메뉴 건너뛰기




Volumn 10, Issue 2, 2009, Pages 93-102

Curcumin induces apoptosis through the mitochondria-mediated apoptotic pathway in HT-29 cells

Author keywords

Apoptosis; Curcumin; HT 29 cells; Mitochondrial pathway

Indexed keywords

CASPASE 3; CURCUMIN; CYTOCHROME C; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SURVIVIN; ANTINEOPLASTIC AGENT; BIRC5 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN BCL X;

EID: 62249220640     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B0820238     Document Type: Article
Times cited : (95)

References (38)
  • 2
    • 0037453223 scopus 로고    scopus 로고
    • 2+ depletion and cytochrome c release
    • [doi:10.1016/S0006-291X(03)00479-0]
    • 2+ depletion and cytochrome c release. Biochem. Biophys. Res. Commun., 303 (4):1073-1079. [doi:10.1016/S0006-291X(03)00479-0]
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , Issue.4 , pp. 1073-1079
    • Bae, J.H.1    Park, J.W.2    Kwon, T.K.3
  • 3
    • 0034644797 scopus 로고    scopus 로고
    • Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells
    • [doi:10.1016/S0014-5793(00)02089-5]
    • Bhaumik, S., Jyothi, M.D., Khar, A., 2000. Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells. FEBS Lett., 483 (1):78-82. [doi:10.1016/S0014-5793(00)02089-5]
    • (2000) FEBS Lett , vol.483 , Issue.1 , pp. 78-82
    • Bhaumik, S.1    Jyothi, M.D.2    Khar, A.3
  • 4
    • 34547657453 scopus 로고    scopus 로고
    • Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells
    • [doi:10.1016/j.freeradbiomed.2007.06.006]
    • Cao, J., Liu, Y., Jia, L., Zhou, H.M., Kong, Y., Yang, G., Jiang, L.P., Li, Q.J., Zhong, L.F., 2007. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic. Biol. Med., 43 (6):968-975. [doi:10.1016/ j.freeradbiomed.2007.06.006]
    • (2007) Free Radic. Biol. Med. , vol.43 , Issue.6 , pp. 968-975
    • Cao, J.1    Liu, Y.2    Jia, L.3    Zhou, H.M.4    Kong, Y.5    Yang, G.6    Jiang, L.P.7    Li, Q.J.8    Zhong, L.F.9
  • 5
    • 48549085442 scopus 로고    scopus 로고
    • Curcumin decreases specificity protein expression in bladder cancer cells
    • [doi:10.1158/0008-5472.CAN-07-6805]
    • Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., Li, X., Safe, S., 2008. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res., 68 (13):5345-5354. [doi:10.1158/0008-5472.CAN-07-6805]
    • (2008) Cancer Res. , vol.68 , Issue.13 , pp. 5345-5354
    • Chadalapaka, G.1    Jutooru, I.2    Chintharlapalli, S.3    Papineni, S.4    Smith, R.5    Li, X.6    Safe, S.7
  • 6
    • 34247842982 scopus 로고    scopus 로고
    • 6-Shogaol (alkanone from Ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism
    • [doi:10.1021/jf0624594]
    • Chen, C.Y., Liu, T.Z., Liu, Y.W., Tseng, W.C., Liu, R.H., Lu, F.J., Lin, Y.S., Chen, C.H., 2007. 6-Shogaol (alkanone from Ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. J. Agric. Food Chem., 55 (3):948-954. [doi:10.1021/jf0624594]
    • (2007) J. Agric. Food Chem. , vol.55 , Issue.3 , pp. 948-954
    • Chen, C.Y.1    Liu, T.Z.2    Liu, Y.W.3    Tseng, W.C.4    Liu, R.H.5    Lu, F.J.6    Lin, Y.S.7    Chen, C.H.8
  • 7
    • 44849131305 scopus 로고    scopus 로고
    • T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes
    • [doi:10.1631/jzus.B0820013]
    • Chen, J.H., Cao, J.L., Chu, Y.L., Wang, Z.L., Yang, Z.T., Wang, H.L., 2008. T-2 toxin-induced apoptosis involving Fas, p53, Bcl-xL, Bcl-2, Bax and caspase-3 signaling pathways in human chondrocytes. J. Zhejiang Univ. Sci. B, 9 (6):455-463. [doi:10.1631/jzus.B0820013]
    • (2008) J. Zhejiang Univ. Sci. B , vol.9 , Issue.6 , pp. 455-463
    • Chen, J.H.1    Cao, J.L.2    Chu, Y.L.3    Wang, Z.L.4    Yang, Z.T.5    Wang, H.L.6
