메뉴 건너뛰기




Volumn 40, Issue 3, 2014, Pages 519-529

The emerging role of glutathione in alzheimer's disease

Author keywords

Alzheimer's disease; amyloid peptide; biomarker; glutathione; oxidative stress

Indexed keywords

APOLIPOPROTEIN E; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; REACTIVE OXYGEN METABOLITE;

EID: 84901911564     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-132483     Document Type: Review
Times cited : (140)

References (114)
  • 1
    • 34249697099 scopus 로고    scopus 로고
    • Forecasting the global burden of Alzheimer's disease
    • DOI 10.1016/j.jalz.2007.04.381, PII S155252600700475X
    • Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM (2007) Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 3, 186-191. (Pubitemid 46825511)
    • (2007) Alzheimer's and Dementia , vol.3 , Issue.3 , pp. 186-191
    • Brookmeyer, R.1    Johnson, E.2    Ziegler-Graham, K.3    Arrighi, H.M.4
  • 3
    • 34648859471 scopus 로고    scopus 로고
    • Oxidative damage in mild cognitive impairment and early Alzheimer's disease
    • DOI 10.1002/jnr.21346
    • Lovell MA, Markesbery WR (2007) Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res 85, 3036-3040. (Pubitemid 350057358)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.14 , pp. 3036-3040
    • Lovell, M.A.1    Markesbery, W.R.2
  • 4
    • 0030915855 scopus 로고    scopus 로고
    • Oxidative stress hypothesis in Alzheimer's disease
    • DOI 10.1016/S0891-5849(96)00629-6, PII S0891584996006296
    • Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 23, 134-147. (Pubitemid 27217017)
    • (1997) Free Radical Biology and Medicine , vol.23 , Issue.1 , pp. 134-147
    • Markesbery, W.R.1
  • 6
    • 75149118997 scopus 로고    scopus 로고
    • Role of oxidative stress in the progression of Alzheimer's disease
    • Sultana R, Butterfield DA (2010) Role of oxidative stress in the progression of Alzheimer's disease. J Alzheimers Dis 19, 341-353.
    • (2010) J Alzheimers Dis , vol.19 , pp. 341-353
    • Sultana, R.1    Butterfield, D.A.2
  • 7
    • 20444373701 scopus 로고    scopus 로고
    • Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation: Effects of Alzheimer disease and identification of lipoxidation targets
    • DOI 10.1074/jbc.M502255200
    • Pamplona R, Dalfo E, Ayala V, Bellmunt MJ, Prat J, Ferrer I, Portero-OtinM(2005) Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets. J Biol Chem 280, 21522-21530. (Pubitemid 40805718)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.22 , pp. 21522-21530
    • Pamplona, R.1    Dalfo, E.2    Ayala, V.3    Bellmunt, M.J.4    Prat, J.5    Ferrer, I.6    Portero-Otin, M.7
  • 8
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • DOI 10.1002/ana.410360510
    • Mecocci P, MacGarvey U, Beal MF (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36, 747-751. (Pubitemid 24337634)
    • (1994) Annals of Neurology , vol.36 , Issue.5 , pp. 747-751
    • Mecocci, P.1    Macgarvey, U.2    Beal, M.F.3
  • 9
    • 75949121583 scopus 로고    scopus 로고
    • Oxidative stress in the progression of Alzheimer disease in the frontal cortex
    • Ansari MA, Scheff SW (2010) Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J Neuropathol Exp Neurol 69, 155-167.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 155-167
    • Ma, A.1    Scheff, S.W.2
  • 12
    • 33646144212 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease
    • Butterfield DA, Poon HF, St Clair D, Keller JN, Pierce WM, Klein JB, Markesbery WR (2006) Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease. Neurobiol Dis 22, 223-232.
    • (2006) Neurobiol Dis , vol.22 , pp. 223-232
    • Butterfield, D.A.1    Poon, H.F.2    St Clair, D.3    Keller, J.N.4    Pierce, W.M.5    Klein, J.B.6    Markesbery, W.R.7
  • 14
    • 40849120274 scopus 로고    scopus 로고
    • Redox proteomic identification of 4-hydroxy-2- nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease
    • Reed T, Perluigi M, Sultana R, Pierce WM, Klein JB, Turner DM, Coccia R, Markesbery WR, Butterfield DA (2008) Redox proteomic identification of 4-hydroxy-2- nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease. Neurobiol Dis 30, 107-120.
