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Volumn 2, Issue 1, 2009, Pages 77-82

Altered glutamate neurotransmission and behaviour in dementia: Evidence from studies of memantine

Author keywords

Agitation; Alzheimer's disease; Glutamate; Neurofibrillary tangles; Tau

Indexed keywords

CHOLINESTERASE INHIBITOR; DIZOCILPINE; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN; AMINO ACID RECEPTOR BLOCKING AGENT;

EID: 77449135256     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467210902010077     Document Type: Article
Times cited : (55)

References (63)
  • 1
    • 0029815299 scopus 로고    scopus 로고
    • The evolution of psychiatric symptoms in Alzheimer's disease: A natural history study
    • Jost, B. C.; Grossberg, G. T. The evolution of psychiatric symptoms in Alzheimer's disease: a natural history study. J. Am. Geriatr. Soc. 1996, 44(9), 1078-1081.
    • (1996) J. Am. Geriatr. Soc , vol.44 , Issue.9 , pp. 1078-1081
    • Jost, B.C.1    Grossberg, G.T.2
  • 7
    • 0023297731 scopus 로고
    • Institutionalization of Alzheimer's disease patients: Reducing precipitating factors through family counseling
    • Ferris, S. H.; Steinberg, G.; Shulman, E.; Kahn, R. N.; Reisberg, B. Institutionalization of Alzheimer's disease patients: reducing precipitating factors through family counseling. Home Health Care Serv. Q. 1987, 8, 23-51.
    • (1987) Home Health Care Serv. Q , vol.8 , pp. 23-51
    • Ferris, S.H.1    Steinberg, G.2    Shulman, E.3    Kahn, R.N.4    Reisberg, B.5
  • 8
    • 0037165667 scopus 로고    scopus 로고
    • Patient and caregiver characteristics and nursing home placement in patients with dementia
    • Yaffe, K.; Fox, P.; Newcomer, R.; Sands, L.; Lindquist, K.; Dane, K.; Covinsky, K. E. Patient and caregiver characteristics and nursing home placement in patients with dementia. JAMA 2002, 287(16), 2090-2097.
    • (2002) JAMA , vol.287 , Issue.16 , pp. 2090-2097
    • Yaffe, K.1    Fox, P.2    Newcomer, R.3    Sands, L.4    Lindquist, K.5    Dane, K.6    Covinsky, K.E.7
  • 9
    • 0022922450 scopus 로고
    • Agitated behaviors in the elderly. II. Preliminary results in the cognitively deteriorated
    • Cohen-Mansfield, J. Agitated behaviors in the elderly. II. Preliminary results in the cognitively deteriorated. J. Am. Geriatr. Soc. 1986, 34(10), 722-727.
    • (1986) J. Am. Geriatr. Soc , vol.34 , Issue.10 , pp. 722-727
    • Cohen-Mansfield, J.1
  • 10
    • 0031014243 scopus 로고    scopus 로고
    • Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up
    • McShane, R.; Keene, J.; Gedling, K.; Fairburn, C.; Jacoby, R.; Hope, T. Do neuroleptic drugs hasten cognitive decline in dementia? Prospective study with necropsy follow up. BMJ 1997, 314, 266-270.
    • (1997) BMJ , vol.314 , pp. 266-270
    • McShane, R.1    Keene, J.2    Gedling, K.3    Fairburn, C.4    Jacoby, R.5    Hope, T.6
  • 11
    • 33645527991 scopus 로고    scopus 로고
    • The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease
    • Ballard, C.; Waite, J. The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease. Cochrane Database Syst. Rev. 2006:CD003476.
    • (2006) Cochrane Database Syst. Rev
    • Ballard, C.1    Waite, J.2
  • 12
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atyipcal antipsychotic drug treatment for dementia
    • Schneider, L. S.; Dagerman, K. S.; Insel, P. Risk of death with atyipcal antipsychotic drug treatment for dementia. JAMA 2005, 294, 1934-1943.
    • (2005) JAMA , vol.294 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 13
    • 12844274439 scopus 로고    scopus 로고
    • Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence
    • Sink, K. M.; Holden, K. F.; Yaffe, K. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA 2005, 293(5), 596-608.
    • (2005) JAMA , vol.293 , Issue.5 , pp. 596-608
    • Sink, K.M.1    Holden, K.F.2    Yaffe, K.3
  • 14
    • 0036942425 scopus 로고    scopus 로고
    • Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease
    • Donepezil MSAD Study Investigators Group
    • Gauthier, S.; Feldman, H.; Hecker, J.; Vellas, B.; Ames, D.; Subbiah, P.; Whalen, E.; Emir, B.; Donepezil MSAD Study Investigators Group. Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease. Int. Psychogeriatr. 2002, 14, 389-404.
