메뉴 건너뛰기




Volumn 5, Issue 5, 2013, Pages 1531-1543

Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia

Author keywords

5 MTHF; Clinical trial; Folate rich diet; Folic acid; Homocysteine; MTHFR genotype

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYTOSINE; FOLIC ACID; HOMOCYSTEINE; PLACEBO; THYMINE;

EID: 84877753918     PISSN: 20726643     EISSN: None     Source Type: Journal    
DOI: 10.3390/nu5051531     Document Type: Article
Times cited : (59)

References (27)
  • 1
    • 79955862230 scopus 로고    scopus 로고
    • Homocysteine and vascular disease: Review of published results of the homocysteine-lowering trials
    • Clarke, R.; Halsey, J.; Bennett, D.; Lewington, S. Homocysteine and vascular disease: Review of published results of the homocysteine-lowering trials. J. Inherit. Metab. Dis. 2011, 34, 83-91.
    • (2011) J. Inherit. Metab. Dis , vol.34 , pp. 83-91
    • Clarke, R.1    Halsey, J.2    Bennett, D.3    Lewington, S.4
  • 2
    • 78650634569 scopus 로고    scopus 로고
    • B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: A systematic review
    • Dangour, A.D.; Withouse, P.J.; Rafferty, K.; Mitchell, S.A.; Smith, L.; Hawkesworth, S.; Vellas, B. B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: A systematic review. J. Alzheimers Dis. 2010, 22, 205-224.
    • (2010) J. Alzheimers Dis , vol.22 , pp. 205-224
    • Dangour, A.D.1    Withouse, P.J.2    Rafferty, K.3    Mitchell, S.A.4    Smith, L.5    Hawkesworth, S.6    Vellas, B.7
  • 3
    • 77952990224 scopus 로고    scopus 로고
    • Effect of folic acid, with or without other B vitamins, on cognitive disorders: Meta-analysis of randomized trials
    • Wald, D.S.; Kasturiratne, A.; Simmonds, M. Effect of folic acid, with or without other B vitamins, on cognitive disorders: Meta-analysis of randomized trials. Am. J. Med. 2010, 123, 522-527e2.
    • (2010) Am. J. Med , vol.123
    • Wald, D.S.1    Kasturiratne, A.2    Simmonds, M.3
  • 4
    • 34250197957 scopus 로고    scopus 로고
    • Folate and colorectal cancer: An evidence based critical review
    • Kim, Y.I. Folate and colorectal cancer: An evidence based critical review. Mol. Nutr. Food Res. 2007, 51, 267-292.
    • (2007) Mol. Nutr. Food Res , vol.51 , pp. 267-292
    • Kim, Y.I.1
  • 6
    • 84855439245 scopus 로고    scopus 로고
    • Effects and safety of periconceptional folate supplementation for preventing birth defects
    • doi:10.1002/14651858.CD007950.pub2
    • De-Regie, L.M.; Fernandez-Gaxiola, A.C.; Donswell, T.; Pena-Rosas, J.P. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst. Rev. 2010, CD007950, doi:10.1002/14651858.CD007950.pub2.
    • (2010) Cochrane Database Syst. Rev
    • De-Regie, L.M.1    Fernandez-Gaxiola, A.C.2    Donswell, T.3    Pena-Rosas, J.P.4
  • 7
    • 48249134365 scopus 로고    scopus 로고
    • Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant and child development
    • Molloy, A.M.; Kirke, P.N.; Brody, L.C.; Scott, J.M.; Mills, J.L. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant and child development. Food Nutr. Bull. 2008, 29 (2 Suppl.), S101-S111.
    • (2008) Food Nutr. Bull , vol.29 , Issue.2 SUPPL.
    • Molloy, A.M.1    Kirke, P.N.2    Brody, L.C.3    Scott, J.M.4    Mills, J.L.5
  • 10
    • 0032987543 scopus 로고    scopus 로고
    • Patterns of food and nutrient intakes in Italy and their application to the development of food-based dietary guidelines
