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Volumn 29, Issue 2, 2014, Pages 409-419

The fat mass and obesity-associated FTO rs9939609 polymorphism is associated with elevated homocysteine levels in patients with multiple sclerosis screened for vascular risk factors

Author keywords

Body mass index (BMI); FTO; Homocysteine; Multiple sclerosis (MS); Obesity

Indexed keywords

CHOLESTEROL; CORTISONE; FOLIC ACID; HOMOCYSTEINE; BIOLOGICAL MARKER; FTO PROTEIN, HUMAN; PROTEIN;

EID: 84901621192     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-014-9486-7     Document Type: Article
Times cited : (36)

References (52)
  • 1
    • 77953191271 scopus 로고    scopus 로고
    • FTO genetic variation and association with obesity in West Africans and African Americans
    • Adeyemo A, Chen G, Zhou J, Shriner D, Doumatey A, Huang H, Rotimi C (2010) FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes 59:1549-54
    • (2010) Diabetes , vol.59 , pp. 1549-1554
    • Adeyemo, A.1    Chen, G.2    Zhou, J.3    Shriner, D.4    Doumatey, A.5    Huang, H.6    Rotimi, C.7
  • 5
    • 77957257906 scopus 로고    scopus 로고
    • A community based study of the relationship between homocysteine and some of the life style factors
    • doi:10.1007/s12291-010-0044-8
    • Das M, Ghose M, Borah NC, Choudhury N (2010) A community based study of the relationship between homocysteine and some of the life style factors. IJCB 25(3):295-301. doi:10.1007/s12291-010-0044-8
    • (2010) IJCB , vol.25 , Issue.3 , pp. 295-301
    • Das, M.1    Ghose, M.2    Borah, N.C.3    Choudhury, N.4
  • 6
    • 84887620420 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase A1298C polymorphismbut not of C677T with multiple sclerosis in Tunisian patients
    • doi:10.1016/j.clineuro.2013.02.025
    • Fekih Mrissa N, Mrad M, Klai S, Zaouali J, Sayeh A, Mazigh C, Nsiri B, Machgoul S, Gritili N, Mrissa R (2013) Association of methylenetetrahydrofolate reductase A1298C polymorphismbut not of C677T with multiple sclerosis in Tunisian patients. Clin Neurol Neurosurg 115(9):1657-1660. doi:10.1016/j. clineuro.2013.02.025
    • (2013) Clin Neurol Neurosurg , vol.115 , Issue.9 , pp. 1657-1660
    • Fekih Mrissa, N.1    Mrad, M.2    Klai, S.3    Zaouali, J.4    Sayeh, A.5    Mazigh, C.6    Nsiri, B.7    Machgoul, S.8    Gritili, N.9    Mrissa, R.10
  • 9
    • 42249083837 scopus 로고    scopus 로고
    • The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
    • DOI 10.1210/en.2007-1457
    • Fredriksson R, Hagglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM, Levine AS, Lindblom J, Schiöth HB (2008) The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 149:2062-71 (Pubitemid 351574484)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2062-2071
    • Fredriksson, R.1    Hagglund, M.2    Olszewski, P.K.3    Stephansson, O.4    Jacobsson, J.A.5    Olszewska, A.M.6    Levine, A.S.7    Lindblom, J.8    Schioth, H.B.9
  • 11
    • 84870065126 scopus 로고    scopus 로고
    • Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents: The Helena Study
    • Gonzalez-Gross M, Benser J, Breidenassel C et al (2012) Gender and age influence blood folate, vitamin B12, vitamin B6, and homocysteine levels in European adolescents: the Helena Study. Nutr Res 32:817-26
    • (2012) Nutr Res , vol.32 , pp. 817-826
    • Gonzalez-Gross, M.1    Benser, J.2    Breidenassel, C.3
  • 12
    • 78649671320 scopus 로고    scopus 로고
    • Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia
    • doi:10.1152/ajpendo.00367.2010
    • He l, Zeng H, Li F et al (2010) Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia. Am J Physiol Endocrinol Metab 299(6):E1061-E1065. doi:10.1152/ajpendo.00367.2010
