Reduced dopamine response to amphetamine in subjects at ultra-high risk for addiction

Biological Psychiatry

Volumn 76, Issue 1, 2014, Pages 23-30

  Casey, Kevin F ^a   Benkelfat, Chawki ^a   Cherkasova, Mariya V ^a   Baker, Glen B ^b   Dagher, Alain ^a   Leyton, Marco ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c and Applied Physiology   (Canada)

Author keywords

Dopamine; PET; stimulants; substance dependence; vulnerability

Indexed keywords

AMPHETAMINE; DOPAMINE; RACLOPRIDE C 11; CENTRAL STIMULANT AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; RACLOPRIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DRUG DEPENDENCE; DRUG USE; FEMALE; HIGH RISK POPULATION; HUMAN; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SUBSTANCE ABUSE; CASE CONTROL STUDY; CONTROLLED CLINICAL TRIAL; DIAGNOSTIC USE; FAMILY HEALTH; FUNCTIONAL NEUROIMAGING; METABOLISM; PRODROMAL SYMPTOM; SCINTISCANNING; SUBSTANCE-RELATED DISORDERS; YOUNG ADULT;

AMPHETAMINE; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM STIMULANTS; CORPUS STRIATUM; DOPAMINE; DOPAMINE ANTAGONISTS; FAMILY HEALTH; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PRODROMAL SYMPTOMS; RACLOPRIDE; SUBSTANCE-RELATED DISORDERS; YOUNG ADULT;

EID: 84902153741     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.08.033     Document Type: Article

References (71)

