메뉴 건너뛰기




Volumn 54, Issue , 2014, Pages 140-148

Neurotransmitter-based strategies for the treatment of cognitive dysfunction in Down syndrome

Author keywords

Alzheimer's disease; Down syndrome; Formoterol; L Dops; Locus coeruleus

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ATOMOXETINE; DIZOCILPINE; FLUOXETINE; FORMOTEROL; MEMANTINE; NEUROTRANSMITTER; NORADRENALIN; RG 1662; RIVASTIGMINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; THREO 3,4 DIHYDROXYPHENYLSERINE; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS;

EID: 84902485883     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2014.05.004     Document Type: Review
Times cited : (23)

References (114)
  • 1
    • 84892949427 scopus 로고    scopus 로고
    • Harnessing the potential of epigenetic therapy to target solid tumors
    • Ahuja N., Easwaran H., Baylin S.B. Harnessing the potential of epigenetic therapy to target solid tumors. J Clin Invest 2014, 124:56-63.
    • (2014) J Clin Invest , vol.124 , pp. 56-63
    • Ahuja, N.1    Easwaran, H.2    Baylin, S.B.3
  • 2
    • 0035445736 scopus 로고    scopus 로고
    • Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome
    • Altafaj X., Dierssen M., Baamonde C., Marti E., Visa J., Guimera J., et al. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum Mol Genet 2001, 10:1915-1923.
    • (2001) Hum Mol Genet , vol.10 , pp. 1915-1923
    • Altafaj, X.1    Dierssen, M.2    Baamonde, C.3    Marti, E.4    Visa, J.5    Guimera, J.6
  • 3
    • 56749154434 scopus 로고    scopus 로고
    • Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome
    • Altafaj X., Ortiz-Abalia J., Fernandez M., Potier M.C., Laffaire J., Andreu N., et al. Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiol Dis 2008, 32:377-384.
    • (2008) Neurobiol Dis , vol.32 , pp. 377-384
    • Altafaj, X.1    Ortiz-Abalia, J.2    Fernandez, M.3    Potier, M.C.4    Laffaire, J.5    Andreu, N.6
  • 4
    • 0032127166 scopus 로고    scopus 로고
    • 10years of genomics, chromosome 21, and Down syndrome
    • Antonarakis S.E. 10years of genomics, chromosome 21, and Down syndrome. Genomics 1998, 51:1-16.
    • (1998) Genomics , vol.51 , pp. 1-16
    • Antonarakis, S.E.1
  • 5
    • 84905858594 scopus 로고    scopus 로고
    • The effects of combine treatment of memantine and donepezil on Alzheimer's disease patients and its relationship with cerebral blood flow in the prefrontal area
    • [in press]
    • Araki T1., Wake R., Miyaoka T., Kawakami K., Nagahama M., Furuya M., et al. The effects of combine treatment of memantine and donepezil on Alzheimer's disease patients and its relationship with cerebral blood flow in the prefrontal area. Int J Geriatr Psychiatry 2014, [in press]. 10.1002/gps.4074.
    • (2014) Int J Geriatr Psychiatry
    • Araki, T.1.1    Wake, R.2    Miyaoka, T.3    Kawakami, K.4    Nagahama, M.5    Furuya, M.6
  • 6
    • 0032769072 scopus 로고    scopus 로고
    • Intrahippocampal grafts containing cholinergic and serotonergic fetal neurons ameliorate spatial reference but not working memory in rats with fimbria-fornix/cingular bundle lesions
    • Balse E., Lazarus C., Kelche C., Jeltsch H., Jackisch R., Cassel J.C. Intrahippocampal grafts containing cholinergic and serotonergic fetal neurons ameliorate spatial reference but not working memory in rats with fimbria-fornix/cingular bundle lesions. Brain Res Bull 1999, 49:263-272.
    • (1999) Brain Res Bull , vol.49 , pp. 263-272
    • Balse, E.1    Lazarus, C.2    Kelche, C.3    Jeltsch, H.4    Jackisch, R.5    Cassel, J.C.6
  • 7
    • 77952426708 scopus 로고    scopus 로고
    • Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study
    • Beacher F1., Daly E., Simmons A., Prasher V., Morris R., Robinson C., et al. Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study. Psychol Med 2010, 40:611-619.
    • (2010) Psychol Med , vol.40 , pp. 611-619
    • Beacher, F.1.1    Daly, E.2    Simmons, A.3    Prasher, V.4    Morris, R.5    Robinson, C.6
  • 9
    • 34548795562 scopus 로고    scopus 로고
    • Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships
    • Belichenko P.V., Kleschevnikov A.M., Salehi A., Epstein C.J., Mobley W.C. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J Comp Neurol 2007, 504:329-345.
    • (2007) J Comp Neurol , vol.504 , pp. 329-345
    • Belichenko, P.V.1    Kleschevnikov, A.M.2    Salehi, A.3    Epstein, C.J.4    Mobley, W.C.5
  • 10
    • 85047691446 scopus 로고    scopus 로고
    • Harm avoidance, anxiety, and response to novelty in the adolescent S-100 beta transgenic mouse: role of serotonin and relevance to Down syndrome
    • Bell K., Shokrian D., Potenzieri C., Whitaker-Azmitia P.M. Harm avoidance, anxiety, and response to novelty in the adolescent S-100 beta transgenic mouse: role of serotonin and relevance to Down syndrome. Neuropsychopharmacology 2003, 28:1810-1816.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1810-1816
    • Bell, K.1    Shokrian, D.2    Potenzieri, C.3    Whitaker-Azmitia, P.M.4
  • 11
    • 77954412951 scopus 로고    scopus 로고
    • Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome
    • Bianchi P., Ciani E., Guidi S., Trazzi S., Felice D., Grossi G., et al. Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. J Neurosci 2010, 30:8769-8779.
