Dopamine ups and downs in vulnerability to addictions: A neurodevelopmental model

Trends in Pharmacological Sciences

Volumn 35, Issue 6, 2014, Pages 268-276

  Leyton, Marco ^a,b   Vezina, Paul ^c  

^a MCGILL UNIVERSITY   (Canada)

^b Department of Neurology and Neurosurgery McGill University ^*  (Canada)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

alcohol abuse; allostasis; conditioning; drug abuse; externalizing; incentive salience; reward; sensitization

Indexed keywords

DOPAMINE;

ADDICTION; BEHAVIOR CONTROL; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC TRANSMISSION; DRUG SEEKING BEHAVIOR; DRUG USE; EVENT RELATED POTENTIAL; HUMAN; IMPULSIVENESS; NERVE CELL DIFFERENTIATION; NEUROPSYCHOLOGY; PRIORITY JOURNAL; REVIEW; REWARD; SUBSTANCE ABUSE; WITHDRAWAL SYNDROME;

ALCOHOL ABUSE; ALLOSTASIS; CONDITIONING; DRUG ABUSE; EXTERNALIZING; INCENTIVE SALIENCE; REWARD; SENSITIZATION;

BEHAVIOR, ADDICTIVE; DOPAMINE; HUMANS; NERVOUS SYSTEM; SUBSTANCE-RELATED DISORDERS;

EID: 84901764935     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.04.002     Document Type: Review

References (142)

