Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain

Anesthesiology

Volumn 117, Issue 1, 2012, Pages 64-71

  Liu, Jia Ren ^a,b   Liu, Qian ^c,d   Li, Jing ^d   Baek, Chongwha ^e   Han, Xiao Hui ^a,b   Athiraman, Umeshkumar ^a,b   Soriano, Sulpicio G ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GANNAN MEDICAL UNIVERSITY   (China)

^d CHONGQING MEDICAL UNIVERSITY   (China)

^e Chung Ang University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN D1; DNA NUCLEOTIDYLEXOTRANSFERASE; FREUND ADJUVANT; GLYCOGEN SYNTHASE KINASE 3BETA; KETAMINE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL DEATH; COHORT ANALYSIS; CONTROLLED STUDY; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NEUROAPOPTOSIS; NICK END LABELING; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; BRAIN; CASPASE 3; CYCLIN D1; FREUND'S ADJUVANT; GLYCOGEN SYNTHASE KINASE 3; KETAMINE; PAIN; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862755784     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31825ae693     Document Type: Article

References (42)

1. Loepke AW, Soriano SG: An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg 2008; 106:1681-707
2. Anand KJ, Soriano SG: Anesthetic agents and the immature brain: Are these toxic or therapeutic? ANESTHESIOLOGY 2004; 101:527-30 (Pubitemid 38988508)
3. Johnston CC, Walker CD, Boyer K: Animal models of longterm consequences of early exposure to repetitive pain. Clin Perinatol 2002; 29:395-414
4. Sternberg WF, Scorr L, Smith LD, Ridgway CG, Stout M: Long-term effects of neonatal surgery on adulthood pain behavior. Pain 2005; 113:347-53 (Pubitemid 40127517)
5. Anand KJ: Pain, plasticity, and premature birth: A prescription for permanent suffering? Nat Med 2000; 6:971-3
6. Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M, Ma D: Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiol Dis 2012; 45:743-50
7. Anand KJ, Garg S, Rovnaghi CR, Narsinghani U, Bhutta AT, Hall RW: Ketamine reduces the cell death following inflammatory pain in newborn rat brain. Pediatr Res 2007; 62: 283-90 (Pubitemid 47301476)
8. Hur EM, Zhou FQ: GSK3 signalling in neural development. Nat Rev Neurosci 2010; 11:539-51
9. Takadera T, Ishida A, Ohyashiki T: Ketamine-induced apoptosis in cultured rat cortical neurons. Toxicol Appl Pharmacol 2006; 210:100-7 (Pubitemid 41790557)
10. Straiko MM, Young C, Cattano D, Creeley CE, Wang H, Smith DJ, Johnson SA, Li ES, Olney JW: Lithium protects against anesthesia-induced developmental neuroapoptosis. ANESTHESIOLOGY 2009; 110:862-8
11. Sanders RD, Sun P, Patel S, Li M, Maze M, Ma D: Dexmedetomidine provides cortical neuroprotection: Impact on anaesthetic-induced neuroapoptosis in the rat developing brain. Acta Anaesthesiol Scand 2010; 54:710-6
12. Soriano SG, Liu Q, Li J, Liu JR, Han XH, Kanter JL, Bajic D, Ibla JC: Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. ANESTHESIOLOGY 2010; 112:1155-63
13. Yeste-Velasco M, Folch J, Trullàs R, Abad MA, Enguita M, Pallàs M, Camins A: Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells. Neuropharmacology 2007; 53:295-307 (Pubitemid 47187455)
14. Institute of Laboratory Animal Research Commission on Life Sciences NRC. Guide for the Care and Use of Laboratory Animals. Washington, D.C.: The National Academy Press; 1996
15. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM: Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. ANESTHESIOLOGY 2009; 110:813-25
16. Zou X, Patterson TA, Sadovova N, Twaddle NC, Doerge DR, Zhang X, Fu X, Hanig JP, Paule MG, Slikker W, Wang C: Potential neurotoxicity of ketamine in the developing rat brain. Toxicol Sci 2009; 108:149-58
17. Ruda MA, Ling QD, Hohmann AG, Peng YB, Tachibana T: Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science 2000; 289:628-31
18. Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T: Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli. ANESTHESIOLOGY 2010; 112:418-31
19. Treede RD, Kenshalo DR, Gracely RH, Jones AK: The cortical representation of pain. Pain 1999; 79:105-11 (Pubitemid 29076744)