    • (2010) J Neurosci , vol.30 , pp. 8769-8779
    • Bianchi, P.1    Ciani, E.2    Guidi, S.3    Trazzi, S.4    Felice, D.5    Grossi, G.6
  • 12
    • 84866076171 scopus 로고    scopus 로고
    • Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial
    • Boada R., Hutaff-Lee C., Schrader A., Weitzenkamp D., Benke T.A., Goldson E.J., et al. Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial. Transl Psychiatry 2012, 2:e141.
    • (2012) Transl Psychiatry , vol.2
    • Boada, R.1    Hutaff-Lee, C.2    Schrader, A.3    Weitzenkamp, D.4    Benke, T.A.5    Goldson, E.J.6
  • 13
    • 78649651245 scopus 로고    scopus 로고
    • Opponency revisited: competition and cooperation between dopamine and serotonin
    • Boureau Y.L., Dayan P. Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology 2011, 36:74-97.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 74-97
    • Boureau, Y.L.1    Dayan, P.2
  • 14
    • 33748089366 scopus 로고    scopus 로고
    • Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome
    • Capone G., Goyal P., Ares W., Lannigan E. Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome. Am J Med Genet C Semin Med Genet 2006, 1(42C):158-172.
    • (2006) Am J Med Genet C Semin Med Genet , vol.1 , Issue.42 C , pp. 158-172
    • Capone, G.1    Goyal, P.2    Ares, W.3    Lannigan, E.4
  • 16
    • 0033869715 scopus 로고    scopus 로고
    • Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
    • Cataldo A.M., Peterhoff C.M., Troncoso J.C., Gomez-Isla T., Hyman B.T., Nixon R.A. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 2000, 157:277-286.
    • (2000) Am J Pathol , vol.157 , pp. 277-286
    • Cataldo, A.M.1    Peterhoff, C.M.2    Troncoso, J.C.3    Gomez-Isla, T.4    Hyman, B.T.5    Nixon, R.A.6
  • 18
    • 77954466984 scopus 로고    scopus 로고
    • Folic Acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model
    • Chen T.F., Huang R.F., Lin S.E., Lu J.F., Tang M.C., Chiu M.J. Folic Acid potentiates the effect of memantine on spatial learning and neuronal protection in an Alzheimer's disease transgenic model. J Alzheimers Dis 2010, 20:607-615.
    • (2010) J Alzheimers Dis , vol.20 , pp. 607-615
    • Chen, T.F.1    Huang, R.F.2    Lin, S.E.3    Lu, J.F.4    Tang, M.C.5    Chiu, M.J.6
  • 19
    • 2942591228 scopus 로고    scopus 로고
    • Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion
    • Cooper J.D., Salehi A., Delcroix J.D., Howe C.L., Belichenko P.V., Chua-Couzens J., et al. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A 2001, 98:10439-10444.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10439-10444
    • Cooper, J.D.1    Salehi, A.2    Delcroix, J.D.3    Howe, C.L.4    Belichenko, P.V.5    Chua-Couzens, J.6
  • 21
    • 84864018180 scopus 로고    scopus 로고
    • Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
    • Cossec J.C., Lavaur J., Berman D.E., Rivals I., Hoischen A., Stora S., et al. Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes. Hum Mol Genet 2012, 21:3156-3172.
    • (2012) Hum Mol Genet , vol.21 , pp. 3156-3172
    • Cossec, J.C.1    Lavaur, J.2    Berman, D.E.3    Rivals, I.4    Hoischen, A.5    Stora, S.6
  • 22
    • 43649094588 scopus 로고    scopus 로고
    • Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test
    • Costa A.C., Scott-McKean J.J., Stasko M.R. Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology 2008, 33:1624-1632.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1624-1632
    • Costa, A.C.1    Scott-McKean, J.J.2    Stasko, M.R.3
  • 23
    • 77952649081 scopus 로고    scopus 로고
    • Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain
    • [2010 Jun]
    • Craciunescu C.N1., Johnson A.R., Zeisel S.H. Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain. J Nutr 2010, 140(6):1162-1166. [2010 Jun].
    • (2010) J Nutr , vol.140 , Issue.6 , pp. 1162-1166
    • Craciunescu, C.N.1.1    Johnson, A.R.2    Zeisel, S.H.3
  • 24
    • 84864932030 scopus 로고    scopus 로고
    • From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome
    • Cramer N., Galdzicki Z. From abnormal hippocampal synaptic plasticity in down syndrome mouse models to cognitive disability in down syndrome. Neural Plast 2012, 2012:101542.
    • (2012) Neural Plast , vol.2012 , pp. 101542
    • Cramer, N.1    Galdzicki, Z.2
  • 26
    • 84902460205 scopus 로고    scopus 로고
    • Improving noradrenergic signaling in the treatment of cognitive dysfunction in the Ts65dn mouse model of down syndrome
    • Society of Neuroscience Meeting
    • Dang V., Martin K., Moghadam S., Medina B., Lin B., Patel D., et al. Improving noradrenergic signaling in the treatment of cognitive dysfunction in the Ts65dn mouse model of down syndrome. Poster 348.12/M8 2012.