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , Issue.6
    • He, L.1    Zeng, H.2    Li, F.3
  • 13
    • 84866034486 scopus 로고    scopus 로고
    • High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women
    • Hedström AK, Olsson T, Alfredsson L (2012) High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler 18:1334-6
    • (2012) Mult Scler , vol.18 , pp. 1334-1336
    • Hedström, A.K.1    Olsson, T.2    Alfredsson, L.3
  • 15
    • 81355146483 scopus 로고    scopus 로고
    • N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
    • Jia G, Fu Y, Zhao X et al (2011) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7: 885-7
    • (2011) Nat Chem Biol , vol.7 , pp. 885-887
    • Jia, G.1    Fu, Y.2    Zhao, X.3
  • 16
    • 0033796739 scopus 로고    scopus 로고
    • Consumption of energy-dense, nutrient-poor foods by adult Americans: Nutritional and health implications. The third National Health and Nutrition Examination Survey, 1988-1994
    • Kant AK (2000) Consumption of energy-dense, nutrient-poor foods by adult Americans: nutritional and health implications. The third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 72:929-36
    • (2000) Am J Clin Nutr , vol.72 , pp. 929-936
    • Kant, A.K.1
  • 17
    • 84881257670 scopus 로고    scopus 로고
    • A link between FTO, ghrelin, and impaired brain food-cue responsivity
    • Karra E, O'Daly OG, Choudhury AI et al (2013) A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest 123: 3539-51
    • (2013) J Clin Invest , vol.123 , pp. 3539-3551
    • Karra, E.1    O'Daly, O.G.2    Choudhury, A.I.3
  • 18
    • 0030849362 scopus 로고    scopus 로고
    • Biological methylation of myelin basic protein: Enzymology and biological significance
    • DOI 10.1016/S1357-2725(97)00009-5, PII S1357272597000095
    • Kim S, Lim IK, Park GH, Paik WK (1997) Biological methylation of myelin basic protein: enzymology and biological significance. Int J Biochem Cell Biol 29:743-51 (Pubitemid 27323163)
    • (1997) International Journal of Biochemistry and Cell Biology , vol.29 , Issue.5 , pp. 743-751
    • Kim, S.1    Lim, I.K.2    Park, G.-H.3    Paik, W.K.4
  • 19
    • 72249107090 scopus 로고    scopus 로고
    • The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study
    • Klotz L, Farkas M, Bain N et al (2010) The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study. Neurosci Lett 468:183-5
    • (2010) Neurosci Lett , vol.468 , pp. 183-185
    • Klotz, L.1    Farkas, M.2    Bain, N.3
  • 20
    • 0036124199 scopus 로고    scopus 로고
    • Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells
    • DOI 10.1016/S0021-9150(01)00670-0, PII S0021915001006700
    • Koga T, Claycombe K, Meydani M (2002) Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells. Atherosclerosis 161:365-374 (Pubitemid 34219189)
    • (2002) Atherosclerosis , vol.161 , Issue.2 , pp. 365-374
    • Koga, T.1    Claycombe, K.2    Meydani, M.3
  • 22
    • 84867893982 scopus 로고    scopus 로고
    • Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats
    • Koz ST, Etem EO, Baydas G, Yuce H, Ozercan HI, Kuloǧlu T, Koz S, Etem A, Demir N (2012) Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats. Brain Res 1484:29-38
    • (2012) Brain Res , vol.1484 , pp. 29-38
    • Koz, S.T.1    Etem, E.O.2    Baydas, G.3    Yuce, H.4    Ozercan, H.I.5    Kuloǧlu, T.6    Koz, S.7    Etem, A.8    Demir, N.9
  • 23
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 33:1444-1452
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 24
    • 84873666865 scopus 로고    scopus 로고
    • Childhood obesity and risk of pediatricmultiple sclerosis and clinically isolated syndrome
