Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

Nature Medicine

Volumn 16, Issue 3, 2010, Pages 308-312

  Yadav, Vijay K ^a   Balaji, Santhanam ^b   Suresh, Padmanaban S ^c   Liu, X Sherry ^d   Lu, Xin ^d   Li, Zhishan ^a   Guo, X Edward ^d   Mann, J John ^e   Balapure, Anil K ^f   Gershon, Michael D ^a   Medhamurthy, Rudraiah ^c   Vidal, Marc ^b   Karsenty, Gerard ^a   Ducy, Patricia ^a  

^a NewYork Presbyterian Hospital   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c INDIAN INSTITUTE OF SCIENCE   (India)

^d Columbia University ^*  (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS AFFECTING METABOLISM; DEOXYPYRIDINOLINE; GUT DERIVED SEROTONIN; LP 533401; OXYGENASE INHIBITOR; PARATHYROID HORMONE; SEROTONIN; SEROTONIN ANTAGONIST; TRYPTOPHAN HYDROXYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MASS; CELL PROLIFERATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SCREENING; FEMALE; FEMUR; GASTROINTESTINAL TRANSIT; LOW DRUG DOSE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SEROTONIN BLOOD LEVEL; STOMACH EMPTYING; SYNTHESIS; VERTEBRA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL TRACT; HUMANS; MICE; MICE, INBRED C57BL; OSTEOGENESIS; OSTEOPOROSIS; OSTEOPOROSIS, POSTMENOPAUSAL; PYRIMIDINES; RATS; SEROTONIN; SEROTONIN AGENTS; TRYPTOPHAN HYDROXYLASE;

RODENTIA;

EID: 77949270283     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2098     Document Type: Article

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