    • (2012) Poster 348.12/M8
    • Dang, V.1    Martin, K.2    Moghadam, S.3    Medina, B.4    Lin, B.5    Patel, D.6
  • 27
    • 84891624989 scopus 로고    scopus 로고
    • Formoterol, a long-acting β2 adrenergic agonist, improves cognitive function and promotes dendritic complexity in a mouse model of Down syndrome
    • Dang V., Medina B., Das D., Moghadam S., Martin K.J., Lin B., et al. Formoterol, a long-acting β2 adrenergic agonist, improves cognitive function and promotes dendritic complexity in a mouse model of Down syndrome. Biol Psychiatry 2014, 2014(75):179-188.
    • (2014) Biol Psychiatry , vol.2014 , Issue.75 , pp. 179-188
    • Dang, V.1    Medina, B.2    Das, D.3    Moghadam, S.4    Martin, K.J.5    Lin, B.6
  • 29
    • 0025731856 scopus 로고
    • Memory retrieval enhancement by locus coeruleus stimulation: evidence for mediation by beta-receptors
    • Devauges V., Sara S.J. Memory retrieval enhancement by locus coeruleus stimulation: evidence for mediation by beta-receptors. Behav Brain Res 1991, 43:93-97.
    • (1991) Behav Brain Res , vol.43 , pp. 93-97
    • Devauges, V.1    Sara, S.J.2
  • 30
    • 57349119307 scopus 로고    scopus 로고
    • Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease
    • Dong H., Yuede C.M., Coughlan C., Lewis B., Csernansky J.G. Effects of memantine on neuronal structure and conditioned fear in the Tg2576 mouse model of Alzheimer's disease. Neuropsychopharmacology 2008, 33:3226-3236.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 3226-3236
    • Dong, H.1    Yuede, C.M.2    Coughlan, C.3    Lewis, B.4    Csernansky, J.G.5
  • 31
    • 0023848325 scopus 로고
    • Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn superoxide dismutase: implication for gene dosage effects in Down syndrome
    • Elroy-Stein O., Groner Y. Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn superoxide dismutase: implication for gene dosage effects in Down syndrome. Cell 1988, 52:259-267.
    • (1988) Cell , vol.52 , pp. 259-267
    • Elroy-Stein, O.1    Groner, Y.2
  • 32
    • 79958203027 scopus 로고    scopus 로고
    • Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of beta1-adrenergic receptor by xamoterol as a potential cognitive enhancer
    • Faizi M., Bader P.L., Tun C., Encarnacion A., Kleschevnikov A., Belichenko P., et al. Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of beta1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis 2011, 43:397-413.
    • (2011) Neurobiol Dis , vol.43 , pp. 397-413
    • Faizi, M.1    Bader, P.L.2    Tun, C.3    Encarnacion, A.4    Kleschevnikov, A.5    Belichenko, P.6
  • 34
    • 77449135256 scopus 로고    scopus 로고
    • Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine
    • [2009 Jan]
    • Francis P.T. Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine. Curr Mol Pharmacol 2009, 2(1):77-82. [2009 Jan].
    • (2009) Curr Mol Pharmacol , vol.2 , Issue.1 , pp. 77-82
    • Francis, P.T.1
  • 35
    • 77952321608 scopus 로고    scopus 로고
    • Chronic treatment with fluoxetine decreases cerebral metabolic responses to the 5-HT1A agonist 8-hydroxy-2(di-N-propylamino)tetralin and increases those to the 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and to the dopaminergic agonist apomorphine
    • Freo U., Merico A., Ermani M., Ori C. Chronic treatment with fluoxetine decreases cerebral metabolic responses to the 5-HT1A agonist 8-hydroxy-2(di-N-propylamino)tetralin and increases those to the 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and to the dopaminergic agonist apomorphine. Brain Res 2010, 1335:24-34.
    • (2010) Brain Res , vol.1335 , pp. 24-34
    • Freo, U.1    Merico, A.2    Ermani, M.3    Ori, C.4
  • 36
    • 0030337503 scopus 로고    scopus 로고
    • Interneurons of the hippocampus
    • Freund T.F., Buzsaki G. Interneurons of the hippocampus. Hippocampus 1996, 6:347-470.
    • (1996) Hippocampus , vol.6 , pp. 347-470
    • Freund, T.F.1    Buzsaki, G.2
  • 37
    • 0025179273 scopus 로고
    • Dietary increase in serotonin reduces self-injurious behaviour in a Down's syndrome adult
    • Gedye A. Dietary increase in serotonin reduces self-injurious behaviour in a Down's syndrome adult. J Ment Defic Res 1990, 34(Pt 2):195-203.
    • (1990) J Ment Defic Res , vol.34 , Issue.PART 2 , pp. 195-203
    • Gedye, A.1
  • 38
    • 0025856934 scopus 로고
    • Serotonergic treatment for aggression in a Down's syndrome adult showing signs of Alzheimer's disease
    • Gedye A. Serotonergic treatment for aggression in a Down's syndrome adult showing signs of Alzheimer's disease. J Ment Defic Res 1991, 35(Pt 3):247-258.