    • (2008) Neurobiol Dis , vol.30 , pp. 107-120
    • Reed, T.1    Perluigi, M.2    Sultana, R.3    Pierce, W.M.4    Klein, J.B.5    Turner, D.M.6    Coccia, R.7    Markesbery, W.R.8    Butterfield, D.A.9
  • 15
    • 27644446857 scopus 로고    scopus 로고
    • Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment
    • DOI 10.1002/ana.20629
    • Markesbery WR, Kryscio RJ, Lovell MA, Morrow JD (2005) Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. Ann Neurol 58, 730- 735. (Pubitemid 41552548)
    • (2005) Annals of Neurology , vol.58 , Issue.5 , pp. 730-735
    • Markesbery, W.R.1    Kryscio, R.J.2    Lovell, M.A.3    Morrow, J.D.4
  • 16
    • 33744935554 scopus 로고    scopus 로고
    • Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2005.06.004, PII S0197458005001740
    • Williams TI, Lynn BC, Markesbery WR, Lovell MA (2006) Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease. Neurobiol Aging 27, 1094-1099. (Pubitemid 43850642)
    • (2006) Neurobiology of Aging , vol.27 , Issue.8 , pp. 1094-1099
    • Williams, T.I.1    Lynn, B.C.2    Markesbery, W.R.3    Lovell, M.A.4
  • 19
    • 72649096229 scopus 로고    scopus 로고
    • Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease
    • Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C (2010) Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett 469, 6-10.
    • (2010) Neurosci Lett , vol.469 , pp. 6-10
    • Padurariu, M.1    Ciobica, A.2    Hritcu, L.3    Stoica, B.4    Bild, W.5    Stefanescu, C.6
  • 20
    • 0031418498 scopus 로고    scopus 로고
    • Neurodegenerative disorders in humans: The role of glutathione in oxidative stress-mediated neuronal death
    • DOI 10.1016/S0165-0173(97)00045-3, PII S0165017397000453
    • Bains JS, Shaw CA (1997) Neurodegenerative disorders in humans: The role of glutathione in oxidative stressmediated neuronal death. Brain Res Brain Res Rev 25, 335-358. (Pubitemid 28071452)
    • (1997) Brain Research Reviews , vol.25 , Issue.3 , pp. 335-358
    • Bains, J.S.1    Shaw, C.A.2
  • 21
  • 22
    • 0034955787 scopus 로고    scopus 로고
    • Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes
    • DOI 10.1016/S0168-8278(01)00037-X, PII S016882780100037X
    • Hammond CL, Lee TK, Ballatori N (2001) Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J Hepatol 34, 946-954. (Pubitemid 32595199)
    • (2001) Journal of Hepatology , vol.34 , Issue.6 , pp. 946-954
    • Hammond, C.L.1    Lee, T.K.2    Ballatori, N.3
  • 23
    • 0034672943 scopus 로고    scopus 로고
    • Metabolism and functions of glutathione in brain
    • DOI 10.1016/S0301-0082(99)00060-X, PII S030100829900060X
    • Dringen R (2000) Metabolism and functions of glutathione in brain. Prog Neurobiol 62, 649-671. (Pubitemid 30407139)
    • (2000) Progress in Neurobiology , vol.62 , Issue.6 , pp. 649-671
    • Dringen, R.1
  • 24
    • 0024324666 scopus 로고
    • Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons
    • DOI 10.1016/0006-8993(89)91178-5
    • Raps SP, Lai JC, Hertz L, Cooper AJ (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res 493, 398-401. (Pubitemid 19183160)
    • (1989) Brain Research , vol.493 , Issue.2 , pp. 398-401
    • Raps, S.P.1    Lai, J.C.K.2    Hertz, L.3    Cooper, A.J.L.4
  • 27
    • 0033841759 scopus 로고    scopus 로고
    • Depletion of brain glutathione potentiates the effect of 6-hydroxydopamine in a rat model of Parkinson's disease
    • Garcia JC, Remires D, Leiva A, Gonzalez R (2000) Depletion of brain glutathione potentiates the effect of 6- hydroxydopamine in a rat model of Parkinson's disease. J Mol Neurosci 14, 147-153. (Pubitemid 30660804)
    • (2000) Journal of Molecular Neuroscience , vol.14 , Issue.3 , pp. 147-153
    • Garcia, J.C.1    Remires, D.2    Leiva, A.3    Gonzalez, R.4
  • 28
    • 0038636003 scopus 로고    scopus 로고
    • Glutathione pathways in the brain
    • DOI 10.1515/BC.2003.059
    • Dringen R, Hirrlinger J (2003) Glutathione pathways in the brain. Biol Chem 384, 505-516. (Pubitemid 36609167)
    • (2003) Biological Chemistry , vol.384 , Issue.4 , pp. 505-516
    • Dringen, R.1    Hirrlinger, J.2
  • 29
    • 0036767657 scopus 로고    scopus 로고
    • Glutathione depletion and oxidative stress
    • DOI 10.1016/S1353-8020(02)00018-4, PII S1353802002000184
    • Mytilineou C, Kramer BC, Yabut JA (2002) Glutathione depletion and oxidative stress. Parkinsonism Relat Disord 8, 385-387. (Pubitemid 36151653)
    • (2002) Parkinsonism and Related Disorders , vol.8 , Issue.6 , pp. 385-387
    • Mytilineou, C.1    Kramer, B.C.2    Yabut, J.A.3
  • 30
    • 78650000995 scopus 로고    scopus 로고
    • Selective neuronal vulnerability to oxidative stress in the brain
    • Wang X, Michaelis EK (2010) Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2, 12.
