives on cancer chemoprevention research and drug development. Adv in Cancer Res 78: 199-334, 2000.
    • (2000) Adv in Cancer Res , vol.78 , pp. 199-334
    • Kelloff, G.J.1
  • 2
    • 78649766048 scopus 로고    scopus 로고
    • Effects of polysaccharides derived from Orostachys japonicus on induction of cell cycle arrest and apoptotic cell death in human colon cancer cells
    • Ryu DS, Baek GO, Kim EY, Kim KH and Lee DS: Effects of polysaccharides derived from Orostachys japonicus on induction of cell cycle arrest and apoptotic cell death in human colon cancer cells. BMB Rep 43: 750-755, 2010.
    • (2010) BMB Rep , vol.43 , pp. 750-755
    • Ryu, D.S.1    Baek, G.O.2    Kim, E.Y.3    Kim, K.H.4    Lee, D.S.5
  • 3
    • 33748429711 scopus 로고    scopus 로고
    • Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine
    • Choi SY, Chung MJ, Seo WD, Shin JH, Shon MY and Sung NJ: Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine. J Agric Food Chem 54: 6075-6078, 2006.
    • (2006) J Agric Food Chem , vol.54 , pp. 6075-6078
    • Choi, S.Y.1    Chung, M.J.2    Seo, W.D.3    Shin, J.H.4    Shon, M.Y.5    Sung, N.J.6
  • 4
    • 37549034600 scopus 로고    scopus 로고
    • Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice
    • Jung HJ, Choi J, Nam JH and Park HJ: Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice. J Med Food 10: 702-706, 2007.
    • (2007) J Med Food , vol.10 , pp. 702-706
    • Jung, H.J.1    Choi, J.2    Nam, J.H.3    Park, H.J.4
  • 5
    • 84862793604 scopus 로고    scopus 로고
    • Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: Suppression of NF-ΚB activation and MAPK signaling
    • Lee HS, Ryu DS, Lee GS and Lee DS: Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: Suppression of NF-ΚB activation and MAPK signaling. J Ethnopharmacol 140: 271-276, 2012.
    • (2012) J Ethnopharmacol , vol.140 , pp. 271-276
    • Lee, H.S.1    Ryu, D.S.2    Lee, G.S.3    Lee, D.S.4
  • 8
    • 84861214355 scopus 로고    scopus 로고
    • Effect of the ethylacetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells
    • Ryu DS, Lee HS, Lee GS and Lee DS: Effect of the ethylacetate extract of Orostachys japonicus on induction of apoptosis through the p53-mediated signaling pathway in human gastric cancer cells. Biol Pharm Bull 35: 660-665, 2012.
    • (2012) Biol Pharm Bull , vol.35 , pp. 660-665
    • Ryu, D.S.1    Lee, H.S.2    Lee, G.S.3    Lee, D.S.4
  • 10
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL and Levin AJ: The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908, 2005.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levin, A.J.2
  • 11
    • 57049114832 scopus 로고    scopus 로고
    • The genetics of the p53 pathway, apoptosis and cancer therapy
    • Vazquez A, Bond EE, Levine AJ and Bond GL: The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 7: 979-987, 2008.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 979-987
    • Vazquez, A.1    Bond, E.E.2    Levine, A.J.3    Bond, G.L.4
  • 12
    • 4344691959 scopus 로고    scopus 로고
    • Caspases, IAPs and Smac/DIABLO: Mechanisms from structural biology
    • Shiozaki EN and Shi Y: Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends Biochem Sci 29: 486-494, 2004.
    • (2004) Trends Biochem Sci , vol.29 , pp. 486-494
    • Shiozaki, E.N.1    Shi, Y.2
  • 13
    • 0036487232 scopus 로고    scopus 로고
    • Bcl-2 family of proteins: Life-or-death switch in mitochondria
    • Tsujimoto Y: Bcl-2 family of proteins: life-or-death switch in mitochondria. Biosci Rep 22: 47-58, 2002.
    • (2002) Biosci Rep , vol.22 , pp. 47-58
    • Tsujimoto, Y.1
  • 14
    • 0043025262 scopus 로고    scopus 로고
    • Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatinand carboplatin-induced growth inhibition and apoptotic death
    • Dhanalakshmi S, Agarwal P, Globe L and Agarwal R: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatinand carboplatin-induced growth inhibition and apoptotic death. Int J Cancer 106: 699-705, 2003.