1. K.R. Merikangas, M. Stolar, D.E. Stevens, J. Goulet, M.A. Preisig, and B. Fenton et al. Familial transmission of substance use disorders Arch Gen Psychiatry 55 1998 973 979
2. D.A. Dawson, T.C. Harford, and B.F. Grant Family history as a predictor of alcohol dependence Alcohol Clin Exp Res 16 1992 572 575
3. S.F. Stoltenberg, S.A. Mudd, F.C. Blow, and E.M. Hill Evaluating measures of family history of alcoholism: Density versus dichotomy Addiction 93 1998 1511 1520
4. J.D. Salamone Functions of mesolimbic dopamine: Changing concepts and shifting paradigms Psychopharmacology (Berl) 191 2007 389
5. K.C. Berridge, and T.E. Robinson Parsing reward Trends Neurosci 26 2003 507 513
6. P. Vezina, and M. Leyton Conditioned cues and the expression of stimulant sensitization in animals and humans Neuropharmacology 56 suppl 1 2009 160 168
7. S.B. Flagel, J.J. Clark, T.E. Robinson, L. Mayo, A. Czuj, and I. Willuhn et al. A selective role for dopamine in stimulus-reward learning Nature 469 2011 53 57
8. G. Di Chiara, and A. Imperato Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc Natl Acad Sci U S A 85 1988 5274 5278
9. C.W. Bradberry, R.J. Gruen, C.W. Berridge, and R.H. Roth Individual differences in behavioral measures: Correlations with nucleus accumbens dopamine measured by microdialysis Pharmacol Biochem Behav 39 1991 877 882
10. F. Weiss, M.T. Lorang, F.E. Bloom, and G.F. Koob Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: Genetic and motivational determinants J Pharmacol Exp Ther 267 1993 250 258
11. A. Zocchi, C. Orsini, S. Cabib, and S. Puglisi-Allegra Parallel strain-dependent effect of amphetamine on locomotor activity and dopamine release in the nucleus accumbens: An in vivo study in mice Neuroscience 82 1998 521 528
12. A. Honkanen, P. Hyytiä, E.R. Korpi, and L. Ahtee Effects of morphine on metabolism of dopamine and serotonin in brains of alcohol-preferring AA and alcohol-avoiding ANA rats Alcohol 18 1999 3 10
13. S.N. Katner, and F. Weiss Neurochemical characteristics associated with ethanol preference in selected alcohol-preferring and -nonpreferring rats: A quantitative microdialysis study Alcohol Clin Exp Res 25 2001 198 205
14. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, S.J. Gatley, and R. Hitzemann et al. Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects Nature 386 1997 830 833
15. N.D. Volkow, G.-J. Wang, F. Telang, J.S. Fowler, J. Logan, and M. Jayne et al. Profound decreases in dopamine release in striatum in detoxified alcoholics: Possible orbitofrontal involvement J Neurosci 27 2007 12700 12706
16. D. Martinez, R. Gil, M. Slifstein, D.-R. Hwang, Y. Huang, and A. Perez et al. Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum Biol Psychiatry 58 2005 779 786
17. D. Martinez, R. Narendran, R.W. Foltin, M. Slifstein, D.-R. Hwang, and A. Broft et al. Amphetamine-induced dopamine release: Markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine Am J Psychiatry 164 2007 622 629
18. D. Martinez, K.M. Carpenter, F. Liu, M. Slifstein, A. Broft, and A.C. Friedman et al. Imaging dopamine transmission in cocaine dependence: Link between neurochemistry and response to treatment Am J Psychiatry 168 2011 634 641
19. F.A. Wagner, and J.C. Anthony From first drug use to drug dependence: Developmental periods of risk for dependence upon marijuana, cocaine, and alcohol Neuropsychopharmacology 26 2002 479 488
20. C. Lopez-Quintero, J.P. de los Cobos, D.S. Hasin, M. Okuda, S. Wang, B.F. Grant, and C. Blanco Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) Drug Alcohol Depend 115 2011 120 130
21. First MB, Spitzer RL, Gibbon M, Williams JBW (2002): Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-patient Edition. (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute.
22. NIH (1992): Family Interview for Genetics Study (FIGS): A Manual for FIGS. Bethesda: National Institute of Mental Health, Clinical Neurogenetics Branch, Intramural Research Program.
23. 11C]raclopride study in healthy men Neuropsychopharmacology 27 2002 1027 1035
24. 11C]raclopride/positron emission tomography study in healthy men Arch Gen Psychiatry 63 2006 1386 1395
25. 11C]raclopride study in healthy men Neuropsychopharmacology 29 2004 427 432