  • 8
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl-2 family: Regulators of the cellular life-or-death switch
    • [doi:10.1038/nrc883]
    • Cory, S., Adams, J.M., 2002. The Bcl-2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer, 2 (9):647-656. [doi:10.1038/nrc883]
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.9 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 9
    • 0037007014 scopus 로고    scopus 로고
    • FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
    • [doi:10.1073/pnas.261702698]
    • Desai, B.N., Myers, B.R., Schreiber, S.L., 2002. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA, 99 (7):4319-4324. [doi:10.1073/pnas.261702698]
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.7 , pp. 4319-4324
    • Desai, B.N.1    Myers, B.R.2    Schreiber, S.L.3
  • 10
    • 2942624044 scopus 로고    scopus 로고
    • Immunomodulatory activity of curcumin: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro
    • [doi:10.1016/j.bcp.2004.03.015]
    • Gao, X., Kuo, J., Jiang, H., Deeb, D., Liu, Y., Divine, G., Chapman, R.A., Dulchavsky, S.A., Gautam, S.C., 2004. Immunomodulatory activity of curcumin: Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. Biochem. Pharmacol., 68 (1):51-61. [doi:10.1016/j.bcp.2004.03.015]
    • (2004) Biochem. Pharmacol. , vol.68 , Issue.1 , pp. 51-61
    • Gao, X.1    Kuo, J.2    Jiang, H.3    Deeb, D.4    Liu, Y.5    Divine, G.6    Chapman, R.A.7    Dulchavsky, S.A.8    Gautam, S.C.9
  • 11
    • 0034616946 scopus 로고    scopus 로고
    • Apoptotic pathways: Paper wraps stone blunts scissors
    • [doi:10.1016/S0092-8674(00)00003-9]
    • Green, D.R., 2000. Apoptotic pathways: Paper wraps stone blunts scissors. Cell, 102 (1):1-4. [doi:10.1016/S0092-8674(00)00003-9]
    • (2000) Cell , vol.102 , Issue.1 , pp. 1-4
    • Green, D.R.1
  • 12
    • 13844281064 scopus 로고    scopus 로고
    • Involvement of mtDNA damage in free fatty acid-induced apoptosis
    • [doi:10.1016/j.freeradbiomed.2004.11.023]
    • Grishko, V., Rachek, L., Musiyenko, S., Ledoux, S.P., Wilson, G.L., 2005. Involvement of mtDNA damage in free fatty acid-induced apoptosis. Free Radic. Biol. Med., 38 (6):755-762. [doi:10.1016/ j.freeradbiomed.2004.11.023]
    • (2005) Free Radic. Biol. Med. , vol.38 , Issue.6 , pp. 755-762
    • Grishko, V.1    Rachek, L.2    Musiyenko, S.3    Ledoux, S.P.4    Wilson, G.L.5
  • 13
    • 33745114177 scopus 로고    scopus 로고
    • A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma
    • [doi:10.1007/s00384-005-0002-8]
    • Khor, T.O., Gul, Y.A., Ithnin, H., Seow, H.F., 2006. A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma. Int. J. Colorectal Dis., 21(4):291-300. [doi:10.1007/ s00384-005-0002-8]
    • (2006) Int. J. Colorectal Dis. , vol.21 , Issue.4 , pp. 291-300
    • Khor, T.O.1    Gul, Y.A.2    Ithnin, H.3    Seow, H.F.4
  • 14
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • [doi:10.1126/science.275.5303.1132]
    • Kluck, R.M., Bossy-Wetzel, E., Green, D.R., Newmeyer, D.D., 1997. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science, 275(5303):1132-1136. [doi:10.1126/ science.275.5303.1132]
    • (1997) Science , vol.275 , Issue.5303 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 15
    • 47549110163 scopus 로고    scopus 로고
    • Quantitative analysis of survivin in colorectal adenocarcinoma: Increased expression and correlation with telomerase activity
    • [doi:10.1016/j.humpath.2008.01.001]
    • Lam, A.K., Saleh, S., Smith, R.A., Ho, Y., 2008. Quantitative analysis of survivin in colorectal adenocarcinoma: Increased expression and correlation with telomerase activity. Human Pathol., 39(8):1229-1233. [doi:10.1016/j.humpath.2008.01.001]
