Are addictions diseases or choices?

Journal of Psychiatry and Neuroscience

Volumn 38, Issue 4, 2013, Pages 219-221

  Leyton, Marco ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b Dept of Electrical and Computer Engineering   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; DOPAMINE; NICOTINE;

ADDICTION; CONDUCT DISORDER; DRUG EXPOSURE; DRUG RESPONSE; DRUG SEEKING BEHAVIOR; EDITORIAL; ENVIRONMENTAL FACTOR; GENE EXPRESSION; HEREDITY; HUMAN; IMPULSIVENESS; MENTAL DISEASE; MORBIDITY; NEUROPSYCHIATRY; PHOBIA; PHYSICAL DISEASE BY BODY FUNCTION; POSTTRAUMATIC STRESS DISORDER; RISK; SCHIZOPHRENIA; SENSATION SEEKING; SUBSTANCE ABUSE;

EID: 84879623722     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.130097     Document Type: Editorial

References (50)

1. Heyman GM. Addiction: A Disorder of Choice. Cambridge: Harvard University Press; 2009.
2. Harris AH, Ellerbe L, Reeder RN, et al. Pharmacotherapy for alcohol dependence: perceived treatment barriers and action strategies among veterans health administration service providers. Psychol Serv 2013 Jan 28 [Epub ahead of print].
3. Robins LN, Helzer JE, Davis DH. Narcotic use in Southeast Asia and afterward. Arch Gen Psychiatry 1975;32:955-61.
4. Klingemann H, Sobell MA, Sobell LC. Continuities and changes in self-change research. Addiction 2010;105:1510-8.
5. Slutske WS. Natural recovery and treatment-seeking in pathological gambling: results from two U.S. national surveys. Am J Psychiatry 2006;163:297-302.
6. Heather N. Interpreting the evidence on brief interventions for excessive drinkers: the need for caution. Alcohol Alcohol 1995;30:287-96.
7. Smith R. In search of "non-disease." BMJ 2002;324:883-5.
8. Washton AM, Gold MS. Cocaine: A Clinician's Handbook. New York: The Guilford Press; 1987.
9. Rehm J, Gnam W, Popova S, et al. The costs of alcohol, illegal drugs, and tobacco in Canada, 2002. J Stud Alcohol Drugs 2007;68: 886-95.
10. Collins PY, Patel V, Joestl SS, et al. Grand challenges in global mental health. Nature 2011;475:27-30.
11. Murray CJL, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-201: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2197-223.
12. Anthony JC. Epidemiology of drug dependence. In: Davis KL, Charney D, Coyle JT, et al., editors. Neuropsychopharmacology: The Fifth Generation of Progress. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 1557-74.
13. Merikangas KR, Stolar M, Stevens DE, et al. Familial transmission of substance use disorders. Arch Gen Psychiatry 1998;55:973-9.
14. Tsuang MT, Lyons MJ, Eisen SA, et al. Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. Am J Med Genet 1996;67:473-7.
15. Tsuang MT, Lyons MJ, Meyer JM, et al. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry 1998;55:967-72.
16. Kendler KS, Karkowski LM, Neale MC, et al. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population based sample of male twins. Arch Gen Psychiatry 2000;57:261-9.
17. Cadoret RJ, Troughton E, O'Gorman TW, et al. An adoption study of genetic and environmental factors in drug abuse. Arch Gen Psychiatry 1986;43:1131-6.
18. Kendler KS, Sundquist K, Ohlsson H, et al. Genetic and familial environmental influences on the risk of drug abuse: a national Swedish adoption study. Arch Gen Psychiatry 2012;69:690-7.
19. Bierut LJ. Genetic vulnerability and susceptibility to substance dependence. Neuron 2011;69:618-27.
20. Agrawal A, Verweij KJH, Gillespie NA, et al. The genetics of addiction - a translational approach. Transl Psychiatry 2012;2:e140.
21. Wang J-C, Foroud T, Hinrichs AL, et al. A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. Mol Psychiatry 10.1038/mp.2012.143. 2012 Oct 23 [Epub ahead of print].
22. Belsky DW, Moffitt TE, Baker TB, et al. Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. JAMA Psychiatry 2013;70:534-42.
23. Conrod PJ, Pihl RO, Stewart SH, et al. Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors substance abuse. Psychol Addict Behav 2000;14:243-56.