    • (1991) J Ment Defic Res , vol.35 , Issue.PART 3 , pp. 247-258
    • Gedye, A.1
  • 41
    • 0034672405 scopus 로고    scopus 로고
    • Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome
    • Gulesserian T., Engidawork E., Cairns N., Lubec G. Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome. Neurosci Lett 2000, 296:53-57.
    • (2000) Neurosci Lett , vol.296 , pp. 53-57
    • Gulesserian, T.1    Engidawork, E.2    Cairns, N.3    Lubec, G.4
  • 42
    • 37849004936 scopus 로고    scopus 로고
    • Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events
    • Haier R.J1., Head K., Head E., Lott I.T. Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events. Neuroimage 2008, 39:1324-1332.
    • (2008) Neuroimage , vol.39 , pp. 1324-1332
    • Haier, R.J.1.1    Head, K.2    Head, E.3    Lott, I.T.4
  • 43
    • 53149111135 scopus 로고    scopus 로고
    • Molecular biology of 5-HT receptors
    • Hannon J., Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 2008, 195:198-213.
    • (2008) Behav Brain Res , vol.195 , pp. 198-213
    • Hannon, J.1    Hoyer, D.2
  • 44
    • 33846986326 scopus 로고    scopus 로고
    • The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome
    • Hanson J.E., Blank M., Valenzuela R.A., Garner C.C., Madison D.V. The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. J Physiol 2007, 579:53-67.
    • (2007) J Physiol , vol.579 , pp. 53-67
    • Hanson, J.E.1    Blank, M.2    Valenzuela, R.A.3    Garner, C.C.4    Madison, D.V.5
  • 45
    • 0033816844 scopus 로고    scopus 로고
    • Beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis
    • Harkany T., Abraham I., Timmerman W., Laskay G., Toth B., Sasvari M., et al. Beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis. Eur J Neurosci 2000, 12:2735-2745.
    • (2000) Eur J Neurosci , vol.12 , pp. 2735-2745
    • Harkany, T.1    Abraham, I.2    Timmerman, W.3    Laskay, G.4    Toth, B.5    Sasvari, M.6
  • 46
    • 0035319804 scopus 로고    scopus 로고
    • To err (meiotically) is human: the genesis of human aneuploidy
    • Hassold T., Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2001, 2:280-291.
    • (2001) Nat Rev Genet , vol.2 , pp. 280-291
    • Hassold, T.1    Hunt, P.2
  • 48
    • 33847747419 scopus 로고    scopus 로고
    • Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention
    • Head E., Lott I.T., Patterson D., Doran E., Haier R.J. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. J Alzheimers Dis 2007, 11:61-76.
    • (2007) J Alzheimers Dis , vol.11 , pp. 61-76
    • Head, E.1    Lott, I.T.2    Patterson, D.3    Doran, E.4    Haier, R.J.5
  • 49
    • 84864910192 scopus 로고    scopus 로고
    • Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome
    • Heinen M., Hettich M.M., Ryan D.P., Schnell S., Paesler K., Ehninger D. Adult-onset fluoxetine treatment does not improve behavioral impairments and may have adverse effects on the Ts65Dn mouse model of Down syndrome. Neural Plast 2012, 2012:467251.
    • (2012) Neural Plast , vol.2012 , pp. 467251
    • Heinen, M.1    Hettich, M.M.2    Ryan, D.P.3    Schnell, S.4    Paesler, K.5    Ehninger, D.6
  • 51
    • 32544449785 scopus 로고    scopus 로고
    • Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
    • Heneka M.T., Ramanathan M., Jacobs A.H., Dumitrescu-Ozimek L., Bilkei-Gorzo A., Debeir T., et al. Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci 2006, 26:1343-1354.
    • (2006) J Neurosci , vol.26 , pp. 1343-1354
    • Heneka, M.T.1    Ramanathan, M.2    Jacobs, A.H.3    Dumitrescu-Ozimek, L.4    Bilkei-Gorzo, A.5    Debeir, T.6
  • 53
    • 0346023036 scopus 로고    scopus 로고
    • The human raphe nuclei and the serotonergic system
    • Hornung J.P. The human raphe nuclei and the serotonergic system. J Chem Neuroanat 2003, 26:331-343.
    • (2003) J Chem Neuroanat , vol.26 , pp. 331-343
    • Hornung, J.P.1
  • 54
    • 0346995344 scopus 로고    scopus 로고
    • Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region
    • Ji J.Z., Zhang X.H., Li B.M. Deficient spatial memory induced by blockade of beta-adrenoceptors in the hippocampal CA1 region. Behav Neurosci 2003, 117:1378-1384.
    • (2003) Behav Neurosci , vol.117 , pp. 1378-1384
    • Ji, J.Z.1    Zhang, X.H.2    Li, B.M.3
  • 55
    • 33747754751 scopus 로고    scopus 로고
    • Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes
    • Juric D.M., Miklic S., Carman-Krzan M. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain Res 2006, 1108:54-62.
    • (2006) Brain Res , vol.1108 , pp. 54-62
    • Juric, D.M.1    Miklic, S.2    Carman-Krzan, M.3
  • 56
    • 43449135636 scopus 로고    scopus 로고
    • L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience
    • [2008 Mar]
    • Kaufmann H. l-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience. Clin Auton Res 2008, 18(Suppl. 1):19-24. [2008 Mar].