    • (2003) Int J Cancer , vol.106 , pp. 699-705
    • Dhanalakshmi, S.1    Agarwal, P.2    Globe, L.3    Agarwal, R.4
  • 15
    • 16644381714 scopus 로고    scopus 로고
    • Cyclin, cyclin-dependent kinases, and cyclindependent kinase inhibitors: Detection methods and activity measurements
    • Brooks G: Cyclin, cyclin-dependent kinases, and cyclindependent kinase inhibitors: detection methods and activity measurements. Methods Mol Biol 296: 291-298, 2005.
    • (2005) Methods Mol Biol , vol.296 , pp. 291-298
    • Brooks, G.1
  • 17
    • 0034722894 scopus 로고    scopus 로고
    • Development of anticancer drugs targeting the MAP kinase pathway
    • Sebolt-Leopold JS: Development of anticancer drugs targeting the MAP kinase pathway. Oncogene 19: 6594-6599, 2000.
    • (2000) Oncogene , vol.19 , pp. 6594-6599
    • Sebolt-Leopold, J.S.1
  • 18
    • 10344258041 scopus 로고    scopus 로고
    • Targeting the mitogenactivated protein kinase cascade to treat cancer
    • Sebolt-Leopold JS and Herrera R: Targeting the mitogenactivated protein kinase cascade to treat cancer. Nat Rev Cancer 4: 937-947, 2004.
    • (2004) Nat Rev Cancer , vol.4 , pp. 937-947
    • Sebolt-Leopold, J.S.1    Herrera, R.2
  • 19
    • 79960099474 scopus 로고    scopus 로고
    • Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells
    • Jeong JH, Ryu DS, Suk DH and Lee DS: Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells. BMB Rep 44: 399-404, 2011.
    • (2011) BMB Rep , vol.44 , pp. 399-404
    • Jeong, J.H.1    Ryu, D.S.2    Suk, D.H.3    Lee, D.S.4
  • 20
    • 84880507052 scopus 로고    scopus 로고
    • Anti-inflammatory effect of the hexane fraction from Orostachys japonicus in RAW 264.7 cells by suppression of NF-ΚB and PI3K-Akt signaling
    • Lee HS, Bilehal D, Lee GS, Ryu DS, Kim HK, Suk DH and Lee DS: Anti-inflammatory effect of the hexane fraction from Orostachys japonicus in RAW 264.7 cells by suppression of NF-ΚB and PI3K-Akt signaling. J Funct Foods 5: 1217-1225, 2013.
    • (2013) J Funct Foods , vol.5 , pp. 1217-1225
    • Lee, H.S.1    Bilehal, D.2    Lee, G.S.3    Ryu, D.S.4    Kim, H.K.5    Suk, D.H.6    Lee, D.S.7
  • 21
    • 0035575679 scopus 로고    scopus 로고
    • Programmed cell death: Alive and well in the new millennium
    • Kaufmann SH and Henqartner MO: Programmed cell death: alive and well in the new millennium. Trends Cell Biol 11: 526-534, 2001.
    • (2001) Trends Cell Biol , vol.11 , pp. 526-534
    • Kaufmann, S.H.1    Henqartner, M.O.2
  • 22
    • 71549141334 scopus 로고    scopus 로고
    • Anti-proliferative effect of polysaccharides from Salicornia herbacea on induction of G2/M arrest and apoptosis in human colon cancer cells
    • Ryu DS, Kim SH and Lee DS: Anti-proliferative effect of polysaccharides from Salicornia herbacea on induction of G2/M arrest and apoptosis in human colon cancer cells. J Microbiol Biotechnol 19: 1482-1489, 2009.
    • (2009) J Microbiol Biotechnol , vol.19 , pp. 1482-1489
    • Ryu, D.S.1    Kim, S.H.2    Lee, D.S.3
  • 23
    • 33748308716 scopus 로고    scopus 로고
    • Genetic instability in cancer cells by impaired cell cycle checkpoints
    • Nakanishi M, Shimada N and Niida H: Genetic instability in cancer cells by impaired cell cycle checkpoints. Cancer Sci 97: 984-989, 2006.
    • (2006) Cancer Sci , vol.97 , pp. 984-989
    • Nakanishi, M.1    Shimada, N.2    Niida, H.3
  • 24
    • 0028075611 scopus 로고
    • CDK inhibitors; on the threshold of checkpoints and development
    • Elledge SJ and Harpae JW: CDK inhibitors; on the threshold of checkpoints and development. Curr Opin Cell Biol 6: 847-852, 1994.
