메뉴 건너뛰기




Volumn 99, Issue 3, 2012, Pages 132-137

Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

Author keywords

BMI; Children; Demethylase; Genetics; Leukocytes; Lymphocytes

Indexed keywords

ADOLESCENT; ALLELE; ARTICLE; BCAS3 GENE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEXI GENE; DNA METHYLATION; EPIGENETICS; FEMALE; FTO GENE; GENE FUNCTION; GENE IDENTIFICATION; GENE PRODUCT; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; KARS GENE; MSI1 GENE; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; STON1 GENE; TERF2IP GENE;

EID: 84857503338     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2011.12.007     Document Type: Article
Times cited : (126)

References (50)
  • 1
    • 0030843960 scopus 로고    scopus 로고
    • Genetic and environmental factors in relative body weight and human adiposity
    • Maes H.H., Neale M.C., Eaves L.J. Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 1997, 27:325-351.
    • (1997) Behav. Genet. , vol.27 , pp. 325-351
    • Maes, H.H.1    Neale, M.C.2    Eaves, L.J.3
  • 2
    • 59149105634 scopus 로고    scopus 로고
    • A supersized list of obesity genes
    • Hofker M., Wijmenga C. A supersized list of obesity genes. Nat. Genet. 2009, 41:139-140.
    • (2009) Nat. Genet. , vol.41 , pp. 139-140
    • Hofker, M.1    Wijmenga, C.2
  • 3
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes E.K., Willer C.J., Berndt S.I., Monda K.L., Thorleifsson G., Jackson A.U., Allen H.L., Lindgren C.M., Luan J., Magi R., Randall J.C., Vedantam S., Winkler T.W., Qi L., Workalemahu T., Heid I.M., Steinthorsdottir V., Stringham H.M., Weedon M.N., Wheeler E., Wood A.R., Ferreira T., Weyant R.J., Segre A.V., Estrada K., Liang L., Nemesh J., Park J.H., Gustafsson S., Kilpelainen T.O., Yang J., Bouatia-Naji N., Esko T., Feitosa M.F., Kutalik Z., Mangino M., Raychaudhuri S., Scherag A., Smith A.V., Welch R., Zhao J.H., Aben K.K., Absher D.M., Amin N., Dixon A.L., Fisher E., Glazer N.L., Goddard M.E., Heard-Costa N.L., Hoesel V., Hottenga J.J., Johansson A., Johnson T., Ketkar S., Lamina C., Li S., Moffatt M.F., Myers R.H., Narisu N., Perry J.R., Peters M.J., Preuss M., Ripatti S., Rivadeneira F., Sandholt C., Scott L.J., Timpson N.J., Tyrer J.P., van Wingerden S., Watanabe R.M., White C.C., Wiklund F., Barlassina C., Chasman D.I., Cooper M.N., Jansson J.O., Lawrence R.W., Pellikka N., Prokopenko I., Shi J., Thiering E., Alavere H., Alibrandi M.T., Almgren P., Arnold A.M., Aspelund T., Atwood L.D., Balkau B., Balmforth A.J., Bennett A.J., Ben-Shlomo Y., Bergman R.N., Bergmann S., Biebermann H., Blakemore A.I., Boes T., Bonnycastle L.L., Bornstein S.R., Brown M.J., Buchanan T.A., Busonero F., Campbell H., Cappuccio F.P., Cavalcanti-Proenca C., Chen Y.D., Chen C.M., Chines P.S., Clarke R., Coin L., Connell J., Day I.N., den Heijer M., Duan J., Ebrahim S., Elliott P., Elosua R., Eiriksdottir G., Erdos M.R., Eriksson J.G., Facheris M.F., Felix S.B., Fischer-Posovszky P., Folsom A.R., Friedrich N., Freimer N.B., Fu M., Gaget S., Gejman P.V., Geus E.J., Gieger C., Gjesing A.P., Goel A., Goyette P., Grallert H., Grassler J., Greenawalt D.M., Groves C.J., Gudnason V., Guiducci C., Hartikainen A.L., Hassanali N., Hall