    • (2010) Front Aging Neurosci , vol.2 , pp. 12
    • Wang, X.1    Michaelis, E.K.2
  • 32
    • 84858161403 scopus 로고    scopus 로고
    • Elevation of glutathione as a therapeutic strategy in Alzheimer disease
    • Pocernich CB, Butterfield DA (2011) Elevation of glutathione as a therapeutic strategy in Alzheimer disease. Biochim Biophys Acta 1822, 625-630.
    • (2011) Biochim Biophys Acta , pp. 625-630
    • Pocernich, C.B.1    Butterfield, D.A.2
  • 33
    • 84860170321 scopus 로고    scopus 로고
    • A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons
    • Ghosh D, LeVault KR, Barnett AJ, Brewer GJ (2012) A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci 32, 5821-5832.
    • (2012) J Neurosci , vol.32 , pp. 5821-5832
    • Ghosh, D.1    Levault, K.R.2    Barnett, A.J.3    Brewer, G.J.4
  • 35
    • 84863230675 scopus 로고    scopus 로고
    • Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease
    • Zhang C, Rodriguez C, Spaulding J, Aw TY, Feng J (2012) Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease. J Alzheimers Dis 28, 655-666.
    • (2012) J Alzheimers Dis , vol.28 , pp. 655-666
    • Zhang, C.1    Rodriguez, C.2    Spaulding, J.3    Aw, T.Y.4    Feng, J.5
  • 38
    • 84864346149 scopus 로고    scopus 로고
    • Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: Implications for neurodegeneration in Alzheimer's disease
    • Venkateshappa C, Harish G, MahadevanA, Srinivas Bharath MM, Shankar SK (2012) Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: Implications for neurodegeneration in Alzheimer's disease. Neurochem Res 37, 1601-1614.
    • (2012) Neurochem Res , vol.37 , pp. 1601-1614
    • Venkateshappa, C.1    Harish, G.2    Mahadevana Srinivas Bharath, M.M.3    Shankar, S.K.4
  • 39
    • 0028129137 scopus 로고
    • Evidence of an oxidative challenge in the Alzheimer's brain
    • Balazs L, LeonM(1994) Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem Res 19, 1131-1137. (Pubitemid 24284787)
    • (1994) Neurochemical Research , vol.19 , Issue.9 , pp. 1131-1137
    • Balazs, L.1    Leon, M.2
  • 40
    • 0023157146 scopus 로고
    • Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease
    • DOI 10.1002/ana.410210403
    • Perry TL, YongVW, Bergeron C, Hansen S, Jones K (1987) Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease. Ann Neurol 21, 331-336. (Pubitemid 17053268)
    • (1987) Annals of Neurology , vol.21 , Issue.4 , pp. 331-336
    • Perry, T.L.1    Yong, V.W.2    Bergeron, C.3
  • 41
    • 0026343873 scopus 로고
    • Alzheimer's and Parkinson's disease Brain levels of glutathione, glutathione disulfide, and vitamin
    • Adams JD, Jr., Klaidman LK, Odunze IN, Shen HC, Miller CA (1991) Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin, E. Mol Chem Neuropathol 14, 213-226.
