Hyperhomocysteinemia is associated with cognitive impairment in multiple sclerosis

Journal of Neurology

Volumn 255, Issue 1, 2008, Pages 64-69

  Russo, C ^b   Morabito, F ^c   Luise, F ^a   Piromalli, A ^a   Battaglia, L ^b   Vinci, A ^b   Trapani Lombardo, V ^a   De Marco, V ^e   Morabito, P ^b   Condino, F ^e   Quattrone, A ^d,e   Aguglia, U ^d  

^a Thrombosis and Hemostasis's Centre

^b Azienda Ospedaliera   (Italy)

^c Azienda Ospedaliera   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^e INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

Author keywords

Cognitive performance; Homocysteine; Multiple sclerosis; Neuropsychology

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; AGED; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; FEMALE; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TEST; PHYSICAL DISABILITY; PREDICTION; PRIORITY JOURNAL; SMOKING HABIT; UNIVARIATE ANALYSIS;

AGE OF ONSET; BRAIN; COGNITION DISORDERS; DISABILITY EVALUATION; DISEASE PROGRESSION; FOLIC ACID; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; UP-REGULATION; VITAMIN B 12 DEFICIENCY;

EID: 38549106012     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-007-0668-7     Document Type: Article

References (30)

1. Amato MP, Ponziani G, Siracusa G, Sorbi S (2001) Cognitive dysfunction in early-onset multiple sclerosis. A reappraisal after 10 years. Arch Neurol 58:1602-1606
2. Piras MR, Magnano I, Canu ED, Paulus KS, Satta WM, Soddu A, Conti M, Achee A, Solinas G, Aiello I (2003) Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings. J Neurol Neurosurg Psychiatry 74:878-885
3. Kujala P, Portin R, Ruutiainen J (1997) The progress of cognitive decline in multiple sclerosis. A controlled 3-year follow-up. Brain 120:289-297
4. Rovaris M, Filippi M, Falautano M, Minicucci L, Rocca MA, Martinelli V, Comi G (1998) Relation between MR abnormalies and patterns of cognitive impairment in multiple sclerosis. Neurology 6:1601-1608
5. Selhub J, Miller JW (1992)The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55:131-138
6. Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr 19:217-246
7. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476-483
8. Diaz-Arrastia R (2000) Homocysteine and Neurologic Disease. Arch Neurol 57:1422-1427
9. Dufouil C, Alperovitch A, Ducros V, Tzourio C (2003) Homocysteine, White Matter Hyperintensities, and Cognition in Healthy Elderly People. Ann Neurol 53:214-221
10. Prins ND, Den Heijer T, Hofman A, Koudstaal PJ, Jolles J, Clarke R, Breteler MM (2002) Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 59:1375-1380
11. Rio J, Montalban J, Tintore M, Codina A, Malinow MR (1994) Serum homocysteine levels in multiple sclerosis. Arch Neurol 51:1181
12. Vrethem M, Mattsson E, Hebelka H, Leerbeck K, Osterberg A, Landtblom AM, Balla B, Nilsson H, Hultgren M, Brattstrom L, Kagedal B (2003) Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid. Mult Scler 9:239-245
13. Ramsaransing GSM, Fokkema MR, Teelken A, Arutjunyan AV, Koch M, De Keyser J (2006) Plasma homocysteine levels in multiple sclerosis. J Neurol Neurosurg Psychiatry 77:189-192
14. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, Lublin FD, Metz LM, McFarland HF, O'Connor PW, Sandberg-Wollheim M, Thompson AJ, Weinshenker BG, Wolinsky JS (2005) Diagnostic criteria for Multiple Sclerosis: 2005 Revisions to the "Mc- Donald Criteria". Ann Neurol 58:840-846
15. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561-571
16. Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444-1452
17. Basso A, Capitani E, Laiacona M (1987) Raven's coloured progressive matrices: normative values on 305 adult normal controls. Funct Neurol 2:189-194
18. Spinnler H, Tognoni G (1987) Gruppo Italiano per lo Studio Neuropsicologico dell'Invecchiamento: Standardizzazione e taratura italiana di test neuropsicologici. Ital J Neurol Sci (Suppl 8):6
19. Giovagnoli AR, Del Pesce M, Mascheroni S, Simoncelli M, Laiacona M, Capitani E (1996) Trail making test: normative values from 287 normal adult controls. Ital J Neurol Sci 17:305-309
20. Novelli G, Papagno C, Capitani E, Laiacona M, Vallar G, Cappa S (1986) Tre test clinici di memoria verbale a lungo termine. Taratura su soggetti normali. Arch Psicol Neurol Psichiatr 47:278-296
21. Caffarra P, Vezzadini G, Dieci F, Zonato F, Venneri A (2002) Rey-Osterrieth complex figure: normative values in an Italian population sample. Neurol Sci 22:443-447
22. Novelli G, Papagno C, Capitani E, Laiacona M, Vallar G, Cappa S (1986) Tre test clinici di ricerca e produzione lessicale. Taratura su soggetti normali. Arch Psicol Neurol Psichiatr 47:477-506
23. Frantzen F, Faaren AL, Alfheim I, Nordheim AK (1998) Enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem 44:311-316
24. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuve LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylene tetrahydrofolate reductase. Nat Genet 10:111-113
25. Feng L, Ng TP, Chuah L, Niti M, Kua EH (2006) Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study. Am J Clin Nutr 84:1506-1512
26. Teunissen CE, van Boxtel MP, Jolles J, de Vente J, Vreeling F, Verhey F, Polman CH, Dijkstra CD, Blom HJ (2005) Homocysteine in relation to cognitive performance in pathological and nonpathological conditions. Clin Chem Lab Med 43:1089-1095
27. Savettieri G, Messina D, Andreoli V, Bonavita S, Caltagirone C, Cittadella R, Farina D, Fazio MC, Girlanda P, Le Pira F, Liguori M, Lugaresi A, Nocentini U, Reggio A, Salemi G, Tedeschi G, Trojano M, Valentino P, Quattrone A (2004) Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. J Neurol 251:1208-1214
28. Calabrese P (2006) Neuropsychology of multiple sclerosis. An overview. J Neurol 253 (Suppl 1):10-15
29. Amato MP, Zipoli V, Portaccio E (2006) Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies. J Neurol Sci 245:41-46
30. den Heijer T, Vermeer SE, Clarke R, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MM (2003) Homocysteine and brain atrophy on MRI of non-demented elderly. Brain 126:170-175