Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers

Retrovirology

Volumn 11, Issue 1, 2014, Pages

  Arnold, Philipp ^a,d   Himmels, Patricia ^b,e   Weiß, Svenja ^b   Decker, Tim Michael ^a,f   Markl, Jürgen ^a   Gatterdam, Volker ^c   Tampé, Robert ^c   Bartholomäus, Patrick ^b,g   Dietrich, Ursula ^b   Dürr, Ralf ^b,h  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f Munich Center for Integrated Protein Science   (Germany)

^g INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^h NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3D EM; CCR5; CD4 binding site; CXCR4; HIV 1; Open structure; Single particle analysis; Soluble gp140 Env; Tropism; V3 loop

Indexed keywords

CD4 ANTIGEN; EPITOPE; GLYCOPROTEIN GP 140; VIRUS ENVELOPE PROTEIN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GP140 ENVELOPE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGENICITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; IMMUNOGENICITY; MOLECULAR DOCKING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; PROCEDURES; SERODIAGNOSIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; ANTIGENS, CD4; CHO CELLS; CRICETULUS; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; NEUTRALIZATION TESTS; RECEPTORS, CCR5; RECEPTORS, CXCR4;

EID: 84902112501     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-11-42     Document Type: Article

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