20. Rovnaghi CR, Garg S, Hall RW, Bhutta AT, Anand KJ: Ketamine analgesia for inflammatory pain in neonatal rats: A factorial randomized trial examining long-term effects. Behav Brain Func 2008; 4:35
21. Brambrink AM, Avidan MS, Dissen GA, Creeley C, Olney JW. Neurotoxic impact of isoflurane versus ketamine on the neonatal versus fetal rhesus macaque brain. Paper presented at: annual meeting of the American Society of Anesthesiologists; October 15-19, 2011; Chicago, IL
22. Ben-Ari Y: Excitatory actions of gaba during development: The nature of the nurture. Nat Rev Neurosci 2002; 3:728-39 (Pubitemid 135706678)
23. Edwards DA, Shah HP, Cao W, Gravenstein N, Seubert CN, Martynyuk AE: Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain. ANESTHESIOLOGY 2010; 112:567-75
24. Lipton SA, Nakanishi N: Shakespeare in love-with NMDA receptors? Nat Med 1999; 5:270-1
25. Hardingham GE, Bading H: Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders. Nat Rev Neurosci 2010; 11:682-96
26. Peterson BS, Vohr B, Staib LH, Cannistraci CJ, Dolberg A, Schneider KC, Katz KH, Westerveld M, Sparrow S, Anderson AW, Duncan CC, Makuch RW, Gore JC, Ment LR: Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. JAMA 2000; 284:1939-47
27. Peters JW, Schouw R, Anand KJ, van Dijk M, Duivenvoorden HJ, Tibboel D: Does neonatal surgery lead to increased pain sensitivity in later childhood? Pain 2005; 114:444-54 (Pubitemid 40385882)
28. Fitzgerald M: The development of nociceptive circuits. Nat Rev Neurosci 2005; 6:507-20 (Pubitemid 40942818)
29. Hayashi H, Dikkes P, Soriano SG: Repeated administration of ketamine may lead to neuronal degeneration in the developing rat brain. Paediatr Anaesth 2002; 12:770-4 (Pubitemid 36051344)
30. Scallet AC, Schmued LC, Slikker W Jr, Grunberg N, Faustino PJ, Davis H, Lester D, Pine PS, Sistare F, Hanig JP: Developmental neurotoxicity of ketamine: Morphometric confirma-tion, exposure parameters, and multiple fluorescent labeling of apoptotic neurons. Toxicol Sci 2004; 81:364-70 (Pubitemid 39377966)
31. Raghavendra V, Tanga FY, DeLeo JA: Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS. Eur J Neurosci 2004; 20:467-73 (Pubitemid 38969631)
32. Bie B, Brown DL, Naguib M: Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation. Eur J Pharmacol 2011; 653:26-31
33. Leslie AT, Akers KG, Martinez-Canabal A, Mello LE, Covolan L, Guinsburg R: Neonatal inflammatory pain increases hippocampal neurogenesis in rat pups. Neurosci Lett 2011; 501:78-82
34. Leslie AT, Guinsburg R, Mello LE, Covolan L: Repetitive nociceptive stimuli in newborn rats do not alter the hippocampal neurogenesis. Pediatr Res 2008; 63:154-7
35. Stein C, Millan MJ, Herz A: Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: Alterations in behavior and nociceptive thresholds. Pharmacol Biochem Behav 1988; 31:445-51 (Pubitemid 19275167)
36. Yahalom B, Athiraman U, Soriano SG, Zurakowski D, Carpino EA, Corfas G, Berde CB: Spinal anesthesia in infant rats: Development of a model and assessment of neurologic outcomes. ANESTHESIOLOGY 2011; 114:1325-35
37. Slikker W Jr, Paule MG, Wright LK, Patterson TA, Wang C: Systems biology approaches for toxicology. J Appl Toxicol 2007; 27:201-17 (Pubitemid 46663415)
38. Wei H: The role of calcium dysregulation in anestheticmediated neurotoxicity. Anesth Analg 2011; 113:972-4
39. Sanders RD, Xu J, Shu Y, Fidalgo A, Ma D, Maze M: General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Anesth Analg 2008; 106:1708-11
40. Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL: Effects of intrathecal ketamine in the neonatal rat: Evaluation of apoptosis and long-term functional outcome. ANESTHESIOLOGY 2010; 113:147-59
41. Jevtovic-Todorovic V, Hartman RE, Izumi Y, Benshoff ND, Dikranian K, Zorumski CF, Olney JW, Wozniak DF: Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003; 23:876-82 (Pubitemid 36206178)
42. Paule MG, Li M, Allen RR, Liu F, Zou X, Hotchkiss C, Hanig JP, Patterson TA, Slikker W Jr, Wang C: Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys. Neurotoxicol Teratol 2011; 33: 220-30