Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells

BMB Reports

Volumn 44, Issue 6, 2011, Pages 399-404

  Jeong, Jae Han ^a   Ryu, Deok Seon ^a   Suk, Dong Hee ^a   Lee, Dong Seok ^a  

^a Inje University   (South Korea)

Author keywords

Anti inflammation; Nuclear factor kappa B (NF b); Orostachys japonicus; RAW 264.7 cell; Signaling pathway

Indexed keywords

ALCOHOL; ANTIINFLAMMATORY AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; CRASSULACEAE; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; METABOLISM; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CRASSULACEAE; ETHANOL; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

OROSTACHYS;

EID: 79960099474     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2011.44.6.399     Document Type: Article

References (38)

1. Choi, S. Y., Chung, M. J., Seo, W. D., Shin, J. H., Shon, M. Y. and Sung, N. J. (2006) Inhibitory effects of Orostachys japonicus extracts on the formation of N-nitrosodimethylamine. J. Agric. Food Chem. 54, 6075-6078.
2. Park, H. J., Young, H. S., Park, K. Y., Rhee, S. H., Chung, H. Y. and Choi, J. S. (1991) Flavonoids from the whole plants of Orostachys japonicus. Arch. Pharm. Res. 14, 167-71.
3. Ma, C. J., Jung, W. J., Lee, K. Y., Kim, Y. C. and Sung, S. H. (2009) Calpain inhibitory flavonoids isolated from Orostachys japonicus. J. Enzyme Inhib. Med. Chem. 24, 676-679.
4. Jung, H. J., Choi, J., Nam, J. H. and Park, H. J. (2007) Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice. J. Med. Food. 10, 702-706.
5. Kim, H. J., Lee, J. Y., Kim, S. M., Park, D. A., Jin, C., Hong, S. P. and Lee, Y. S. (2009) A new epicatechin gallate and calpain inhibitory activity from Orostachys japonicus. Fitoterapia. 80, 73-76.
6. Lee, J. H., Lee, S. J., Park, S., Kim, H. K., Jeong, W. Y., Choi, J. Y., Sung, N. J., Lee, W. S., Lim, C. S., Kim, G. S. and Shin, S. C. (2011) Characterisation of flavonoids in Orostachys japonicus A. Berger using HPLC-MS/MS: Contribution to the overall antioxidant effect. Food Chem. 124, 1627-633.
7. 2-induced apoptosis in GT1-1 mouse hypothalamic neuronal cell line. J. Ethnopharmacol. 69, 73-78.
8. Yoon, N. Y., Min, B. S., Lee, H. K., Park, J. C. and Choi, J. S. (2005) A potent anti-complementary acylated sterol glucoside from Orostachys japonicus. Arch. Pharm. Res. 28, 892-896.
9. Hancock, J. T. (1997) Superoxide, hydrogen peroxide and nitric oxide as signalling molecules: their production and role in disease. Br. J. Biomed. Sci. 54, 8-46.
10. Huerre, M. R. and Gounon. P. (1996) Inflammation: patterns and new concepts. Res. Immunol. 147, 417-434.
11. Islam, M. S., Yoshida, H., Matsuki, N., Ono, K., Nagasaka, R., Ushio, H., Guo, Y., Hiramatsu, T., Hosoya, T., Murata, T., Hori, M. and Ozaki, H. (2009) Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies. J. Pharmacol. Sci. 111, 328-337.
12. Guzik, T. J., Korbut, R. and Adamek-Guzik, T. (2003) Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54, 469-87.
13. Nathan, C. (2002) Points of control in inflammation. Nature 420, 846-852.
14. Rankin, J. A. (2004) Biological mediators of acute inflammation. AACN Clin. Issues. 15, 3-17.
15. Cobb, M. H. and Goldsmith, E. J. (1995) How MAP kinases are regulated. J. Biol. Chem. 270, 14843-14846.
16. Han, J., Lee, J. D., Bibbs, L. and Ulevitch, R. J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265, 808-11.
17. Jeong, W. S., Kim, I. W., Hu, R. and Kong, A. N. (2004) Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm. Res. 21, 661-670.
