Homocysteine induces inflammatory transcriptional signaling in monocytes

Frontiers in Bioscience

Volumn 18, Issue 2, 2013, Pages 685-695

  Meng, Shu ^a   Ciment, Stephen ^a   Jan, Michael ^a   Tran, Tran ^a   Pham, Hung ^a   Cueto, Ramon ^a   Yang, Xiao Feng ^a   Wang, Hong ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene Expression; Homocysteine; Inflammation; Monocyte Differentiation; Transcription Factor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HOMOCYSTEINE; INTERLEUKIN 10; TRANSCRIPTION FACTOR;

ARTICLE; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; HYPERHOMOCYSTEINEMIA; METABOLISM; MONOCYTE; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CYTOKINES; GENE EXPRESSION REGULATION; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INTERFERON-GAMMA; INTERLEUKIN-10; MONOCYTES; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MLCS; MLOWN;

EID: 84878810018     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4131     Document Type: Article

References (53)

1. B. A. Maron and J. Loscalzo: The treatment of hyperhomocysteinemia. Annu Rev Med, 60, 39-54 (2009)
2. M. D. Jamaluddin, I. Chen, F. Yang, X. Jiang, M. Jan, X. Liu, A. I. Schafer, W. Durante, X. Yang and H. Wang: Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene. Blood, 110(10), 3648-55 (2007) (Pubitemid 350159633)
3. C. J. Boushey, S. A. Beresford, G. S. Omenn and A. G. Motulsky: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Jama, 274(13), 1049-57 (1995)
4. J. Joseph, D. E. Handy and J. Loscalzo: Quo vadis: whither homocysteine research? Cardiovasc Toxicol, 9(2), 53-63 (2009)
5. Q. Yang, L. D. Botto, J. D. Erickson, R. J. Berry, C. Sambell, H. Johansen and J. M. Friedman: Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation, 113(10), 1335-43 (2006) (Pubitemid 43739455)
6. G. Saposnik, J. G. Ray, P. Sheridan, M. McQueen and E. Lonn: Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke, 40(4), 1365-72 (2009)
7. H. Wang, X. Jiang, F. Yang, J. W. Gaubatz, L. Ma, M. J. Magera, X. Yang, P. B. Berger, W. Durante, H. J. Pownall and A. I. Schafer: Hyperhomocysteinemia accelerates atherosclerosis in cystathionine betasynthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood, 101(10), 3901-7 (2003)
8. M. A. Hofmann, E. Lalla, Y. Lu, M. R. Gleason, B. M. Wolf, N. Tanji, L. J. Ferran, Jr., B. Kohl, V. Rao, W. Kisiel, D. M. Stern and A. M. Schmidt: Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest, 107(6), 675-83 (2001) (Pubitemid 32225353)
9. J. Zhou, J. Moller, C. C. Danielsen, J. Bentzon, H. B. Ravn, R. C. Austin and E. Falk: Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice. Arterioscler Thromb Vasc Biol, 21(9), 1470-6 (2001)
10. H. Wang, X. Jiang, F. Yang, G. B. Chapman, W. Durante, N. E. Sibinga and A. I. Schafer: Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition. Blood, 99(3), 939-45 (2002) (Pubitemid 34525556)
11. H. Tan, X. Jiang, F. Yang, Z. Li, D. Liao, J. Trial, M. J. Magera, W. Durante, X. Yang and H. Wang: Hyperhomocysteinemia inhibits post-injury reendothelialization in mice. Cardiovasc Res, 69(1), 253-62 (2006) (Pubitemid 41818973)
12. J. C. Tsai, H. Wang, M. A. Perrella, M. Yoshizumi, N. E. Sibinga, L. C. Tan, E. Haber, T. H. Chang, R. Schlegel and M. E. Lee: Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest, 97(1), 146-53 (1996) (Pubitemid 26021705)
13. D. Zhang, X. Jiang, P. Fang, Y. Yan, J. Song, S. Gupta, A. I. Schafer, W. Durante, W. D. Kruger, X. Yang and H. Wang: Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation, 120(19), 1893-902 (2009)
14. E. Galkina and K. Ley: Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol, 27, 165-97 (2009)
15. P. A. Outinen, S. K. Sood, S. I. Pfeifer, S. Pamidi, T. J. Podor, J. Li, J. I. Weitz and R. C. Austin: Homocysteineinduced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood, 94(3), 959-67 (1999) (Pubitemid 29361827)
