Mechanism of inhibition of novel tryptophan hydroxylase inhibitors revealed by co-crystal structures and kinetic analysis

Current Chemical Genomics

Volumn 4, Issue 1, 2010, Pages 19-26

  Cianchetta, Giovanni ^a   Stouch, Terry ^a   Yu, Wangsheng ^a   Shi, Zhi Cai ^a   Tari, Leslie W ^b   Swanson, Ronald V ^b   Hunter, Michael J ^b   Hoffman, Isaac D ^b   Liu, Qingyun ^a,c  

^a LEXICON PHARMACEUTICALS INC   (United States)

^b Activesight Inc   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Carcinoid; Gastrointestinal disorder; Kinetics; Monooxygenase; Serotonin; Structure

Indexed keywords

6 METHYLTETRAHYDROPTERIN; ENZYME INHIBITOR; LP 521834; LP 533401; LP 534193; PHENYLALANINE 4 MONOOXYGENASE; PTERIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE; TRYPTOPHAN HYDROXYLASE 1; TRYPTOPHAN HYDROXYLASE INHIBITOR; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG MECHANISM; ENZYME INHIBITION; ENZYME KINETICS; HYDROXYLATION; PRIORITY JOURNAL; PROTEIN PURIFICATION;

EID: 78249279684     PISSN: None     EISSN: 18753973     Source Type: Journal    
DOI: 10.2174/1875397301004010019     Document Type: Article

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