    • (2008) Human Pathol. , vol.39 , Issue.8 , pp. 1229-1233
    • Lam, A.K.1    Saleh, S.2    Smith, R.A.3    Ho, Y.4
  • 16
    • 33745714787 scopus 로고    scopus 로고
    • Role of the survivin gene in pathophysiology
    • [doi:10.2353/ajpath.2006.060121]
    • Li, F., Brattain, M.G., 2006. Role of the survivin gene in pathophysiology. Am. J. Pathol., 169(1):1-10. [doi:10.2353/ ajpath.2006.060121]
    • (2006) Am. J. Pathol. , vol.169 , Issue.1 , pp. 1-10
    • Li, F.1    Brattain, M.G.2
  • 17
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • [doi:10.1016/S0092-8674(00)80434-1]
    • Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., Wang, X., 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91(4):479-489. [doi:10.1016/S0092-8674(00)80434-1]
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 18
    • 36749087040 scopus 로고    scopus 로고
    • Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells
    • [doi:10.1158/1535-7163.MCT-07-0117]
    • Moiseeva, E.P., Almeida, G.M., Jones, G.D.D., Manson, M.M., 2007. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol. Cancer Ther., 6(11):3071-3079. [doi:10.1158/1535-7163.MCT-07-0117]
    • (2007) Mol. Cancer Ther. , vol.6 , Issue.11 , pp. 3071-3079
    • Moiseeva, E.P.1    Almeida, G.M.2    Jones, G.D.D.3    Manson, M.M.4
  • 19
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • [doi:10. 1021/np030096l]
    • Newman, D.J., Cragg, G.M., Snader, K.M., 2003. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod., 66(7):1022-1037. [doi:10. 1021/np030096l]
    • (2003) J. Nat. Prod. , vol.66 , Issue.7 , pp. 1022-1037
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 20
    • 0034836540 scopus 로고    scopus 로고
    • Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells
    • [doi:10.1021/jf001129v]
    • Pan, M.H., Chang, W.L., Lin-Shiau, S.Y., Ho, C.T., Lin, J.K., 2001. Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. J. Agric. Food Chem., 49(3):1464-1474. [doi:10.1021/jf001129v]
    • (2001) J. Agric. Food Chem. , vol.49 , Issue.3 , pp. 1464-1474
    • Pan, M.H.1    Chang, W.L.2    Lin-Shiau, S.Y.3    Ho, C.T.4    Lin, J.K.5
  • 21
    • 0033563646 scopus 로고    scopus 로고
    • A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells
    • [doi:10.1006/excr.1999.4480]
    • Piwocka, K., Zabłocki, K., Wieckowski, M.R., Skierski, J., Feiga, I., Szopa, J., Drela, N., Wojtczak, L., Sikora, E., 1999. A novel apoptosis-like pathway, independent of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells. Exp. Cell Res., 249 (2):299-307. [doi:10.1006/excr.1999.4480]
    • (1999) Exp. Cell Res. , vol.249 , Issue.2 , pp. 299-307
    • Piwocka, K.1    Zabłocki, K.2    Wieckowski, M.R.3    Skierski, J.4    Feiga, I.5    Szopa, J.6    Drela, N.7    Wojtczak, L.8    Sikora, E.9
  • 22
    • 0031586327 scopus 로고    scopus 로고
    • Induction of apoptosis and potentiation of TNF and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609
    • [doi:10.1006/excr.1997.3641]
    • Porn-Ares, M.I., Chow, S.C., Slotte, J.P., Orrenius, S., 1997. Induction of apoptosis and potentiation of TNF and Fas-mediated apoptosis in U937 cells by the xanthogenate compound D609. Exp. Cell Res., 235(1):48-54. [doi:10.1006/excr.1997.3641]
    • (1997) Exp. Cell Res. , vol.235 , Issue.1 , pp. 48-54
    • Porn-Ares, M.I.1    Chow, S.C.2    Slotte, J.P.3    Orrenius, S.4
  • 23
    • 0037434845 scopus 로고    scopus 로고
    • Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases
    • [doi:10.1016/S0014-5793(03)00099-1]
    • Rashmi, R., Santhosh Kumar, T.R., Karunagaran, D., 2003. Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Lett., 538(1-3):19-24. [doi:10.1016/S0014-5793(03)00099-1]
