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Volumn 23, Issue 7, 2014, Pages 965-977

Modulation of autophagy for the treatment of liver diseases

Author keywords

Chloroquine; Cirrhosis; Hepatic; Ischemia; Non alcoholic fatty liver disease

Indexed keywords

2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; 3 METHYLADENINE; BAFILOMYCIN A1; BORTEZOMIB; CARBAMAZEPINE; CHLOROQUINE; CISPLATIN; DACTOLISIB; EVEROLIMUS; FERROQUINE; HYDROXYCHLOROQUINE; LIPID; NILOTINIB; OXALIPLATIN; RAPAMYCIN; SORAFENIB; VORINOSTAT;

EID: 84902340150     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2014.912274     Document Type: Review
Times cited : (31)

References (96)
  • 1
    • 79956095420 scopus 로고    scopus 로고
    • Autophagosome formation and molecular mechanism of autophagy
    • Tanida I. Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal 2011;14:2201-14
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2201-2214
    • Tanida, I.1
  • 3
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-Activated protein kinase connects energy sensing to mitophagy
    • Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-Activated protein kinase connects energy sensing to mitophagy. Science 2011;331:456-61
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3
  • 4
    • 84872586081 scopus 로고    scopus 로고
    • Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy
    • Kim J, Kim YC, Fang C, et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 2013;152:290-303
    • (2013) Cell , vol.152 , pp. 290-303
    • Kim, J.1    Kim, Y.C.2    Fang, C.3
  • 5
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010;140:313-26
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 7
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature 2009;458:1131-5
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 8
    • 77955789211 scopus 로고    scopus 로고
    • Altered lipid content inhibits autophagic vesicular fusion
    • Koga H, Kaushik S, Cuervo AM. Altered lipid content inhibits autophagic vesicular fusion. FASEB J 2010;24:3052-65
    • (2010) FASEB J , vol.24 , pp. 3052-3065
    • Koga, H.1    Kaushik, S.2    Cuervo, A.M.3
  • 9
    • 84873178472 scopus 로고    scopus 로고
    • Effect of short- And long-term high-fat feeding on autophagy flux and lysosomal activity in rat liver
    • Papackova Z, Dankova H, Palenickova E, et al. Effect of short- And long-term high-fat feeding on autophagy flux and lysosomal activity in rat liver. Physiol Res 2012;61(Suppl 2):S67-76
    • (2012) Physiol Res , vol.61 , Issue.SUPPL. 2
    • Papackova, Z.1    Dankova, H.2    Palenickova, E.3
  • 12
    • 77951227871 scopus 로고    scopus 로고
    • -dependent control of autophagy: Biting the hand that feeds
    • TOR
    • Neufeld TP. TOR-dependent control of autophagy: Biting the hand that feeds. Curr Opin Cell Biol 2010;22:157-68
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 157-168
    • Neufeld, T.P.1
  • 13
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-19 (Pubitemid 44100518
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 14
    • 71449091240 scopus 로고    scopus 로고
    • Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: Inhibition of FoxO1- dependent expression of key autophagy genes by insulin
    • Liu HY, Han J, Cao SY, et al. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: Inhibition of FoxO1- dependent expression of key autophagy genes by insulin. J Biol Chem 2009;284:31484-92
    • (2009) J Biol Chem , vol.284 , pp. 31484-31492
    • Liu, H.Y.1    Han, J.2    Cao, S.Y.3
  • 16
    • 84880567639 scopus 로고    scopus 로고
    • Differential contribution of insulin and amino acids to the mtorc1-Autophagy pathway in the liver and muscle
    • Naito T, Kuma A, Mizushima N. Differential contribution of insulin and amino acids to the mTORC1-Autophagy pathway in the liver and muscle. J Biol Chem 2013;288:21074-81
