Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells

Phytomedicine

Volumn 17, Issue 1, 2010, Pages 47-54

  Huang, Sheng Teng ^a   Wang, Chen Yu ^b   Yang, Rong Chi ^c   Chu, Chih Ju ^a   Wu, Hsiao Ting ^a   Pang, Jong Hwei S ^d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Bax Bcl 2; Scutellaria baicalensis; Telomerase activity; Wogonin

Indexed keywords

BAICALEIN; BAICALIN; BETA GLUCURONIDASE; CASPASE 3; DNA; HUMAN TELOMERASE ASSOCIATED PROTEIN 1; MESSENGER RNA; MYC PROTEIN; PROTEIN BAX; PROTEIN BCL 2; SCUTELLARIA BAICALENSIS EXTRACT; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; WOGONIN; WOGOSIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LEUKEMIA CELL; MASS SPECTROMETRY; ONCOGENE C MYC; PRIORITY JOURNAL; SCUTELLARIA BAICALENSIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FLAVANONES; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MEMBRANE TRANSPORT PROTEINS; PLANT EXTRACTS; RNA, MESSENGER; SCUTELLARIA BAICALENSIS; TELOMERASE; TRANSCRIPTION FACTORS;

SCUTELLARIA BAICALENSIS;

EID: 70649104033     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.06.005     Document Type: Article

References (32)