    • Langer-Gould A, Brara SM, Beaber BE, Koebnick C (2013) Childhood obesity and risk of pediatricmultiple sclerosis and clinically isolated syndrome. Neurology 80:548-52
    • (2013) Neurology , vol.80 , pp. 548-552
    • Langer-Gould, A.1    Brara, S.M.2    Beaber, B.E.3    Koebnick, C.4
  • 25
    • 84871717518 scopus 로고    scopus 로고
    • Phytochemicals and their impact on adipose tissue inflammation and diabetes
    • Leiherer A, Mündlein A, Drexel H (2013) Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vascul Pharmacol 58(1-2):3-20
    • (2013) Vascul Pharmacol , vol.58 , Issue.1-2 , pp. 3-20
    • Leiherer, A.1    Mündlein, A.2    Drexel, H.3
  • 26
    • 77955051399 scopus 로고    scopus 로고
    • Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population
    • Liu Y, Liu Z, Song Yet al (2010) Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity 18:1619-24
    • (2010) Obesity , vol.18 , pp. 1619-1624
    • Liu, Y.1    Liu, Z.2    Song, Y.3
  • 28
    • 77950209814 scopus 로고    scopus 로고
    • Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis
    • Marrie RA, Rudick R, Horwitz R, Cutter G, Tyry T, Campagnolo D, Vollmer T (2010) Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis. Neurology 74: 1041-7
    • (2010) Neurology , vol.74 , pp. 1041-1047
    • Marrie, R.A.1    Rudick, R.2    Horwitz, R.3    Cutter, G.4    Tyry, T.5    Campagnolo, D.6    Vollmer, T.7
  • 29
    • 0037364417 scopus 로고    scopus 로고
    • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    • DOI 10.1016/S0166-2236(03)00032-8
    • Mattson MP, Shea TB (2003) Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. Trends Neurosci 26:137-146 (Pubitemid 36183675)
    • (2003) Trends in Neurosciences , vol.26 , Issue.3 , pp. 137-146
    • Mattson, M.P.1    Shea, T.B.2
  • 32
    • 1542286032 scopus 로고    scopus 로고
    • Interferon-beta treatment decreases cholesterol plasma levels in multiple sclerosis patients
    • Morra VB, Coppola G, Orefice G, De Michele G, Vacca G, Filla A, Bonavita V (2004) Interferon-beta treatment decreases cholesterol plasma levels in multiple sclerosis patients. Neurology 62:829-30 (Pubitemid 38298972)
    • (2004) Neurology , vol.62 , Issue.5 , pp. 829-830
    • Brescia, M.V.1    Coppola, G.2    Orefice, G.3    De Michele, G.4    Vacca, G.5    Filla, A.6    Bonavita, V.7
  • 34
    • 0028788020 scopus 로고
    • Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study
    • Nygård O, Vollset SE, Refsum H (1995) Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 274(19):1526-1533
    • (1995) JAMA , vol.274 , Issue.19 , pp. 1526-1533
    • Nygård, O.1    Vollset, S.E.2    Refsum, H.3
  • 35
    • 0031692918 scopus 로고    scopus 로고
    • Homocysteine stimulates the production and secretion of cholesterol in hepatic cells
    • O K Lynn EG, Chung YH, Siow YL, Man RY, Choy PC (1998) Homocysteine stimulates the production and secretion of cholesterol in hepatic cells. Biochim Biophys Acta 1393:317-24
    • (1998) Biochim Biophys Acta , vol.1393 , pp. 317-324
    • K, O.1    Lynn, E.G.2    Chung, Y.H.3    Siow, Y.L.4    Man, R.Y.5    Choy, P.C.6
  • 36
    • 33646747001 scopus 로고    scopus 로고
    • Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia
    • DOI 10.1016/j.febslet.2006.04.088, PII S001457930600545X
    • Obeid R, Hermann W (2006) Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 580:2994-3005 (Pubitemid 43744523)
    • (2006) FEBS Letters , vol.580 , Issue.13 , pp. 2994-3005
    • Obeid, R.1    Herrmann, W.2
  • 37
    • 84868288658 scopus 로고    scopus 로고
    • Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
    • Ortega-Azorin C, Sorli JV, Asensio EM et al (2012) Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol 11:137