18. Xie, Q. W., Kashiwabara, Y. and Nathan, C. (1994) Role of transcription factor NF-kappaB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269, 705-4708.
19. Park, S. Y., Park, G. Y., Ko, W. S. and Kim, Y. (2009) Dichroa febrifuga Lour. inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB, MAPK and Akt activation in macrophages. J. Ethnopharmacol. 125, 246-251.
20. Aggarwal, B. B. and Natarajan, K. (1996) Tumor necrosis factors: developments during the last decade. Eur. Cytokine. Netw. 7, 93-124.
21. Cho, W., Nam, J. W., Kang, H. J., Windono, T., Seo, E. K. and Lee, K. T. (2009) Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages. nt. Immunopharmacol. 9, 1049-1057.
22. Doyle, S. L. and O'Neill, L. A. (2006) Toll-like receptors: from the discovery of NFkappa B to new insights into transcriptional regulations in innate immunity. Biochem. Pharmacol. 72, 1102-1113.
23. Feldmann, M., Brennan, F. M., Chantry, D., Haworth, C., Turner, M., Katsikis, P., Londei, M., Abney, E., Buchan, G. and Barrett, K. (1991) Cytokine assays: role in evaluation of the pathogenesis of autoimmunity. Immunol. Rev. 119, 105-123.
24. Ha, H. H., Park, S. Y., Ko, W. S. and Kim, Y. (2008) Gleditsia sinensis thorns inhibit the production of NO through NF-kappaB supression in LPS-stimulated macrophages. J. Ethnopharmacol. 118, 429-434.
25. Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J. and Chen, Z. J. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 46-351.
26. Minagar, A., Shapshak, P., Fujimura, R., Ownby, R., Heyes, M. and Eisdorfer, C. (2002) The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J. Neurol. Sci. 202, 13-23.
27. Guha, M. and Mackman, N. (2001) LPS induction of gene expression in human monocytes. Cell Signal. 13, 85-94.
28. Kim, J. H., Jeong, J. H., Jeon, S. T., Kim, H., Ock, J., Suk, K., Kim, S. I., Song, K. S. and Lee, W. H. (2006) Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol. Pharmacol. 69, 1783-1790.
29. Lin, Y. L. and Lin, J. K. (1997) (-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB. Mol. Pharmacol. 52, 465-472.
30. Rafi, M. M. and Shafaie, Y. (2007) Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7). Mol. Nutr. Food Res. 51, 333-340.
31. Tak, P. P. and Firestein, G. S. (2001) NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 107, 7-11.
32. Vane, J. R., Mitchell, J. A., Appleton, I., Tomlinson, A., Bishop-Bailey, D., Croxtall, J. and Willoughby, D. A. (1994) Inducible isoforms of cyclo-oxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A. 91, 2046-2050.
33. Nakagawa, T. and Yokozawa, T. (2002) Direct scavenging of nitric oxide and superoxide by green tea. Food Chem. Toxicol. 40, 1745-1750.
34. Hultqvist, M., Olsson, L. M., Gelderman, K. A. and Holmdahl, R. (2009) The protective role of ROS in autoimmune disease. Trends Immunol. 30, 201-08.
35. Hancock, J. T., Desikan, R. and Neill, S. J. (2001) Role of reactive oxygen species in cell signalling pathways. Biochem. Soc. Trans. 29, 345-350.
36. Nhiem, N. X., Tai, B. H., Quang, T. H., Kiem, P. H., Minh, C. V., Nam, N. H., Kim, J. H., Im, L. R., Lee, Y. M. and Kim, Y. H. (2011) A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells. Bioorg. Med. Chem. Lett. 21, 1777-1781.
37. Oh, J. H., Lee, Y. J., Park, J. W. and Kwon, T. K. (2008) Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-kappaB in RAW 264.7 cells. Eur. J. Pharmacol. 599, 11-17.
38. Malyshev, I. Y. and Shnyra, A. (2003) Controlled modulation of inflammatory, stress and apoptotic responses in macrophages. Curr. Drug Targets Immune Endocr. Metabol. Disord. 3, 1-22.