    • (1991) E. Mol Chem Neuropathol , vol.14 , pp. 213-226
    • Adams Jr., J.D.1    Klaidman, L.K.2    Odunze, I.N.3    Shen, H.C.4    Miller, C.A.5
  • 44
    • 0033010755 scopus 로고    scopus 로고
    • Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione
    • DOI 10.1046/j.1471-4159.1999.0722092.x
    • White AR, Bush AI, Beyreuther K, Masters CL, Cappai R (1999) Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione. J Neurochem 72, 2092-2098. (Pubitemid 29186015)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.5 , pp. 2092-2098
    • White, A.R.1    Bush, A.I.2    Beyreuther, K.3    Masters, C.L.4    Cappai, R.5
  • 45
    • 0037361527 scopus 로고    scopus 로고
    • Glutathione cycle impairment mediates A-induced cell toxicity
    • DOI 10.1080/1071576021000041023
    • Cardoso SM, Oliveira CR (2003) Glutathione cycle impairment mediates A beta-induced cell toxicity. Free Radic Res 37, 241-250. (Pubitemid 36181880)
    • (2003) Free Radical Research , vol.37 , Issue.3 , pp. 241-250
    • Cardoso, S.M.1    Oliveira, C.R.2
  • 47
    • 0038452658 scopus 로고    scopus 로고
    • Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity
    • Abramov AY, Canevari L, Duchen MR (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J Neurosci 23, 5088-5095. (Pubitemid 36793236)
    • (2003) Journal of Neuroscience , vol.23 , Issue.12 , pp. 5088-5095
    • Abramov, A.Y.1    Canevari, L.2    Duchen, M.R.3
  • 48
    • 0036403832 scopus 로고    scopus 로고
    • Amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons
    • DOI 10.1006/nbdi.2002.0516
    • Casley CS, Land JM, Sharpe MA, Clark JB, Duchen MR, Canevari L (2002) Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol Dis 10, 258-267. (Pubitemid 35217579)
    • (2002) Neurobiology of Disease , vol.10 , Issue.3 , pp. 258-267
    • Casley, C.S.1    Land, J.M.2    Sharpe, M.A.3    Clark, J.B.4    Duchen, M.R.5    Canevari, L.6
  • 49
    • 0031678044 scopus 로고    scopus 로고
    • Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease
    • Lovell MA, Xie C, Markesbery WR (1998) Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease. Neurology 51, 1562-1566. (Pubitemid 28565232)
    • (1998) Neurology , vol.51 , Issue.6 , pp. 1562-1566
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 50
    • 56349091788 scopus 로고    scopus 로고
    • Protein levels and activity of some antioxidant enzymes in hippocampus of subjects with amnestic mild cognitive impairment
    • Sultana R, Piroddi M, Galli F, Butterfield DA (2008) Protein levels and activity of some antioxidant enzymes in hippocampus of subjects with amnestic mild cognitive impairment. Neurochem Res 33, 2540-2546.
    • (2008) Neurochem Res , vol.33 , pp. 2540-2546
    • Sultana, R.1    Piroddi, M.2    Galli, F.3    Butterfield, D.A.4
  • 55
    • 39749157595 scopus 로고    scopus 로고
    • Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment
    • DOI 10.1080/10715760701861373, PII 790807039
    • Bermejo P, Martin-Aragon S, Benedi J, Susin C, Felici E, Gil P, Ribera JM, Villar AM (2008) Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment. Free Radic Res 42, 162-170. (Pubitemid 351298365)
    • (2008) Free Radical Research , vol.42 , Issue.2 , pp. 162-170
    • Bermejo, P.1    Martin-Aragon, S.2    Benedi, J.3    Susin, C.4    Felici, E.5    Gil, P.6    Ribera, J.M.7    Villar, A.Ma.8
  • 57
    • 84857037658 scopus 로고    scopus 로고
    • Peripheral markers in neurodegenerative patients and their first-degree relatives
    • Cristalli DO, Arnal N, Marra FA, de Alaniz MJ, Marra CA (2011) Peripheral markers in neurodegenerative patients and their first-degree relatives. J Neurol Sci 314, 48-56.
    • (2011) J Neurol Sci , vol.314 , pp. 48-56
    • Cristalli, D.O.1    Arnal, N.2    Marra, F.A.3    De Alaniz, M.J.4    Marra, C.A.5
  • 61
    • 67650921433 scopus 로고    scopus 로고
    • Vitamin e paradox in Alzheimer's disease: It does not prevent loss of cognition and may even be detrimental
    • Lloret A, Badia MC, Mora NJ, Pallardo FV, Alonso MD, Vina J (2009) Vitamin E paradox in Alzheimer's disease: It does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis 17, 143-149.