    • (2008) Clin Auton Res , vol.18 , Issue.SUPPL. 1 , pp. 19-24
    • Kaufmann, H.1
  • 57
    • 84899494039 scopus 로고    scopus 로고
    • Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome
    • Kaur G., Sharma A., Xu W., Gerum S., Alldred M.J., Subbanna S., et al. Glutamatergic transmission aberration: a major cause of behavioral deficits in a murine model of Down's syndrome. J Neurosci 2014, 34:5099-5106.
    • (2014) J Neurosci , vol.34 , pp. 5099-5106
    • Kaur, G.1    Sharma, A.2    Xu, W.3    Gerum, S.4    Alldred, M.J.5    Subbanna, S.6
  • 58
    • 84874629526 scopus 로고    scopus 로고
    • Metabotropic NMDA receptor function is required for beta-amyloid-induced synaptic depression
    • Kessels H.W., Nabavi S., Malinow R. Metabotropic NMDA receptor function is required for beta-amyloid-induced synaptic depression. Proc Natl Acad Sci U S A 2013, 110:4033-4038.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 4033-4038
    • Kessels, H.W.1    Nabavi, S.2    Malinow, R.3
  • 59
    • 0024573517 scopus 로고
    • Down's syndrome individuals begin life with normal levels of brain cholinergic markers
    • Kish S., Karlinsky H., Becker L., Gilbert J., Rebbetoy M., Chang L.J., et al. Down's syndrome individuals begin life with normal levels of brain cholinergic markers. J Neurochem 1989, 52:1183-1187.
    • (1989) J Neurochem , vol.52 , pp. 1183-1187
    • Kish, S.1    Karlinsky, H.2    Becker, L.3    Gilbert, J.4    Rebbetoy, M.5    Chang, L.J.6
  • 61
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • Kleschevnikov A.M., Belichenko P.V., Villar A.J., Epstein C.J., Malenka R.C., Mobley W.C. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J Neurosci 2004, 24:8153-8160.
    • (2004) J Neurosci , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Villar, A.J.3    Epstein, C.J.4    Malenka, R.C.5    Mobley, W.C.6
  • 62
    • 70349192800 scopus 로고    scopus 로고
    • The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction
    • Knust H., Achermann G., Ballard T., Buettelmann B., Gasser R., Fischer H., et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett 2009, 19:5940-5944.
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 5940-5944
    • Knust, H.1    Achermann, G.2    Ballard, T.3    Buettelmann, B.4    Gasser, R.5    Fischer, H.6
  • 63
    • 4444336568 scopus 로고    scopus 로고
    • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
    • Kurt M.A., Kafa M.I., Dierssen M., Davies D.C. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res 2004, 1022:101-109.
    • (2004) Brain Res , vol.1022 , pp. 101-109
    • Kurt, M.A.1    Kafa, M.I.2    Dierssen, M.3    Davies, D.C.4
  • 65
    • 84875717632 scopus 로고    scopus 로고
    • Environmental novelty activates beta2-adrenergic signaling to prevent the impairment of hippocampal LTP by abeta oligomers
    • Li S., Jin M., Zhang D., Yang T., Koeglsperger T., Fu H., et al. Environmental novelty activates beta2-adrenergic signaling to prevent the impairment of hippocampal LTP by abeta oligomers. Neuron 2013, 77:929-941.
    • (2013) Neuron , vol.77 , pp. 929-941
    • Li, S.1    Jin, M.2    Zhang, D.3    Yang, T.4    Koeglsperger, T.5    Fu, H.6
  • 66
    • 79955723158 scopus 로고    scopus 로고
    • Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome
    • Lockrow J., Boger H., Bimonte-Nelson H., Granholm A.C. Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome. Behav Brain Res 2011, 221:610-622.
    • (2011) Behav Brain Res , vol.221 , pp. 610-622
    • Lockrow, J.1    Boger, H.2    Bimonte-Nelson, H.3    Granholm, A.C.4
  • 67
    • 0023889961 scopus 로고
    • The pathological association between Down syndrome and Alzheimer disease
    • Mann D.M. The pathological association between Down syndrome and Alzheimer disease. Mech Ageing Dev 1988, 43:99-136.
    • (1988) Mech Ageing Dev , vol.43 , pp. 99-136
    • Mann, D.M.1
  • 68
    • 0021814284 scopus 로고
    • Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age
    • [1985 Jun]
    • Mann D.M., Yates P.O., Marcyniuk B., Ravindra C.R. Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J Ment Defic Res 1985, 29(Pt 2):125-135. [1985 Jun].
    • (1985) J Ment Defic Res , vol.29 , Issue.PART 2 , pp. 125-135
    • Mann, D.M.1    Yates, P.O.2    Marcyniuk, B.3    Ravindra, C.R.4
  • 69
    • 0022919237 scopus 로고
    • The topography of plaques and tangles in Down's syndrome patients of different ages
    • [1986 Sep-Oct]
    • Mann D.M., Yates P.O., Marcyniuk B., Ravindra C.R. The topography of plaques and tangles in Down's syndrome patients of different ages. Neuropathol Appl Neurobiol 1986, 12(5):447-457. [1986 Sep-Oct].
    • (1986) Neuropathol Appl Neurobiol , vol.12 , Issue.5 , pp. 447-457
    • Mann, D.M.1    Yates, P.O.2    Marcyniuk, B.3    Ravindra, C.R.4
  • 71
    • 84875217416 scopus 로고    scopus 로고
    • An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy
    • Millan M.J. An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy. Neuropharmacology 2013, 68:2-82.