    • (2002) Int. Psychogeriatr , vol.14 , pp. 389-404
    • Gauthier, S.1    Feldman, H.2    Hecker, J.3    Vellas, B.4    Ames, D.5    Subbiah, P.6    Whalen, E.7    Emir, B.8
  • 16
    • 0036045137 scopus 로고    scopus 로고
    • Glutamate receptors as a target for Alzheimer's disease - are clinical results supporting the hope?
    • Winblad, B.; Möbius, H. J.; Stöffler, A. Glutamate receptors as a target for Alzheimer's disease - are clinical results supporting the hope? J Neural. Transm. 2002, (Suppl) 62, 217-225.
    • (2002) J Neural. Transm , Issue.SUPPL.
    • Winblad, B.1    Möbius, H.J.2    Stöffler, A.3
  • 18
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil. A randomized controlled trial
    • Memantine Study Group
    • Tariot, P. N.; Farlow, M. R.; Grossberg, G. T.; Graham, S. M.; McDonald, S.; Gergel, I.; Memantine Study Group. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil. A randomized controlled trial. JAMA 2004, 291(3), 317-324.
    • (2004) JAMA , vol.291 , Issue.3 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3    Graham, S.M.4    McDonald, S.5    Gergel, I.6
  • 19
    • 77953733342 scopus 로고    scopus 로고
    • Ebixa EPAR
    • European Medicines Evaluation Agency, Scientific Discussion. November
    • European Medicines Evaluation Agency. Ebixa EPAR, CHMP Variation Assessment Report. Scientific Discussion. November 2005.
    • (2005) CHMP Variation Assessment Report
  • 20
    • 0027985334 scopus 로고
    • The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
    • Cummings, J. L.; Mega, M.; Gray, K.; Rosenberg-Thompson, S.; Carusi, D. A.; Gornbein, J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 1994, 44, 2308-2314.
    • (1994) Neurology , vol.44 , pp. 2308-2314
    • Cummings, J.L.1    Mega, M.2    Gray, K.3    Rosenberg-Thompson, S.4    Carusi, D.A.5    Gornbein, J.6
  • 21
    • 0030958347 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients
    • Cummings, J. L. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology 1997, 48(5 Suppl 6), S10-S16.
    • (1997) Neurology , vol.48 , Issue.5 SUPPL. 6
    • Cummings, J.L.1
  • 22
    • 19144372322 scopus 로고    scopus 로고
    • Effects of memantine on behavioural symptoms in Alzheimer's disease patients: An analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies
    • Gauthier, S.; Wirth, Y.; Möbius, H. J. Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies. Int. J. Geriatr. Psychiatry 2005, 20(5), 459-464.
    • (2005) Int. J. Geriatr. Psychiatry , vol.20 , Issue.5 , pp. 459-464
    • Gauthier, S.1    Wirth, Y.2    Möbius, H.J.3
  • 23
    • 44249126470 scopus 로고    scopus 로고
    • Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: A pooled data analysis
    • Gauthier, S.; Loft, H.; Cummings, J. Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis. Int. J. Geriatr. Psychiatry 2008, 23(5), 537-545.
    • (2008) Int. J. Geriatr. Psychiatry , vol.23 , Issue.5 , pp. 537-545
    • Gauthier, S.1    Loft, H.2    Cummings, J.3
  • 24
    • 33746825134 scopus 로고    scopus 로고
    • Behavioural effects of memantine in Alzheimer's disease patients receiving donepezil treatment
    • Cummings, J. L.; Schneider, E.; Tariot, P. N.; Graham, S. M. Behavioural effects of memantine in Alzheimer's disease patients receiving donepezil treatment. Neurology 2006, 67, 57-63.
    • (2006) Neurology , vol.67 , pp. 57-63
    • Cummings, J.L.1    Schneider, E.2    Tariot, P.N.3    Graham, S.M.4
  • 25
    • 42249111378 scopus 로고    scopus 로고
    • Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: A pooled analysis of 3 studies
    • Wilcock, G. K.; Ballard, C. G.; Cooper, J. A.; Loft, H. Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. J. Clin. Psychiatry 2008, 69(3), 341-348.
    • (2008) J. Clin. Psychiatry , vol.69 , Issue.3 , pp. 341-348
    • Wilcock, G.K.1    Ballard, C.G.2    Cooper, J.A.3    Loft, H.4
  • 27
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt, N. C. Glutamate uptake. Prog. Neurobiol. 2001, 65(1), 1-105.
