Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 439-445

  Ahn, Jiyun ^a,b   Lee, Hyunjung ^a   Jang, Jayoung ^a,c   Kim, Suna ^d   Ha, Taeyoul ^a,b  

^a Korea Food Research Institute   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c World Institute of Kimchi an Annex of Korea Food Research Institute   (South Korea)

^d Korea National Open University   (South Korea)

Author keywords

Anti adipogenesis; Anti obesity; Glabridin; Licorice; Supercritical carbon dioxide extract

Indexed keywords

CARBON DIOXIDE; CARNITINE PALMITOYLTRANSFERASE I; CCAAT ENHANCER BINDING PROTEIN ALPHA; GLABRIDIN; GLUCOSE 6 PHOSPHATASE; GLYCYRRHIZA GLABRA EXTRACT; GLYCYRRHIZIC ACID; ISOLIQUIRITIGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ADIPOCYTE; ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SIZE; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID OXIDATION; FATTY LIVER; GLUCONEOGENESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; SUPERCRITICAL FLUID EXTRACTION; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-OBESITY AGENTS; BODY WEIGHT; CARBON DIOXIDE; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCYRRHIZA; ISOFLAVONES; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; PHENOLS; PLANT EXTRACTS; PPAR GAMMA;

GLYCYRRHIZA; GLYCYRRHIZA GLABRA; MUS;

EID: 84869875123     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.08.048     Document Type: Article

References (31)

1. Aoki F., Honda S., Kishida H., Kitano M., Arai N., Tanaka H., Yokota S., Nakagawa K., Asakura T., Nakai Y., Mae T. Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. Biosci. Biotechnol. Biochem. 2007, 71:206-214.
2. Birari R.B., Gupta S., Mohan C.G., Bhutani K.K. Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. Phytomedicine 2011, 18:795-801.
3. Choi E.M. The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. Biochem. Pharmacol. 2005, 70:363-368.
4. Commerford S.R., Ferniza J.B., Bizeau M.E., Thresher J.S., Willis W.T., Pagliassotti M.J. Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats. Am. J. Physiol. Endocrinol. Metab. 2002, 283:E545-555.
5. Day C.P., James O.F. Steatohepatitis: a tale of two " hits" ?. Gastroenterology 1998, 114:842-845.
6. Dobbins R.L., Szczepaniak L.S., Bentley B., Esser V., Myhill J., McGarry J.D. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 2001, 50:123-130.
7. Eu C.H., Lim W.Y., Ton S.H., bin Abdul Kadir K. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids Health Dis. 2010, 9:81.
8. Evans R.M., Barish G.D., Wang Y.X. PPARs and the complex journey to obesity. Nat. Med. 2004, 10:355-361.
9. Fanelli M.T., Kaplan M.L. Effects of high-fat and high carbohydrate diets on the body composition and oxygen consumption of ob/ob mice. J. Nutr. 1978, 108:1491-1500.
10. Fuhrman B., Buch S., Vaya J., Belinky P.A., Coleman R., Hayek T., Aviram M. Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am. J. Clin. Nutr. 1997, 66:267-275.
11. Hamaguchi M., Kojima T., Takeda N., Nakagawa T., Taniguchi H., Fujii K., Omatsu T., Nakajima T., Sarui H., Shimazaki M., Kato T., Okuda J., Ida K. The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann. Intern. Med. 2005, 143:722-728.
12. Ho C.H., Kingree J.B., Thompson M.P. Associations between juvenile delinquency and weight-related variables: analyses from a national sample of high school students. Int. J. Eat. Disord. 2006, 39:477-483.
13. Kamisoyama H., Honda K., Tominaga Y., Yokota S., Hasegawa S. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats. Biosci. Biotechnol. Biochem. 2008, 72:3225-3231.
14. Klejdus B., Lojkova L., Lapcik O., Koblovska R., Moravcova J., Kuban V. Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry. J. Sep. Sci. 2005, 28:1334-1346.
15. Larson K.A., King M.L. Evaluation of supercritical fluid extraction in the pharmaceutical industry. Biotechnol. Prog. 1986, 2:73-82.
16. Larsson B., Bjorntorp P., Tibblin G. The health consequences of moderate obesity. Int. J. Obes. 1981, 5:97-116.
17. Lee J.W., Choe S.S., Jang H., Kim J., Jeong H.W., Jo H., Jeong K.H., Tadi S., Park M.G., Kwak T.H., Kim J.M., Hyun D.H., Kim J.B. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J. Lipid Res. 2012.
18. Lucien F.P., Liong K.K., Cotton N.J., Macnaughton S.J., Foster N.R. Separation of biomolecules using supercritical fluid extraction. Australas. Biotechnol. 1993, 3:143-147.
19. Makimura H., Mizuno T.M., Beasley J., Silverstein J.H., Mobbs C.V. Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity. BMC Physiol. 2003, 3:4.
20. Marongiu B., Porcedda S., Piras A., Rosa A., Deiana M., Dessi M.A. Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora. Phytother. Res. 2004, 18:789-792.
21. Miyachi H., Manabe A., Tokumori T., Sumida Y., Yoshida T., Nishibe S., Agata I., Nomura T., Okuda T. Application of supercritical fluid extraction to components of crude drugs and plants. II. Extraction of coumarins, lignans and prenylflavonoids. Yakugaku Zasshi 1987, 107:435-439.
22. Nakagawa K., Kishida H., Arai N., Nishiyama T., Mae T. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice. Biol. Pharm. Bull. 2004, 27:1775-1778.
23. Park H.J., Della-Fera M.A., Hausman D.B., Rayalam S., Ambati S., Baile C.A. Genistein inhibits differentiation of primary human adipocytes. J. Nutr. Biochem. 2009, 20:140-148.
24. Park Y.S., Yoon Y., Ahn H.S. Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high-fat feeding in obese rats. World J. Gastroenterol. 2007, 13:3493-3499.
25. Plutzky J. Emerging concepts in metabolic abnormalities associated with coronary artery disease. Curr. Opin. Cardiol. 2000, 15:416-421.
26. Shibata S. A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 2000, 120:849-862.
27. Visavadiya N.P., Soni B., Dalwadi N. Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra root using in vitro models. Int. J. Food Sci. Nutr. 2009, 60(Suppl. 2):135-149.
28. Weiss R., Dziura J., Burgert T.S., Tamborlane W.V., Taksali S.E., Yeckel C.W., Allen K., Lopes M., Savoye M., Morrison J., Sherwin R.S., Caprio S. Obesity and the metabolic syndrome in children and adolescents. N. Engl. J. Med. 2004, 350:2362-2374.
29. Wu C.H., Yang M.Y., Chan K.C., Chung P.J., Ou T.T., Wang C.J. Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice. J. Agric. Food Chem. 2010, 58:7075-7081.
30. Wu Z., Xie Y., Bucher N.L., Farmer S.R. Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis. Genes Dev. 1995, 9:2350-2363.
31. Yun J.W. Possible anti-obesity therapeutics from nature - a review. Phytochemistry 2010, 71:1625-1641.