Homocysteine levels in morbidly obese patients. Its association with waist circumference and insulin resistance

Clinical Hemorheology and Microcirculation

Volumn 52, Issue 1, 2012, Pages 49-56

  Vayá, Amparo ^a   Rivera, Leonor ^a   Hernández Mijares, Antonio ^b   De La Fuente, Miguel ^a   Solá, Eva ^b   Romagnoli, Marco ^c   Alis, R ^c   Laiz, Begoa ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b HOSPITAL UNIVERSITARIO DR PESET   (Spain)

^c UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR   (Spain)

Author keywords

Homocysteine; insulin resistance; morbid obesity; waist circumference

Indexed keywords

C REACTIVE PROTEIN; CYANOCOBALAMIN; FIBRINOGEN; FOLIC ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FIBRINOGEN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HYPERHOMOCYSTEINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MORBID OBESITY; PROTEIN BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; BLOOD GLUCOSE; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INSULIN RESISTANCE; LEPTIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY, ABDOMINAL; OBESITY, MORBID; WAIST CIRCUMFERENCE;

EID: 84866867773     PISSN: 13860291     EISSN: 18758622     Source Type: Journal    
DOI: 10.3233/CH-2012-1544     Document Type: Article

References (36)

1. Anonymous, Ethical guidelines for publication in Hemorheology and Microcirculation, Clin Hemorheol Microcirc 44 (2010), 1-2.
2. E. Bravo, S. Palleschi, P. Aspichueta, X. Buqué, B. Rossi, A. Cano, M. Napolitano, B. Ochoa and K.M. Botham, High fat diet-induced non-alcoholic fatty liver disease in rats is associated with hyperhomocysteinemia caused by down regulation of the transsulphuration pathway, Lipids Health Dis 19 (2011), 10-60.
3. P. Dandona, A. Aljada and A. Bandyopadhyay, Inflammation: The link between insulin resistance, obesity and diabetes, Trends immunol 25 (2004), 4-7.
4. G. De Pergola, N. Pannacciulli, M. Zamboni, A. Minenna, G. Brocco, M. Sciaraffia and G.R. Bosello, Homocysteine plasma levels are independently associated with insulin resistance in normal weight, overweight and obese pre-menopausalwomen, Diabetes nutr Metab 14 (2001), 253-258.
5. J.B. Dixon, M.E. Dixon and P.E. O'Brien, Elevated homocysteine levels with weight loss alter Lap-Band surgery: Higher folate and vitamin B12 levels required to maintain homocysteine level, Int J Relat Metab Disord 25 (2001), 219-227.
6. E.V. Economou, A.V. Malamitsi-Puchner, C.P. Pitsavos, E.E. Kouskouni, I. Magaziotou-Elefsinioti and G. Creatsas, Lowgrade systemic inflammation profile, unrelated to homocysteinemia, in obese children, Mediators inflamm 6 (2005), 337-342.
7. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III), JAMA 285 (2001), 2486-2497.
8. S. Gallistl, H. Sudi, H. Mangge,W. Erwa and M. Borkenstein, Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents, Diabetes care 23 (2000), 1348-1352.
9. S.M. Grundy, J.I. Cleeman, S.R. Daniels, K.A. Donato, R.H. Eckel, B.A. Franklin, D.J. Gordon, R.M. Krauss, P.J. Savage, S.C. Smith Jr., J.A. Spertus and F. Costa, American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: An American heart association/national heart, lung, and blood institute scientific statement: Executive summary, Circulation 112 (2005), 2735-2752.
10. K. Guzelmeric, N. Alkan, M. Pirimoglu, O. Unal and C. Turan, Chronic inflammation and elevated homocysteine levels are associated with increased body mass index in women with polycystic ovary syndrome, Gynecol Endocrinol 23 (2007), 505-510.
11. G.R. Hajer,Y. van der Graaf, J.K. Olijhoek, M.C.Verhaar and F.L.Visseren, SMART Study Group, Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk, in contrast to patients without the metabolic syndrome, Heart 93 (2007), 216-220.
12. P.J. Havel, Control of energy homeostasis and insulin action by adipocyte hormones: Leptin, acylation stimulating protein, and adiponectin, Curr Opin Lipidol 13 (2002), 51-59.
13. S. Hirsch, J. Poniachick, M. Avedaño, A. Csendes, P. Burdiles, G. Smok, J.C. Diaz and M.P. De la Maza, Serum folate and homocysteine levels in obese females with non-alcoholic fatty liver, Nutrition 21 (2005), 137-141.