    • (2001) Prog. Neurobiol , vol.65 , Issue.1 , pp. 1-105
    • Danbolt, N.C.1
  • 28
    • 0027269660 scopus 로고
    • Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives
    • Francis, P. T.; Sims, N. R.; Procter, A. W.; Bowen, D. M. Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: investigative and therapeutic perspectives. J. Neuro-chem. 1993, 60(5), 1589-1604.
    • (1993) J. Neuro-Chem , vol.60 , Issue.5 , pp. 1589-1604
    • Francis, P.T.1    Sims, N.R.2    Procter, A.W.3    Bowen, D.M.4
  • 29
    • 28944433580 scopus 로고    scopus 로고
    • The interplay of neurotransmitters in Alzheimer's disease
    • Francis, P. T. The interplay of neurotransmitters in Alzheimer's disease. CNS Spectr. 2005, 10, 6-9.
    • (2005) CNS Spectr , vol.10 , pp. 6-9
    • Francis, P.T.1
  • 30
    • 33745920510 scopus 로고    scopus 로고
    • Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease
    • Kirvell, S. L.; Esiri, M.; Francis, P. T. Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease. J. Neurochem. 2006, 98(3), 939-950.
    • (2006) J. Neurochem , vol.98 , Issue.3 , pp. 939-950
    • Kirvell, S.L.1    Esiri, M.2    Francis, P.T.3
  • 31
    • 0031979134 scopus 로고    scopus 로고
    • Schizophrenia and glutamatergic transmission
    • Tamminga, C. A. Schizophrenia and glutamatergic transmission. Crit. Rev. Neurobiol. 1998, 12(1-2), 21-36.
    • (1998) Crit. Rev. Neurobiol , vol.12 , Issue.1-2 , pp. 21-36
    • Tamminga, C.A.1
  • 32
    • 25144509345 scopus 로고    scopus 로고
    • Mechanism of action of antipsychotic drugs: From dopamine D(2) receptor antagonism to glutamate NMDA facilitation
    • Laruelle, M.; Frankle, W. G.; Narendran, R.; Kegeles, L. S.; Abi-Dargham, A. Mechanism of action of antipsychotic drugs: from dopamine D(2) receptor antagonism to glutamate NMDA facilitation. Clin. Ther. 2005, 27(Suppl A), S16-S24.
    • (2005) Clin. Ther , vol.27 , Issue.SUPPL. A
    • Laruelle, M.1    Frankle, W.G.2    Narendran, R.3    Kegeles, L.S.4    Abi-Dargham, A.5
  • 33
    • 0346461630 scopus 로고    scopus 로고
    • Glutamate and depression: Clinical and preclinical studies
    • Paul, I. A.; Skolnick, P. Glutamate and depression: clinical and preclinical studies. Ann. N Y Acad. Sci. 2003, 1003, 250-272.
    • (2003) Ann. N Y Acad. Sci , vol.1003 , pp. 250-272
    • Paul, I.A.1    Skolnick, P.2
  • 34
    • 28544439503 scopus 로고    scopus 로고
    • 5-HT1B receptors and aggression: A review
    • Olivier, B.; van Oorschot, R. 5-HT1B receptors and aggression: a review. Eur. J. Pharmacol. 2005, 526(1-3), 207-217.
    • (2005) Eur. J. Pharmacol , vol.526 , Issue.1-3 , pp. 207-217
    • Olivier, B.1    van Oorschot, R.2
  • 35
    • 0035091670 scopus 로고    scopus 로고
    • Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease
    • Tekin, S.; Mega, M. S.; Masterman, D. M.; Chow, T.; Garakian, J.; Vinters, H. V.; Cummings, J. L. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Ann. Neurol. 2001, 49, 355-361.
    • (2001) Ann. Neurol , vol.49 , pp. 355-361
    • Tekin, S.1    Mega, M.S.2    Masterman, D.M.3    Chow, T.4    Garakian, J.5    Vinters, H.V.6    Cummings, J.L.7
  • 36
    • 0032892343 scopus 로고    scopus 로고
    • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data
    • Parsons, C. G.; Danysz, W.; Quack, G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 1999, 38, 735-767.
    • (1999) Neuropharmacology , vol.38 , pp. 735-767
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 37
    • 34948842904 scopus 로고    scopus 로고
    • Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse
    • Parsons, C. G.; Stöffler, A.; Danysz, W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 2007, 53(6), 699-723.
