High resolution quantitative computed tomography-based assessment of trabecular microstructure and strength estimates by finite-element analysis of the spine, but not DXA, reflects vertebral fracture status in men with glucocorticoid-induced osteoporosis

Bone

Volumn 52, Issue 2, 2013, Pages 568-577

  Graeff, Christian ^a   Marin, Fernando ^b   Petto, Helmut ^b   Kayser, Ole ^a   Reisinger, Andreas ^c   Peña, Jaime ^a   Zysset, Philippe ^c   Glüer, Claus Christian ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Department of Medical Research ^*  (Austria)

^c VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Bone mineral density; Finite element analysis; Glucocorticoid induced osteoporosis; High resolution quantitative computed tomography; Vertebral fracture

Indexed keywords

ADULT; ARTICLE; BONE DENSITY; BONE MASS; BONE STRENGTH; BONE STRUCTURE; CONTROLLED STUDY; CORTICAL THICKNESS (BONE); CORTICOSTEROID INDUCED OSTEOPOROSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; DUAL ENERGY X RAY ABSORPTIOMETRY; FINITE ELEMENT ANALYSIS; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; QUANTITATIVE ANALYSIS; SPINE FRACTURE; SPINE RADIOGRAPHY; TRABECULAR BONE;

ABSORPTIOMETRY, PHOTON; ADULT; BIOMECHANICS; FINITE ELEMENT ANALYSIS; GLUCOCORTICOIDS; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; OSTEOPOROSIS; REGRESSION ANALYSIS; SPINAL FRACTURES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84875013666     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.10.036     Document Type: Article

References (60)