    • (2013) J Biol Chem , vol.288 , pp. 21074-21081
    • Naito, T.1    Kuma, A.2    Mizushima, N.3
  • 17
    • 80052511813 scopus 로고    scopus 로고
    • The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
    • Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011;13:1016-23
    • (2011) Nat Cell Biol , vol.13 , pp. 1016-1023
    • Mihaylova, M.M.1    Shaw, R.J.2
  • 18
    • 74349090643 scopus 로고    scopus 로고
    • The role of AMPactivated protein kinase in the cardiovascular system
    • Nagata D, Hirata Y. The role of AMPactivated protein kinase in the cardiovascular system. Hypertens Res 2010;33:22-8
    • (2010) Hypertens Res , vol.33 , pp. 22-28
    • Nagata, D.1    Hirata, Y.2
  • 19
    • 77953724901 scopus 로고    scopus 로고
    • A comprehensive glossary of autophagy-related molecules and processes
    • Klionsky DJ, Codogno P, Cuervo AM, et al. A comprehensive glossary of autophagy-related molecules and processes. Autophagy 2010;6:438-48
    • (2010) Autophagy , vol.6 , pp. 438-448
    • Klionsky, D.J.1    Codogno, P.2    Cuervo, A.M.3
  • 20
    • 84878699998 scopus 로고    scopus 로고
    • Chronic caloric restriction and exercise improve metabolic conditions of dietary-induced obese mice in autophagy correlated manner without involving AMPK
    • Cui M, Yu H, Wang J, et al. Chronic caloric restriction and exercise improve metabolic conditions of dietary-induced obese mice in autophagy correlated manner without involving AMPK. J Diabetes Res 2013;2013:852754
    • (2013) J Diabetes Res , vol.2013 , pp. 852754
    • Cui, M.1    Yu, H.2    Wang, J.3
  • 21
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L, Li P, Fu S, et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab 2010;11:467-78
    • (2010) Cell Metab , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3
  • 23
    • 69549134165 scopus 로고    scopus 로고
    • Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance
    • Zhou L, Zhang J, Fang Q, et al. Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance. Mol Pharmacol 2009;76:596-603
    • (2009) Mol Pharmacol , vol.76 , pp. 596-603
    • Zhou, L.1    Zhang, J.2    Fang, Q.3
  • 24
    • 79959346132 scopus 로고    scopus 로고
    • Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest
    • Ganley IG, Wong PM, Gammoh N, et al. Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell 2011;42:731-43
    • (2011) Mol Cell , vol.42 , pp. 731-743
    • Ganley, I.G.1    Wong, P.M.2    Gammoh, N.3
  • 25
    • 84876287362 scopus 로고    scopus 로고
    • Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-Alcoholic fatty liver conditions in mice
    • Lin CW, Zhang H, Li M, et al. Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-Alcoholic fatty liver conditions in mice. J Hepatol 2013;58:993-9
    • (2013) J Hepatol , vol.58 , pp. 993-999
    • Lin, C.W.1    Zhang, H.2    Li, M.3
  • 26
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • DOI 10.1002/hep.21655
    • Yamaguchi K, Yang L, McCall S, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 2007;45:1366-74 (Pubitemid 46918320
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Xing, X.Y.5    Pandey, S.K.6    Bhanot, S.7    Monia, B.P.8    Li, Y.-X.9    Diehl, A.M.10
  • 28
    • 84869085771 scopus 로고    scopus 로고
    • Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice
    • Han X, Turdi S, Hu N, et al. Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice. J Nutr Biochem 2012;23:1592-9
    • (2012) J Nutr Biochem , vol.23 , pp. 1592-1599
    • Han, X.1    Turdi, S.2    Hu, N.3
  • 29
    • 84886797274 scopus 로고    scopus 로고
    • Autophagy in infection, inflammation and immunity
    • Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol 2013;13:722-37
    • (2013) Nat Rev Immunol , vol.13 , pp. 722-737