    • Turrini, A.; Leclercq, C.; D'Amicis, A. Patterns of food and nutrient intakes in Italy and their application to the development of food-based dietary guidelines. Br. J. Nutr. 1999, 81 (Suppl. 2), S83-S89.
    • (1999) Br. J. Nutr , vol.81 , Issue.2 SUPPL.
    • Turrini, A.1    Leclercq, C.2    D'amicis, A.3
  • 12
    • 0023628783 scopus 로고
    • Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detector
    • Araki, A.; Sako, Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detector. J. Chromatogr. 1987, 422, 43-52.
    • (1987) J. Chromatogr , vol.422 , pp. 43-52
    • Araki, A.1    Sako, Y.2
  • 13
    • 0032824284 scopus 로고    scopus 로고
    • Prevalence of mild hyperhomocisteinemia and association with thrombophilic genotypes (Factor V Leiden and factor II G20210A) in Italian patients with venous thromboembolic disease
    • De Stefano, V.; Zappacosta, B.; Persichilli, S.; Rossi, E.; Casorelli, I.; Paciaroni, K.; Chiusolo, P.; Leone, A.M.; Giardina, B.; Leone, G. et al. Prevalence of mild hyperhomocisteinemia and association with thrombophilic genotypes (Factor V Leiden and factor II G20210A) in Italian patients with venous thromboembolic disease. Br. J. Haematol. 1999, 106, 564-568.
    • (1999) Br. J. Haematol , vol.106 , pp. 564-568
    • de Stefano, V.1    Zappacosta, B.2    Persichilli, S.3    Rossi, E.4    Casorelli, I.5    Paciaroni, K.6    Chiusolo, P.7    Leone, A.M.8    Giardina, B.9    Leone, G.10    Et al.11
  • 14
    • 0033634904 scopus 로고    scopus 로고
    • Erythrocyte folate analysis: Saponin added during lysis of whole blood can increase apparent folate concentrations, depending on hemolysate pH
    • Wright, A.J.A.; Finglas, P.M.; Southon, S. Erythrocyte folate analysis: Saponin added during lysis of whole blood can increase apparent folate concentrations, depending on hemolysate pH. Clin. Chem. 2000, 46, 1978-1986.
    • (2000) Clin. Chem , vol.46 , pp. 1978-1986
    • Wright, A.J.A.1    Finglas, P.M.2    Southon, S.3
  • 16
    • 0036156638 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women
    • Fohr, I.P.; Prinz-Langenohl, R.; Brönstrup, A.; Bohlmann, A.M.; Nau, H.; Berthold, H.K.; Pietrzik, K. 5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women. Am. J. Clin. Nutr. 2002, 75, 275-282.
    • (2002) Am. J. Clin. Nutr , vol.75 , pp. 275-282
    • Fohr, I.P.1    Prinz-Langenohl, R.2    Brönstrup, A.3    Bohlmann, A.M.4    Nau, H.5    Berthold, H.K.6    Pietrzik, K.7
  • 17
    • 0037371082 scopus 로고    scopus 로고
    • Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: A randomized placebo-controlled study
    • Venn, B.J.; Green, T.J.; Moser, R.; Mann, J.I. Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: A randomized placebo-controlled study. Am. J. Clin. Nutr. 2003, 77, 658-662.
    • (2003) Am. J. Clin. Nutr , vol.77 , pp. 658-662
    • Venn, B.J.1    Green, T.J.2    Moser, R.3    Mann, J.I.4
  • 18
    • 71649105130 scopus 로고    scopus 로고
    • 5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase
    • Prinz-Langenohl, R.; Brämswig, S.; Tobolski, O.; Smulders, Y.M.; Smith, D.E.C.; Finglas, P.M.; Pietrzik, K. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase. Br. J. Pharmacol. 2009, 158, 2014-2021.
    • (2009) Br. J. Pharmacol , vol.158 , pp. 2014-2021
    • Prinz-Langenohl, R.1    Brämswig, S.2    Tobolski, O.3    Smulders, Y.M.4    Smith, D.E.C.5    Finglas, P.M.6    Pietrzik, K.7