A.S., Havulinna A.S., Hayward C., Heath A.C., Hengstenberg C., Hicks A.A., Hinney A., Hofman A., Homuth G., Hui J., Igl W., Iribarren C., Isomaa B., Jacobs K.B., Jarick I., Jewell E., John U., Jorgensen T., Jousilahti P., Jula A., Kaakinen M., Kajantie E., Kaplan L.M., Kathiresan S., Kettunen J., Kinnunen L., Knowles J.W., Kolcic I., Konig I.R., Koskinen S., Kovacs P., Kuusisto J., Kraft P., Kvaloy K., Laitinen J., Lantieri O., Lanzani C., Launer L.J., Lecoeur C., Lehtimaki T., Lettre G., Liu J., Lokki M.L., Lorentzon M., Luben R.N., Ludwig B., Manunta P., Marek D., Marre M., Martin N.G., McArdle W.L., McCarthy A., McKnight B., Meitinger T., Melander O., Meyre D., Midthjell K., Montgomery G.W., Morken M.A., Morris A.P., Mulic R., Ngwa J.S., Nelis M., Neville M.J., Nyholt D.R., O'Donnell C.J., O'Rahilly S., Ong K.K., Oostra B., Pare G., Parker A.N., Perola M., Pichler I., Pietilainen K.H., Platou C.G., Polasek O., Pouta A., Rafelt S., Raitakari O., Rayner N.W., Ridderstrale M., Rief W., Ruokonen A., Robertson N.R., Rzehak P., Salomaa V., Sanders A.R., Sandhu M.S., Sanna S., Saramies J., Savolainen M.J., Scherag S., Schipf S., Schreiber S., Schunkert H., Silander K., Sinisalo J., Siscovick D.S., Smit J.H., Soranzo N., Sovio U., Stephens J., Surakka I., Swift A.J., Tammesoo M.L., Tardif J.C., Teder-Laving M., Teslovich T.M., Thompson J.R., Thomson B., Tonjes A., Tuomi T., van Meurs J.B., van Ommen G.J., Vatin V., Viikari J., Visvikis-Siest S., Vitart V., Vogel C.I., Voight B.F., Waite L.L., Wallaschofski H., Walters G.B., Widen E., Wiegand S., Wild S.H., Willemsen G., Witte D.R., Witteman J.C., Xu J., Zhang Q., Zgaga L., Ziegler A., Zitting P., Beilby J.P., Farooqi I.S., Hebebrand J., Huikuri H.V., James A.L., Kahonen M., Levinson D.F., Macciardi F., Nieminen M.S., Ohlsson C., Palmer L.J., Ridker P.M., Stumvoll M., Beckmann J.S., Boeing H., Boerwinkle E., Boomsma D.I., Caulfield M.J., Chanock S.J., Collins F.S., Cupples L.A., Smith G.D., Erdmann J., Froguel P., Gronberg H., Gyllensten U., Hall P., Hansen T., Harris T.B., Hattersley A.T., Hayes R.B., Heinrich J., Hu F.B., Hveem K., Illig T., Jarvelin M.R., Kaprio J., Karpe F., Khaw K.T., Kiemeney L.A., Krude H., Laakso M., Lawlor D.A., Metspalu A., Munroe P.B., Ouwehand W.H., Pedersen O., Penninx B.W., Peters A., Pramstaller P.P., Quertermous T., Reinehr T., Rissanen A., Rudan I., Samani N.J., Schwarz P.E., Shuldiner A.R., Spector T.D., Tuomilehto J., Uda M., Uitterlinden A., Valle T.T., Wabitsch M., Waeber G., Wareham N.J., Watkins H., Wilson J.F., Wright A.F., Zillikens M.C., Chatterjee N., McCarroll S.A., Purcell S., Schadt E.E., Visscher P.M., Assimes T.L., Borecki I.B., Deloukas P., Fox C.S., Groop L.C., Haritunians T., Hunter D.J., Kaplan R.C., Mohlke K.L., O'Connell J.R., Peltonen L., Schlessinger D., Strachan D.P., van Duijn C.M., Wichmann H.E., Frayling T.M., Thorsteinsdottir U., Abecasis G.R., Barroso I., Boehnke M., Stefansson K., North K.E., McCarthy M.I., Hirschhorn J.N., Ingelsson E., Loos R.J. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 2010, 42:937-948.