    • (2007) Neuropharmacology , vol.53 , Issue.6 , pp. 699-723
    • Parsons, C.G.1    Stöffler, A.2    Danysz, W.3
  • 38
    • 0001788650 scopus 로고    scopus 로고
    • Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease - a unified glutamatergic hypothesis on the mechanism of action
    • Danysz, W.; Parsons, C. G.; Mobius, H. J.; Stoffler, A.; Quack, G. Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease - a unified glutamatergic hypothesis on the mechanism of action. Neurotox. Res. 2000, 2(2-3), 85-97.
    • (2000) Neurotox. Res , vol.2 , Issue.2-3 , pp. 85-97
    • Danysz, W.1    Parsons, C.G.2    Mobius, H.J.3    Stoffler, A.4    Quack, G.5
  • 39
    • 0027731677 scopus 로고
    • Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)
    • Parsons, C. G.; Gruner, R.; Rozental, J.; Millar, J.; Lodge, D. Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacology 1993, 32(12), 1337-1350.
    • (1993) Neuropharmacology , vol.32 , Issue.12 , pp. 1337-1350
    • Parsons, C.G.1    Gruner, R.2    Rozental, J.3    Millar, J.4    Lodge, D.5
  • 42
    • 0028821928 scopus 로고
    • Modulation of learning processes by ionotropic glutamate receptor ligands
    • Danysz, W.; Zajaczkowski, W.; Parsons, C. G. Modulation of learning processes by ionotropic glutamate receptor ligands. Behav. Pharmacol. 1995, 6, 455-474.
    • (1995) Behav. Pharmacol , vol.6 , pp. 455-474
    • Danysz, W.1    Zajaczkowski, W.2    Parsons, C.G.3
  • 43
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss, T. V.; Collingridge, G. L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993, 361(6407), 31-39.
    • (1993) Nature , vol.361 , Issue.6407 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 44
    • 0032122422 scopus 로고    scopus 로고
    • Memory and the brain: Unexpected chemistries and a new pharmacology
    • Lynch, G. Memory and the brain: unexpected chemistries and a new pharmacology. Neurobiol. Learn. Mem. 1998, 70(1-2), 82-100.
    • (1998) Neurobiol. Learn. Mem , vol.70 , Issue.1-2 , pp. 82-100
    • Lynch, G.1
  • 45
    • 0141483708 scopus 로고    scopus 로고
    • Glutamatergic systems in Alzheimer's disease
    • Francis, P. T. Glutamatergic systems in Alzheimer's disease. Int. J Geriatr. Psychiatry 2003, 18(Suppl 1), S15-S21.
    • (2003) Int. J Geriatr. Psychiatry , vol.18 , Issue.SUPPL. 1
    • Francis, P.T.1
  • 47
    • 0030714092 scopus 로고    scopus 로고
    • Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease
    • Lovell, M. A.; Ehmann, W. D.; Mattson, M. P.; Markesbery, W. R. Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease. Neurobiol. Aging 1997, 18(5), 457-461.
    • (1997) Neurobiol. Aging , vol.18 , Issue.5 , pp. 457-461
    • Lovell, M.A.1    Ehmann, W.D.2    Mattson, M.P.3    Markesbery, W.R.4
  • 49
    • 0032950029 scopus 로고    scopus 로고
    • The glutamatergic system and neurodegeneration in dementia: Preventive strategies in Alzheimer's disease
    • Cacabelos, R.; Takeda, M.; Winblad, B. The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease. Int. J. Geriatr. Psychiatry 1999, 14(1), 3-47.
    • (1999) Int. J. Geriatr. Psychiatry , vol.14 , Issue.1 , pp. 3-47
    • Cacabelos, R.1    Takeda, M.2    Winblad, B.3
  • 51
    • 43849088152 scopus 로고    scopus 로고
    • Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors
    • Abbott, J. J.; Howlett, D. R.; Francis, P. T.; Williams, R. J. Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors. Neurobiol. Aging 2007, 29(7), 992-1001.
    • (2007) Neurobiol. Aging , vol.29 , Issue.7 , pp. 992-1001
    • Abbott, J.J.1    Howlett, D.R.2    Francis, P.T.3    Williams, R.J.4
  • 52
    • 32944454301 scopus 로고    scopus 로고
    • "Sundowning" and other temporally associated agitation states in dementia patients
    • Bachman, D.; Rabins, P. "Sundowning" and other temporally associated agitation states in dementia patients. Annu. Rev. Med. 2006, 57, 499-511.