    • (2003) FEBS Lett. , vol.538 , Issue.1-3 , pp. 19-24
    • Rashmi, R.1    Santhosh Kumar, T.R.2    Karunagaran, D.3
  • 24
    • 0032409781 scopus 로고    scopus 로고
    • Bcl-2 family proteins
    • [doi:10.1038/sj.onc.1202591]
    • Reed, J.C., 1998. Bcl-2 family proteins. Oncogene, 17 (25):3225-3236. [doi:10.1038/sj.onc.1202591]
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3225-3236
    • Reed, J.C.1
  • 25
    • 0030612749 scopus 로고    scopus 로고
    • 6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
    • [doi:10.1016/S0014-5793(97)00669-8]
    • 6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis. FEBS Lett., 411(1):77-82. [doi:10.1016/S0014-5793(97)00669-8]
    • (1997) FEBS Lett. , vol.411 , Issue.1 , pp. 77-82
    • Salvioli, S.1    Ardizzoni, A.2    Franceschi, C.3    Cossarizza, A.4
  • 26
    • 8844261849 scopus 로고    scopus 로고
    • Curcumin-induced GADD153 gene up-regulation in human colon cancer cells
    • [doi:10.1093/carcin/bgh239]
    • Scott, D.W., Loo, G., 2004. Curcumin-induced GADD153 gene up-regulation in human colon cancer cells. Carcinogenesis, 25(11):2155-2164. [doi:10.1093/carcin/bgh239]
    • (2004) Carcinogenesis , vol.25 , Issue.11 , pp. 2155-2164
    • Scott, D.W.1    Loo, G.2
  • 27
    • 18844461634 scopus 로고    scopus 로고
    • Curcumin enhances Vinorelbine-mediated apoptosis in NSCLC cells by the mitochondrial pathway
    • [doi:10.1016/j.bbrc.2005.04. 044]
    • Sen, S., Sharma, H., Singh, N., 2005. Curcumin enhances Vinorelbine-mediated apoptosis in NSCLC cells by the mitochondrial pathway. Biochem. Biophys. Res. Commun., 331(4):1245-1252. [doi:10.1016/ j.bbrc.2005.04. 044]
    • (2005) Biochem. Biophys. Res. Commun. , vol.331 , Issue.4 , pp. 1245-1252
    • Sen, S.1    Sharma, H.2    Singh, N.3
  • 28
    • 27144458235 scopus 로고    scopus 로고
    • Death-associated protein kinase as a sensor of mitochondrial membrane potential: Role of lysosome in mitochondrial toxin-induced cell death
    • [doi:10.1074/jbc.M506466200]
    • Shang, T., Joseph, J., Hillard, C.J., Kalyanaraman, B., 2005. Death-associated protein kinase as a sensor of mitochondrial membrane potential: Role of lysosome in mitochondrial toxin-induced cell death. J. Biol. Chem., 280(41):34644-34653. [doi:10.1074/jbc.M506466200]
    • (2005) J. Biol. Chem. , vol.280 , Issue.41 , pp. 34644-34653
    • Shang, T.1    Joseph, J.2    Hillard, C.J.3    Kalyanaraman, B.4
  • 29
    • 27144545998 scopus 로고    scopus 로고
    • Curcumin: The story so far
    • [doi:10.1016/j.ejca.2005.05.009]
    • Sharma, R.A., Gescher, A.J., Steward, W.P., 2005. Curcumin: The story so far. Eur. J. Cancer, 41(13):1955-1968. [doi:10.1016/j.ejca.2005.05.009]
    • (2005) Eur. J. Cancer , vol.41 , Issue.13 , pp. 1955-1968
    • Sharma, R.A.1    Gescher, A.J.2    Steward, W.P.3
  • 30
    • 33244476761 scopus 로고    scopus 로고
    • Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells
    • [doi:10.1016/j.cellbi.2005.10.024]
    • Shi, M., Cai, Q., Yao, L., Mao, Y., Ming, Y., Ouyang, G., 2006. Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells. Cell Biol. Internat., 30 (3):221-226. [doi:10.1016/ j.cellbi.2005.10.024]
    • (2006) Cell Biol. Internat. , vol.30 , Issue.3 , pp. 221-226
    • Shi, M.1    Cai, Q.2    Yao, L.3    Mao, Y.4    Ming, Y.5    Ouyang, G.6
  • 31
    • 23044479821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive NF-κB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
    • [doi:10. 1016/j.bcp.2005.04.043]
    • Shishodia, S., Amin, H.M., Lai, R., Aggarwal, B.B., 2005a. Curcumin (diferuloylmethane) inhibits constitutive NF-κB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem. Pharmacol., 70(5):700-713. [doi:10. 1016/ j.bcp.2005.04.043]
