Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain

Neuropharmacology

Volumn 77, Issue , 2014, Pages 90-99

  Wang, Wen Yuan ^a   Luo, Yan ^b   Jia, Li Jie ^b   Hu, Shuang Fei ^a   Lou, Xiao Kan ^a   Shen, She Liang ^a   Lu, Han ^b   Zhang, Hong Hai ^c   Yang, Rui ^b   Wang, Hua ^b   Ma, Zheng Wen ^b   Xue, Qing Sheng ^b   Yu, Bu Wei ^b  

^a ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cyclin dependent kinase 5; Hippocampus; Isoflurane; Learning and memory; Neurotoxicity

Indexed keywords

CASPASE 3; CYCLIN DEPENDENT KINASE 5; CYSTEINE PROTEINASE INHIBITOR; HISTONE H1; ISOFLURANE; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2A; N BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P25; PROTEIN P35; ROSCOVITINE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; COGNITION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; GENETIC TRANSFECTION; IN VITRO STUDY; LEARNING DISORDER; NERVE CELL; NEUROTOXICITY; NONHUMAN; PERINATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

APOPTOSIS; CA(2+)-ACTIVATED PROTEASE; CALPAIN; CDK5; CYCLIN-DEPENDENT KINASE 5; DAY IN VITRO; DIV; DN CDK5; DOMINANT-NEGATIVE CYCLIN-DEPENDENT KINASE 5; FCM; FLOW CYTOMETRY; HIPPOCAMPUS; ISOFLURANE; LASER SCANNING CONFOCAL MICROSCOPE; LEARNING AND MEMORY; LSCM; MDL 28170; MEF2; MORRIS WATER MAZE; MWM; MYOCYTE ENHANCER FACTOR 2; N-BENZYLOXYCARBONYL-VALINE-ALANINE-ASPARTATE FLUOROMETHYLKETONE; N-BENZYLOXYCARBONYLVALYLPHENYLALANINAL; NEUROTOXICITY; PND; POSTNATAL DAY; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-MEDIATED DUTP NICK-END-LABELING; TUNEL; Z-VAD.FMK;

ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 5; HIPPOCAMPUS; ISOFLURANE; MAZE LEARNING; NEURODEGENERATIVE DISEASES; NEURONS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; PURINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84886264672     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.09.006     Document Type: Article

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