    • (2010) Nat. Genet. , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3    Monda, K.L.4    Thorleifsson, G.5    Jackson, A.U.6    Allen, H.L.7    Lindgren, C.M.8    Luan, J.9    Magi, R.10    Randall, J.C.11    Vedantam, S.12    Winkler, T.W.13    Qi, L.14    Workalemahu, T.15    Heid, I.M.16    Steinthorsdottir, V.17    Stringham, H.M.18    Weedon, M.N.19    Wheeler, E.20    more..
  • 8
    • 67651152853 scopus 로고    scopus 로고
    • Individuality and epigenetics in obesity
    • Campion J., Milagro F.I., Martinez J.A. Individuality and epigenetics in obesity. Obes. Rev. 2009, 10:383-392.
    • (2009) Obes. Rev. , vol.10 , pp. 383-392
    • Campion, J.1    Milagro, F.I.2    Martinez, J.A.3
  • 10
    • 34047142805 scopus 로고    scopus 로고
    • Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
    • Heijmans B.T., Kremer D., Tobi E.W., Boomsma D.I., Slagboom P.E. Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum. Mol. Genet. 2007, 16:547-554.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 547-554
    • Heijmans, B.T.1    Kremer, D.2    Tobi, E.W.3    Boomsma, D.I.4    Slagboom, P.E.5
  • 19
    • 31344466008 scopus 로고    scopus 로고
    • DNA methylation and gene silencing in cancer
    • Baylin S.B. DNA methylation and gene silencing in cancer. Nat. Clin. Pract. Oncol. 2005, 2(Suppl. 1):S4-11.
    • (2005) Nat. Clin. Pract. Oncol. , vol.2 , Issue.SUPPL. 1
    • Baylin, S.B.1
  • 22
    • 78650272670 scopus 로고    scopus 로고
    • Epigenetics and obesity: the devil is in the details
    • Franks P.W., Ling C. Epigenetics and obesity: the devil is in the details. BMC Med. 2010, 8:88.
    • (2010) BMC Med. , vol.8 , pp. 88
    • Franks, P.W.1    Ling, C.2
  • 23
    • 79954611176 scopus 로고    scopus 로고
    • A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss
    • Milagro F.I., Campion J., Cordero P., Goyenechea E., Gomez-Uriz A.M., Abete I., Zulet M.A., Martinez J.A. A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss. FASEB J. 2011, 25:1378-1389.
    • (2011) FASEB J. , vol.25 , pp. 1378-1389
    • Milagro, F.I.1    Campion, J.2    Cordero, P.3    Goyenechea, E.4    Gomez-Uriz, A.M.5    Abete, I.6    Zulet, M.A.7    Martinez, J.A.8
  • 25
    • 0344196810 scopus 로고    scopus 로고
    • The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes
    • Tan M., Wei C., Price C.M. The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes. Gene 2003, 323:1-10.
    • (2003) Gene , vol.323 , pp. 1-10
    • Tan, M.1    Wei, C.2    Price, C.M.3
  • 26
    • 77958460546 scopus 로고    scopus 로고
    • Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions
    • Kabir S., Sfeir A., de Lange T. Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 2010, 9:4061-4067.
    • (2010) Cell Cycle , vol.9 , pp. 4061-4067
    • Kabir, S.1    Sfeir, A.2    de Lange, T.3
  • 29
    • 69949183262 scopus 로고    scopus 로고
    • Chapter 1: the physiological role of lysyl tRNA synthetase in the immune system
    • Nechushtan H., Kim S., Kay G., Razin E. Chapter 1: the physiological role of lysyl tRNA synthetase in the immune system. Adv. Immunol. 2009, 103:1-27.
    • (2009) Adv. Immunol. , vol.103 , pp. 1-27
    • Nechushtan, H.1    Kim, S.2    Kay, G.3    Razin, E.4
  • 31
    • 78650510776 scopus 로고    scopus 로고
    • Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: the Women's Genome Health Study
