Treatment of functional decline in adults with down syndrome using selective serotonin-reuptake inhibitor drugs

Journal of Geriatric Psychiatry and Neurology

Volumn 10, Issue 3, 1997, Pages 99-104

  Geldmacher, David S ^a,b,c   Lerner, Alan J ^a,b   Voci, J Mathew ^a,b   Noelker, Elizabeth A ^a   Somple, Lauren C ^a   Whitehouse, Peter J ^a,b  

^a UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University Alzheimer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ADULT; AGGRESSION; ALZHEIMER DISEASE; ARTICLE; CAREGIVER; CLINICAL ARTICLE; CLINICAL FEATURE; COMPULSION; DEPRESSION; DOWN SYNDROME; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PRODUCTIVITY; PSYCHOSOCIAL WITHDRAWAL; WORKPLACE;

EID: 0030691103     PISSN: 08919887     EISSN: None     Source Type: Journal    
DOI: 10.1177/089198879701000302     Document Type: Article

References (19)

1. Cork L. Neuropathology of Down syndrome and Alzheimer disease. Am J Med Genet Suppl 1990; 7:282-286.
2. Das JP, Divis B, Alexander J, et al. Cognitive decline due to aging among persons with Down syndrome. Res Dev Disabil 1995; 16:461-478.
3. Haveman MJ, Maaskant MA, van Schrojenstein Lantman HM, et al. Mental health problems in elderly people with and without Down's syndrome. J Intellect Disabil Res 1994; 38: 341-355.
4. Lai F. Clinicopathologic features of Alzheimer disease in Down syndrome. In: Nadel L, Epstein CJ, eds. Down syndrome and Alzheimer disease. New York: Wiley-Liss, 1992:15-34.
5. Nelson L, Lott I, Touchette P, et al. Detection of Alzheimer disease in individuals with Down syndrome. Am J Ment Retard 1995; 99:616-622.
6. Prasher VP, Filer A. Behavioral disturbance in people with Down's syndrome and dementia. J Intellect Disabil Res 1995; 39:432-436.
7. Myers BA, Pueschel SM. Major depression in a small group of adults with Down syndrome. Res Dev Disabil 1995; 16:285-299.
8. Godridge H, Reynolds GP, Czudek C, et al. Alzheimer-like neurotransmitter deficits in adult Down's syndrome brain tissue. J Neurol Neurosurg Psychiatry 1987; 50:775-778.
9. Yates CM, Simpson J, Gordon A. Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neurosci Lett 1986; 65:189-192.
10. Warren AC, Holroyd S, Folstein MF. Major depression in Down's syndrome. Br J Psychiatry 1989; 155:202-205.
11. Gedye A. Dietary increase in serotonin reduces self-injurious behaviour in a Down's syndrome adult. J Ment Defic Res 1990; 34:195-203.
12. Meins W. Are depressive mood disturbances in adults with Down's syndrome an early sign of dementia? J Nerv Ment Dis 1995; 183:663-664.
13. Lott IT, Lai F. Dementia in Down syndrome. Ann Neurol 1982; 12:210.
14. Ternaux JP, Mattei JF, Faudon M, et al. Peripheral and central 5-hydroxytryptamine in trisomy 21. Life Sci 1979; 25:2017-2022.
15. Mann DM, Yates PO, Marcyniuk B, Ravindra CR. Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J Ment Defic Res 1985; 29:125-135.
16. Volicer L, Crino PB. Involvement of free radicals in dementia of the Alzheimer type: a hypothesis. Neurobiol Aging 1990; 11:567-571.
17. Groner Y, Elroy-Stein O, Avraham KB, et al. Cell damage by excess CuZnSOD and Down's syndrome. Biomed Pharmacother 1994; 48(5-6):231-240.
18. Kiss J, Schlumpf M, Balazs R. Selective retardation of the development of the basal forebrain cholinergic and pontine catecholaminergic nuclei in the brain of trisomy 16 mouse, an animal model of Down's syndrome. Brain Res Dev Brain Res 1989; 50:251-264.
19. Kesslak JP, Nagata SF, Lott I, Nalcioglu O. Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome. Neurology 1994; 44:1039-1045.