Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Huang, Hsin Lien ^a   Hsieh, Ming Ju ^a,b   Chien, Ming Hsien ^c,d   Chen, Hui Yu ^a   Yang, Shun Fa ^a,e   Hsiao, Pei Ching ^a,e  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; CASPASE 9; GLABRIDIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 9; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; STRESS ACTIVATED PROTEIN KINASE 1; CASPASE; ENZYME INHIBITOR; ISOFLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENOL DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HL 60 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PROMYELOCYTIC LEUKEMIA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR CELL DESTRUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; ISOFLAVONES; LEUKEMIA, PROMYELOCYTIC, ACUTE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOLS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION;

EID: 84902531846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098943     Document Type: Article

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