    • (2009) J Alzheimers Dis , vol.17 , pp. 143-149
    • Lloret, A.1    Badia, M.C.2    Mora, N.J.3    Pallardo, F.V.4    Alonso, M.D.5    Vina, J.6
  • 62
    • 0032840299 scopus 로고    scopus 로고
    • Detection of glutathione in the human brain in vivo by means of double quantum coherence filtering
    • DOI 10.1002/ (SICI) 1522-2594 (199908) 42:2<283::AID-MRM10>3.0. CO;2-Q
    • Trabesinger AH, Weber OM, Duc CO, Boesiger P (1999) Detection of glutathione in the human brain in vivo by means of double quantum coherence filtering.Magn Reson Med 42, 283-289. (Pubitemid 29364707)
    • (1999) Magnetic Resonance in Medicine , vol.42 , Issue.2 , pp. 283-289
    • Trabesinger, A.H.1    Weber, O.M.2    Duc, C.O.3    Boesiger, P.4
  • 63
    • 0038262775 scopus 로고    scopus 로고
    • Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra
    • DOI 10.1002/mrm.10499
    • Terpstra M, Henry PG, Gruetter R (2003) Measurement of reduced glutathione (GSH) in human brain using LCmodel analysis of difference-edited spectra. Magn Reson Med 50, 19-23. (Pubitemid 36841855)
    • (2003) Magnetic Resonance in Medicine , vol.50 , Issue.1 , pp. 19-23
    • Terpstra, M.1    Henry, P.-G.2    Gruetter, R.3
  • 64
    • 80051999965 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy study of the antioxidant defense system in schizophrenia
    • Matsuzawa D, Hashimoto K (2011) Magnetic resonance spectroscopy study of the antioxidant defense system in schizophrenia. Antioxid Redox Signal 15, 2057-2065.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2057-2065
    • Matsuzawa, D.1    Hashimoto, K.2
  • 65
    • 33847277510 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy (MRS) and its application in Alzheimer's disease
    • Mandal PK (2007) Magnetic resonance spectroscopy (MRS) and its application in Alzheimer's disease. Concept Magn Reson A 30A, 40-64.
    • (2007) Concept Magn Reson A , pp. 40-64
    • Mandal, P.K.1
  • 66
    • 2442582930 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
    • DOI 10.1016/j.brainres.2004.02.079, PII S0006899304004779
    • Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG (2004) Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res 1012, 60-65. (Pubitemid 38648899)
    • (2004) Brain Research , vol.1012 , Issue.1-2 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.-K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 67
    • 78649337928 scopus 로고    scopus 로고
    • Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: A model of sporadic Alzheimer's disease
    • Labak M, Foniok T, Kirk D, Rushforth D, Tomanek B, Jasinski A, Grieb P (2010) Metabolic changes in rat brain following intracerebroventricular injections of streptozotocin: A model of sporadic Alzheimer's disease. Acta Neurochir Suppl 106, 177-181.
    • (2010) Acta Neurochir Suppl , vol.106 , pp. 177-181
    • Labak, M.1    Foniok, T.2    Kirk, D.3    Rushforth, D.4    Tomanek, B.5    Jasinski, A.6    Grieb, P.7
  • 68
    • 84855796946 scopus 로고    scopus 로고
    • Brain oxidative stress: Detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy
    • Mandal PK, Tripathi M, Sugunan S (2012) Brain oxidative stress: Detection and mapping of anti-oxidant marker 'Glutathione' in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy. Biochem Biophys Res Commun 417, 43-48.
    • (2012) Biochem Biophys Res Commun , vol.417 , pp. 43-48
    • Mandal, P.K.1    Tripathi, M.2    Sugunan, S.3
  • 70
    • 0032917662 scopus 로고    scopus 로고
    • The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's disease
    • DOI 10.1007/s007020050161
    • Palmer AM (1999) The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's disease. J Neural Transm 106, 317-328. (Pubitemid 29196935)
    • (1999) Journal of Neural Transmission , vol.106 , Issue.3-4 , pp. 317-328
    • Palmer, A.M.1
  • 71
    • 0029073455 scopus 로고
    • Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
    • Lovell MA, Ehmann WD, Butler SM, Markesbery WR (1995) Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45, 1594-1601.