  • 20
    • 0029967412 scopus 로고    scopus 로고
    • Effect of increasing dietary folate on red-cell folate: Implications for prevention of neural tube defects
    • Cuskelly, G.J.; McNulty, H.; Scott, J.M. Effect of increasing dietary folate on red-cell folate: Implications for prevention of neural tube defects. Lancet 1996, 347, 657-659.
    • (1996) Lancet , vol.347 , pp. 657-659
    • Cuskelly, G.J.1    McNulty, H.2    Scott, J.M.3
  • 21
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homocysteine with folic acid-based supplements: Meta-analysis of randomised trials
    • Homocysteine Lowering Trialists' Collaboration
    • Homocysteine Lowering Trialists' Collaboration. Lowering blood homocysteine with folic acid-based supplements: Meta-analysis of randomised trials. BMJ 1998, 316, 894-898.
    • (1998) BMJ , vol.316 , pp. 894-898
  • 23
    • 0030750822 scopus 로고    scopus 로고
    • Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid
    • Ward, M.; McNulty, H.; McPartlin, J.; Strain, J.J.; Weir, D.G.; Scott, J.M. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Quart. J. Med. 1997, 90, 519-524.
    • (1997) Quart J. Med , vol.90 , pp. 519-524
    • Ward, M.1    McNulty, H.2    McPartlin, J.3    Strain, J.J.4    Weir, D.G.5    Scott, J.M.6
  • 24
    • 0035993861 scopus 로고    scopus 로고
    • Assessment of three levels of folic acid on serum folate and plasma homocysteine: A randomised placebo-controlled double-blind dietary intervention trial
    • Venn, B.J.; Mann, J.L.; Williams, S.M.; Riddell, L.J.; Chisholm, A.; Harper, M.J.; Aitken, W.; Rossaak, J.L. Assessment of three levels of folic acid on serum folate and plasma homocysteine: A randomised placebo-controlled double-blind dietary intervention trial. Eur. J. Clin. Nutr. 2002, 56, 748-754.
    • (2002) Eur. J. Clin. Nutr , vol.56 , pp. 748-754
    • Venn, B.J.1    Mann, J.L.2    Williams, S.M.3    Riddell, L.J.4    Chisholm, A.5    Harper, M.J.6    Aitken, W.7    Rossaak, J.L.8
  • 25
    • 18444363017 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low dose folic acid supplement: A randomized controlled trial
    • Ashfield-Watt, P.A.L.; Pullin, C.H.; Whiting, J.M.; Clark, Z.E.; Moat, S.J.; Newcombe, R.G.; Burr, M.L.; Lewis, M.J.; Powers, H.J.; McDowell, I.F.W. Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low dose folic acid supplement: A randomized controlled trial. Am. J. Clin. Nutr. 2002, 76, 180-186.
    • (2002) Am. J. Clin. Nutr , vol.76 , pp. 180-186
    • Ashfield-Watt, P.A.L.1    Pullin, C.H.2    Whiting, J.M.3    Clark, Z.E.4    Moat, S.J.5    Newcombe, R.G.6    Burr, M.L.7    Lewis, M.J.8    Powers, H.J.9    McDowell, I.F.W.10
  • 26
    • 0037324282 scopus 로고    scopus 로고
    • A comparison of the effect of advice to eat either "5-a-day" fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine
    • Ashfield-Watt, P.A.L.; Whiting, J.M.; Clark, Z.E.; Moat, S.J.; Newcombe, R.G.; Burr, M.L.; McDowell, I.F.W. A comparison of the effect of advice to eat either "5-a-day" fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine. Eur. J. Clin. Nutr. 2003, 57, 316-323.
    • (2003) Eur. J. Clin. Nutr , vol.57 , pp. 316-323
    • Ashfield-Watt, P.A.L.1    Whiting, J.M.2    Clark, Z.E.3    Moat, S.J.4    Newcombe, R.G.5    Burr, M.L.6    McDowell, I.F.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.