    • (2005) Biochem. Pharmacol. , vol.70 , Issue.5 , pp. 700-713
    • Shishodia, S.1    Amin, H.M.2    Lai, R.3    Aggarwal, B.B.4
  • 32
    • 29744451509 scopus 로고    scopus 로고
    • Curcumin: Getting back to the roots
    • [doi:10.1196/annals.1352.010]
    • Shishodia, S., Sethi, G., Aggarwal, B.B., 2005b. Curcumin: Getting back to the roots. Ann. N. Y. Acad. Sci., 1056(1):206-217. [doi:10.1196/ annals.1352.010]
    • (2005) Ann. N. Y. Acad. Sci. , vol.1056 , Issue.1 , pp. 206-217
    • Shishodia, S.1    Sethi, G.2    Aggarwal, B.B.3
  • 33
    • 30544455551 scopus 로고    scopus 로고
    • Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression
    • [doi:10.1590/S0100-879X2005001200007]
    • Song, G., Mao, Y.B., Cai, Q.F., Yao, L.M., Ouyang, G.L., Bao, D., 2005. Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression. Braz. J. Med. Biol. Res., 38(12):1791-1798. [doi:10.1590/ S0100-879X2005001200007]
    • (2005) Braz. J. Med. Biol. Res. , vol.38 , Issue.12 , pp. 1791-1798
    • Song, G.1    Mao, Y.B.2    Cai, Q.F.3    Yao, L.M.4    Ouyang, G.L.5    Bao, D.6
  • 34
    • 0034594915 scopus 로고    scopus 로고
    • Survivin initiates procaspase-3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death
    • [doi:10.1038/sj.onc.1203429]
    • Suzuki, A., Ito, T., Hayashida, M., Hayasaki, Y., Tuutomi, Y., Akahane, K., Nakano, T., Miura, M., Shiraki, K., 2000. Survivin initiates procaspase-3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene, 19(10):1346-1353. [doi:10.1038/sj.onc.1203429]
    • (2000) Oncogene , vol.19 , Issue.10 , pp. 1346-1353
    • Suzuki, A.1    Ito, T.2    Hayashida, M.3    Hayasaki, Y.4    Tuutomi, Y.5    Akahane, K.6    Nakano, T.7    Miura, M.8    Shiraki, K.9
  • 35
    • 23844515938 scopus 로고    scopus 로고
    • Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma
    • Tan, H.Y., Liu, J., Wu, S.M., Luo, H.S., 2005. Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma. World J. Gastroenterol., 11(30):4689-4692.
    • (2005) World J. Gastroenterol. , vol.11 , Issue.30 , pp. 4689-4692
    • Tan, H.Y.1    Liu, J.2    Wu, S.M.3    Luo, H.S.4
  • 36
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang, X., 2001. The expanding role of mitochondria in apoptosis. Genes Dev., 15(22):2922-2933.
    • (2001) Genes Dev. , vol.15 , Issue.22 , pp. 2922-2933
    • Wang, X.1
  • 37
    • 31344443290 scopus 로고    scopus 로고
    • An overview of apoptosis and the prevention of colorectal cancer
    • [doi:10.1016/j.critrevonc.2005.06. 005]
    • Watson, A.J.M., 2006. An overview of apoptosis and the prevention of colorectal cancer. Crit. Rev. Oncol. Hematol., 57(2):107-121. [doi:10.1016/j.critrevonc.2005.06. 005]
    • (2006) Crit. Rev. Oncol. Hematol. , vol.57 , Issue.2 , pp. 107-121
    • Watson, A.J.M.1
  • 38
    • 0042169007 scopus 로고    scopus 로고
    • Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-xL and IAP, the release of cytochrome c and inhibition of Akt
    • [doi:10.1093/carcin/bgg082]
    • Woo, J.H., Kim, Y.H., Choi, Y.J., Kim, D.G., Lee, K.S., Bae, J.H., Mindo, S., Chang, J.S., Jeong, Y.J., Lee, Y.H., et al., 2003. Molecular mechanisms of curcumin-induced cytotoxicity: Induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-xL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis, 24(7):1199-1208. [doi:10.1093/carcin/bgg082]
    • (2003) Carcinogenesis , vol.24 , Issue.7 , pp. 1199-1208
    • Woo, J.H.1    Kim, Y.H.2    Choi, Y.J.3    Kim, D.G.4    Lee, K.S.5    Bae, J.H.6    Mindo, S.7    Chang, J.S.8    Jeong, Y.J.9    Lee, Y.H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.