1. World Health Organization Management of Substance Abuse: The Global Burden 2013 World Health Organization http://www.who.int/substance-abuse/facts/ global-burden/en/
2. H. Harwood Updating Estimates of the Economic Costs of Alcohol Abuse in The United States: Estimates, Update, and Data 2000 US Department of Health and Human Services, US Public Health Service, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism
3. Office of National Drug Control Policy The Economic Costs of Drug Abuse in the United States, 1992-1998 2001 Executive Office of the President
4. United States Department of Justice The Economic Impact of Illicit Drug Use on American Society 2011 United States Department of Justice http://www.justice.gov/ndic
5. P.V. Piazza et al. Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administration Brain Res. 567 1991 169 174
6. G.F. Koob, and M. Le Moal Drug abuse: hedonic homeostatic dysregulation Science 278 1997 52 58 (Pubitemid 27446270)
7. K. Blum et al. 'Liking' and 'wanting' linked to reward deficiency syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry Curr. Pharm. Des. 18 2012 113 118
8. T.E. Robinson, and K.C. Berridge The incentive sensitization theory of addiction: some current issues Philos. Trans. R. Soc. Lond. B: Biol. Sci. 363 2008 3137 3146
9. P. Vezina Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs Neurosci. Biobehav. Rev. 27 2004 827 839 (Pubitemid 38199613)
10. P.J. Conrod et al. Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse Psychol. Addict. Behav. 14 2000 243 256
11. R.E. Tarter et al. Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder Am. J. Psychiatry 160 2003 1078 1085 (Pubitemid 41070966)
12. K.S. Kendler et al. Genetic and familial environmental influences on the risk for drug abuse: a national Swedish adoption study Arch. Gen. Psychiatry 69 2012 690 697
13. K.S. Kendler et al. Dimensions of parental alcohol use/problems and offspring temperament, externalizing behaviors, and alcohol use/problems Alcohol. Clin. Exp. Res. 37 2013 2118 2127
14. T.E. Moffitt et al. A gradient of childhood self-control predicts health, wealth, and public safety Proc. Natl. Acad. Sci. U.S.A. 108 2011 2693 2698
15. B.M. Hicks et al. Genetic and environmental influences on the familial transmission of externalizing disorders in adoptive and twin offspring JAMA Psychiatry 70 2013 1076 1083
16. B.M. Hicks et al. Identifying childhood characteristics that underlie premorbid risk for substance use disorders: socialization and boldness Dev. Psychopathol. 26 2013 1 17
17. J.B. Pingault et al. Childhood trajectories of inattention, hyperactivity and oppositional behaviors and prediction of substance abuse/dependence: a 15-year longitudinal population-based study Mol. Psychiatry 18 2013 806 812
18. D.M. Dick et al. Adolescent alcohol use is predicted by childhood temperament factors before age 5, with mediation through personality and peers Alcohol. Clin. Exp. Res. 37 2013 2108 2117
19. M. Leyton Are addictions diseases or choices? J. Psychiatry Neurosci. 38 2013 219 221
20. M. Rutter Developmental psychopathology: a paradigm shift or just a relabeling? Dev. Psychopathol. 25 2013 1201 1213
21. J.P. Newman, and A.R. Lorenz Response modulation and emotion processing: implications for psychopathy and other dysregulatory psychopathology R.J. Davidson, Handbook of Affective Sciences 2002 Oxford University Press 1043 1067
22. S.V. Mahler, and H. de Wit Cue-reactors: individual differences in cue-induced craving after food or smoking abstinence PLoS ONE 5 2010 e15475
23. V.D. Bohbot et al. Caudate nucleus-dependent navigational strategies are associated with increased use of addictive drugs Hippocampus 23 2013 973 984
24. S.D. Lane, and D.R. Cherek Risk taking by adolescents with maladaptive behavior histories Exp. Clin. Psychopharmacol. 9 2001 74 82 (Pubitemid 32852216)
25. J.R. Séguin et al. Response perseveration in adolescent boys with stable and unstable histories of physical aggression: the role of underlying processes J. Child Psychol. Psychiatry 43 2002 481 494 (Pubitemid 36939234)
26. G. Fairchild The developmental psychopathology of motivation in adolescence Dev. Cogn. Neurosci. 1 2011 414 429