24. Ayduk O, Mendoza-Denton R, Mishel W, et al. Regulating the interpersonal self: strategic self-regulation for coping with rejection sensitivity. J Pers Soc Psychol 2000;79:776-92.
25. Pingault J-B, Côté SM, Galéra C, et al. Childhood trajectories of inattention, hyperactivity and oppositional behaviors and prediction of substance abuse/dependence: a 15-year longitudinal population based study. Mol Psychiatry 10.1038/mp.2012.87. 2012 Jun 26 [Epub ahead of print].
26. Tarter RE, Kirisci L, Mezzich A, et al. Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. Am J Psychiatry 2003;160:1078-85.
27. Dawson DA, Goldtstein RB, Moss HB, et al. Gender differences in the relationship of internalizing and externalizing psychopathology to alcohol dependence: likelihood, expression and course. Drug Alcohol Depend 2010;112:9-17.
28. Kushner MG, Wall MW, Krueger RF, et al. Alcohol dependence is related to overall internalizing psychopathology load rather than to particular internalizing disorders: Evidence from a National Sample. Alcohol Clin Exp Res 2012;36:325-31.
29. Blanco C, Krueger RF, Hasin DS, et al. Mapping common psychiatric disorders: structure and predictive validity in the National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiatry 2013;70:199-208.
30. Vrieze SI, Hicks BM, Iacono WG, et al. Decline in genetic influence on the co-occurrence of alcohol, marijuana, and nicotine dependence symptoms from age 14 to 29. Am J Psychiatry 2012;169:1073-81.
31. Edenberg HJ. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 2007;30:5-13.
32. O'Loughlin J, Paradis G, Kim W, et al. Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tob Control 2004;13:422-8.
33. Kendler KS, Jacobson KC, Prescott CA, et al. Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 2003;160:687-95.
34. Fox NA, Rutter M. Introduction to the special section on the effects of early experience on development. Child Dev 2010;81:23-7.
35. Bergen SE, Gardner CO, Kendler KS. Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: a meta-analysis. Twin Res Hum Genet 2007;10:423-33.
36. Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 2006;29:565-98.
37. Robinson TE, Berridge KC. The incentive sensitization theory of addiction: some current issues. Phil Trans R Soc Lond B Biol Sci 2008;363:3137-46.
38. 11C]raclopride/PET study in healthy volunteers. Arch Gen Psychiatry 2006;63:1386-95.
39. Leyton M, Vezina P. Striatal ups and downs: their roles in vulnerability to addictions. Neurosci Biobehav Rev 10.1016/j.neubiorev.2013.01.018. 2013 Jan 16 [Epub ahead of print].
40. Goldstein RZ, Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 2011;12:652-69.
41. Volkow ND, Wang G-J, Fowler JS, et al. Addiction circuitry in the human brain. Annu Rev Pharmacol Toxicol 2012;52:321-36.
42. Everitt BJ, Robbins TW. From the ventral to the dorsal striatum: devolving views of their roles in drug addiction. Neurosci Biobehav Rev 10.1016/j.neubiorev.2013.02.010 2013 Feb 21 [Epub ahead of print].
43. Krueger RF. The structure of common mental disorders. Arch Gen Psychiatry 1999;56:921-6.
44. Caspi A, Moffitt TE. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 2006;7:583-90.
45. Craddock N, Owen MJ. The Kraepelinian dichotomy - going, going.but still not gone. Br J Psychiatry 2010;196:92-5.
46. Kessler RC, Ormel J, Petukhova M, et al. Development of lifetime comorbidity in the World Health Organization Mental Health Surveys. Arch Gen Psychiatry 2011;68:90-100.
47. Kapur S, Phillips AG, Insel TR. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psychiatry 2012;17:1174-9.
48. Craddock N, Sklar P. Bipolar disorder 1. Lancet 2013;381:1654-62.
49. Smoller JW, Craddock JW, Kendler K, et al.; Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genomewide analysis. Lancet 2013;381:1371-9.
50. Leyton M, Cox SML. Impulsivity, substance abuse and dependence. In: Vaccarino F, editor. Substance Abuse in Canada: Concurrent Disorders. Ottawa: CCSA; 2009.