26. S.J. Asghar, G.B. Baker, G.A. Rauw, and P.H. Silverstone A rapid method of determining amphetamine in plasma samples using pentafluorobenzenesulfonyl chloride and electron-capture gas chromatography J Pharmacol Toxicol Methods 46 2001 111 115
27. J. Talairach, and P. Tournoux Co-planar Stereotaxic Atlas of the Human Brain 1988 Georg Thieme Verlag Stuttgart, Germany
28. D.L. Collins, P. Neelin, T.M. Peters, and A.C. Evans Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space J Comput Assist Tomogr 18 1994 192 205
29. A.C. Evans, S. Marrett, P. Neelin, L. Collins, K. Worsley, and W. Dai et al. Anatomical mapping of functional activation in stereotactic coordinate space Neuroimage 1 1992 43 53
30. N. Costes, A. Dagher, K. Larcher, A.C. Evans, D.L. Collins, and A. Reilhac Motion correction of multi-frame PET data in neuroreceptor mapping: Simulation based validation Neuroimage 47 2009 1496 1505
31. R.N. Gunn, A.A. Lammertsma, S.P. Hume, and V.J. Cunningham Parametric imaging of ligand-receptor binding in PET using a simplified reference region model Neuroimage 6 1997 279 287
32. R.B. Innis, V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, and R.N. Gunn et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 2007 1533 1539
33. M. Laruelle Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review J Cereb Blood Flow Metab 20 2000 423 451
34. M. Laruelle, C.D. D'Souza, R.M. Baldwin, A. Abi-Dargham, S.J. Kanes, and C.L. Fingado et al. Imaging D2 receptor occupancy by endogenous dopamine in humans Neuropsychopharmacology 17 1997 162 174
35. M. Laruelle, R.N. Iyer, M.S. al-Tikriti, Y. Zea-Ponce, R. Malison, and S.S. Zoghbi et al. Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates Synapse 25 1997 1 14
36. J.A. Aston, R.N. Gunn, K.J. Worsley, Y. Ma, A.C. Evans, and A. Dagher A statistical method for the analysis of positron emission tomography neuroreceptor ligand data Neuroimage 12 2000 245 256
37. K.J. Worsley, S. Marrett, P. Neelin, A.C. Vandal, K.J. Friston, and A.C. Evans A unified statistical approach for determining significant signals in images of cerebral activation Hum Brain Mapp 4 1996 58 73
38. O. Mawlawi, D. Martinez, M. Slifstein, A. Broft, R. Chatterjee, and D.R. Hwang et al. Imaging human mesolimbic dopamine transmission with positron emission tomography: I. Accuracy and precision of D(2) receptor parameter measurements in ventral striatum J Cereb Blood Flow Metab 21 2001 1034 1057
39. S.R. Gross, S.P. Barrett, J.S. Shestowsky, and R.O. Pihl Ecstasy and drug consumption patterns: A Canadian rave population study Can J Psychiatry 47 2002 546 551
40. C.C. Cruickshank, and K.R. Dyer A review of the clinical pharmacology of methamphetamine Addiction 104 2009 1085 1099
41. N.D. Volkow, J.S. Fowler, G.J. Wang, R. Hitzemann, J. Logan, and D.J. Schlyer et al. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers Synapse 14 1993 169 177
42. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, R. Hitzemann, and Y.S. Ding et al. Decreases in dopamine receptors but not in dopamine transporters in alcoholics Alcohol Clin Exp Res 20 1996 1594 1598
43. N.D. Volkow, L. Chang, G.J. Wang, J.S. Fowler, Y.S. Ding, and M. Sedler et al. Low level of brain dopamine D2 receptors in methamphetamine abusers: Association with metabolism in the orbitofrontal cortex Am J Psychiatry 158 2001 2015 2021
44. N.D. Volkow, G.-J. Wang, H. Begleiter, B. Porjesz, J.S. Fowler, and F. Telang et al. High levels of dopamine D2 receptors in unaffected members of alcoholic families: Possible protective factors Arch Gen Psychiatry 63 2006 999 1008
45. C.A. Munro, M.E. McCaul, L.M. Oswald, D.F. Wong, Y. Zhou, and J. Brasic et al. Striatal dopamine release and family history of alcoholism Alcohol Clin Exp Res 30 2006 1143 1151
46. R.J. Moore, S.L. Vinsant, M.A. Nader, L.J. Porrino, and D.P. Friedman Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys Synapse 30 1998 88 96
47. E.S. Davidson, J.F. Finch, and S. Schenk Variability in subjective responses to cocaine: Initial experiences of college students Addict Behav 18 1993 445 453
48. N.M. Lambert, M. McLeod, and S. Schenk Subjective responses to initial experience with cocaine: An exploration of the incentive-sensitization theory of drug abuse Addiction 101 2006 713 725