27. P.V. Piazza et al. Factors that predict individual vulnerability to amphetamine self-administration Science 245 1989 1511 1513 (Pubitemid 19243245)
28. P.J. Pierre, and P. Vezina Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug Psychopharmacology 129 1997 277 284 (Pubitemid 27085399)
29. N. Suto et al. Locomotor response to novelty predicts a rat's propensity to self-administer nicotine Psychopharmacology 158 2001 175 180 (Pubitemid 33020836)
30. M. Marinelli The many facets of the locomotor response to a novel environment test: theoretical comment on Mitchell, Cunningham, and Mark (2005) Behav. Neurosci. 1194 2005 1144 1151 (Pubitemid 41377267)
31. V. Deroche-Gamonet et al. Evidence for addiction-like behavior in the rat Science 305 2004 1014 1017 (Pubitemid 39071778)
32. L.J.M.J. Vanderschuren, and B.J. Everitt Drug seeking becomes compulsive after prolonged cocaine self-administration Science 305 2004 1017 1019 (Pubitemid 39071779)
33. D. Belin, and V. Deroche-Gamonet Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model Cold Spring Harb. Perspect. Med. 2 2012 a011940
34. M.S. Hooks et al. Sensitization and individual differences in IP amphetamine, cocaine, or caffeine following repeated intracranial amphetamine infusions Ann. N. Y. Acad. Sci. 654 1992 444 447
35. T.L. Sills, and J.N. Crawley Individual differences in sugar consumption predict amphetamine-induced dopamine overflow in nucleus accumbens Eur. J. Pharmacol. 303 1996 177 181 (Pubitemid 26197854)
36. S.B. Flagel et al. A selective role for dopamine in stimulus-reward learning Nature 469 2011 53 59
37. T.L. Sills, and F.J. Vaccarino Individual differences in sugar intake predict the locomotor response to acute and repeated amphetamine administration Psychopharmacology 116 1994 1 8 (Pubitemid 24279590)
38. A. Zocchi et al. Parallel strain-dependent effect of amphetamine on locomotor activity and dopamine release in the nucleus accumbens: an in vivo study in mice Neuroscience 82 1998 521 528 (Pubitemid 27461637)
39. M. Marinelli, and F.J. White Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons J. Neurosci. 20 2000 8876 8885
40. J.R. Taylor, and B.A. Horger Enhanced responding for conditioned reward by intra-accumbens amphetamine is potentiated after cocaine sensitization Psychopharmacology 142 1999 31 40 (Pubitemid 29196061)
41. J. Schweimer et al. Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making Behav. Neurosci. 119 2005 1687 1692 (Pubitemid 43145741)
42. J.D. Salamone et al. Dopamine, behavioral economics, and effort Front. Behav. Neurosci. 3 2009 1 12
43. C.A. Winstanley et al. Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice J. Neurosci. 24 2004 4718 4722 (Pubitemid 38668195)
44. S.B. Floresco, and S. Ghods-Sharifi Amygdala-prefrontal cortical circuitry regulates effort-based decision making Cereb. Cortex 17 2007 251 260 (Pubitemid 46052764)
45. M.W. Howe et al. Prolonged dopamine signalling in striatum signals proximity and value of distant rewards Nature 500 2013 575 579
46. M.M. van Gaalen et al. Behavioral disinhibition requires dopamine receptor activation Psychopharmacology 187 2006 73 85 (Pubitemid 43876919)
47. T. Pattij et al. Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control Psychopharmacology (Berl.) 191 2007 587 598 (Pubitemid 46355887)
48. C.A. Winstanley et al. Dopaminergic modulation of the orbitofrontal cortex affects attention, motivation and impulsive responding in rats performing the five-choice serial reaction time task Behav. Brain Res. 210 2010 263 272
49. M. Leyton The neurobiology of desire: dopamine and the regulation of mood and motivational states in humans M.L. Kringelbach, K.C. Berridge, Pleasures of the Brain 2009 Oxford University Press 222 243
50. 11C]raclopride study in healthy men Neuropsychopharmacology 27 2002 1027 1035 (Pubitemid 35447639)
51. J.W. Buckholtz et al. Dopaminergic network differences in human impulsivity Science 329 2010 532
52. J.W. Buckholtz et al. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits Nat. Neurosci. 13 2010 419 421
53. 11C]raclopride study Neuropsychopharmacology 2013 10.1038/npp.2013.349
54. A. Galvan et al. Risk-taking and the adolescent brain: who is at risk? Dev. Sci. 10 2007 F8 F14