    • Deretic, V.1    Saitoh, T.2    Akira, S.3
  • 31
    • 54449101892 scopus 로고    scopus 로고
    • Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response
    • Sir D, Chen WL, Choi J, et al. Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response. Hepatology 2008;48:1054-61
    • (2008) Hepatology , vol.48 , pp. 1054-1061
    • Sir, D.1    Chen, W.L.2    Choi, J.3
  • 32
    • 84875279443 scopus 로고    scopus 로고
    • Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagy
    • Shinohara Y, Imajo K, Yoneda M, et al. Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagy. Biochem Biophys Res Commun 2013;432:326-32
    • (2013) Biochem Biophys Res Commun , vol.432 , pp. 326-332
    • Shinohara, Y.1    Imajo, K.2    Yoneda, M.3
  • 33
    • 69549135689 scopus 로고    scopus 로고
    • The autophagy machinery is required to initiate hepatitis C virus replication
    • Dreux M, Gastaminza P, Wieland SF, et al. The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci USA 2009;106:14046-51
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14046-14051
    • Dreux, M.1    Gastaminza, P.2    Wieland, S.F.3
  • 34
    • 84868125839 scopus 로고    scopus 로고
    • Hepatitis C virus-induced autophagy is independent of the unfolded protein response
    • Mohl BP, Tedbury PR, Griffin S, et al. Hepatitis C virus-induced autophagy is independent of the unfolded protein response. J Virol 2012;86:10724-32
    • (2012) J Virol , vol.86 , pp. 10724-10732
    • Mohl, B.P.1    Tedbury, P.R.2    Griffin, S.3
  • 35
    • 77949264265 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus replication by chloroquine targeting virus-Associated autophagy
    • Mizui T, Yamashina S, Tanida I, et al. Inhibition of hepatitis C virus replication by chloroquine targeting virus-Associated autophagy. J Gastroenterol 2010;45:195-203
    • (2010) J Gastroenterol , vol.45 , pp. 195-203
    • Mizui, T.1    Yamashina, S.2    Tanida, I.3
  • 36
    • 84890410562 scopus 로고    scopus 로고
    • HCV infection selectively impairs type I but not type III IFN signaling
    • Chandra PK, Bao L, Song K, et al. HCV infection selectively impairs type I but not type III IFN signaling. Am J Pathol 2014;184:214-29
    • (2014) Am J Pathol , vol.184 , pp. 214-229
    • Chandra, P.K.1    Bao, L.2    Song, K.3
  • 37
    • 77749292148 scopus 로고    scopus 로고
    • The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication
    • Sir D, Tian Y, Chen WL, et al. The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci USA 2010;107:4383-8
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4383-4388
    • Sir, D.1    Tian, Y.2    Chen, W.L.3
  • 38
    • 58949098335 scopus 로고    scopus 로고
    • Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via upregulation of beclin 1 expression
    • Tang H, Da L, Mao Y, et al. Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via upregulation of beclin 1 expression. Hepatology 2009;49:60-71
    • (2009) Hepatology , vol.49 , pp. 60-71
    • Tang, H.1    Da L Mao, Y.2
  • 39
    • 84879605965 scopus 로고    scopus 로고
    • The antimalarial ferroquine is an inhibitor of hepatitis C virus
    • Vausselin T, Calland N, Belouzard S, et al. The antimalarial ferroquine is an inhibitor of hepatitis C virus. Hepatology 2013;58:86-97
    • (2013) Hepatology , vol.58 , pp. 86-97
    • Vausselin, T.1    Calland, N.2    Belouzard, S.3
  • 40
    • 81355161371 scopus 로고    scopus 로고
    • A role for autophagy during hepatic stellate cell activation
    • Thoen LF, Guimaraes EL, Dolle L, et al. A role for autophagy during hepatic stellate cell activation. J Hepatol 2011;55:1353-60
    • (2011) J Hepatol , vol.55 , pp. 1353-1360
    • Thoen, L.F.1    Guimaraes, E.L.2    Dolle, L.3
  • 41
    • 84859444880 scopus 로고    scopus 로고
    • Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