    • (1995) Neurology , vol.45 , pp. 1594-1601
    • Ma, L.1    Ehmann, W.D.2    Butler, S.M.3    Markesbery, W.R.4
  • 74
    • 43249123968 scopus 로고    scopus 로고
    • Atrophy accelerates with conversion from mild cognitive impairment to Alzheimer disease
    • DOI 10.1212/01.wnl.0000311448.61194.0f, PII 0000611420080506100002
    • Mueller SG, Dickerson BC (2008) Atrophy accelerates with conversion from mild cognitive impairment to Alzheimer disease. Neurology 70, 1728-1729. (Pubitemid 351653948)
    • (2008) Neurology , vol.70 , pp. 1728-1729
    • Mueller, S.G.1    Dickerson, B.C.2
  • 77
    • 33645775687 scopus 로고    scopus 로고
    • Antioxidant protection and neurodegenerative disease: The role of amyloid-beta and tau
    • Castellani RJ, Lee HG, Perry G, Smith MA (2006) Antioxidant protection and neurodegenerative disease: The role of amyloid-beta and tau. Am J Alzheimers Dis Other Demen 21, 126-130.
    • (2006) Am J Alzheimers Dis Other Demen , vol.21 , pp. 126-130
    • Castellani, R.J.1    Lee, H.G.2    Perry, G.3    Ma, S.4
  • 79
    • 0032088451 scopus 로고    scopus 로고
    • Is oxidative damage central to the pathogenesis of Alzheimer disease ?
    • Perry G, Smith MA (1998) Is oxidative damage central to the pathogenesis of Alzheimer disease? Acta Neurol Belg 98, 175-179. (Pubitemid 128522756)
    • (1998) Acta Neurologica Belgica , vol.98 , Issue.2 , pp. 175-179
    • Perry, G.1    Smith, M.A.2
  • 80
    • 84855866955 scopus 로고    scopus 로고
    • Oxidative stress and betaamyloid protein in Alzheimer's disease
    • Cai Z, Zhao B, Ratka A (2011) Oxidative stress and betaamyloid protein in Alzheimer's disease. Neuromolecular Med 13, 223-250.
    • (2011) Neuromolecular Med , vol.13 , pp. 223-250
    • Cai, Z.1    Zhao, B.2    Ratka, A.3
  • 81
    • 84858297656 scopus 로고    scopus 로고
    • In vivo proton magnetic resonance spectroscopic signal processing for the absolute quantitation of brain metabolites
    • Mandal PK (2012) In vivo proton magnetic resonance spectroscopic signal processing for the absolute quantitation of brain metabolites. Eur J Radiol 81, e653-e664.
    • (2012) Eur J Radiol , vol.81
    • Mandal, P.K.1
  • 82
    • 84866846195 scopus 로고    scopus 로고
    • Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease
    • Mandal PK, Akolkar H, TripathiM(2012) Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease. J Alzheimers Dis 31(Suppl 3), S75-S86.
    • (2012) J Alzheimers Dis , vol.31 , Issue.SUPPL. 3
    • Mandal, P.K.1    Akolkar, H.2    Tripathi, M.3
  • 83
    • 84901950513 scopus 로고    scopus 로고
    • Glutathione levels in the brain of epileptic patients measured by proton-magnetic resonance spectroscopy
    • Mueller SG, Trabesinger AH, Boesiger P,WieserHG(1999) Glutathione levels in the brain of epileptic patients measured by proton-magnetic resonance spectroscopy. Epilepsia 40, 14-14.
    • (1999) Epilepsia , vol.40 , pp. 14-14
    • Mueller, S.G.1    Trabesinger, A.H.2    Boesiger, P.3    Wieser, H.G.4
  • 88
    • 79953232727 scopus 로고    scopus 로고
    • Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T
    • Choi IY, Lee SP, Denney DR, Lynch SG (2011) Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T. Mult Scler 17, 289-296.
    • (2011) Mult Scler , vol.17 , pp. 289-296
    • Choi, I.Y.1    Lee, S.P.2    Denney, D.R.3    Lynch, S.G.4
  • 89
    • 77349125827 scopus 로고    scopus 로고
    • MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis
    • Srinivasan R, Ratiney H, Hammond-Rosenbluth KE, Pelletier D, Nelson SJ (2010) MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis. Magn Reson Imaging 28, 163-170.