55. J.M. Bjork et al. Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents J. Child Psychol. Psychiatry 51 2010 827 837
56. J.M. Bjork et al. Psychosocial problems and recruitment of incentive neurocircuitry: exploring individual differences in health adolescents Dev. Cogn. Neurosci. 1 2011 570 577
57. C.C. Wu et al. Affective traits link to reliable markers of incentive anticipation Neuroimage 84 2014 279 289
58. J.R. Chumbley et al. Fatal attraction: ventral striatum predicts costly choice errors in humans Neuroimage 89 2014 1 9
59. K.E. Demos et al. Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior J. Neurosci. 32 2012 5549 5552
60. M. Leyton Conditioned and sensitized responses to stimulant drugs in humans Prog. Neuropsychopharmacol. Biol. Psychiatry 31 2007 1601 1613 (Pubitemid 47625706)
61. A. Dagher, and T.W. Robbins Personality, addiction, dopamine: insights from Parkinson's disease Neuron 61 2009 502 510
62. P. Trifilieff, and D. Martinez Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity Neuropharmacology 76 2014 498 509
63. A. Nagano-Saito et al. Dopamine facilitates fronto-striatal functional connectivity during a set-shifting task J. Neurosci. 28 2008 3697 3706
64. A. Nagano-Saito et al. From anticipation to action, the role of dopamine in perceptual decision-making: an fMRI-tyrosine depletion study J. Neurophysiol. 108 2012 501 512
65. J.M. Bjork et al. Dietary tyrosine/phenylalanine depletion effects on behavioral and brain signatures of human motivational processing Neuropsychopharmacology 39 2014 595 604
66. M.J. Frank et al. By carrot or by stick: cognitive reinforcement learning in Parkinsonism Science 306 2004 1940 1943 (Pubitemid 39627859)
67. M. Leyton et al. Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion J. Psychiatry Neurosci. 32 2007 129 136 (Pubitemid 46597959)
68. S.P. Barrett et al. The role of dopamine in alcohol self-administration in humans: individual differences Eur. Neuropsychopharmacol. 18 2008 439 447
69. V.V. Venugopalan et al. Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction Neuropsychopharmacology 36 2011 2469 2476
70. E.I. Cawley et al. Dopamine and light: dissecting effects on mood and motivational states in women with sub-syndromal seasonal affective disorder J. Psychiatry Neurosci. 38 2013 388 397
71. A.C. Simioni et al. Dissecting the effects of disease and treatment on impulsivity in Parkinson's disease J. Int. Neuropsychol. Soc. 18 2012 942 951
72. A. Pine et al. Dopamine, time, and impulsivity in humans J. Neurosci. 30 2010 8888 8896
73. D.A. Regier et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study JAMA 264 1990 2511 2518
74. 11C]raclopride/PET study in healthy volunteers Arch. Gen. Psychiatry 63 2006 1386 1395 (Pubitemid 44878522)
75. O.G. O'Daly et al. Investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers Arch. Gen. Psychiatry 68 2011 545 554
76. M. Leyton, and P. Vezina Striatal ups and downs: their roles in vulnerability to addictions in humans Neurosci. Biobehav. Rev. 37 2013 1999 2014
77. J. Stewart, and R. Eikelboom Conditioned drug effects L.L. Iversen, Handbook of Psychopharmacology 1987 Plenum Press 1 57
78. B.J. Aragona et al. Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats Eur. J. Neurosci. 30 2009 1889 1899
79. P. Di Ciano et al. Conditioned changes in dopamine oxidation currents in the nucleus accumbens of rats by stimuli paired with self-administration or yoked-administration of d-amphetamine Eur. J. Neurosci. 10 1998 1121 1127 (Pubitemid 28375637)
80. R. Ito et al. Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats J. Neurosci. 20 2000 7489 7495
81. F. Weiss et al. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens Proc. Natl. Acad. Sci. U.S.A. 97 2000 4321 4326 (Pubitemid 30226131)
82. T.E. Robinson et al. On the motivational properties of reward cues: individual differences Neuropharmacology 76 2014 450 459
83. S.B. Flagel et al. An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction Neuropsychopharmacology 35 2010 388 400
84. L.V. Panlilio et al. Human cocaine-seeking behavior and its control by drug-associated stimuli in the laboratory Neuropsychopharmacology 30 2005 433 443 (Pubitemid 40129495)
85. E. Childs, and H. de Wit Amphetamine-induced place preference in humans Biol. Psychiatry 65 2009 900 904