    • Hernández-Gea V, Ghiassi-Nejad Z, Rozenfeld R, et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology 2012;142:938-46
    • (2012) Gastroenterology , vol.142 , pp. 938-946
    • Hernández-Gea, V.1    Ghiassi-Nejad, Z.2    Rozenfeld, R.3
  • 42
    • 77954597127 scopus 로고    scopus 로고
    • An autophagy-enhancing drug promotes degradation of mutant alpha1-Antitrypsin Z and reduces hepatic fibrosis
    • Hidvegi T, Ewing M, Hale P, et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-Antitrypsin Z and reduces hepatic fibrosis. Science 2010;329:229-32
    • (2010) Science , vol.329 , pp. 229-232
    • Hidvegi, T.1    Ewing, M.2    Hale, P.3
  • 43
    • 84882946866 scopus 로고    scopus 로고
    • Autophagy-enhancing drug carbamazepine diminishes hepatocellular death in fibrinogen storage disease
    • Puls F, Goldschmidt I, Bantel H, et al. Autophagy-enhancing drug carbamazepine diminishes hepatocellular death in fibrinogen storage disease. J Hepatol 2013;59:626-30
    • (2013) J Hepatol , vol.59 , pp. 626-630
    • Puls, F.1    Goldschmidt, I.2    Bantel, H.3
  • 44
    • 77954601195 scopus 로고    scopus 로고
    • Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis
    • Sasaki M, Miyakoshi M, Sato Y, et al. Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis. Lab Invest 2010;90:835-43
    • (2010) Lab Invest , vol.90 , pp. 835-843
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3
  • 45
    • 84856634376 scopus 로고    scopus 로고
    • A possible involvement of p62/ sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis
    • Sasaki M, Miyakoshi M, Sato Y, et al. A possible involvement of p62/ sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. Liver Int 2012;32:487-99
    • (2012) Liver Int , vol.32 , pp. 487-499
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3
  • 46
    • 84872147588 scopus 로고    scopus 로고
    • Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis
    • Sasaki M, Miyakoshi M, Sato Y, et al. Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis. Liver Int 2013;33:312-20
    • (2013) Liver Int , vol.33 , pp. 312-320
    • Sasaki, M.1    Miyakoshi, M.2    Sato, Y.3
  • 47
    • 79955377420 scopus 로고    scopus 로고
    • Autophagy-deficient mice develop multiple liver tumors
    • Takamura A, Komatsu M, Hara T, et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 2011;25:795-800
    • (2011) Genes Dev , vol.25 , pp. 795-800
    • Takamura, A.1    Komatsu, M.2    Hara, T.3
  • 48
    • 79955492012 scopus 로고    scopus 로고
    • Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
    • Inami Y, Waguri S, Sakamoto A, et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol 2011;193:275-84
    • (2011) J Cell Biol , vol.193 , pp. 275-284
    • Inami, Y.1    Waguri, S.2    Sakamoto, A.3
  • 49
    • 73449102143 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells
    • Song J, Qu Z, Guo X, et al. Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy 2009;5:1131-44
    • (2009) Autophagy , vol.5 , pp. 1131-1144
    • Song, J.1    Qu, Z.2    Guo, X.3
  • 50
    • 84857698541 scopus 로고    scopus 로고
    • Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma
    • Shimizu S, Takehara T, Hikita H, et al. Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer 2012;131:548-57
    • (2012) Int J Cancer , vol.131 , pp. 548-557
    • Shimizu, S.1    Takehara, T.2    Hikita, H.3
  • 51
    • 84868203239 scopus 로고    scopus 로고
    • Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma
    • Hui B, Shi YH, Ding ZB, et al. Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma. Cancer 2012;118:5560-71
    • (2012) Cancer , vol.118 , pp. 5560-5571
    • Hui, B.1    Shi, Y.H.2    Ding, Z.B.3
  • 52
    • 84873273329 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A mediates bortezomibinduced autophagy in hepatocellular carcinoma independent of proteasome