    • (2013) Neuropharmacology , vol.68 , pp. 2-82
    • Millan, M.J.1
  • 72
    • 84858380551 scopus 로고    scopus 로고
    • Neurobiological elements of cognitive dysfunction in down syndrome: exploring the role of APP
    • Millan Sanchez M., Heyn S.N., Das D., Moghadam S., Martin K.J., Salehi A. Neurobiological elements of cognitive dysfunction in down syndrome: exploring the role of APP. Biol Psychiatry 2012, 71(5):403-409.
    • (2012) Biol Psychiatry , vol.71 , Issue.5 , pp. 403-409
    • Millan Sanchez, M.1    Heyn, S.N.2    Das, D.3    Moghadam, S.4    Martin, K.J.5    Salehi, A.6
  • 74
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    • Nagahara A.H., Merrill D.A., Coppola G., Tsukada S., Schroeder B.E., Shaked G.M., et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009, 15:331-337.
    • (2009) Nat Med , vol.15 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3    Tsukada, S.4    Schroeder, B.E.5    Shaked, G.M.6
  • 75
    • 25444442381 scopus 로고    scopus 로고
    • An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes
    • O'Doherty A., Ruf S., Mulligan C., Hildreth V., Errington M.L., Cooke S., et al. An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 2005, 309:2033-2037.
    • (2005) Science , vol.309 , pp. 2033-2037
    • O'Doherty, A.1    Ruf, S.2    Mulligan, C.3    Hildreth, V.4    Errington, M.L.5    Cooke, S.6
  • 76
    • 7444231620 scopus 로고    scopus 로고
    • A chromosome 21 critical region does not cause specific Down syndrome phenotypes
    • Olson L.E., Richtsmeier J.T., Leszl J., Reeves R.H. A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science 2004, 306:687-690.
    • (2004) Science , vol.306 , pp. 687-690
    • Olson, L.E.1    Richtsmeier, J.T.2    Leszl, J.3    Reeves, R.H.4
  • 77
    • 65249091454 scopus 로고    scopus 로고
    • Epilepsy and cognitive impairments in Alzheimer disease
    • Palop J.J., Mucke L. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 2009, 66:435-440.
    • (2009) Arch Neurol , vol.66 , pp. 435-440
    • Palop, J.J.1    Mucke, L.2
  • 78
    • 85058035167 scopus 로고    scopus 로고
    • Structural and functional brain networks: from connections to cognition
    • Park H.J., Friston K. Structural and functional brain networks: from connections to cognition. Nature 2013, 342:6158.
    • (2013) Nature , vol.342 , pp. 6158
    • Park, H.J.1    Friston, K.2
  • 79
    • 0027731677 scopus 로고
    • Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)
    • Parsons C.G., Gruner R., Rozental J., Millar J., Lodge D. Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology 1993, 32:1337-1350.
    • (1993) Neuropharmacology , vol.32 , pp. 1337-1350
    • Parsons, C.G.1    Gruner, R.2    Rozental, J.3    Millar, J.4    Lodge, D.5
  • 80
    • 1242264014 scopus 로고    scopus 로고
    • Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?
    • Paula-Lima A.C., Louzada P.R., De Mello F.G., Ferreira S.T. Neuroprotection against Abeta and glutamate toxicity by melatonin: are GABA receptors involved?. Neurotox Res 2003, 5:323-327.
    • (2003) Neurotox Res , vol.5 , pp. 323-327
    • Paula-Lima, A.C.1    Louzada, P.R.2    De Mello, F.G.3    Ferreira, S.T.4
  • 81
    • 1842370350 scopus 로고    scopus 로고
    • The effect of inhaled formoterol and budesonide on exacerbatins of asthma
    • Pauwels, Lofdahl, Postma, Tattersfield, O'Bryne, Barnes, et al. The effect of inhaled formoterol and budesonide on exacerbatins of asthma. N Engl J Med 1997, 337:1405-1411.
    • (1997) N Engl J Med , vol.337 , pp. 1405-1411
    • Pauwels, L.1    Postma, T.2    O'Bryne, B.3
  • 82
    • 0027792558 scopus 로고
    • Seizures associated with fluoxetine therapy
    • Prasher V.P. Seizures associated with fluoxetine therapy. Seizure 1993, 2:315-317.
    • (1993) Seizure , vol.2 , pp. 315-317
    • Prasher, V.P.1
  • 84
    • 0036119913 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease - pilot study
    • Prasher V.P., Huxley A., Haque M.S. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease - pilot study. Int J Geriatr Psychiatry 2002, 17:270-278.
    • (2002) Int J Geriatr Psychiatry , vol.17 , pp. 270-278
    • Prasher, V.P.1    Huxley, A.2    Haque, M.S.3
  • 85
    • 84872092886 scopus 로고    scopus 로고
    • Rivastigmine transdermal patches in the treatment of dementia in Alzheimer's disease in adults with Down syndrome-pilot study
    • Prasher V.P., Sachdeva N., Adams C., Haque M.S. Rivastigmine transdermal patches in the treatment of dementia in Alzheimer's disease in adults with Down syndrome-pilot study. Int J Geriatr Psychiatry 2013, 28:219-220.