86. L.M. Mayo et al. Conditioned preference to a methamphetamine-associated contextual cue in humans Neuropsychopharmacology 38 2013 921 929
87. E. Childs, and H. de Wit Contextual conditioning enhances the psychostimulant and incentive properties of d-amphetamine in humans Addict. Biol. 18 2013 985 992
88. 11C]raclopride study with amphetamine J. Neurosci. 27 2007 3998 4003 (Pubitemid 46597158)
89. D.W. Tang et al. Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies Physiol. Behav. 106 2012 317 324
90. B.D. Bartholow et al. Specificity of P3 event-related potential reactivity to alcohol cues in individuals low in alcohol sensitivity Psychol. Addict. Behav. 24 2010 220 228
91. D.A. Kareken et al. Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings Alcohol. Clin. Exp. Res. 28 2004 550 557 (Pubitemid 38506888)
92. D.A. Kareken et al. Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers Neuroimage 50 2010 267 276
93. A.D. Dager et al. Influence of alcohol use and family history of alcoholism on neural response to alcohol cues in college drinkers Alcohol. Clin. Exp. Res. 37 Suppl. 1 2013 E161 E171
94. E.D. Claus et al. Identifying neurobiological phenotypes associated with alcohol use disorder severity Neuropsychopharmacology 36 2011 2086 2096
95. F.M. Filbey et al. Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry Neuropsychopharmacology 33 2008 1391 1401 (Pubitemid 351521721)
96. B.G. Oberlin et al. Beer flavor provokes striatal dopamine release in male drinkers: mediation by family history of alcoholism Neuropsychopharmacology 38 2013 1617 1624
97. P.C. Holland Occasion setting in Pavlovian conditioning D.L. Medin, The Psychology of Learning and Motivation 1992 Academic press 69 125
98. A.A. Grace et al. Regulation of firing of dopaminergic neurons and control of goal-directed behaviors Trends Neurosci. 30 2007 220 227 (Pubitemid 46654234)
99. P. Vezina, and M. Leyton Conditioned cues and the expression of stimulant sensitization in animals and humans Neuropharmacology 56 Suppl. 1 2009 160 168
100. J.B. Mitchell, and J. Stewart Facilitation of sexual behaviors in the male rat in the presence of stimuli previously paired with systemic injections of morphine Pharmacol. Biochem. Behav. 35 1990 367 372 (Pubitemid 20075580)
101. C.L. Duvauchelle et al. Conditioned increases in behavioral activity and accumbens dopamine levels produced by intravenous cocaine Behav. Neurosci. 114 2000 1156 1166 (Pubitemid 32001894)
102. J. Stewart, and P. Vezina Conditioning and behavioral sensitization P.W. Kalivas, C.D. Barnes, Sensitization in the Nervous System 1988 Telford Press 207 224
103. S.G. Anagnostaras, and T.E. Robinson Sensitization to the psychomotor stimulant effects of amphetamine: modulation by associative learning Behav. Neurosci. 110 1996 1397 1414 (Pubitemid 27009202)
104. A.M. Guillory et al. Effects of conditioned inhibition on neurotransmitter overflow in the nucleus accumbens Soc. Neurosci. Abstr. 32 2006 483.3
105. J. Stewart, and P. Vezina Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine Behav. Pharmacol. 2 1991 65 71
106. S.G. Anagnostaras et al. Memory processes governing amphetamine-induced psychomotor sensitization Neuropsychopharmacology 26 2002 703 715 (Pubitemid 34455023)
107. J.J. Cortright et al. Previous exposure to nicotine enhances the incentive motivational effects of amphetamine via nicotine-associated contextual stimuli Neuropsychopharmacology 37 2012 2277 2284
108. N.M. Neugebauer et al. Exposure to nicotine enhances its subsequent self-administration: contribution of nicotine-associated contextual stimuli Behav. Brain Res. 260 2014 155 161
109. J.M. Wray et al. The magnitude and reliability of cue-specific craving in nondependent smokers Drug Alcohol Depend. 134 2014 304 308
110. M.M. Andrews et al. Individuals family history positive for alcoholism show functional resonance imaging differences in reward sensitivity that are related to impulsivity factors Biol. Psychiatry 69 2011 675 683
111. S. Schneider et al. Risk taking and the adolescent reward system: a potential common link to substance abuse Am. J. Psychiatry 169 2012 39 46