    • Yu HC, Hou DR, Liu CY, et al. Cancerous inhibitor of protein phosphatase 2A mediates bortezomibinduced autophagy in hepatocellular carcinoma independent of proteasome. PLoS One 2013;8:e55705
    • (2013) PLoS One , vol.8
    • Yu, H.C.1    Hou, D.R.2    Liu, C.Y.3
  • 53
    • 84863834241 scopus 로고    scopus 로고
    • Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell
    • Xu N, Zhang J, Shen C, et al. Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell. Biochem Biophys Res Commun 2012;423:826-31
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 826-831
    • Xu, N.1    Zhang, J.2    Shen, C.3
  • 54
    • 80053554108 scopus 로고    scopus 로고
    • Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation
    • Ding ZB, Hui B, Shi YH, et al. Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation. Clin Cancer Res 2011;17:6229-38
    • (2011) Clin Cancer Res , vol.17 , pp. 6229-6238
    • Ding, Z.B.1    Hui, B.2    Shi, Y.H.3
  • 55
    • 84856003912 scopus 로고    scopus 로고
    • Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    • Lazova R, Camp RL, Klump V, et al. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res 2012;18:370-9
    • (2012) Clin Cancer Res , vol.18 , pp. 370-379
    • Lazova, R.1    Camp, R.L.2    Klump, V.3
  • 56
    • 84901405852 scopus 로고    scopus 로고
    • Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrial beta-oxidation
    • doi:10.1007/s00535-013-0835-9
    • Toshima T, Shirabe K, Matsumoto Y, et al. Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrial beta-oxidation. J Gastroenterol 2013;doi:10.1007/s00535-013-0835-9
    • (2013) J Gastroenterol
    • Toshima, T.1    Shirabe, K.2    Matsumoto, Y.3
  • 57
    • 84880070521 scopus 로고    scopus 로고
    • Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation
    • Yu HC, Lin CS, Tai WT, et al. Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation. J Biol Chem 2013;288:18249-59
    • (2013) J Biol Chem , vol.288 , pp. 18249-18259
    • Yu, H.C.1    Lin, C.S.2    Tai, W.T.3
  • 58
    • 79958809001 scopus 로고    scopus 로고
    • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Role of AMPK-dependent activation of autophagy
    • Vara D, Salazar M, Olea-Herrero N, et al. Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Role of AMPK-dependent activation of autophagy. Cell Death Differ 2011;18:1099-111
    • (2011) Cell Death Differ , vol.18 , pp. 1099-1111
    • Vara, D.1    Salazar, M.2    Olea-Herrero, N.3
  • 59
    • 78649299438 scopus 로고    scopus 로고
    • Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma
    • Liu YL, Yang PM, Shun CT, et al. Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma. Autophagy 2010;6:1057-65
    • (2010) Autophagy , vol.6 , pp. 1057-1065
    • Liu, Y.L.1    Yang, P.M.2    Shun, C.T.3
  • 60
    • 84878997506 scopus 로고    scopus 로고
    • Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelialmesenchymal transition
    • Li J, Yang B, Zhou Q, et al. Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelialmesenchymal transition. Carcinogenesis 2013;34:1343-51
    • (2013) Carcinogenesis , vol.34 , pp. 1343-1351
    • Li, J.1    Yang, B.2    Zhou, Q.3
  • 61
    • 84884161479 scopus 로고    scopus 로고
    • Promoting colonization in metastatic HCC cells by modulation of autophagy
    • Peng YF, Shi YH, Shen YH, et al. Promoting colonization in metastatic HCC cells by modulation of autophagy. PLoS One 2013;8:e74407
    • (2013) PLoS One , vol.8
    • Peng, Y.F.1    Shi, Y.H.2    Shen, Y.H.3
  • 63
    • 0037229864 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning
    • Jaeschke H. Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol 2003;284:G15-26
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Jaeschke, H.1
  • 64
    • 84885956744 scopus 로고    scopus 로고
    • Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu
    • Peralta C, Jimenez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: Effects on the liver sinusoidal milieu. J Hepatol 2013;59:1094-106
    • (2013) J Hepatol , vol.59 , pp. 1094-1106
    • Peralta, C.1    Jimenez-Castro, M.B.2    Gracia-Sancho, J.3
  • 65
    • 68349136834 scopus 로고    scopus 로고
    • Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning
    • Minor T, Stegemann J, Hirner A, et al. Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning. Liver Transpl 2009;15:798-805
    • (2009) Liver Transpl , vol.15 , pp. 798-805
    • Minor, T.1    Stegemann, J.2    Hirner, A.3
  • 66
    • 65249154907 scopus 로고    scopus 로고
    • Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation
    • Gotoh K, Lu Z, Morita M, et al. Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy 2009;5:351-60
    • (2009) Autophagy , vol.5 , pp. 351-360
    • Gotoh, K.1    Lu, Z.2    Morita, M.3
  • 67
    • 84877925296 scopus 로고    scopus 로고
    • Simvastatin maintains function and viability of steatotic rat livers procured for transplantation
    • Gracia-Sancho J, Garcia-Caldero H, Hide D, et al. Simvastatin maintains function and viability of steatotic rat livers procured for transplantation. J Hepatol 2013;58:1140-6
    • (2013) J Hepatol , vol.58 , pp. 1140-1146
    • Gracia-Sancho, J.1    Garcia-Caldero, H.2    Hide, D.3
  • 69
    • 81855221944 scopus 로고    scopus 로고
    • Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice
    • Wang JH, Ahn IS, Fischer TD, et al. Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology 2011;141:2188-99
    • (2011) Gastroenterology , vol.141 , pp. 2188-2199
    • Wang, J.H.1    Ahn, I.S.2    Fischer, T.D.3
  • 70
    • 84878694814 scopus 로고    scopus 로고
    • Autophagy lessens ischemic liver injury by reducing oxidative damage
    • Sun K, Xie X, Liu Y, et al. Autophagy lessens ischemic liver injury by reducing oxidative damage. Cell Biosci 2013;3:26-3
    • (2013) Cell Biosci , vol.3 , pp. 26-33
    • Sun, K.1    Xie, X.2    Liu, Y.3
  • 71
    • 70349829009 scopus 로고    scopus 로고
    • Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy
    • Domart MC, Esposti DD, Sebagh M, et al. Concurrent induction of necrosis, apoptosis, and autophagy in ischemic preconditioned human livers formerly treated by chemotherapy. J Hepatol 2009;51:881-9
    • (2009) J Hepatol , vol.51 , pp. 881-889
    • Domart, M.C.1    Esposti, D.D.2    Sebagh, M.3
  • 72
    • 79959997977 scopus 로고    scopus 로고
    • Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes
    • Degli ED, Sebagh M, Pham P, et al. Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes. Cell Death Dis 2011;2:e111
    • (2011) Cell Death Dis , vol.2
    • Degli, E.D.1    Sebagh, M.2    Pham, P.3
  • 73
    • 43749108141 scopus 로고    scopus 로고
    • Activation of peroxisome proliferatoractivated receptor-gamma during hepatic ischemia is age-dependent
    • Shin T, Kuboki S, Huber N, et al. Activation of peroxisome proliferatoractivated receptor-gamma during hepatic ischemia is age-dependent. J Surg Res 2008;147:200-5
    • (2008) J Surg Res , vol.147 , pp. 200-205
    • Shin, T.1    Kuboki, S.2    Huber, N.3
  • 74
    • 68949194361 scopus 로고    scopus 로고
    • Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/ reperfusion injury
    • Cardinal J, Pan P, Dhupar R, et al. Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/ reperfusion injury. Hepatology 2009;50:565-74
    • (2009) Hepatology , vol.50 , pp. 565-574
    • Cardinal, J.1    Pan, P.2    Dhupar, R.3
  • 75
    • 84879526538 scopus 로고    scopus 로고
    • Chronic lithium treatment protects against liver ischemia/reperfusion injury in rats
    • Liu A, Fang H, Dahmen U, et al. Chronic lithium treatment protects against liver ischemia/reperfusion injury in rats. Liver Transpl 2013;19:762-72