    • (2010) Magn Reson Imaging , vol.28 , pp. 163-170
    • Srinivasan, R.1    Ratiney, H.2    Hammond-Rosenbluth, K.E.3    Pelletier, D.4    Nelson, S.J.5
  • 91
    • 84861179603 scopus 로고    scopus 로고
    • Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders
    • Hermens DF, Lagopoulos J, Naismith SL, Tobias-Webb J, Hickie IB (2012) Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders. Transl Psychiatry 2, e110.
    • (2012) Transl Psychiatry , vol.2
    • Hermens, D.F.1    Lagopoulos, J.2    Naismith, S.L.3    Tobias-Webb, J.4    Hickie, I.B.5
  • 92
    • 84865296409 scopus 로고    scopus 로고
    • Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology
    • Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ (2012) Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 25, 1073-1087.
    • (2012) NMR Biomed , vol.25 , pp. 1073-1087
    • Shungu, D.C.1    Weiduschat, N.2    Murrough, J.W.3    Mao, X.4    Pillemer, S.5    Dyke, J.P.6    Medow, M.S.7    Natelson, B.H.8    Stewart, J.M.9    Mathew, S.J.10
  • 94
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 95
    • 84877072330 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1- 42)-induced oxidative stress in Alzheimer disease: Importance in disease pathogenesis and progression
    • Butterfield DA, Swomley AM, Sultana R (2013) Amyloid beta-peptide (1-42)-induced oxidative stress in Alzheimer disease: Importance in disease pathogenesis and progression. Antioxid Redox Signal 19, 823-835.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 823-835
    • Butterfield, D.A.1    Swomley, A.M.2    Sultana, R.3
  • 97
    • 0033860372 scopus 로고    scopus 로고
    • Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
    • Varadarajan S, Yatin S, Aksenova M, Butterfield DA (2000) Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130, 184-208.
    • (2000) J Struct Biol , vol.130 , pp. 184-208
    • Varadarajan, S.1    Yatin, S.2    Aksenova, M.3    Butterfield, D.A.4
  • 98
    • 0033583252 scopus 로고    scopus 로고
    • Alzheimer's amyloid -peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: Protective effect of vitamin e
    • DOI 10.1016/S0304-3940(99)00101-9, PII S0304394099001019
    • Yatin SM, Yatin M, Aulick T, Ain KB, Butterfield DA (1999) Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: Protective effect of vitamin E. Neurosci Lett 263, 17-20. (Pubitemid 29138952)
    • (1999) Neuroscience Letters , vol.263 , Issue.1 , pp. 17-20
    • Yatin, S.M.1    Yatin, M.2    Aulick, T.3    Ain, K.B.4    Butterfield, D.A.5
  • 100
    • 0036829434 scopus 로고    scopus 로고
    • Amyloid- and τ serve antioxidant functions in the aging and Alzheimer brain
    • DOI 10.1016/S0891-5849(02)01021-3, PII S0891584902010213
    • Smith MA, Casadesus G, Joseph JA, Perry G (2002) Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic Biol Med 33, 1194- 1199. (Pubitemid 35246587)
    • (2002) Free Radical Biology and Medicine , vol.33 , Issue.9 , pp. 1194-1199
    • Smith, M.A.1    Casadesus, G.2    Joseph, J.A.3    Perry, G.4
  • 102
    • 84865418346 scopus 로고    scopus 로고
    • Amyloid-beta production: Major link between oxidative stress and BACE1
    • Tamagno E, Guglielmotto M, Monteleone D, Tabaton M (2012) Amyloid-beta production: Major link between oxidative stress and BACE1. Neurotox Res 22, 208-219.
    • (2012) Neurotox Res , vol.22 , pp. 208-219
    • Tamagno, E.1    Guglielmotto, M.2    Monteleone, D.3    Tabaton, M.4
  • 103
    • 79751480420 scopus 로고    scopus 로고
    • Oxidative balance in Alzheimer's disease: Relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-beta
    • Tayler H, Fraser T, Miners JS, Kehoe PG, Love S (2010) Oxidative balance in Alzheimer's disease: Relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-beta. J Alzheimers Dis 22, 1363- 1373.
    • (2010) J Alzheimers Dis , vol.22 , pp. 1363-1373
    • Tayler, H.1    Fraser, T.2    Miners, J.S.3    Kehoe, P.G.4    Love, S.5
  • 104
    • 0029076397 scopus 로고
    • Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide
    • Yan SD,Yan SF, Chen X, Fu J, Chen M,Kuppusamy P, Smith MA, Perry G, Godman GC, Nawroth P, Zweier JL, Stern D (1995) Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide. Nat Med 1, 693-699.