112. W-Y.W. Yau et al. Nucleus accumbens response to incentive stimuli anticipation in children of alcoholics: relationships with precursive behavioral risk and lifetime alcohol use J. Neurosci. 32 2012 2544 2551
113. S.M. Cox et al. Striatal dopamine responses to intranasal cocaine self-administration in humans Biol. Psychiatry 15 2009 846 850
114. K.F. Casey et al. Reduced dopamine response to amphetamine in subjects at ultra-high risk for addiction Biol. Psychiatry 2013 10.1016/j.biopsych.2013.08. 033
115. W. Schultz Updating dopamine reward signals Curr. Opin. Neurobiol. 23 2013 229 238
116. F. Toates Motivational Systems 1986 Cambridge University Press
117. J. Stewart, and R.A. Wise Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction Psychopharmacology 108 1992 79 84
118. D.M. Hutcheson et al. The role of withdrawal in heroin addiction: enhances reward or promotes avoidance? Nat. Neurosci. 4 2001 943 947 (Pubitemid 32801599)
119. M. Minhas, and F. Leri The effect of heroin dependence on resumption of heroin self-administration in rats Drug Alcohol Depend. 138 2014 24 31
120. E. Setiawan et al. Differential striatal dopamine responses following oral alcohol in individuals at varying risk for dependence Alcohol. Clin. Exp. Res. 38 2014 126 134
121. V. Lovic et al. Impulsive rats are less maternal Dev. Psychobiol. 53 2011 13 22
122. T.A. Kosten et al. Enhanced acquisition of cocaine self-administration in adult rats with neonatal isolation stress experience Brain Res. 875 2000 44 50
123. M.J. Meaney et al. Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse? Psychoneuroendocrinology 27 2002 127 138 (Pubitemid 34028162)
124. A.M. Lomanowska et al. Inadequate early social experience increases the incentive salience of reward-related cues in adulthood Behav. Brain Res. 220 2011 91 99
125. S.M. Antelman et al. Interchangeability of stress and amphetamine in sensitization Science 207 1980 329 331 (Pubitemid 10151636)
126. M. Leyton, and J. Stewart Pre-exposure to repeated footshock sensitizes the locomotor activity from systemic morphine and intra-nucleus accumbens amphetamine Pharmacol. Biochem. Behav. 37 1990 303 310 (Pubitemid 20339385)
127. P.W. Kalivas, and J. Stewart Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity Brain Res. Rev. 16 1991 223 244
128. E.C. Nelson et al. Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study Psychol. Med. 36 2006 1473 1483 (Pubitemid 44355982)
129. P.J. Conrod et al. Effectiveness of a selective, personality-targeted prevention program for adolescent alcohol use and misuse: a cluster randomized controlled trial JAMA Psychiatry 70 2013 334 342
130. N.D. Volkow et al. Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues Neuroimage 39 2008 1266 1273
131. 11C]raclopride PET study Brain 132 2009 1376 1385
132. J. Joutsa et al. Mesolimbic dopamine release is linked to symptom severity in pathological gambling Neuroimage 60 2012 1992 1999
133. G.J. Wang et al. Enhanced striatal dopamine release during food stimulation in binge eating disorder Obesity 19 2011 1601 1608
134. 11C]-(+)-PHNO Mol. Psychiatry 2013 10.1038/mp.2013.163
135. A. Broft et al. Striatal dopamine in bulimia nervosa: a PET imaging study Int. J. Eat. Disord. 45 2012 648 656
136. J. Linnet et al. Dopamine release in ventral striatum of pathological gamblers losing money Acta Psychiatr. Scand. 122 2010 326 333
137. J. Linnet et al. Inverse association between dopaminergic neurotransmission and Iowa Gambling Task performance in pathological gamblers and healthy controls Scand. J. Psychol. 52 2011 28 34
138. D. Martinez et al. Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment Am. J. Psychiatry 168 2011 634 641
139. G.J. Wang et al. Decreased dopamine activity predicts relapse in methamphetamine abusers Mol. Psychiatry 17 2012 918 925
140. J.M. Schmitz et al. Contingency management and levodopa-carbidopa for cocaine treatment: a comparison of three behavioral targets Exp. Clin. Psychopharmacol. 18 2010 238 244
141. B. Le Foll, and I. Boileau Repurposing buspirone for drug addiction treatment Int. J. Neuropsychopharmacol. 16 2013 251 253
142. P. Steensland et al. The monoamine stabilizer (-)-OSU6162 attenuates voluntary ethanol intake and ethanol-induced dopamine output in nucleus accumbens Biol. Psychiatry 72 2012 823 831