Activation of leukemia-associated RhoGEF by Gα13 with significant conformational rearrangements in the interface

Journal of Biological Chemistry

Volumn 284, Issue 8, 2009, Pages 5000-5009

  Suzuki, Nobuchika ^a,b   Tsumoto, Kouhei ^b   Hajicek, Nicole ^c   Daigo, Kenji ^a   Tokita, Reiko ^b   Minami, Shiro ^b   Kodama, Tatsuhiko ^a   Hamakubo, Takao ^a   Kozasa, Tohru ^a,c,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; BIOCHEMICAL METHODS; C-TERMINAL REGIONS; COMPLEX FORMATIONS; CONFORMATIONAL CHANGE; CONTACT POSITION; ENTROPY CHANGES; G PROTEIN; G PROTEIN COUPLED RECEPTORS; GTPASE-ACTIVATING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANINE NUCLEOTIDES; HEAT CAPACITY CHANGE; HYDROPHOBIC SURFACES; INDUCED-FIT MECHANISM; MOLECULAR MECHANISM; PLECKSTRIN HOMOLOGY; PROTEIN-PROTEIN INTERACTIONS; THERMO DYNAMIC ANALYSIS;

HYDROPHOBICITY; NUCLEOTIDES; POSITIVE IONS; PROTEINS; SURFACE CHEMISTRY; SURFACE PLASMON RESONANCE; THERMOANALYSIS;

CHEMICAL ACTIVATION;

ALANINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA13 SUBUNIT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LEUKEMIA ASSOCIATED RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; UNCLASSIFIED DRUG; ARHGEF12 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENTROPY; HEAT EXCHANGE; HUMAN; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; THERMODYNAMICS; CHEMISTRY; GENETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 64149093844     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804073200     Document Type: Article

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