1. Marshall D., Johnell O., Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. Br Med J 1996, 312:1254-1259.
2. Siris E.S., Chen Y.T., Abbott T.A., Barrett-Connor E., Miller P.D., Wehren L.E., et al. Bone mineral density thresholds for pharmacological intervention to prevent fractures. Arch Intern Med 2004, 164:1108-1112.
3. Chen P., Krege J.H., Adachi J.D., Prior J.C., Tenenhouse A., Brown J.P., et al. Vertebral fracture status and the World Health Organization risk factors for predicting osteoporotic fracture risk. J Bone Miner Res 2009, 24:495-502.
4. Kanis J.A., Johnell O., Oden A., Johansson H., McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 2008, 19:385-397.
5. van Staa T.P., Leufkens H.G., Abenhaim L., Zhang B., Cooper C. Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford) 2000, 39:1383-1389.
6. Canalis E., Bilezikian J.P., Angeli A., Giustina A. Perspectives on glucocorticoid-induced osteoporosis. Bone 2004, 34:593-598.
7. Dempster D.W. Bone histomorphometry in glucocorticoid-induced osteoporosis. J Bone Miner Res 1989, 4:137-141.
8. Dalle Carbonare L., Arlot M.E., Chavassieux P.M., Roux J.P., Portero N.R., Meunier P.J. Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis. J Bone Miner Res 2001, 16:97-103.
9. Chappard D., Josselin N., Rougé-Maillart C., Legrand E., Baslé M.F., Audran M. Bone microarchitecture in males with corticosteroid-induced osteoporosis. Osteoporos Int 2007, 18:487-494.
10. Weinstein R.S., Jilka R.L., Parfitt A.M., Manolagas S.C. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 1998, 102:274-282.
11. Kalpakcioglu B.B., Engelke K., Genant H.K. Advanced imaging assessment of bone fragility in glucocorticoid-induced osteoporosis. Bone 2011, 48:1221-1231.
12. Canalis E., Mazziotti G., Giustina A., Bilezikian J.P. Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int 2007, 18:1319-1328.
13. Van Staa T.P., Laan R.F., Barton I.P., Cohen S., Reid D.M., Cooper C. Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 2003, 48:3224-3229.
14. Genant H.K., Engelke K., Prevrhal S. Advanced CT bone imaging in osteoporosis. Rheumatology (Oxford) 2008, 47(Suppl. 4):iv9-iv16.
15. Krebs A., Graeff C., Frieling I., Kurz B., Timm W., Engelke K., et al. High resolution computed tomography of the vertebrae yields accurate information on trabecular distances if processed by 3D fuzzy segmentation approaches. Bone 2009, 44:145-152.
16. Graeff C., Timm W., Nickelsen T.N., Farrerons J., Marin F., Barker C., et al. Monitoring teriparatide-associated changes in vertebral microstructure by high-resolution CT in vivo: results from the EUROFORS study. J Bone Miner Res 2007, 22:1426-1433.
17. Ito M., Ikeda K., Nishiguchi M., Shindo H., Uetani M., Hosoi T., et al. Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res 2005, 20:1828-1836.
18. Genant H.K., Wu C.Y., van Kuijk C., Nevitt M.C. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 1993, 8:1137-1148.
19. Chevalier Y., Charlebois M., Pahra D., Varga P., Heini P., Schneider E., et al. A patient-specific finite element methodology to predict damage accumulation in vertebral bodies under axial compression, sagittal flexion and combined loads. Comput Methods Biomech Biomed Engin 2008, 11:477-487.
20. Simmons C.A., Hipp J.A. Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone. J Bone Miner Res 1997, 12:942-947.
21. Graeff C. Bone Strength Surrogate Markers. Ph.D. Thesis, 2010 Shaker Verlag, 2010, ISBN: 978-3-8322-9994-1.
22. Genant H.K., Grampp S., Gluer C.C., Faulkner K.G., Jergas M., Engelke K., et al. Universal standardization for dual x-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res 1994, 9:1503-1514.
23. Hanson J. Standardization of femur bone mineral density. J Bone Miner Res 1997, 12:1316-1317.
24. Popp A.W., Isenegger J., Buergi E.M., Buergi U., Lippuner K. Glucocorticosteroid-induced spinal osteoporosis: scientific update on pathophysiology and treatment. Eur Spine J 2006, 15:1035-1049.
25. Fields A.J., Eswaran S.K., Jekir M.G., Keaveny T.M. Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior. J Bone Miner Res 2009, 24:1523-1530.
26. Nazarian A., Stauber M., Zurakowski D., Snyder B.D., Muller R. The interaction of microstructure and volume fraction in predicting failure in cancellous bone. Bone 2006, 39:1196-1202.
27. Diederichs G., Link T.M., Kentenich M., Schwieger K., Huber M.B., Burghardt A.J., et al. Assessment of trabecular bone structure of the calcaneus using multi-detector CT: correlation with microCT and biomechanical testing. Bone 2009, 44:976-983.
28. Homminga J., McCreadie B.R., Ciarelli T.E., Weinans H., Goldstein S.A., Huiskes R. Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level. Bone 2002, 30:759-764.
29. Rockoff S.D., Swett E., Bleustein J. The relative contribution of trabecular and cortical bone to the strength of human vertebrae. Calcif Tissue Res 1969, 3:163-175.
30. Mosekilde L. Normal vertebral body size and compressive strength: relations to age and to vertebral and iliac trabecular bone compressive strength. Bone 1986, 7:207-212.
31. Ladinsky G.A., Vasilic B., Popescu A.M., Wald M., Zemel B.S., Snyder P.J., et al. Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD. J Bone Miner Res 2008, 23:64-74.
32. Majumdar S., Link T.M., Augat P., Lin J.C., Newitt D., Lane N.E., et al. Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Osteoporos Int 1999, 10:231-239.