    • (2006) Annu. Rev. Med , vol.57 , pp. 499-511
    • Bachman, D.1    Rabins, P.2
  • 53
    • 0037200813 scopus 로고    scopus 로고
    • Homer-1 mRNA in the rat suprachiasmatic nucleus is regulated differentially by the retinohypothalamic tract transmitters pituitary adenylate cyclase activating polypeptide and glutamate at time points where light phase-shifts the endogenous rhythm
    • Neilsen, H. S.; Georg, B.; Hannibal, J.; Fahrenkrug, J. Homer-1 mRNA in the rat suprachiasmatic nucleus is regulated differentially by the retinohypothalamic tract transmitters pituitary adenylate cyclase activating polypeptide and glutamate at time points where light phase-shifts the endogenous rhythm. Brain Res. Mol. Brain Res. 2002, 105, 79-85.
    • (2002) Brain Res. Mol. Brain Res , vol.105 , pp. 79-85
    • Neilsen, H.S.1    Georg, B.2    Hannibal, J.3    Fahrenkrug, J.4
  • 54
    • 2442465965 scopus 로고    scopus 로고
    • Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration
    • Li, L.; Sengupta, A.; Haque, N.; Grundke-Iqbal, I.; Iqbal, K. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS Lett. 2004, 566, 261-269.
    • (2004) FEBS Lett , vol.566 , pp. 261-269
    • Li, L.1    Sengupta, A.2    Haque, N.3    Grundke-Iqbal, I.4    Iqbal, K.5
  • 55
    • 0034859101 scopus 로고    scopus 로고
    • The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
    • Grimes, C. A.; Jope, R. S. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog. Neurobiol. 2001, 65(4), 391-426.
    • (2001) Prog. Neurobiol , vol.65 , Issue.4 , pp. 391-426
    • Grimes, C.A.1    Jope, R.S.2
  • 56
    • 31844447759 scopus 로고    scopus 로고
    • In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors
    • De Sarno, P.; Bijur, G. N.; Zmijewska, A. A.; Li, X.; Jope, R. S. In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors. Neurobiol. Aging 2006, 27, 413-422.
    • (2006) Neurobiol. Aging , vol.27 , pp. 413-422
    • de Sarno, P.1    Bijur, G.N.2    Zmijewska, A.A.3    Li, X.4    Jope, R.S.5
  • 57
    • 0035887601 scopus 로고    scopus 로고
    • An NMDA receptor signaling complex with protein phosphatase 2A
    • Chan, S. F.; Sucher, N. J. An NMDA receptor signaling complex with protein phosphatase 2A. J. Neurosci. 2001, 21, 7985-7992.
    • (2001) J. Neurosci , vol.21 , pp. 7985-7992
    • Chan, S.F.1    Sucher, N.J.2
  • 59
    • 0034175581 scopus 로고    scopus 로고
    • Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy
    • Ruberti, F.; Capsoni, S.; Comparini, A.; Di Daniel, E.; Franzot, J.; Gonfloni, S.; Rossi, G.; Berardi, N.; Cattaneo, A. Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. J. Neurosci. 2000, 20(7), 2589-2601.
    • (2000) J. Neurosci , vol.20 , Issue.7 , pp. 2589-2601
    • Ruberti, F.1    Capsoni, S.2    Comparini, A.3    Di Daniel, E.4    Franzot, J.5    Gonfloni, S.6    Rossi, G.7    Berardi, N.8    Cattaneo, A.9
  • 60
    • 2942580026 scopus 로고    scopus 로고
    • Early events of Alzheimer-like neurodegeneration in anti-nerve growth factor transgenic mice
    • Capsoni, S.; Giannotta, S.; Cattaneo, A. Early events of Alzheimer-like neurodegeneration in anti-nerve growth factor transgenic mice. Brain Aging 2002, 2(4), 24-43.
    • (2002) Brain Aging , vol.2 , Issue.4 , pp. 24-43
    • Capsoni, S.1    Giannotta, S.2    Cattaneo, A.3
  • 61
    • 33745370049 scopus 로고    scopus 로고
    • Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by memantine
    • Chohan, M. O.; Khatoon, S.; Iqbal, I. -G.; Iqbal, K. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by memantine. FEBS Lett. 2006, 580, 3973-3979.
    • (2006) FEBS Lett , vol.580 , pp. 3973-3979
    • Chohan, M.O.1    Khatoon, S.2    Iqbal I., -G.3    Iqbal, K.4
  • 63
    • 33646362786 scopus 로고    scopus 로고
    • Update on the biological treatment of aggression
    • Volavka, J.; Citrome, L.; Huertas, D. Update on the biological treatment of aggression. Actas Esp. Psiquiatr. 2006, 34(2), 123-135.
    • (2006) Actas Esp. Psiquiatr , vol.34 , Issue.2 , pp. 123-135
    • Volavka, J.1    Citrome, L.2    Huertas, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.