Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice

Journal of Medicinal Food

Volumn 10, Issue 4, 2007, Pages 702-706

  Jung, Hyun Ju ^a   Choi, Jongwon ^b   Nam, Jung Hwan ^c   Park, Hee Juhn ^c  

^a Wonkwang University   (South Korea)

^b Kyungsung University   (South Korea)

^c Sangji University   (South Korea)

Author keywords

Analgesic effect; Crassulaceae; Orostachys japonicus; Peptic ulcer

Indexed keywords

3,7 DI O GLUCOSYLKAEMPFEROL; 7 O GLUCOSYL 3 O RHAMNOSYLKAEMPFEROL; ACETYLSALICYLIC ACID; ALCOHOL; ANTIULCER AGENT; ASTRAGALIN; BETHANECHOL; FLAVONOID; HERBACEOUS AGENT; HYDROCHLORIC ACID; INDOMETACIN; ISOQUERCITRIN; KAEMPFEROL; KAEMPFEROL 3 RHAMNOSIDE; KAEMPFEROL DERIVATIVE; LUTEOLIN 7 GLUCOSIDE; METHANOL; MORPHINE; OROSTACHYS JAPONICUS EXTRACT; QUERCETIN; QUERCITRIN; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INDICATION; DRUG ISOLATION; HERB; HOT PLATE TEST; KOREA; MALE; MOUSE; NONHUMAN; OROSTACHYS JAPONICUS; PRIORITY JOURNAL; STOMACH ACID; STOMACH JUICE; STOMACH PAIN; STOMACH ULCER; TRADITIONAL MEDICINE; WRITHING TEST;

ANALGESIA; ANALGESICS; ANIMALS; BETHANECHOL; CRASSULACEAE; FLAVONOIDS; GASTRIC JUICE; HYDROCHLORIC ACID; INDOMETHACIN; MALE; METHANOL; MICE; PLANT EXTRACTS; STOMACH ULCER; TRITERPENES;

CRASSULACEAE; MUS; OROSTACHYS;

EID: 37549034600     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2006.223     Document Type: Article

References (20)

1. Jung BS, Shin MK: Dictionary of the Medicinal Plants. Younglim-Sa, Seoul, 1990, pp. 600-601.
2. Park HJ, Moon SH, Kim JO, Lee SH, Choi JS: A study on the chemical constituents of Orostachys japonicus A Berger. Korean J Pharmacogn 1991;22:78-84.
3. Park HJ, Young HS, Park KY, Rhee SH, Chung HY, Choi JS: Flavonoids from the whole plants of Orostachys japonicus. Arch Pharm Res 1991;14:167-171.
4. Park HJ, Moon SH, Park KY, Choi JS, Chung HY, Young HS, Suh SS: Antimutagenic effect of Orostachys japonicus. Yakhak Hoeji 1991;35:253-257.
5. Yoon NY, Min BS, Lee HK, Park JC, Choi JS: A potent anticomplementary acylated sterol glucoside from Orostachys japonicus. Arch Pharm Res 2005;28:892-896.
6. Sung SH, Jung WJ, Kim YC: A novel flavonol lyxoside of Orostachys japonicus herb. Nat Prod Lett 2002;16:29-32.
7. Park JG, Park JC, Hur JM, Park SJ, Choi DR, Shin DY, Park KY, Cho HW, Kim MS: Phenolic compound from Orostachys japonicus having anti-HIV-1 protease activity. Nat Prod Sci 2000;6:117-121.
8. 2-induced apoptosis in GT1-1 mouse hypothalamic neuronal cell line. J Ethnopharmacol 2000;69:73-78.
9. Kim CH, Park JH, Lim JK, Lee KJ, Chung GY, Jeong HJ: The activity of antioxidants and suppression of cancer cell proliferation in extracts of Orostachys japonicus A. Berger. Korean J Med Crop Sci 2003;11:31-39.
10. Park JC, Han WD, Park JR, Choi SH, Choi JW: Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus. J Ethnopharmacol 2005;102:313-318.
11. Whittle BA: The use of change in capillary permeability to distinguish between narcotic and nonnarcotic. Br J Pharmacol Chemother 1964;22:246-253.
12. Mizui T, Dodeuchi M: Effect of polyamines on acidified ethanol-induced gastric lesions in rats. Jpn J Pharmacol 1983;33:939-945.
13. Rainsford KD: A synergistic interaction between aspirin, or other non-steroidal anti-inflammatory drugs, and stress which produces severe gastric mucosal damage in rats and pigs. Agents Actions 1975;5:553-558.
14. Dai S, Ogle CW: A simple method for the production of peptic ulceration in the rat. Life Sci 1973;12:505-512.
15. Toma W, Hiruma-Lima CA, Guerrero RO, Brito AR: Preliminary studies of Mammea americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer models in mice. Phytomedicine 2005;12:345-350.
16. Andreo MA, Ballesteros KVR, Hiruma-Lima CA, Machado da Rocha LR, Souza Brito AR, Vilegas W: Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. J Ethnopharmacol 2006;107:431-441.
17. Ustun O, Ozcelik B, Akyoen Y, Abbsoglu U, Yesilada E: Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves. J Ethnopharmacol 2006;107:457-461.
18. Sannomiya M, Fonseca VB, da Silva MA, Rocha LR, dos Santos LC, Hiruma-Lima CA, Souza Brito AR, Vilegas W: Flavonoids and antiulcerogenic activity from Byrsonima crassa leaves extracts. J Ethnopharmacol 2005;97:1-6.
19. Yesilada E, Tsuchiya K, Takaishi Y, Kawazoe K: Isolation and characterization of free radical scavenging flavonoid glycosides from the flowers of Spartium junceum by activity-guided fractionation. J Ethnopharmacol 2000;73:471-478.
20. Queiroga CL, Silva GF, Dias PC, Possenti A, de Carvalho JE: Evaluation of the antiulcerogenic activity of friedelan-3β-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae). J Ethnopharmacol 2000;72:465-468.