    • (2013) Int J Geriatr Psychiatry , vol.28 , pp. 219-220
    • Prasher, V.P.1    Sachdeva, N.2    Adams, C.3    Haque, M.S.4
  • 87
    • 79954994735 scopus 로고    scopus 로고
    • Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease
    • Rissman R.A., Mobley W.C. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem 2011, 117:613-622.
    • (2011) J Neurochem , vol.117 , pp. 613-622
    • Rissman, R.A.1    Mobley, W.C.2
  • 88
    • 39149111255 scopus 로고    scopus 로고
    • Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome
    • Rueda N., Florez J., Martinez-Cue C. Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome. Neurosci Lett 2008, 433:22-27.
    • (2008) Neurosci Lett , vol.433 , pp. 22-27
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 89
    • 77954972900 scopus 로고    scopus 로고
    • Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome
    • Rueda N., Llorens-Martin M., Florez J., Valdizan E., Banerjee P., Trejo J.L., et al. Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome. J Alzheimers Dis 2010, 21:277-290.
    • (2010) J Alzheimers Dis , vol.21 , pp. 277-290
    • Rueda, N.1    Llorens-Martin, M.2    Florez, J.3    Valdizan, E.4    Banerjee, P.5    Trejo, J.L.6
  • 90
    • 84862333723 scopus 로고    scopus 로고
    • Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
    • Rueda N., Flórez J., Martínez-Cué C. Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast 2012, 2012.
    • (2012) Neural Plast , vol.2012
    • Rueda, N.1    Flórez, J.2    Martínez-Cué, C.3
  • 91
    • 0032568615 scopus 로고    scopus 로고
    • Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities
    • Sago H., Carlson E.J., Smith D.J., Kilbridge J., Rubin E.M., Mobley W.C., et al. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A 1998, 95:6256-6261.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6256-6261
    • Sago, H.1    Carlson, E.J.2    Smith, D.J.3    Kilbridge, J.4    Rubin, E.M.5    Mobley, W.C.6
  • 92
    • 0028271519 scopus 로고
    • Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus
    • Salehi A., Lucassen P.J., Pool C.W., Gonatas N.K., Ravid R., Swaab D.F. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience 1994, 59:871-880.
    • (1994) Neuroscience , vol.59 , pp. 871-880
    • Salehi, A.1    Lucassen, P.J.2    Pool, C.W.3    Gonatas, N.K.4    Ravid, R.5    Swaab, D.F.6
  • 94
    • 33745512851 scopus 로고    scopus 로고
    • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
    • Salehi A., Delcroix J.-D., Belichenko P.V., Zhan K., Wu C., Valletta J.S., et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron 2006, 51:29-42.
    • (2006) Neuron , vol.51 , pp. 29-42
    • Salehi, A.1    Delcroix, J.-D.2    Belichenko, P.V.3    Zhan, K.4    Wu, C.5    Valletta, J.S.6
  • 96
  • 97
    • 80055034688 scopus 로고    scopus 로고
    • Hippocampal network alterations in Alzheimer's disease and Down syndrome: from structure to therapy
    • Sanchez M.M., Moghadam S., Naik P., Martin K.J., Salehi A. Hippocampal network alterations in Alzheimer's disease and Down syndrome: from structure to therapy. J Alzheimers Dis 2011, 26(Suppl 3):29-47.
    • (2011) J Alzheimers Dis , vol.26 , Issue.SUPPL 3 , pp. 29-47
    • Sanchez, M.M.1    Moghadam, S.2    Naik, P.3    Martin, K.J.4    Salehi, A.5
  • 98
    • 60549092240 scopus 로고    scopus 로고
    • The locus coeruleus and noradrenergic modulation of cognition
    • Sara S.J. The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci 2009, 10:211-223.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 211-223
    • Sara, S.J.1
  • 99
    • 79955727727 scopus 로고    scopus 로고
    • The cholinergic system in aging and neuronal degeneration
    • [2011 Aug 10]
    • Schliebs R1., Arendt T. The cholinergic system in aging and neuronal degeneration. Behav Brain Res 2011, 221(2):555-563. [2011 Aug 10].
    • (2011) Behav Brain Res , vol.221 , Issue.2 , pp. 555-563
    • Schliebs, R.1.1    Arendt, T.2
  • 100
    • 79959389773 scopus 로고    scopus 로고
    • Lack of evidence for the efficacy of memantine in mild Alzheimer disease
    • Schneider L.S., Dagerman K.S., Higgins J.P., McShane R. Lack of evidence for the efficacy of memantine in mild Alzheimer disease. Arch Neurol 2011, 68:991-998.
    • (2011) Arch Neurol , vol.68 , pp. 991-998
    • Schneider, L.S.1    Dagerman, K.S.2    Higgins, J.P.3    McShane, R.4
  • 101
    • 0032729863 scopus 로고    scopus 로고
    • Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
    • Siarey R.J., Carlson E.J., Epstein C.J., Balbo A., Rapoport S.I., Galdzicki Z. Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 1999, 38:1917-1920.
    • (1999) Neuropharmacology , vol.38 , pp. 1917-1920
    • Siarey, R.J.1    Carlson, E.J.2    Epstein, C.J.3    Balbo, A.4    Rapoport, S.I.5    Galdzicki, Z.6
  • 103
    • 0034941330 scopus 로고    scopus 로고
    • Nerve growth factor signaling, neuroprotection, and neural repair
    • Sofroniew M.V., Howe C.L., Mobley W.C. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 2001, 24:1217-1281.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 1217-1281
    • Sofroniew, M.V.1    Howe, C.L.2    Mobley, W.C.3
  • 104
    • 84876433023 scopus 로고    scopus 로고
    • Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of Down syndrome
    • Stagni F., Magistretti J., Guidi S., Ciani E., Mangano C., Calza L., et al. Pharmacotherapy with fluoxetine restores functional connectivity from the dentate gyrus to field CA3 in the Ts65Dn mouse model of Down syndrome. PLoS One 2013, 8:e61689.