16. H. Li and M. S. Goligorsky: Endothelial gene responses to homocysteine: relation to atherosclerosis. Exp Nephrol, 10(2), 164-9 (2002) (Pubitemid 34293684)
17. G. Wang and K. O: Homocysteine stimulates the expression of monocyte chemoattractant protein-1 receptor (CCR2) in human monocytes: possible involvement of oxygen free radicals. Biochem J, 357(Pt 1), 233-40 (2001) (Pubitemid 32642921)
18. S. J. Su, L. W. Huang, L. S. Pai, H. W. Liu and K. L. Chang: Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression. Nutrition, 21(10), 994-1002 (2005)
19. X. Zeng, J. Dai, D. G. Remick and X. Wang: Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res, 93(4), 311-20 (2003) (Pubitemid 37048243)
20. Y. S. Xiong, Y. H. Zhou, G. H. Rong, W. L. Wu, Y. Liang, Z. X. Yang, H. L. Geng and R. Q. Zhong: Siglec-1 on monocytes is a potential risk marker for monitoring disease severity in coronary artery disease. Clin Biochem, 42(10-11), 1057-63 (2009)
21. J. Dai, X. Wang, J. Feng, W. Kong, Q. Xu, X. Shen and X. Wang: Regulatory role of thioredoxin in homocysteineinduced monocyte chemoattractant protein-1 secretion in monocytes/macrophages. FEBS Lett, 582(28), 3893-8 (2008)
22. X. F. Yang, P. Fang, S. Meng, M. Jan, X. Xiong, Y. Yin and H. Wang: The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Front Biosci (Schol Ed), 1, 420-36 (2009)
23. V. Matys, E. Fricke, R. Geffers, E. Gossling, M. Haubrock, R. Hehl, K. Hornischer, D. Karas, A. E. Kel, O. V. Kel-Margoulis, D. U. Kloos, S. Land, B. Lewicki- Potapov, H. Michael, R. Munch, I. Reuter, S. Rotert, H. Saxel, M. Scheer, S. Thiele and E. Wingender: TRANSFAC: transcriptional regulation, from patterns to profiles. Nucleic Acids Res, 31(1), 374-8 (2003) (Pubitemid 36150406)
24. N. Ide, C. Keller and N. Weiss: Aged garlic extract inhibits homocysteine-induced CD36 expression and foam cell formation in human macrophages. J Nutr, 136(3 Suppl), 755S-758S (2006) (Pubitemid 43372206)
25. T. Musso, I. Espinoza-Delgado, K. Pulkki, G. L. Gusella, D. L. Longo and L. Varesio: IL-2 induces IL-6 production in human monocytes. J Immunol, 148(3), 795-800 (1992)
26. G. L. Gusella, T. Musso, M. C. Bosco, I. Espinoza-Delgado, K. Matsushima and L. Varesio: IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes. J Immunol, 151(5), 2725-32 (1993) (Pubitemid 23264524)
27. M. R. Alderson, T. W. Tough, S. F. Ziegler and K. H. Grabstein: Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med, 173(4), 923- 30 (1991)
28. T. J. Standiford, R. M. Strieter, R. M. Allen, M. D. Burdick and S. L. Kunkel: IL-7 up-regulates the expression of IL-8 from resting and stimulated human blood monocytes. J Immunol, 149(6), 2035-9 (1992)
29. R. Badolato, A. N. Ponzi, M. Millesimo, L. D. Notarangelo and T. Musso: Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood, 90(7), 2804-9 (1997)
30. A. J. Puren, G. Fantuzzi, Y. Gu, M. S. Su and C. A. Dinarello: Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells. J Clin Invest, 101(3), 711-21 (1998) (Pubitemid 28084257)
31. M. M. Jost, E. Ninci, B. Meder, C. Kempf, N. Van Royen, J. Hua, B. Berger, I. Hoefer, M. Modolell and I. Buschmann: Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity, MCP-1 expression, and matrix metalloproteinase-12: a potential role during arteriogenesis. Faseb J, 17(15), 2281-3 (2003) (Pubitemid 39561466)
32. H. A. Schulze, R. Hasler, N. Mah, T. Lu, S. Nikolaus, C. M. Costello and S. Schreiber: From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD. Genes Immun, 9(3), 240-8 (2008) (Pubitemid 351584190)
33. X. Hu, K. H. Park-Min, H. H. Ho and L. B. Ivashkiv: IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFNgamma responses mediated by Stat1. J Immunol, 175(6), 3637-47 (2005) (Pubitemid 41292023)
34. J. Schug: Using TESS to predict transcription factor binding sites in DNA sequence. Curr Protoc Bioinformatics, Chapter 2, Unit 2 6 (2008)