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 847-852
    • Elledge, S.J.1    Harpae, J.W.2
  • 25
    • 24644438102 scopus 로고    scopus 로고
    • Apoptosis. p53 and PUMA: A deadly duo
    • Vousden KH: Apoptosis. p53 and PUMA: a deadly duo. Science 309: 1685-1686, 2005.
    • (2005) Science , vol.309 , pp. 1685-1686
    • Vousden, K.H.1
  • 26
    • 33646757232 scopus 로고    scopus 로고
    • The complexity of p53 stabilization and activation
    • Lavin MF and Gueven N: The complexity of p53 stabilization and activation. Cell Death Differ 13: 941-950, 2006.
    • (2006) Cell Death Differ , vol.13 , pp. 941-950
    • Lavin, M.F.1    Gueven, N.2
  • 27
    • 33747194161 scopus 로고    scopus 로고
    • Arsenic trioxide induces gallbladder carcinoma cell apoptosis via down regulation of bcl-2
    • Ai Z, Lu W and Qin X: Arsenic trioxide induces gallbladder carcinoma cell apoptosis via down regulation of bcl-2. Biochem Biophys Res Commun 348: 1075-1081, 2006.
    • (2006) Biochem Biophys Res Commun , vol.348 , pp. 1075-1081
    • Ai, Z.1    Lu, W.2    Qin, X.3
  • 28
    • 62249220640 scopus 로고    scopus 로고
    • Curcumin induces apoptosis through the mitochondria-mediated apoptotic pathway in HT-29 cells
    • Wang JB, QI LL, Zheng SD and Wu TX: Curcumin induces apoptosis through the mitochondria-mediated apoptotic pathway in HT-29 cells. J Zhejizng Univ Sci B 10: 93-102, 2009.
    • (2009) J Zhejizng Univ Sci B , vol.10 , pp. 93-102
    • Wang, J.B.1    Ll, Q.I.2    Zheng, S.D.3    Wu, T.X.4
  • 30
    • 0035036133 scopus 로고    scopus 로고
    • Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo
    • Fujita E, Egashira J, Urase K, Kuida K and Momoi T: Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo. Cell Death Differ 8: 335-344, 2001.
    • (2001) Cell Death Differ , vol.8 , pp. 335-344
    • Fujita, E.1    Egashira, J.2    Urase, K.3    Kuida, K.4    Momoi, T.5
  • 31
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R and Krebs EG: The MAPK signaling cascade. FASEB J 9: 726-735, 1995.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 32
    • 0034641980 scopus 로고    scopus 로고
    • Apoptosis in development
    • Meier P, Finch A and Evan G: Apoptosis in development. Nature 407: 796-801, 2000.
    • (2000) Nature , vol.407 , pp. 796-801
    • Meier, P.1    Finch, A.2    Evan, G.3
  • 33
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 34
    • 33644830944 scopus 로고    scopus 로고
    • Targeting the cell cycle: A new approach to cancer therapy
    • Schwartz GK and Shah MA: Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 23: 9408-9421, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 9408-9421
    • Schwartz, G.K.1    Shah, M.A.2
  • 36
    • 0035082454 scopus 로고    scopus 로고
    • The p53 tumor suppressor: Critical regulator of life & death in cancer
    • Fisher DE: The p53 tumor suppressor: critical regulator of life & death in cancer. Apoptosis 6: 7-15, 2001.
    • (2001) Apoptosis , vol.6 , pp. 7-15
    • Fisher, D.E.1
  • 37
    • 0035970721 scopus 로고    scopus 로고
    • Nuclear and mitochondrial apoptotic pathways of p53
    • Moll UM and Zaika A: Nuclear and mitochondrial apoptotic pathways of p53. FEBS Lett 493: 65-69, 2001.
    • (2001) FEBS Lett , vol.493 , pp. 65-69
    • Moll, U.M.1    Zaika, A.2
  • 38
    • 3242690522 scopus 로고    scopus 로고
    • In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
    • Erster S, Mihara M, Kim RH, Petrenko O and Moll UM: In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 24: 6728-6741, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 6728-6741
    • Erster, S.1    Mihara, M.2    Kim, R.H.3    Petrenko, O.4    Moll, U.M.5
  • 39
    • 3943071150 scopus 로고    scopus 로고
    • Cytochrome c-mediated apoptosis
    • Jiang X and Wang X: Cytochrome c-mediated apoptosis. Annu Rev Biochem 73: 87-106, 2004.
