Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats

Acta Pharmacologica Sinica

Volumn 33, Issue 5, 2012, Pages 635-643

  Jiang, Hong ^a   Huang, Yan ^a   Xu, Hui ^a   Hu, Rong ^a   Li, Qi Fang ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Acute lung injury; Hemorrhagic shock; Hypoxia inducible factor 1 ; Inflammation; Trauma; YC 1

Indexed keywords

CASPASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIFICIGUAT; MALONALDEHYDE; MYELOPEROXIDASE; NITRATE; NITRITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; INTESTINE INJURY; LUNG INJURY; LUNG LAVAGE; MALE; NICK END LABELING; NONHUMAN; RAT; WISTAR RAT;

ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CASPASE 3; CYTOPROTECTION; DISEASE MODELS, ANIMAL; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN SITU NICK-END LABELING; INDAZOLES; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTESTINES; LUNG; LUNG INJURY; MALE; MALONDIALDEHYDE; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PEROXIDASE; PULMONARY EDEMA; RATS; RATS, WISTAR; SHOCK, HEMORRHAGIC; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860704732     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.5     Document Type: Article

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