Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome

Neurobiology of Disease

Volumn 58, Issue , 2013, Pages 92-101

  Velazquez, Ramon ^a   Ash, Jessica A ^a,e   Powers, Brian E ^a   Kelley, Christy M ^b   Strawderman, Myla ^a   Luscher, Zoe I ^a   Ginsberg, Stephen D ^c,d   Mufson, Elliott J ^b   Strupp, Barbara J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Down syndrome; Hippocampus; Maternal choline; Neurogenesis; Spatial learning; Ts65Dn

Indexed keywords

CHOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATIONAL STUDY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DOWN SYNDROME; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; FEMALE; GENOTYPE; HIPPOCAMPUS; MALE; MAZE TEST; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SPATIAL LEARNING; STIMULUS RESPONSE; TASK PERFORMANCE; TRISOMY 21;

(2N CH+); (2N); (BDNF); (BFCNS); (DAB); (DCX); (DG); (DS); (HSA21); (MCS); (MMU16); (NGF); (PB); (PND); (TBS); (TBST); (TS65DN CH +); (TS65DN); 3/3′-DIAMINOBENZIDINE TETRAHYDROCHLORIDE; BASAL FOREBRAIN CHOLINERGIC NEURONS; BRAIN-DERIVED NEUROTROPIC FACTOR; DENTATE GYRUS; DISOMIC MICE BORN TO DAMS ON A DIET SUPPLEMENTED WITH ADDITIONAL CHOLINE; DISOMIC MICE BORN TO DAMS ON A NORMAL CHOLINE DIET; DOUBLECORTIN; DOWN SYNDROME; HIPPOCAMPUS; HUMAN CHROMOSOME 21; MATERNAL CHOLINE; MATERNAL CHOLINE SUPPLEMENTATION; MOUSE CHROMOSOME 16; NERVE GROWTH FACTOR; NEUROGENESIS; PHOSPHATE BUFFER; POSTNATAL DAY; SPATIAL LEARNING; TBS WITH TRITON X-100; TRIS-BUFFERED SALINE; TS65DN; TS65DN MICE BORN TO DAMS ON A DIET SUPPLEMENTED WITH ADDITIONAL CHOLINE; TS65DN MICE BORN TO DAMS ON A NORMAL CHOLINE DIET;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CHOLINE; DISEASE MODELS, ANIMAL; DOWN SYNDROME; FEMALE; HIPPOCAMPUS; LEARNING DISORDERS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGENESIS; NEUROPEPTIDES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; SPACE PERCEPTION;

EID: 84879376346     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.04.016     Document Type: Article

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