    • (2004) Annu Rev Biochem , vol.73 , pp. 87-106
    • Jiang, X.1    Wang, X.2
  • 40
    • 0033396491 scopus 로고    scopus 로고
    • Fas ligand-induced apoptosis
    • Nagata S: Fas ligand-induced apoptosis. Annu Rev Genet 33: 29-55, 1999.
    • (1999) Annu Rev Genet , vol.33 , pp. 29-55
    • Nagata, S.1
  • 41
    • 27544446991 scopus 로고    scopus 로고
    • Life in the balance: How BH3-only proteins induce apoptosis
    • Willis SN and Adams JM: Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17: 617-625, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 617-625
    • Willis, S.N.1    Adams, J.M.2
  • 42
    • 33646024628 scopus 로고    scopus 로고
    • The apoptosome activates caspase-9 by dimerization
    • Pop C, Timmer J, Sperandio S and Salvesen GS: The apoptosome activates caspase-9 by dimerization. Mol Cell 22: 269-275, 2006.
    • (2006) Mol Cell , vol.22 , pp. 269-275
    • Pop, C.1    Timmer, J.2    Sperandio, S.3    Salvesen, G.S.4
  • 43
    • 0035408265 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway
    • Zhou Z, Sun X and Kang YJ: Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 159: 329-338, 2001.
    • (2001) Am J Pathol , vol.159 , pp. 329-338
    • Zhou, Z.1    Sun, X.2    Kang, Y.J.3
  • 44
  • 45
    • 77950947401 scopus 로고    scopus 로고
    • The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells
    • Zheng Y, Zhou M, Ye A, Li Q, Bai Y and Zhang Q: The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. World J Sur Oncol 8: 31, 2010.
    • (2010) World J Sur Oncol , vol.8 , pp. 31
    • Zheng, Y.1    Zhou, M.2    Ye, A.3    Li, Q.4    Bai, Y.5    Zhang, Q.6
  • 46
    • 74549165964 scopus 로고    scopus 로고
    • Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase- 8-dependent pathway in HL-60 human leukemia cells
    • Cho SH, Chung KS, Choi JH, Kim DH and Lee KT: Compound K, a metabolite of ginseng saponin, induces apoptosis via caspase- 8-dependent pathway in HL-60 human leukemia cells. BMC Cancer 9: 449, 2009.
    • (2009) BMC Cancer , vol.9 , pp. 449
    • Cho, S.H.1    Chung, K.S.2    Choi, J.H.3    Kim, D.H.4    Lee, K.T.5
  • 47
    • 0141680424 scopus 로고    scopus 로고
    • Cell signaling and cancer
    • Martin GS: Cell signaling and cancer. Cancer Cell 4: 167-174, 2003.
    • (2003) Cancer Cell , vol.4 , pp. 167-174
    • Martin, G.S.1
  • 48
    • 3343004688 scopus 로고    scopus 로고
    • The role of the mitogenactivated protein kinase cellular signaling pathway in tumor cell survival and apoptosis
    • Freeman SM and Whartenby KA: The role of the mitogenactivated protein kinase cellular signaling pathway in tumor cell survival and apoptosis. Drug News Perspect 17: 237-242, 2004.
    • (2004) Drug News Perspect , vol.17 , pp. 237-242
    • Freeman, S.M.1    Whartenby, K.A.2
  • 49
    • 0042734434 scopus 로고    scopus 로고
    • The true face of JNK activation in apoptosis
    • Lin A and Dibling B: The true face of JNK activation in apoptosis. Aging Cell 1: 112-116, 2002.
    • (2002) Aging Cell , vol.1 , pp. 112-116
    • Lin, A.1    Dibling, B.2
  • 50
    • 55249093243 scopus 로고    scopus 로고
    • Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways
    • Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, Cantoni AM, Salvatore L, Riccioni R and Costanzo A: Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood 112: 2450-2462, 2008.
    • (2008) Blood , vol.112 , pp. 2450-2462
    • Lunghi, P.1    Giuliani, N.2    Mazzera, L.3    Lombardi, G.4    Ricca, M.5    Corradi, A.6    Cantoni, A.M.7    Salvatore, L.8    Riccioni, R.9    Costanzo, A.10
  • 51
    • 0038482086 scopus 로고    scopus 로고
    • Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
    • Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB and Claret FX: Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem 278: 19245-19256, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 19245-19256
    • Mansouri, A.1    Ridgway, L.D.2    Korapati, A.L.3    Zhang, Q.4    Tian, L.5    Wang, Y.6    Siddik, Z.H.7    Mills, G.B.8    Claret, F.X.9


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