Antioxidant effect of polyphenolic glabridin on LDL oxidation

Toxicology and Industrial Health

Volumn 25, Issue 5, 2009, Pages 321-324

  Carmeli, E ^a   Fogelman, Y ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

antiatherosclerotic affects; cardiovascular diseases; glabridin; LDL oxidation; licorice plant; Sienna conference

Indexed keywords

GLABRIDIN; LICOLIFE; LOW DENSITY LIPOPROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIOXIDANT ACTIVITY; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; LIPID OXIDATION; LONGITUDINAL STUDY; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

ADULT; AGED; ANTIOXIDANTS; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FLAVONOIDS; GLYCYRRHIZA; HUMANS; ISOFLAVONES; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENOLS; PLANT EXTRACTS; PLANT ROOTS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

GLYCYRRHIZA; HELICHRYSUM PETIOLARE;

EID: 68849095967     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233709103034     Document Type: Article

References (14)

1. Armanini D, Mattarello MJ, Fiore C, Bonanni G, Scaroni C, Sartorato P (2004) Licorice reduces serum testosterone in healthy women. Steroids 69: 763–766.
2. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH (2007) Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 49: 2379–2393.
3. Cherubini A, Vigna GB, Zuliani G, Ruggiero C, Senin U, Fellin R (2005) Role of antioxidants in atherosclerosis: epidemiological and clinical update. Curr Pharm Des 11: 2017–2032.
4. Choi EM (2005) The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. Biochem Pharmacol 70: 363–368.
5. Cynshi O, Stocker R (2005) Inhibition of lipoprotein lipid oxidation. In: Handbook of Experimental Pharmacology. Springer-Verlag, Germany, vol. 170, pp. 563–590.
6. Flora SJ (2007) Role of free radicals and antioxidants in health and disease. Cell Mol Biol (Noisy-le-grand) 53: 1–2.
7. Fuhrman B, Volkova N, Aviram M (2002) Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase. Atherosclerosis 161: 307–316.
8. Fuhrman B, Volkova N, Kaplan M, Presser D, Attias J, Hayek T (2002) Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. Nutrition 18: 268–273.
9. Fuhrman B, Buch S, Vaya J (1997) Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 66: 267–275.
10. Hatano T, Yasuhara T, Miyamoto K, Okuda T (1998) Anti-human immunodeficiency virus phenolics from licorice. Chem Pharm Bull (Tokyo) 36: 2286–2288.
11. Pang ZJ, Zhou M, Chen Y, Wan J (1999) Macrophage colony-stimulating factor reduces tert-butyl hydroperoxide induced oxidative injury to monocytes/macrophages. Atherosclerosis 147: 33–40.
12. Rudkowska I, Jones PJ (2007) Functional foods for the prevention and treatment of cardiovascular diseases: cholesterol and beyond. Expert Rev Cardiovasc Therapy 5: 477–490.
13. Vaya J, Belinky PA, Aviram M (1997) Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic Biol Med 23: 302–313.
14. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44–84.