Isoflurane anesthesia induced persistent, progressive memory impairment, caused a loss of neural stem cells, and reduced neurogenesis in young, but not adult, rodents

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 5, 2010, Pages 1017-1030

  Zhu, Changlian ^a,b   Gao, Jianfeng ^a,b   Karlsson, Niklas ^a   Li, Qian ^a,b   Zhang, Yu ^a,b   Huang, Zhiheng ^a,b   Li, Hongfu ^a,b   Kuhn, H Georg ^a   Blomgren, Klas ^a,c  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ZHENGZHOU UNIVERSITY   (China)

^c QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

Author keywords

Declarative memory; IntelliCage; Juvenile brain; Object recognition; Procedural memory; Reversal learning

Indexed keywords

BIOLOGICAL MARKER; ISOFLURANE; SYNAPSIN I;

AGE DISTRIBUTION; ANESTHESIA COMPLICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TOXICITY; CELL LOSS; CELL MATURATION; CELL PROLIFERATION; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; GENERAL ANESTHESIA; GRANULE CELL; HIPPOCAMPUS; JUVENILE; LEARNING; LEARNING DISORDER; MALE; MEMORY DISORDER; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RECOGNITION; SPATIAL MEMORY;

ADOLESCENT; ADULT; ANESTHETICS, INHALATION; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; HIPPOCAMPUS; HUMANS; INFANT; INFANT, NEWBORN; ISOFLURANE; LEARNING; MALE; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; NEUROGENESIS; NEURONS; NEUROPSYCHOLOGICAL TESTS; RATS; RATS, WISTAR; STEM CELLS; SYNAPSINS;

EID: 77952009347     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.274     Document Type: Article

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