Depletion of brain glutathione potentiates the effect of 6-hydroxydopamine in a rat model of Parkinson's disease

Journal of Molecular Neuroscience

Volumn 14, Issue 3, 2000, Pages 147-153

  García, Julio C ^a   Remires, Diadelis ^b   Leiva, Aida ^b   González, Ricardo ^b  

^a CETEX/CENPALAB   (Cuba)

^b NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

6 Hydroxydopamine; Diethyl maleate; Glutathione S transferase; Rat

Indexed keywords

GLUTATHIONE; GLUTATHIONE TRANSFERASE; MALEIC ACID DIETHYL ESTER; OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CIRCLING BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; RAT;

ANIMALIA;

EID: 0033841759     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/jmn:14:3:147     Document Type: Article

References (27)

1. Embryonic cell suspension grafts in a rat model of Parkinson's disease
2. Glutathione transferases catalyse the detoxification of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
3. Effects of exogenous factors on the cerebral glutathione in rodents
4. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
5. Effect of diethyl maleate and other glutathione depletors on protein synthesis
6. The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
7. Lesion of nigrostriatal neurons by 6.hydroxydopamine induces changes in rat brain glutathione S-transferase
8. Comparative studies of the specific activity of Glutathione S-transferases in central nervous system in old and young rats
9. Is glutathione S-transferase activity a marker of brain aging?
10. 6-Hydroxy-dopamine: Evidence for superoxide radical as an oxidative intermediate
11. Biochemical toxicology of acetaminophen
12. Oxidative stress as a cause Parkinson's disease
13. Impairment of Bromosulfophthalein hepatic transport and cholestasis induced by diethyl Maleate in the rabbit
14. Pharmacological actions of 6-hydroxydopamine
15. Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational model
16. Methods for depleting brain glutathione
17. Acetaminophen induced hepatic necrosis. IV. Protective role of glutathione
18. Interaction of glutathione with reactive intermediates
19. Prevention of dopamine-induced cell death by thiol antioxidants: Possible implications for treatment of Parkinson's disease
20. Biosynthesis and maintenance of GSH in primary astrocyte culture: Role of L-cystine and ascorbate
21. Oxidation reactions in Parkinson's disease
22. Parkinson's disease: A disorder due to nigral glutathione deficiency?
23. Transition metals, ferritin, glutathione and ascorbic acid in parkinsonian brains
24. Technetium 99m-meso-HMPAO as a potential agent to image cerebral glutathione content
25. 2-2, catalyze detoxication of the dopamine metabolite aminochrome
26. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
27. Brain-derived neurotrophic factors protects dopamine neurons against 6-hydroxy-dopamine and N-methyl-4-phenylpyridinium ion toxicity: Involvement of the glutathione system