Development and biological evaluation of 99mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers

European Journal of Medicinal Chemistry

Volumn 71, Issue , 2014, Pages 374-384

  Akurathi, Vamsidhar ^a   Dubois, Ludwig ^b   Celen, Sofie ^a   Lieuwes, Natasja G ^b   Chitneni, Satish K ^a   Cleynhens, Bernard J ^a   Innocenti, Alessio ^c   Supuran, Claudiu T ^c   Verbruggen, Alfons M ^a   Lambin, Philippe ^b   Bormans, Guy M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Biodistribution; Carbonic anhydrases; Rhenium; Sulfonamides; Technetium 99m

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE IX; DIGLYCINE TECHNETIUM TC 99M; RHENIUM COMPLEX; TECHNETIUM 99M; 4 (2 AMINOETHYL)BENZENE SULFONAMIDE; BIS(AMINOETHANETHIOL); BIS(AMINOETHANETHIOL) 4 (2 AMINOETHYL)BENZENE SULFONAMIDE TECHNETIUM TC 99M; MERCAPTOACETYLDIGLYCINE 4 (2 AMINOETHYL)BENZENE SULFONAMIDE TECHNETIUM TC 99M; MERCAPTOACETYLDIGLYCINE TETRADENATE; MERCAPTOACETYLDIGLYCYLGLUTAMIC ACID BIS 4 (2 AMINOETHYL)BENZENE SULFONAMIDE TECHNETIUM TC 99M; SULFONAMIDE; SULFONAMIDE TECHNETIUM TC 99M; UNCLASSIFIED DRUG; 4 (2 AMINOETHYL)BENZENE SULFONAMIDE BENZYLMERCAPTOACETYLGLYCYLGLYCINE; 4 [BIS(AMINOETHANETHIOL) 2 AMINOETHYL]BENZENE SULFONAMIDE TC 99M; ANTINEOPLASTIC AGENT; BENZOYLMERCAPTOACETYLGLYCYLGLYCINE; BENZYL MERCAPTOACETYLDIGLYCINE; BENZYLMERCAPTOACETYLGLYCYLGLYCINE; BIS TRIPHENYLMETHYL N (TERT BUTYLOXYCARBONYL) N' (ACETIC ACID) 1,2 ETHYLENEDI CYSTEAMINE (BIS TRITYL N TERT BUTYLOXYCARBONYL N' (ACETIC ACID) BIS(AMINOETHANETHIOL); BIS TRITYL N TERT BUTYLOXYCARBONYL N' (ACETIC ACID) BIS(AMINOETHANETHIOL); MERCAPTOACETYLDIGLYCINE 4 (2 AMINOETHYL)BENZENE SULFONAMIDETC 99M; MERCAPTOACETYLDIGLYCINE GLUTAMINE BIS 4 (2 AMINOETHYL)BENZENE SULFONAMIDE TC 99M; RHENIUM; SULFONAMIDE TC 99M; TERT BUTYLOXYCARBONYL GLUTAMINE BIS 4 (2 AMINOETHYL)BENZENE SULFONAMIDE; TRACER; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; CARBONIC ANHYDRASE IX, MOUSE; DIAGNOSTIC AGENT; TECHNETIUM; TUMOR ANTIGEN; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLORECTAL CANCER; CONJUGATION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG CLEARANCE; DRUG RETENTION; DRUG UPTAKE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPOXIA; IN VIVO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MOLECULAR IMAGING; MOUSE; NONHUMAN; PROTEIN TARGETING; RADIOISOTOPE DISTRIBUTION; TISSUE DISTRIBUTION; TUMOR XENOGRAFT; CIRCULATION TIME; COMPLEX FORMATION; DISEASE MARKER; DRUG CONJUGATION; DRUG SCREENING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HT 29 CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOACTIVITY; RADIOCHEMISTRY; RADIOMETRY; SOLID TUMOR; WESTERN BLOTTING; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STABILITY; PHYSICAL CHEMISTRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; ANOXIA; BIODISTRIBUTION; CHEMISTRY; COLORECTAL TUMOR; ENZYMOLOGY; TECHNETIUM-99M; TUMOR CELL LINE;

BIODISTRIBUTION; CARBONIC ANHYDRASES; RHENIUM; SULFONAMIDES; TECHNETIUM-99M;

ANIMALS; ANOXIA; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; HUMANS; MICE; RHENIUM; SULFONAMIDES; TECHNETIUM; TISSUE DISTRIBUTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84891605260     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.027     Document Type: Article

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