    • (1995) Nat Med , vol.1 , pp. 693-699
    • Yan Sdyan, S.F.1    Chen, X.2    Fu, J.3    Chen Mkuppusamy, P.4    Ma, S.5    Perry, G.6    Godman, G.C.7    Nawroth, P.8    Zweier, J.L.9    Stern, D.10
  • 105
    • 84872520228 scopus 로고    scopus 로고
    • Oxidative modification of brain proteins in Alzheimer's disease: Perspective on future studies based on results of redox proteomics studies
    • Sultana R, Butterfield DA (2013) Oxidative modification of brain proteins in Alzheimer's disease: Perspective on future studies based on results of redox proteomics studies. J Alzheimers Dis 33(Suppl 1), S243-S251.
    • (2013) J Alzheimers Dis , vol.33 , Issue.SUPPL. 1
    • Sultana, R.1    Butterfield, D.A.2
  • 109
    • 0031020476 scopus 로고    scopus 로고
    • A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid - Peptide
    • Mark RJ, Lovell MA, Markesbery WR, Uchida K, Mattson MP (1997) A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem 68, 255-264. (Pubitemid 26427315)
    • (1997) Journal of Neurochemistry , vol.68 , Issue.1 , pp. 255-264
    • Mark, R.J.1    Lovell, M.A.2    Markesbery, W.R.3    Uchida, K.4    Mattson, M.P.5
  • 110
    • 16444379174 scopus 로고    scopus 로고
    • γ-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against A(1-42)-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease
    • DOI 10.1002/jnr.20394
    • Boyd-Kimball D, Sultana R, Abdul HM, Butterfield DA (2005) Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Abeta(1-42)-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease. J Neurosci Res 79, 700-706. (Pubitemid 40476449)
    • (2005) Journal of Neuroscience Research , vol.79 , Issue.5 , pp. 700-706
    • Boyd-Kimball, D.1    Sultana, R.2    Mohmmad Abdul, H.3    Butterfield, D.A.4
  • 111
    • 0037468467 scopus 로고    scopus 로고
    • Oxidized glutathione stimulated the amyloid formation of α-synuclein
    • DOI 10.1016/S0014-5793(03)00081-4
    • Paik SR, Lee D, Cho HJ, Lee EN, Chang CS (2003) Oxidized glutathione stimulated the amyloid formation of alpha-synuclein. FEBS Lett 537, 63-67. (Pubitemid 36246677)
    • (2003) FEBS Letters , vol.537 , Issue.1-3 , pp. 63-67
    • Paik, S.R.1    Lee, D.2    Cho, H.-J.3    Lee, E.-N.4    Chang, C.-S.5
  • 112
    • 70149093400 scopus 로고    scopus 로고
    • Effects of glutathione on amyloid fibrillation of hen egg-white lysozyme
    • Wang SS, Chou SW, Liu KN,Wu CH (2009) Effects of glutathione on amyloid fibrillation of hen egg-white lysozyme. Int J Biol Macromol 45, 321-329.
    • (2009) Int J Biol Macromol , vol.45 , pp. 321-329
    • Wang, S.S.1    Chou, S.W.2    Knwu Ch, L.3
  • 113
    • 18844444191 scopus 로고    scopus 로고
    • Role of glutathione in intracellular amyloid-α precursor protein/ carboxy-terminal fragment aggregation and associated cytotoxicity
    • DOI 10.1111/j.1471-4159.2005.03109.x
    • Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS, Montine TJ (2005) Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. J Neurochem 93, 1047-1056. (Pubitemid 40695764)
    • (2005) Journal of Neurochemistry , vol.93 , Issue.4 , pp. 1047-1056
    • Woltjer, R.L.1    Nghiem, W.2    Maezawa, I.3    Milatovic, D.4    Vaisar, T.5    Montine, K.S.6    Montine, T.J.7
  • 114
    • 84863644562 scopus 로고    scopus 로고
    • Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems
    • Cacciatore I, Baldassarre L, Fornasari E, Mollica A, Pinnen F (2012) Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems. Oxid Med Cell Longev 2012, 240146.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 240146
    • Cacciatore, I.1    Baldassarre, L.2    Fornasari, E.3    Mollica, A.4    Pinnen, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.