Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis

Journal of Medicinal Chemistry

Volumn 57, Issue 11, 2014, Pages 4692-4709

  Fu, Hai Jian ^a   Zhou, Yu Ren ^a   Bao, Bei Hua ^a   Jia, Meng Xuan ^a   Zhao, Yang ^a   Zhang, Lei ^a   Li, Jian Xin ^a   He, Hai Lang ^b   Zhou, Xian Mei ^b  

^a NANJING UNIVERSITY   (China)

^b AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL PROPEPTIDE PROCOLLAGEN TYPE 1; ANABOLIC AGENT; MESSENGER RNA; PROCOLLAGEN; SEROTONIN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG; URSOLIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; BONE STRUCTURE; BONE TURNOVER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR DOCKING; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RAT MODEL; SEROTONIN BLOOD LEVEL; SURFACE PLASMON RESONANCE; TISSUE LEVEL;

ANABOLIC AGENTS; ANIMALS; BONE AND BONES; BRAIN; CELL LINE; FEMALE; GASTROINTESTINAL TRACT; HUMANS; MOLECULAR DOCKING SIMULATION; OSTEOPOROSIS; OVARIECTOMY; PROTEIN BINDING; QUINOXALINES; RATS; RNA, MESSENGER; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TRITERPENES; TRYPTOPHAN HYDROXYLASE;

EID: 84902436652     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5002293     Document Type: Article

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