    • Zee R.Y., Ridker P.M., Chasman D.I. Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: the Women's Genome Health Study. Clin. Chim. Acta 2011, 412:199-202.
    • (2011) Clin. Chim. Acta , vol.412 , pp. 199-202
    • Zee, R.Y.1    Ridker, P.M.2    Chasman, D.I.3
  • 32
    • 34547436943 scopus 로고    scopus 로고
    • Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1)
    • Gururaj A.E., Peng S., Vadlamudi R.K., Kumar R. Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1). Mol. Endocrinol. 2007, 21:1847-1860.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 1847-1860
    • Gururaj, A.E.1    Peng, S.2    Vadlamudi, R.K.3    Kumar, R.4
  • 34
    • 0034921914 scopus 로고    scopus 로고
    • Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema
    • Edgar A.J., Birks E.J., Yacoub M.H., Polak J.M. Cloning of dexamethasone-induced transcript: a novel glucocorticoid-induced gene that is upregulated in emphysema. Am. J. Respir. Cell Mol. Biol. 2001, 25:119-124.
    • (2001) Am. J. Respir. Cell Mol. Biol. , vol.25 , pp. 119-124
    • Edgar, A.J.1    Birks, E.J.2    Yacoub, M.H.3    Polak, J.M.4
  • 35
    • 71849085780 scopus 로고    scopus 로고
    • Stonins-specialized adaptors for synaptic vesicle recycling and beyond?
    • Maritzen T., Podufall J., Haucke V. Stonins-specialized adaptors for synaptic vesicle recycling and beyond?. Traffic 2010, 11:8-15.
    • (2010) Traffic , vol.11 , pp. 8-15
    • Maritzen, T.1    Podufall, J.2    Haucke, V.3
  • 36
    • 0032531129 scopus 로고    scopus 로고
    • The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells
    • Good P., Yoda A., Sakakibara S., Yamamoto A., Imai T., Sawa H., Ikeuchi T., Tsuji S., Satoh H., Okano H. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. Genomics 1998, 52:382-384.
    • (1998) Genomics , vol.52 , pp. 382-384
    • Good, P.1    Yoda, A.2    Sakakibara, S.3    Yamamoto, A.4    Imai, T.5    Sawa, H.6    Ikeuchi, T.7    Tsuji, S.8    Satoh, H.9    Okano, H.10
  • 40
    • 79951867607 scopus 로고    scopus 로고
    • The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study
    • Keller L., Xu W., Wang H.X., Winblad B., Fratiglioni L., Graff C. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J. Alzheimers Dis. 2011, 23:461-469.
    • (2011) J. Alzheimers Dis. , vol.23 , pp. 461-469
    • Keller, L.1    Xu, W.2    Wang, H.X.3    Winblad, B.4    Fratiglioni, L.5    Graff, C.6
  • 42
    • 1842482987 scopus 로고    scopus 로고
    • Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    • Poschl E., Schlotzer-Schrehardt U., Brachvogel B., Saito K., Ninomiya Y., Mayer U. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 2004, 131:1619-1628.
    • (2004) Development , vol.131 , pp. 1619-1628
    • Poschl, E.1    Schlotzer-Schrehardt, U.2    Brachvogel, B.3    Saito, K.4    Ninomiya, Y.5    Mayer, U.6
  • 48
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Article3
    • Smyth G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3. Article3.
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 50
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Methodol. 1995, 57:289-300.
    • (1995) J. R. Stat. Soc. Ser. B Methodol. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.