33. Stauber M., Muller R. Volumetric spatial decomposition of trabecular bone into rods and plates - a new method for local bone morphometry. Bone 2006, 38:475-484.
34. Melton L.J., Riggs B.L., Keaveny T.M., Achenbach S.J., Hoffmann P.F., Camp J.J., et al. Structural determinants of vertebral fracture risk. J Bone Miner Res 2007, 22:1885-1892.
35. Homminga J., Weinans H., Gowin W., Felsenberg D., Huiskes R. Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution. Spine 2001, 26:1555-1561.
36. Eswaran S.K., Gupta A., Adams M.F., Keaveny T.M. Cortical and trabecular load sharing in the human vertebral body. J Bone Miner Res 2006, 21:307-314.
37. Eswaran S.K., Gupta A., Keaveny T.M. Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body. Bone 2007, 41:733-739.
38. Fechtenbaum J., Cropet C., Kolta S., Horlait S., Orcel P., Roux C. The severity of vertebral fractures and health-related quality of life in osteoporotic postmenopausal women. Osteoporos Int 2005, 16:2175-2179.
39. Siris E.S., Genant H.K., Laster A.J., Chen P., Misurski D.A., Krege J.H. Enhanced prediction of fracture risk combining vertebral fracture status and BMD. Osteoporos Int 2007, 18:761-770.
40. Delmas P.D., Genant H.K., Crans G.G., Stock J.L., Wong M., Siris E., et al. Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 2003, 33:522-532.
41. Ferrar L., Roux C., Felsenberg D., Gluer C.C., Eastell R. Association between incident and baseline vertebral fractures in European women: vertebral fracture assessment in the Osteoporosis and Ultrasound Study (OPUS). Osteoporos Int 2012, 23:59-65.
42. Ding M., Hvid I. Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone. Bone 2000, 26:291-295.
43. Genant H.K., Delmas P.D., Chen P., Jiang Y., Eriksen E.F., Dalsky G.P., et al. Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int 2007, 18:69-76.
44. Yu W., Gluer C.C., Grampp S., Jergas M., Fuerst T., Wu C.Y., et al. Spinal bone mineral assessment in postmenopausal women: a comparison between dual X-ray absorptiometry and quantitative computed tomography. Osteoporos Int 1995, 5:433-439.
45. Rehman Q., Lang T., Modin G., Lane N.E. Quantitative computed tomography of the lumbar spine, not dual X-ray absorptiometry, is an independent predictor of prevalent vertebral fractures in postmenopausal women with osteopenia receiving long-term glucocorticoid and hormone-replacement therapy. Arthritis Rheum 2002, 46:1292-1297.
46. Walsh L.J., Lewis S.A., Wong C.A., Cooper S., Oborne J., Cawte S.A., et al. The impact of oral corticosteroid use on bone mineral density and vertebral fracture. Am J Respir Crit Care Med 2002, 166:691-695.
47. Li E.K., Zhu T.Y., Tam L.S., Hung V.W., Griffith J.F., Li T.K., et al. Bone microarchitecture assessment by high-resolution peripheral quantitative computed tomography in patients with systemic lupus erythematosus taking corticosteroids. J Rheumatol 2010, 37:1473-1479.
48. Hayashi K., Yamamoto M., Murakawa Y., Yamauchi M., Kaji H., Yamaguchi T., et al. Bone fragility in male glucocorticoid-induced osteoporosis is not defined by bone mineral density. Osteoporos Int 2009, 20:1889-1894.
49. Selby P.L., Hlasey J.P., Adams K.R.H., Klimiuk S.M., Pal B., Stewart I.M., et al. Corticoids do not alter the threshold for vertebral fracture. J Bone Miner Res 2000, 15:952-956.
50. Naganathan V., Jones G., Nash P., Nicholson G., Eisman J., Sambrook P.N. Vertebral fracture risk with long-term corticosteroid therapy. Arch Intern Med 2000, 160:2917-2922.
51. Crawford P., Cann C.E., Keaveny T.M. Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone 2003, 33:744-750.
52. Imai K., Ohnishi I., Bessho M., Nakamura K. Nonlinear finite element model predicts vertebral bone strength and fracture site. Spine 2006, 31:1789-1794.
53. DallD́Ara E., Schmidt R., Pahr D., Varga P., Chevalier Y., Patsch J., et al. A nonlinear finite element model validation study based on a novel experimnetal technique for inducing anterior wedge-shape fractures in human vertebral bodies in vitro. J Biomech 2010, 43:2374-2380.
54. Biewener A.A. Musculoskeletal design in relation to body size. J Biomech 1991, 24(Suppl. 1):19-29.
55. Hayes W.C., Piazza S.J., Zysset P.K. Biomechanics of fracture risk prediction of the hip and spine by quantitative computed tomography. Radiol Clin North Am 1991, 29:1-18.
56. Wang X., Sanyal A., Cawthon P.M., Palermo L., Jekir M., Christensen J., et al. Prediction of new clinical vertebral fractures in elderly men using finite element analysis of CT scans. J Bone Miner Res 2012, 27:808-816.
57. Vilayphiou N., Boutroy S., Sulc P., VanRietbergen B., Muñoz F., Delmas P.D., et al. Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men. J Bone Miner Res 2011, 26:965-973.
58. Amin S., Kopperdahl D.L., Melton L.J., Achenbach S.J., Therneau T.M., Riggs B.L., et al. Association of hip strength estimates by finite-element analysis with fractures in women and men. J Bone Miner Res 2011, 26:1593-1600.
59. O'Neill T.W., Felsenberg D., Varlow J., Cooper C., Kanis J.A., Silman A.J. The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res 1996, 11:1010-1018.
60. Peña J., Graeff C., Krebs A., Glüer C.-C. Cross-calibration of different reconstruction kernels for vertebral trabecular microstructure measures on clinical CT under in-vivo like settings. Bone 2009, 44(Suppl. 2):S380.