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Volumn 110, Issue 2, 2013, Pages 513-518

Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives

Author keywords

AIDS vaccine; Cryoelectron microscopy; gp120; gp41; Virus entry

Indexed keywords

A12 ANTIBODY; ANTIBODY; CD4 ANTIGEN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

EID: 84872189908     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214810110     Document Type: Article
Times cited : (34)

References (30)
  • 1
    • 79960974710 scopus 로고    scopus 로고
    • Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures
    • Harris A, et al. (2011) Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. Proc Natl Acad Sci USA 108(28):11440-11445.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.28 , pp. 11440-11445
    • Harris, A.1
  • 3
    • 84864603281 scopus 로고    scopus 로고
    • Structural mechanism of trimeric HIV-1 envelope glycoprotein activation
    • Tran EEH, et al. (2012) Structural mechanism of trimeric HIV-1 envelope glycoprotein activation. PLoS Pathog 8(7):e1002797.
    • (2012) PLoS Pathog , vol.8 , Issue.7
    • Tran, E.E.H.1
  • 4
    • 81255213876 scopus 로고    scopus 로고
    • Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography
    • White TA, et al. (2011) Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography. J Virol 85(23):12114-12123.
    • (2011) J Virol , vol.85 , Issue.23 , pp. 12114-12123
    • White, T.A.1
  • 5
    • 78651241895 scopus 로고    scopus 로고
    • Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: Strain-dependent variation in quaternary structure
    • White TA, et al. (2010) Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: Strain-dependent variation in quaternary structure. PLoS Pathog 6(12):e1001249.
    • (2010) PLoS Pathog , vol.6 , Issue.12
    • White, T.A.1
  • 6
    • 55949131238 scopus 로고    scopus 로고
    • Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers
    • Chen W, Zhu Z, Feng Y, Dimitrov DS (2008) Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers. Proc Natl Acad Sci USA 105(44):17121-17126.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.44 , pp. 17121-17126
    • Chen, W.1    Zhu, Z.2    Feng, Y.3    Dimitrov, D.S.4
  • 7
    • 84858027347 scopus 로고    scopus 로고
    • Llama antibody fragments have good potential for application as HIV type 1 topical microbicides
    • Gorlani A, et al. (2012) Llama antibody fragments have good potential for application as HIV type 1 topical microbicides. AIDS Res Hum Retroviruses 28(2):198-205.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , Issue.2 , pp. 198-205
    • Gorlani, A.1
  • 8
    • 84864296663 scopus 로고    scopus 로고
    • Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
    • McCoy LE, et al. (2012) Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization. J Exp Med 209(6):1091-1103.
    • (2012) J Exp Med , vol.209 , Issue.6 , pp. 1091-1103
    • McCoy, L.E.1
  • 9
    • 65549146370 scopus 로고    scopus 로고
    • Human monoclonal antibodies and engineered antibody domains as HIV-1 entry inhibitors
    • Chen W, Dimitrov DS (2009) Human monoclonal antibodies and engineered antibody domains as HIV-1 entry inhibitors. Curr Opin HIV AIDS 4(2):112-117.
    • (2009) Curr Opin HIV AIDS , vol.4 , Issue.2 , pp. 112-117
    • Chen, W.1    Dimitrov, D.S.2
  • 10
    • 57349165849 scopus 로고    scopus 로고
    • Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120
    • Forsman A, et al. (2008) Llama antibody fragments with cross-subtype human immunodeficiency virus type 1 (HIV-1)-neutralizing properties and high affinity for HIV-1 gp120. J Virol 82(24):12069-12081.
    • (2008) J Virol , vol.82 , Issue.24 , pp. 12069-12081
    • Forsman, A.1
  • 11
    • 77956300437 scopus 로고    scopus 로고
    • Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity
    • Moulaei T, et al. (2010) Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure 18(9):1104-1115.
    • (2010) Structure , vol.18 , Issue.9 , pp. 1104-1115
    • Moulaei, T.1
  • 12
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger P, Hudson PJ (2005) Engineered antibody fragments and the rise of single domains. Nat Biotechnol 23(9):1126-1136.
    • (2005) Nat Biotechnol , vol.23 , Issue.9 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 13
    • 0037235949 scopus 로고    scopus 로고
    • Engineered antibodies
    • Hudson PJ, Souriau C (2003) Engineered antibodies. Nat Med 9(1):129- 134.
    • (2003) Nat Med , vol.9 , Issue.1 , pp. 129-134
    • Hudson, P.J.1    Souriau, C.2
  • 14
    • 84863238167 scopus 로고    scopus 로고
    • Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C
    • Strokappe N, et al. (2012) Llama antibody fragments recognizing various epitopes of the CD4bs neutralize a broad range of HIV-1 subtypes A, B and C. PLoS ONE 7(3):e33298.
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Strokappe, N.1
  • 15
    • 0027310612 scopus 로고
    • Naturally occurring antibodies devoid of light chains
    • Hamers-Casterman C, et al. (1993) Naturally occurring antibodies devoid of light chains. Nature 363(6428):446-448.
    • (1993) Nature , vol.363 , Issue.6428 , pp. 446-448
    • Hamers-Casterman, C.1
  • 16
    • 0141521564 scopus 로고    scopus 로고
    • Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1
    • Labrijn AF, et al. (2003) Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1. J Virol 77(19):10557-10565.
    • (2003) J Virol , vol.77 , Issue.19 , pp. 10557-10565
    • Labrijn, A.F.1
  • 17
    • 84860584093 scopus 로고    scopus 로고
    • Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging
    • Frank GA, et al. (2012) Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging. J Struct Biol 178(2):165-176.
    • (2012) J Struct Biol , vol.178 , Issue.2 , pp. 165-176
    • Frank, G.A.1
  • 18
    • 77956913427 scopus 로고    scopus 로고
    • Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates
    • Chen W, Xiao X, Wang Y, Zhu Z, Dimitrov DS (2010) Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates. Antiviral Res 88(1):107-115.
    • (2010) Antiviral Res , vol.88 , Issue.1 , pp. 107-115
    • Chen, W.1    Xiao, X.2    Wang, Y.3    Zhu, Z.4    Dimitrov, D.S.5
  • 19
    • 34848868199 scopus 로고    scopus 로고
    • Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
    • Huang CC, et al. (2007) Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. Science 317(5846):1930-1934.
    • (2007) Science , vol.317 , Issue.5846 , pp. 1930-1934
    • Huang, C.C.1
  • 20
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • Kwong PD, et al. (1998) Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393(6686):648-659.
    • (1998) Nature , vol.393 , Issue.6686 , pp. 648-659
    • Kwong, P.D.1
  • 21
    • 0032712246 scopus 로고    scopus 로고
    • Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity
    • LaBranche CC, et al. (1999) Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity. J Virol 73(12):10310-10319.
    • (1999) J Virol , vol.73 , Issue.12 , pp. 10310-10319
    • LaBranche, C.C.1
  • 22
    • 0031985314 scopus 로고    scopus 로고
    • Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype
    • Dumonceaux J, et al. (1998) Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype. J Virol 72(1):512-519.
    • (1998) J Virol , vol.72 , Issue.1 , pp. 512-519
    • Dumonceaux, J.1
  • 23
    • 0036140259 scopus 로고    scopus 로고
    • A variable region 3 (V3) mutation determines a global neutralization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope associated with a broadly cross-reactive, primary virusneutralizing antibody response
    • Zhang PF, et al. (2002) A variable region 3 (V3) mutation determines a global neutralization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope associated with a broadly cross-reactive, primary virusneutralizing antibody response. J Virol 76(2):644-655.
    • (2002) J Virol , vol.76 , Issue.2 , pp. 644-655
    • Zhang, P.F.1
  • 24
    • 0029879295 scopus 로고    scopus 로고
    • Computer visualization of three-dimensional image data using IMOD
    • Kremer JR, Mastronarde DN, McIntosh JR (1996) Computer visualization of three-dimensional image data using IMOD. J Struct Biol 116(1):71-76.
    • (1996) J Struct Biol , vol.116 , Issue.1 , pp. 71-76
    • Kremer, J.R.1    Mastronarde, D.N.2    McIntosh, J.R.3
  • 25
    • 40649105010 scopus 로고    scopus 로고
    • Markov random field based automatic image alignment for electron tomography
    • Amat F, et al. (2008) Markov random field based automatic image alignment for electron tomography. J Struct Biol 161(3):260-275.
    • (2008) J Struct Biol , vol.161 , Issue.3 , pp. 260-275
    • Amat, F.1
  • 26
    • 26444473610 scopus 로고    scopus 로고
    • An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms
    • Bartesaghi A, Sapiro G, Subramaniam S (2005) An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms. IEEE Trans Image Process 14(9):1314-1323.
    • (2005) IEEE Trans Image Process , vol.14 , Issue.9 , pp. 1314-1323
    • Bartesaghi, A.1    Sapiro, G.2    Subramaniam, S.3
  • 27
    • 84873139314 scopus 로고    scopus 로고
    • A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography
    • 10.1016/j.jsb.2012.10.010
    • Kuybeda O, et al. (2012) A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography. J Struct Biol, 10.1016/j.jsb.2012.10.010.
    • (2012) J Struct Biol
    • Kuybeda, O.1
  • 28
    • 33845336533 scopus 로고    scopus 로고
    • Bsoft: Image processing and molecular modeling for electron microscopy
    • Heymann JB, Belnap DM (2007) Bsoft: Image processing and molecular modeling for electron microscopy. J Struct Biol 157(1):3-18.
    • (2007) J Struct Biol , vol.157 , Issue.1 , pp. 3-18
    • Heymann, J.B.1    Belnap, D.M.2
  • 29
    • 4444221565 scopus 로고    scopus 로고
    • UCSF Chimera- A visualization system for exploratory research and analysis
    • Pettersen EF, et al. (2004) UCSF Chimera- a visualization system for exploratory research and analysis. J Comput Chem 25(13):1605-1612.
    • (2004) J Comput Chem , vol.25 , Issue.13 , pp. 1605-1612
    • Pettersen, E.F.1
  • 30
    • 33845332754 scopus 로고    scopus 로고
    • EMAN2: An extensible image processing suite for electron microscopy
    • Tang G, et al. (2007) EMAN2: An extensible image processing suite for electron microscopy. J Struct Biol 157(1):38-46.
    • (2007) J Struct Biol , vol.157 , Issue.1 , pp. 38-46
    • Tang, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.