    • (2013) PLoS One , vol.8
    • Stagni, F.1    Magistretti, J.2    Guidi, S.3    Ciani, E.4    Mangano, C.5    Calza, L.6
  • 105
    • 84879714443 scopus 로고    scopus 로고
    • Ascending monoaminergic systems alterations in Alzheimer's disease; translating basic science into clinical care
    • Trillo L., Das D., Hsieh W., Medina B., Moghadam S., Lin B., et al. Ascending monoaminergic systems alterations in Alzheimer's disease; translating basic science into clinical care. Neurosci Biobehav Rev 2013, 37(8):1363-1379.
    • (2013) Neurosci Biobehav Rev , vol.37 , Issue.8 , pp. 1363-1379
    • Trillo, L.1    Das, D.2    Hsieh, W.3    Medina, B.4    Moghadam, S.5    Lin, B.6
  • 106
    • 21044458854 scopus 로고    scopus 로고
    • A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    • [2005 May]
    • Tuszynski M.H., Thal L., Pay M., Salmon D.P., HS U., Bakay R., et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 2005, 11(5):551-555. [2005 May].
    • (2005) Nat Med , vol.11 , Issue.5 , pp. 551-555
    • Tuszynski, M.H.1    Thal, L.2    Pay, M.3    Salmon, D.P.4    HS, U.5    Bakay, R.6
  • 107
    • 29344448251 scopus 로고    scopus 로고
    • Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model
    • Van Dam D., De Deyn P.P. Cognitive evaluation of disease-modifying efficacy of galantamine and memantine in the APP23 model. Eur Neuropsychopharmacol 2006, 16:59-69.
    • (2006) Eur Neuropsychopharmacol , vol.16 , pp. 59-69
    • Van Dam, D.1    De Deyn, P.P.2
  • 108
    • 84879376346 scopus 로고    scopus 로고
    • Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome
    • Velazquez R., Ash J.A., Powers B.E., Kelley C.M., Strawderman M., Luscher Z.I., et al. Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis 2013, 58:92-101.
    • (2013) Neurobiol Dis , vol.58 , pp. 92-101
    • Velazquez, R.1    Ash, J.A.2    Powers, B.E.3    Kelley, C.M.4    Strawderman, M.5    Luscher, Z.I.6
  • 109
    • 69449092485 scopus 로고    scopus 로고
    • Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    • [2009 Sep]
    • Wang L.Y1., Shofer J.B., Rohde K., Hart K.L., Hoff D.J., McFall Y.H., et al. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatry 2009, 17(9):744-751. [2009 Sep].
    • (2009) Am J Geriatr Psychiatry , vol.17 , Issue.9 , pp. 744-751
    • Wang, L.Y.1.1    Shofer, J.B.2    Rohde, K.3    Hart, K.L.4    Hoff, D.J.5    McFall, Y.H.6
  • 110
    • 0141758248 scopus 로고    scopus 로고
    • A voxel-based morphometric study of nondemented adults with Down syndrome
    • White N.S., Alkire M.T., Haier R.J. A voxel-based morphometric study of nondemented adults with Down syndrome. Neuroimage 2003, 20:393-403.
    • (2003) Neuroimage , vol.20 , pp. 393-403
    • White, N.S.1    Alkire, M.T.2    Haier, R.J.3
  • 111
    • 36849085926 scopus 로고    scopus 로고
    • Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development
    • Whittle N., Sartori S.B., Dierssen M., Lubec G., Singewald N. Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics 2007, 120:e1465-e1471.
    • (2007) Pediatrics , vol.120
    • Whittle, N.1    Sartori, S.B.2    Dierssen, M.3    Lubec, G.4    Singewald, N.5
  • 112
    • 84880117155 scopus 로고    scopus 로고
    • Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis
    • Wilcock D.M., Griffin W.S. Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis. J Neuroinflammation 2013, 16:10-84.
    • (2013) J Neuroinflammation , vol.16 , pp. 10-84
    • Wilcock, D.M.1    Griffin, W.S.2
  • 113
    • 20444481258 scopus 로고    scopus 로고
    • Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats
    • Yamada K., Takayanagi M., Kamei H., Nagai T., Dohniwa M., Kobayashi K., et al. Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats. Behav Brain Res 2005, 162:191-199.
    • (2005) Behav Brain Res , vol.162 , pp. 191-199
    • Yamada, K.1    Takayanagi, M.2    Kamei, H.3    Nagai, T.4    Dohniwa, M.5    Kobayashi, K.6
  • 114
    • 77954461956 scopus 로고    scopus 로고
    • A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
    • Yu T., Li Z., Jia Z., Clapcote S.J., Liu C., Li S., et al. A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet 2010, 19:2780-2791.
    • (2010) Hum Mol Genet , vol.19 , pp. 2780-2791
    • Yu, T.1    Li, Z.2    Jia, Z.3    Clapcote, S.J.4    Liu, C.5    Li, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.