Repeated administration of ketamine can induce hippocampal neurodegeneration and long-term cognitive impairment via the ROS/HIF-1α pathway in developing rats

Cellular Physiology and Biochemistry

Volumn 33, Issue 6, 2014, Pages 1715-1732

  Yan, Jia ^a   Huang, Yan ^a   Lu, Yi ^a   Chen, Jie ^a   Jiang, Hong ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Anesthesia; Apoptosis; Hypoxia inducible factor 1 ; Infant; Ketamine; Neurotoxicity

Indexed keywords

CALCIUM; CARNITINE; CASPASE 3; FLUORESCEIN DIACETATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KETAMINE; LIFICIGUAT; LIOTHYRONINE; NIMODIPINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BNIP3; PROTEIN P53; 3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BENZYLINDAZOLE; ANALGESIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; HIF1A PROTEIN, RAT; INDAZOLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; VITAMIN B COMPLEX; DICHLORODIHYDROFLUORESCEIN DIACETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CALCIUM TRANSPORT; COGNITION; COGNITIVE DEFECT; EMBRYO; FLOW CYTOMETRY; HIPPOCAMPUS; IN VITRO STUDY; NERVE CELL; NERVE DEGENERATION; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DEGENERATIVE DISEASE; DRUG EFFECTS; FEMALE; GENETICS; MALE; MAZE TEST; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CELL GROWTH; CONTROLLED STUDY; DRUG MECHANISM; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS;

ANIMALIA; RATTUS;

ANALGESICS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CARNITINE; CELLS, CULTURED; COGNITION DISORDERS; FEMALE; HIPPOCAMPUS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDAZOLES; KETAMINE; MALE; MAZE LEARNING; NEURODEGENERATIVE DISEASES; NEURONS; NIMODIPINE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VITAMIN B COMPLEX;

EID: 84902034531     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000362953     Document Type: Article

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