1. Bermudez Y., Erasso D., Johnson N.C., Alfonso M.Y., Lowell N.E., and Kruk P.A. Telomerase confers resistance to caspase-mediated apoptosis. Clin. Interv. Aging 1 (2006) 155-167
2. Bonham M., Posakony J., Coleman I., Montgomery B., Simon J., and Nelson P.S. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin. Cancer Res. 11 (2005) 3905-3914
3. Burnett B.P., Jia Q., Zhao Y., and Levy R.M. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J. Med. Food 10 (2007) 442-451
4. Chomczynski P., and Sacchi N. Single-step method of RNA isolated by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
5. Drewes S.E. Chroman and Related Compounds (1974), Verlag Chemie, Wheinheim pp. 41
6. Ersoz T., Saracoglu I., Harput U.S., and Çalis I. Iridoid and phenylpropanoid glycosides from Phlomis grandiflora var. fimbrilligera and Phlomis fruticosa. Turkey J. Chem. 26 (2002) 171-177
7. Himeji M., Ohtsuki T., Fukazawa H., Tanaka M., Yazaki S., Ui S., Nishio K., Yamamoto H., Tasaka K., and Mimura A. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett. 245 (2007) 269-274
8. Hsieh T.C., Lu X., Chea J., and Wu J.M. Prevention and management of prostate cancer using PC-SPES: a scientific perspective. J. Nutr. 132 (2002) 3513S-3517S
9. Hu Y., Yang Y., You Q.D., Liu W., Gu H.Y., Zhao L., Zhang K., Wang W., Wang X.T., and Guo Q.L. Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Biochem. Biophys. Res. Commun. 351 (2006) 521-527
10. Huang S.T., Yang R.C., Yang L.J., Lee P.N., and Pang J.H. Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells. Life Sci. 72 (2003) 1705-1716
11. Kawai-Yamada M., Saito Y., Jin L., Ogawa T., Kim K.M., Yu L.H., Tone Y., Hirata A., Umeda M., and Uchimiya H. A novel Arabidopsis gene causes Bax-like lethality in Saccharomyces cerevisiae. J. Biol. Chem. 280 (2005) 39468-39473
12. Kumagai T., Müller C.I., Desmond J.C., Imai Y., Heber D., and Koeffler H.P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk. Res. 31 (2007) 523-530
13. Lu T., Song J., Huang F., Deng Y., Xie L., Wang G., and Liu X. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J. Ethnopharmacol. 110 (2007) 412-418
14. Ma Y.L., Heuvel H.V., and Claeys M. Characterization of 3-methoxyflavones using fast-atom bombardment and collision-induced dissociation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 13 (1999) 1932-1942
15. Malikov V.M., and Yuldashev M.P. Phenolic compounds of plants of the Scutellaria L. genus: distribution, structure, and properties. Chem. Nat. Compd. 38 (2002) 358-406
16. Meeker A.K., and Marzo A.M. Recent advances in telomere biology: implications for human cancer. Curr. Opin. Oncol. 16 (2004) 32-38
17. Mondello C., and Scovassi A.I. Telomeres, telomerase, and apoptosis. Biochem. Cell Biol. 82 (2004) 498-507
18. Parajuli P., Joshee N., Rimando A.M., Mittal S., and Yadav A.K. In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. Planta Med. 75 (2009) 41-48
19. Pattingre S., Tassa A., Qu X., Garuti R., Liang X.H., Mizushima N., Packer M., Schneider M.D., and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122 (2005) 927-939
20. Pharmacopoeia Commission of the Ministry of Public Health PRC. A coloured atlas of the Chinese material medica. 1995 ed (1995), Guangdong Science & Technology Press, Guangdong, People's Republic of China pp. 397-398
21. Riedl S.J., and Salvesen G.S. The apoptosome: signalling platform of cell death. Nat. Rev. Mol. Cell Biol. 8 (2007) 405-413
22. Rugo H., Shtivelman E., Perez A., Vogel C., Franco S., Chiu E.T., Melisko M., Tagliaferri M., Cohen I., Shoemaker M., Tran Z., and Tripathy D. Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Breast Cancer Res. Treat. 105 (2007) 17-28
23. Sagar S.M., Yance D., and Wong R.K. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr. Oncol. 13 (2006) 14-26
24. Shachaf C.M., Kopelman A.M., Arvanitis C., Karlsson A., Beer S., Mandl S., Bachmann M.H., Borowsky A.D., Ruebner B., Cardiff R.D., Yang Q., Bishop J.M., Contag C.H., and Felsher D.W. Myc inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular carcinoma. Nature 431 (2004) 1112-1117
25. Snow B.E., Erdmann N., Cruickshank J., Goldman H., Gill R.M., Robinson M.O., and Harrington L. Functional conservation of the telomerase protein Est1p in humans. Curr. Biol. 13 8 (2003) 698-704
26. Talanian R.V., Quinlan C., Trautz S., Hackett M.C., Mankovich J.A., Banach D., Ghayur T., Brady K.D., and Wong W.W. Substrate specificities of caspase family proteases. J. Biol. Chem. 272 (1997) 9677-9682
27. Wu K.J., Grandori C., Amacker M., Simon-Vermot N., Polack A., Lingner J., and Dalla-Favera R. Direct activation of TERT transcription by C-myc. Nat. Genet. 21 (1999) 220-224
28. Ye F., Wang H., Jiang S., Wu J., Shao J., Cheng X., Tu Y., and Zhang D.Y. Quality evaluation of commercial extracts of Scutellaria baicalensis. Nutr. Cancer 49 (2004) 217-222
29. Yu C.C., Lo S.C., and Wang T.C. Telomerase is regulated by proteinkinase C-zeta in human nasopharyngeal carcinoma cells. Biochem. J. 355 (2001) 459-464
30. Zhang Y., Wang X., Xu Z., Liu Z., Ni Q., Chu X., Qiu M., Zhao A., and Jia W. Protective effect of flavonoids from Scutellaria baicalensis Georgi on cerebral ischemia injury. J. Ethnopharmacol. 108 (2006) 355-360
31. Zhang D.Y., Wu J., Ye F., Xue L., Jiang S., Yi J., Zhang W., Wei H., Sung M., Wang W., and Li X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res. 63 (2003) 4037-4043
32. Zuo Y.F. Science of Chinese Materia Medica (2002), Publishing House of Shanghai, University of Traditional Chinese medicine, Shanghai pp. 83-87