35. N. C. Chen, F. Yang, L. M. Capecci, Z. Gu, A. I. Schafer, W. Durante, X. F. Yang and H. Wang: Regulation of homocysteine metabolism and methylation in human and mouse tissues. Faseb J, 24(8), 2804-17
36. M. R. Alderson, R. J. Armitage, T. W. Tough, L. Strockbine, W. C. Fanslow and M. K. Spriggs: CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med, 178(2), 669-74 (1993) (Pubitemid 23218216)
37. R. E. Curiel, C. S. Garcia, S. Rottschafer, M. C. Bosco and I. Espinoza-Delgado: Enhanced B7-2 gene expression by interferon-gamma in human monocytic cells is controlled through transcriptional and posttranscriptional mechanisms. Blood, 94(5), 1782-9 (1999)
38. S. Ouellet, E. Muller and M. Rola-Pleszczynski: IFNgamma up-regulates platelet-activating factor receptor gene expression in human monocytes. J Immunol, 152(10), 5092-9 (1994)
39. R. C. Strunk, F. S. Cole, D. H. Perlmutter and H. R. Colten: gamma-Interferon increases expression of class III complement genes C2 and factor B in human monocytes and in murine fibroblasts transfected with human C2 and factor B genes. J Biol Chem, 260(28), 15280-5 (1985)
40. P. E. Newburger, R. A. Ezekowitz, C. Whitney, J. Wright and S. H. Orkin: Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma. Proc Natl Acad Sci U S A, 85(14), 5215-9 (1988)
41. K. C. Wilson and D. S. Finbloom: Interferon gamma rapidly induces in human monocytes a DNA-binding factor that recognizes the gamma response region within the promoter of the gene for the high-affinity Fc gamma receptor. Proc Natl Acad Sci U S A, 89(24), 11964-8 (1992)
42. L. Williams, G. Jarai, A. Smith and P. Finan: IL-10 expression profiling in human monocytes. J Leukoc Biol, 72(4), 800-9 (2002) (Pubitemid 36277852)
43. R. Kleemann, S. Zadelaar and T. Kooistra: Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc Res, 79(3), 360-76 (2008)
44. C. Auffray, M. H. Sieweke and F. Geissmann: Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol, 27, 669-92 (2009)
45. C. Varol, S. Yona and S. Jung: Origins and tissuecontext- dependent fates of blood monocytes. Immunol Cell Biol, 87(1), 30-8 (2009)
46. S. Gordon and P. R. Taylor: Monocyte and macrophage heterogeneity. Nat Rev Immunol, 5(12), 953-64 (2005) (Pubitemid 41746764)
47. P. Zill, R. Engel, T. C. Baghai, G. Juckel, T. Frodl, F. Muller-Siecheneder, P. Zwanzger, C. Schule, C. Minov, S. Behrens, R. Rupprecht, U. Hegerl, H. J. Moller and B. Bondy: Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. Neuropsychopharmacology, 26(4), 489-93 (2002) (Pubitemid 34260998)
48. H. Noels, J. Bernhagen and C. Weber: Macrophage migration inhibitory factor: a noncanonical chemokine important in atherosclerosis. Trends Cardiovasc Med, 19(3), 76-86 (2009)
49. J. Yideng, L. Zhihong, X. Jiantuan, C. Jun, L. Guizhong and W. Shuren: Homocysteine-mediated PPARalpha,gamma DNA methylation and its potential pathogenic mechanism in monocytes. DNA Cell Biol, 27(3), 143-50 (2008) (Pubitemid 351457770)
50. N. Marx, H. Duez, J. C. Fruchart and B. Staels: Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ Res, 94(9), 1168-78 (2004) (Pubitemid 38656403)
51. D. T. Holloway, M. Kon and C. DeLisi: Integrating genomic data to predict transcription factor binding. Genome Inform, 16(1), 83-94 (2005)
52. C. Argyropoulos, G. C. Nikiforidis, M. Theodoropoulou, P. Adamopoulos, S. Boubali, T. N. Georgakopoulos, F. Paliogianni, A. G. Papavassiliou and A. Mouzaki: Mining microarray data to identify transcription factors expressed in naive resting but not activated T lymphocytes. Genes Immun, 5(1), 16-25 (2004) (Pubitemid 38967625)
53. X. F. Yang, D. Mirkovic, S. Zhang, Q. E. Zhang, Y. Yan, Z. Xiong, F. Yang, I. H. Chen, L. Li and H. Wang: Processing sites are different in the generation of HLAA2.1- restricted, T cell reactive tumor antigen epitopes and viral epitopes. Int J Immunopathol Pharmacol, 19(4), 853- 70 (2006) (Pubitemid 46145049)