14. E.K. Hoogeveen, P.J. Kostense, C. Jakobs, J.M. Dekker, G. Nijpels, R.J. Heine, L.M. Bouter and C.D. Stehouwer, Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study, Circulation 101 (2000), 1506-1511.
15. G. Hotamisligil, Inflammation and metabolic disorders, Nature 444 (2006), 860-867.
16. R.L. Jacobs, J.D. House, M.E. Brosnan and J.T. Brosnan, Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat, Diabetes 47 (1998), 1967-1970.
17. S. Ledoux, M. Coupaye, C. Bogard, C. Clerici and S. Msika, Determinants of hyperhomocysteinemia alter gastric bypass surgery in obese subjects, Obes Surg 21 (2011), 78-86.
18. R. Martos, M. Valle, R. Morales, R. Cañete, M.I. Gavilan and V. Sanchez-Margalet, Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepuberal children, Metabolism 55 (2006), 72-77.
19. T. Masaki, F. Anan, M. Anai, K. Higuchi, T. Tsubone, K. Gotoh, C. Seiichi, I. Katsugari, K. Tanaka, T. Kakuma and H. Yoshimatsu, Hyperhomocysteinemia is associated with visceral adiposity in Japanese patients with type 2 diabetes mellitus, Diabetes Res Clin Pract 77 (2007), 168-173.
20. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher and R.C. Turner, Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia 28 (1985), 412-419.
21. J.B. Meigs, P.F. Jacques, J. Selhub, D.E. Singer, D.M. Nathan, N. Rifai, R.B. D'Agostino Sr. and P.W.Wilson, Framingham Offspring Study. Fasting plasma homocysteine levels in the insulin resistance syndrome: The Framingham offspring study, Diabetes Care 24 (2001), 1403-1410.
22. F. Narin, M.E. Atabek, M. Karakukcu, N. Narin, S. Kurtoglu, H. Gumus, B. Coksevim and R. Erez, The association of plasma homocysteine levels with serum leptin and apolipoprotein B levels in childhood obesity, Ann Saudi Med 25 (2005), 209-214.
23. A.F. Perna, I. Sepe, D. Lanza, R.M. Pollastro, N.G. De Santo and D. Ingrosso, Hyperhomocysteinemia in chronic renal failure: Alternative therapeutic strategies, J Ren Nutr 22 (2012), 191-194.
24. P. Poirier, T.D. Giles, G.A. Bray, Y. Hong, J.S. Stern, F.X. Pi-Sunyer and R.H. Eckel, American Heart Association; Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. "Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism", Circulation 113 (2006), 898-918.
25. C.M. Rondinone, Adipocyte-derived hormones, cytokines, and mediators, Endocrine 29 (2006), 81-90.
26. J. Selhub, Homocysteine metabolism, Annu Rev Nutr 19 (1999), 217-246.
27. S. Semiz, S. Rota, O. Ozdemir, A. Ozdemir and B. Kaptanoǧlu, Are C-reactive protein and homocysteine cardiovascular risk factors in obese children and adolescents? Pediatr Int 50 (2008), 419-423.
28. W.H.-H. Sheu, H.-S.Wu, C.-W.Wang, C.-J.Wan andW.-J. Lee, Elevated plasma homocysteine concentrations six months alter gastroplasty in morbidly obese subjetcts, Intern Med 40 (2001), 584-588.
29. P. Singla, A. Bardoloi and A.A. Parkash, Metabolic effects of obesity: A review, World J Diabetes 15 (2010), 76-88.
30. O. Uysal, E. Arikan and B. Cakir, Plasma total homocysteine level and its association with carotid intima-media thickness in obesity, J Endocrinol Invest 28 (2005), 928-934.
31. C. Van Guldener and K. Robinson, Homocysteine and renal disease, Semin Thromb Hemost 26 (2000), 313-324.
32. G. Varela-Moreiras, M.M. Murphy and J.M. Scott, Cobalamin, folic acid and homocysteine, Nutr Rev 67(Suppl 1) (2009), S69-S72.
33. A. Vayá, R. Cámara, A. Hernández-Mijares, M. Romagnoli, E. Solá, D. Corella and B. Laiz, Erythrocyte deformability in morbid obesity before bariatric surgery. Influence of abdominal obesity, Clin Hemorheol Microcirc 46 (2010), 313-320.
34. A. Vayá, P. Carmona, N. Badia, R. Pérez, A. Hernández-Mijares and D. Corella, Homocysteine levels and the metabolic syndrome in a Mediterranean population: A case-control study, Clin Hemorheol Microcirc 47 (2011), 59-66.
35. A. Vayá, A. Hernández-Mijares, M. Suescun, E. Solá, R. Cámara, M. Romagnoli, D. Bautista and B. Laiz, Metabolic alterations in morbid obesity. Influence on haemorheological profile, Clin Hemorheol Microcirc 48 (2011), 247-255.
36. G.N. Welch and J. Loscalzo, Homocysteine and atherothrombosis, N Engl J Med 338 (1998), 1042-1050.