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 137
    • Ortega-Azorin, C.1    Sorli, J.V.2    Asensio, E.M.3
  • 38
    • 38549106012 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis
    • Russo C, Morabito F, Luise F et al (2008) Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis. J Neurol 255:64-9
    • (2008) J Neurol , vol.255 , pp. 64-69
    • Russo, C.1    Morabito, F.2    Luise, F.3
  • 39
    • 72949117252 scopus 로고    scopus 로고
    • Have we finally identified an autoimmune demyelinating disease?
    • Rodriquez M (2009) Have we finally identified an autoimmune demyelinating disease? Ann Neurol 66:572-573
    • (2009) Ann Neurol , vol.66 , pp. 572-573
    • Rodriquez, M.1
  • 40
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19:217-46
    • (1999) Annu Rev Nutr , vol.19 , pp. 217-246
    • Selhub, J.1
  • 41
    • 84863895902 scopus 로고    scopus 로고
    • Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis
    • Shirani A, Zhao Y, Karim ME, Evans C, Kingwell E, van der Kop ML, Tremlett H (2012) Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis. JAMA 308(3):247-256
    • (2012) JAMA , vol.308 , Issue.3 , pp. 247-256
    • Shirani, A.1    Zhao, Y.2    Karim, M.E.3    Evans, C.4    Kingwell, E.5    Van Der Kop, M.L.6    Tremlett, H.7
  • 43
    • 84871361581 scopus 로고    scopus 로고
    • Fasting time and lipid levels in a community-based population: A cross-sectional study
    • Sidhu D, Naugler C (2012) Fasting time and lipid levels in a community-based population: a cross-sectional study. Arch Intern Med 172: 1707-10
    • (2012) Arch Intern Med , vol.172 , pp. 1707-1710
    • Sidhu, D.1    Naugler, C.2
  • 45
    • 39049177338 scopus 로고    scopus 로고
    • Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis
    • van Rensburg SJ, Kotze MJ, Hon D et al (2006) Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis. Metab Brain Dis 21:121-37
    • (2006) Metab Brain Dis , vol.21 , pp. 121-137
    • Van Rensburg, S.J.1    Kotze, M.J.2    Hon, D.3
  • 46
    • 78349270885 scopus 로고    scopus 로고
    • The controversy of CCSVI and iron in multiple sclerosis Is ferritin the key?
    • van Rensburg SJ, van Toorn R (2010) The controversy of CCSVI and iron in multiple sclerosis Is ferritin the key? Neurology 75(18):1581-1582
    • (2010) Neurology , vol.75 , Issue.18 , pp. 1581-1582
    • Van Rensburg, S.J.1    Van Toorn, R.2
  • 49
    • 84877753918 scopus 로고    scopus 로고
    • Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia
    • Zappacosta B, Mastroiacovo P, Persichilli S et al (2013) Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia. Nutrients 5:1531-43
    • (2013) Nutrients , vol.5 , pp. 1531-1543
    • Zappacosta, B.1    Mastroiacovo, P.2    Persichilli, S.3
  • 50
    • 84894599601 scopus 로고    scopus 로고
    • Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases
    • Zheng G, Dahl JA, Niu Y, Fu Y, Klungland A, Yang YG, He C (2013) Sprouts of RNA epigenetics: The discovery of mammalian RNA demethylases. RNA Biol 10(6):915-8
    • (2013) RNA Biol , vol.10 , Issue.6 , pp. 915-918
    • Zheng, G.1    Dahl, J.A.2    Niu, Y.3    Fu, Y.4    Klungland, A.5    Yang, Y.G.6    He, C.7
  • 51
    • 79958127988 scopus 로고    scopus 로고
    • Meta-analysis of the relationship between homocysteine, vitamin B(1)(2), folate, and multiple sclerosis
    • Zhu Y, He ZY, Liu HN (2011) Meta-analysis of the relationship between homocysteine, vitamin B(1)(2), folate, and multiple sclerosis. J Clin Neurosci 18:933-8
    • (2011) J Clin Neurosci , vol.18 , pp. 933-938
    • Zhu, Y.1    He, Z.Y.2    Liu, H.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.