49. R.W. Foltin, and M.W. Fischman Assessment of abuse liability of stimulant drugs in humans: A methodological survey Drug Alcohol Depend 28 1991 3 48
50. H. De Wit, and T.J. Phillips Do initial responses to drugs predict future use or abuse? Neurosci Biobehav Rev 36 2012 1565 1576
51. M. Leyton The neurobiology of desire: Dopamine and the regulation of mood and motivational states in humans M.L. Kringelbach, K.C. Berridge, Pleasures of the Brain 2009 Oxford University Press New York 222 243
52. R.A. Wise Dopamine, learning and motivation Nat Rev Neurosci 5 2004 483 494
53. W.C. Drevets, C. Gautier, J.C. Price, D.J. Kupfer, P.E. Kinahan, and A.A. Grace et al. Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria Biol Psychiatry 49 2001 81 96
54. A. Abi-Dargham, L.S. Kegeles, D. Martinez, R.B. Innis, and M. Laruelle Dopamine mediation of positive reinforcing effects of amphetamine in stimulant naïve healthy volunteers: Results from a large cohort Eur Neuropsychopharmacol 13 2003 459 468
55. M. Laruelle, A. Abi-Dargham, C.H. van Dyck, W. Rosenblatt, Y. Zea-Ponce, and S.S. Zoghbi et al. SPECT imaging of striatal dopamine release after amphetamine challenge J Nucl Med 36 1995 1182 1190
56. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, S.J. Gatley, and C. Wong et al. Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors J Pharmacol Exp Ther 291 1999 409 415
57. D. Martinez, M. Slifstein, A. Broft, O. Mawlawi, D.-R. Hwang, and Y. Huang et al. Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: Amphetamine-induced dopamine release in the functional subdivisions of the striatum J Cereb Blood Flow Metab 23 2003 285 300
58. L.M. Oswald, D.F. Wong, M. McCaul, Y. Zhou, H. Kuwabara, and L. Choi et al. Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine Neuropsychopharmacology 30 2005 821 832
59. U.E. Busto, L. Redden, H. Mayberg, S. Kapur, S. Houle, and L.A. Zawertailo Dopaminergic activity in depressed smokers: A positron emission tomography study Synapse 63 2009 681 689
60. L.M. Oswald, D.F. Wong, Y. Zhou, A. Kumar, J. Brasic, and M. Alexander et al. Impulsivity and chronic stress are associated with amphetamine-induced striatal dopamine release Neuroimage 36 2007 153 166
61. M.R.C. Daglish, T.M. Williams, S.J. Wilson, L.G. Taylor, C.B. Eap, and M. Augsburger et al. Brain dopamine response in human opioid addiction Br J Psychiatry 193 2008 65 72
62. R.B. Rothman, M.H. Baumann, C.M. Dersch, D.V. Romero, K.C. Rice, F.I. Carroll, and J.S. Partilla Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin Synapse 39 2001 32 41
63. A. Der-Avakian, and A. Markou The neurobiology of anhedonia and other reward-related deficits Trends Neurosci 35 2012 68 77
64. A. Colasanti, G.E. Searle, C.J. Long, S.P. Hill, R.R. Reiley, and D. Quelch et al. Endogenous opioid release in the human brain reward system induced by acute amphetamine administration Biol Psychiatry 72 2012 371 377
65. M. Leyton Conditioned and sensitized responses to stimulant drugs in humans Prog Neuropsychopharmacol Biol Psychiatry 31 2007 1601 1613
66. B.J. Rounsaville, T.R. Kosten, M.M. Weissman, B. Prusoff, D. Pauls, S.F. Anton, and K. Merikangas Psychiatric disorders in relatives of probands with opiate addiction Arch Gen Psychiatry 48 1991 33 42
67. K.S. Kendler, C.G. Davis, and R.C. Kessler The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: A family history study Br J Psychiatry 170 1997 541 548
68. K.S. Kendler, K.C. Jacobson, C.A. Prescott, and M.C. Neale Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins Am J Psychiatry 160 2003 687 695
69. L.J. Bierut, S.H. Dinwiddie, H. Begleiter, R.R. Crowe, V. Hesselbrock, and J.I. Nurnberger Jr et al. Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism Arch Gen Psychiatry 55 1998 982 988
70. M.T. Tsuang, M.J. Lyons, J.M. Meyer, T. Doyle, S.A. Eisen, and J. Goldberg et al. Co-occurrence of abuse of different drugs in men: The role of drug-specific and shared vulnerabilities Arch Gen Psychiatry 55 1998 967 972
71. A. Honkanen, J. Mikkola, E.R. Korpi, P. Hyytiä, T. Seppälä, and L. Ahtee Enhanced morphine- and cocaine-induced behavioral sensitization in alcohol-preferring AA rats Psychopharmacology (Berl) 142 1999 244 252