Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking

Journal of Medicinal Chemistry

Volumn 56, Issue 15, 2013, Pages 6146-6155

  Weidel, Elisabeth ^b,c   De Jong, Johannes C ^a   Brengel, Christian ^a   Storz, Michael P ^a   Braunshausen, Andrea ^a   Negri, Matthias ^a   Plaza, Alberto ^a   Steinbach, Anke ^a   Müller, Rolf ^a   Hartmann, Rolf W ^a,b  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c ElexoPharm GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BENZOIC ACID DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; IC 50; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCESS OPTIMIZATION; PSEUDOMONAS INFECTION; SURFACE PLASMON RESONANCE;

4-QUINOLONES; BACTERIAL PROTEINS; BENZAMIDES; BENZOATES; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUINOLONES; QUORUM SENSING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SURFACE PLASMON RESONANCE; TRANSCRIPTION FACTORS;

EID: 84881408976     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4006302     Document Type: Article

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