Synthesis and evaluation of 18F-labeled tertiary benzenesulfonamides for imaging carbonic anhydrase IX expression in tumours with positron emission tomography

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 14, 2014, Pages 3064-3068

  Lau, Joseph ^a   Pan, Jinhe ^a   Zhang, Zhengxing ^a   Hundal Jabal, Navjit ^a   Liu, Zhibo ^b   Bénard, François ^a   Lin, Kuo Shyan ^a  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Carbonic anhydrase IX; Fluorine 18; In vivo defluorination; Positron emission tomography; Tertiary benzenesulfonamides

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE IX; FLUORIDE; FLUORINE 18; TETRABUTYLAMMONIUM; BENZENESULFONAMIDE; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; FLUORINE; SULFONAMIDE; TUMOR ANTIGEN;

ARTICLE; BINDING AFFINITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DEFLUORINATION; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME ACTIVE SITE; FLUORESCENCE IMAGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MOUSE; NONHUMAN; NUCLEOPHILICITY; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SUBSTITUTION REACTION; TUMOR CELL LINE; UPREGULATION; ANIMAL; CHEMISTRY; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; HT 29 CELL LINE; HUMAN; METABOLISM; MOLECULAR IMAGING;

ANIMALS; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; FLUORINE RADIOISOTOPES; HT29 CELLS; HUMANS; MICE; MOLECULAR IMAGING; NEOPLASMS, EXPERIMENTAL; POSITRON-EMISSION TOMOGRAPHY; SULFONAMIDES;

EID: 84902535493     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.021     Document Type: Article

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