    • (2013) Liver Transpl , vol.19 , pp. 762-772
    • Liu, A.1    Fang, H.2    Dahmen, U.3
  • 77
    • 84896488935 scopus 로고    scopus 로고
    • Caffeine stimulates hepatic lipid metabolism via autophagy-lysosomal pathway
    • Sinha RA, Farah BL, Singh BK, et al. Caffeine stimulates hepatic lipid metabolism via autophagy-lysosomal pathway. Hepatology 2014;59(4):1366-80
    • (2014) Hepatology , vol.59 , Issue.4 , pp. 1366-1380
    • Sinha, R.A.1    Farah, B.L.2    Singh, B.K.3
  • 78
    • 84879466547 scopus 로고    scopus 로고
    • Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in hepg2 cells: Involvement of ampk foxo3a axis
    • Nepal S, Park PH. Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/ FoxO3A axis. Biochim Biophys Acta 2013;1833:2111-25
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2111-2125
    • Nepal, S.1    Park, P.H.2
  • 79
    • 78049467743 scopus 로고    scopus 로고
    • Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice
    • Ding WX, Li M, Chen X, et al. Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 2010;139:1740-52
    • (2010) Gastroenterology , vol.139 , pp. 1740-1752
    • Ding, W.X.1    Li, M.2    Chen, X.3
  • 80
    • 84865313269 scopus 로고    scopus 로고
    • Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy
    • Wu D, Wang X, Zhou R, et al. Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy. Free Radic Biol Med 2012;53:1346-57
    • (2012) Free Radic Biol Med , vol.53 , pp. 1346-1357
    • Wu, D.1    Wang, X.2    Zhou, R.3
  • 81
    • 84885504929 scopus 로고    scopus 로고
    • Tert-Butylhydroquinone (tBHQ) Protects Hepatocytes Against Lipotoxicity Via Inducing Autophagy Independently Of Nrf2 Activation
    • Li S, Li J, Shen C, et al. tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation. Biochim Biophys Acta 2013;1841:22-33
    • (2013) Biochim Biophys Acta , vol.1841 , pp. 22-33
    • Li, S.1    Li, J.2    Shen, C.3
  • 82
    • 84888800151 scopus 로고    scopus 로고
    • Resveratrol modulates autophagy and NF-kappaB activity in a murine model for treating non-Alcoholic fatty liver disease
    • Li L, Hai J, Li Z, et al. Resveratrol modulates autophagy and NF-kappaB activity in a murine model for treating non-Alcoholic fatty liver disease. Food Chem Toxicol 2014;63:166-73
    • (2014) Food Chem Toxicol , vol.63 , pp. 166-173
    • Li, L.1    Hai, J.2    Li, Z.3
  • 83
    • 84860011046 scopus 로고    scopus 로고
    • PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice
    • Zeng T, Zhang CL, Song FY, et al. PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice. Toxicology 2012;296:56-66
    • (2012) Toxicology , vol.296 , pp. 56-66
    • Zeng, T.1    Zhang, C.L.2    Song, F.Y.3
  • 84
    • 80054978956 scopus 로고    scopus 로고
    • Rab5 and class III phosphoinositide 3- kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy
    • Su WC, Chao TC, Huang YL, et al. Rab5 and class III phosphoinositide 3- kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. J Virol 2011;85:10561-71
    • (2011) J Virol , vol.85 , pp. 10561-10571
    • Su, W.C.1    Chao, T.C.2    Huang, Y.L.3
  • 85
    • 80052045217 scopus 로고    scopus 로고
    • Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment
    • Li J, Liu Y, Wang Z, et al. Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. J Virol 2011;85:6319-33
    • (2011) J Virol , vol.85 , pp. 6319-6333
    • Li, J.1    Liu, Y.2    Wang, Z.3
  • 86
    • 84877908566 scopus 로고    scopus 로고
    • Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases
    • Shaker ME, Ghani A, Shiha GE, et al. Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases. Biochim Biophys Acta 2013;1833:1992-2003
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 1992-2003
    • Shaker, M.E.1    Ghani, A.2    Shiha, G.E.3
  • 87
    • 84862895179 scopus 로고    scopus 로고
    • MTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma
    • Thomas HE, Mercer CA, Carnevalli LS, et al. mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Sci Transl Med 2012;4:139ra84
    • (2012) Sci Transl Med , vol.4
    • Thomas, H.E.1    Mercer, C.A.2    Carnevalli, L.S.3
  • 88
    • 53349160476 scopus 로고    scopus 로고
    • Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma
    • Longo L, Platini F, Scardino A, et al. Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma. Mol Cancer Ther 2008;7:2476-85
    • (2008) Mol Cancer Ther , vol.7 , pp. 2476-2485
    • Longo, L.1    Platini, F.2    Scardino, A.3
  • 89
    • 77950632400 scopus 로고    scopus 로고
    • Delphinidin induces necrosis in hepatocellular carcinoma cells in the presence of 3-methyladenine, an autophagy inhibitor
    • Feng R, Wang SY, Shi YH, et al. Delphinidin induces necrosis in hepatocellular carcinoma cells in the presence of 3-methyladenine, an autophagy inhibitor. J Agric Food Chem 2010;58:3957-64
    • (2010) J Agric Food Chem , vol.58 , pp. 3957-3964
    • Feng, R.1    Wang, S.Y.2    Shi, Y.H.3
  • 90
    • 84859609587 scopus 로고    scopus 로고
    • Targeting autophagy potentiates chemotherapyinduced apoptosis and proliferation inhibition in hepatocarcinoma cells
    • Guo XL, Li D, Hu F, et al. Targeting autophagy potentiates chemotherapyinduced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett 2012;320:171-9
    • (2012) Cancer Lett , vol.320 , pp. 171-179
    • Guo, X.L.1    Li, D.2    Hu, F.3
  • 91
    • 84883211035 scopus 로고    scopus 로고
    • Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
    • Wang Y, Han C, Lu L, et al. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology 2013;58:995-1010
    • (2013) Hepatology , vol.58 , pp. 995-1010
    • Wang, Y.1    Han, C.2    Lu, L.3
  • 92
    • 70350463830 scopus 로고    scopus 로고
    • Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells
    • Ko H, Kim YJ, Park JS, et al. Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells. Biosci Biotechnol Biochem 2009;73:2183-9
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 2183-2189
    • Ko, H.1    Kim, Y.J.2    Park, J.S.3
  • 93
    • 80053420059 scopus 로고    scopus 로고
    • Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
    • Shi YH, Ding ZB, Zhou J, et al. Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 2011;7:1159-72
    • (2011) Autophagy , vol.7 , pp. 1159-1172
    • Shi, Y.H.1    Ding, Z.B.2    Zhou, J.3
  • 94
    • 84885190019 scopus 로고    scopus 로고
    • AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: A role for melatonin and trimetazidine cocktail
    • Zaouali MA, Boncompagni E, Reiter RJ, et al. AMPK involvement in endoplasmic reticulum stress and autophagy modulation after fatty liver graft preservation: A role for melatonin and trimetazidine cocktail. J Pineal Res 2013;55(1):65-78
    • (2013) J Pineal Res , vol.55 , Issue.1 , pp. 65-78
    • Zaouali, M.A.1    Boncompagni, E.2    Reiter, R.J.3
  • 95
    • 84864883212 scopus 로고    scopus 로고
    • The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice
    • Wang D, Ma Y, Li Z, et al. The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia/reperfusion injury in mice. Autophagy 2012;8:954-62
    • (2012) Autophagy , vol.8 , pp. 954-962
    • Wang, D.1    Ma, Y.2    Li, Z.3
  • 96
    • 84888395956 scopus 로고    scopus 로고
    • Dual role of chloroquine in liver ischemia reperfusion injury: Reduction of liver damage in early phase, but aggravation in late phase
    • Fang H, Liu A, Dahmen U, et al. Dual role of chloroquine in liver ischemia reperfusion injury: Reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis 2013;4:e694.
    • (2013) Cell Death Dis , vol.4
    • Fang, H.1    Liu, A.2    Dahmen, U.3


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