Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits

Journal of Neuroscience

Volumn 23, Issue 3, 2003, Pages 876-882

  Jevtovic Todorovic, Vesna ^a   Hartman, Richard E ^b   Izumi, Yukitoshi ^b   Benshoff, Nicholas D ^b   Dikranian, Krikor ^b   Zorumski, Charles F ^b   Olney, John W ^b   Wozniak, David F ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; GABA agonists; Isoflurane; Midazolam; Nitrous oxide; NMDA antagonists

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ANESTHETIC AGENT; ISOFLURANE; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITROUS OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; FEMALE; GENERAL ANESTHESIA; HIPPOCAMPUS; INHALATION ANESTHESIA; INTRAVENOUS ANESTHESIA; LEARNING DISORDER; MALE; MEMORY; NERVE CELL DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PEDIATRIC ANESTHESIA; PRIORITY JOURNAL; RAT; SYNAPTOGENESIS;

EID: 0037321378     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-03-00876.2003     Document Type: Article

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