Inflammatory profile, age of onset, and the MTHFR polymorphism in patients with multiple sclerosis

Journal of Molecular Neuroscience

Volumn 44, Issue 1, 2011, Pages 6-11

  Alatab, Sudabeh ^a   Hossein Nezhad, Arash ^a   Mirzaei, Khadijeh ^a   Mokhtari, Fatemeh ^a   Shariati, Gholamreza ^b   Najmafshar, Azam ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Age of onset; Inflammatory mediators; MTHFR polymorphism; Multiple sclerosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); C REACTIVE PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; ONSET AGE;

ADULT; AGE OF ONSET; CASE-CONTROL STUDIES; GENOTYPE; HUMANS; INFLAMMATION; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MULTIPLE SCLEROSIS; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 79955923955     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9486-y     Document Type: Article

References (31)

1. Bagley PJ, Selhub J (1998) A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95:13217-13220 (Pubitemid 28509551)
2. Baranzini SE, Wang J, Gibson RA et al (2009) Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 18:767-778
3. Chawla RK, Watson WH, Eastin CE, Lee EY, Schmidt J, Mc Clain CJ (1998) S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury. Am J Physiol 275:G125-129
4. Compston A, Coles A (2008) Multiple sclerosis. Lancet 372(9648):1502-1517
5. Cornacchia E, Golbus J, Maybaum J, Strahler J, Hanash S, Richardson B (1988) Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity. Journal of Immunology 140:2197-2200 (Pubitemid 18098475)
6. Etemadifar M, Janghorbani M, Shaygannejad V, Ashtari F (2006) Prevalence of multiple sclerosis in Isfahan, Iran. Neuroepidemiology 27:39-44
7. Ewing C, Bernard CCA (1998) Insights into the aetiology and pathogenesis of multiple sclerosis. Immunol Cell Biol 76:47-54 (Pubitemid 28194697)
8. Freedman MS (2006) Disease-modifying drugs for multiple sclerosis current and future aspect. Expert Opin Pharmacother 7:S1-S92
9. Friso S, Choi SW, Girelli D et al (2002) A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 99:5606-5611 (Pubitemid 34411596)
10. Frosst P, Blom HJ, Milos R et al (1995) A candidate genetic risk factor for vascular disease. A common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113
11. Giovannoni G, Thorpe JW, Kidd D et al (1996) Soluble E-selectin in multiple sclerosis: raised concentrations in patients with primary progressive disease. J Neurol Neurosurg Psychiatry 60:20-26 (Pubitemid 26012262)
12. Giovannoni G, Miller DH, Losseff NA et al (2001) Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis. J Neurol 248:487-495 (Pubitemid 32663880)
13. Goyette P, Sumner JS, Milos R et al (1994) Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 7:195-200 (Pubitemid 24174661)
14. Haines JL, Ter-Minassian M, Bazyk A et al (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat Genet 13:469-471 (Pubitemid 26256623)
15. Jonasdottir A, Thorlacius T, Fossdal R et al (2003) A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers. J Neuroimmunol 143:88-92 (Pubitemid 37324291)
16. Kalanie H, Kamgooyan M, Sadeghian H, Kalanie AR (2000) Histocompatibility antigen association with multiple sclerosis in Iran. Mult Scler 6:317-319
17. Klotz L, Farkas M, Bain N et al (2010) The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study. Neurosci Lett 468:183-185
18. Kohara K, Fujisawa M, Ando F et al (2003) MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: the NILS-LSA study. Stroke 34:1130-1135 (Pubitemid 36547502)
19. Lin JJ, Yueh KC, Liu CS, Liu JT, Lin SZ (2007) 5,10- Methylenetetrahydrofolate reductase C677T gene polymorphism can influence age at onset of Parkinson's disease. Acta Neurol Taiwan 16:150-157
20. Mager A, Koren-Morag N, Shohat M, Harell D, Battler A (2005) Family history, plasma homocysteine, and age at onset of symptoms of myocardial ischemia in patients with different methylenetetrahydrofolate reductase genotypes. Am J Cardiol 95:1420-1424 (Pubitemid 40824760)
21. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG (2000) Multiple sclerosis. N Engl J Med 343:938-952
22. Purohit V, Abdelmalek MF, Barve S et al (2007) Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium1, 2, 3, 4. Am J Clin Nutr 86:14-24 (Pubitemid 47041588)
23. Ramsaransing GS, Fokkema MR, Teelken A, Arutjunyan AV, Koch M, De Keyser J (2006) Plasma homocysteine levels in multiple sclerosis. J Neurol Neurosurg Psychiatry 77:189-192 (Pubitemid 43220840)
24. Rosati G (2001) The prevalence of multiple sclerosis in the world: an update. Neurol Sci 22:117-139
25. Sadovnick AD, Armstrong H, Rice GP et al (1993) A population-based study of multiple sclerosis in twins: update. Ann Neurol 33:281-285 (Pubitemid 23081159)
26. Soilu-Hänninen M, Koskinen JO, Laaksonen M, Hänninen A, Lilius EM, Waris M (2005) High sensitivity measurement of CRP and disease progression in multiple sclerosis. Neurology 65:153-155 (Pubitemid 40967796)
27. Song Z, Barve S, Chen T et al (2003) S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes. Am J Physiol Gastrointest Liver Physiol 284:G949-G955 (Pubitemid 36597337)
28. Surtees R, Leonard J, Austin S (1991) Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet 338:1550-1554
29. Tajouri L, Martin V, Gasparini C et al (2006) Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis. Brain Res Bull 69:327-331
30. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE (2001) Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22:195-201 (Pubitemid 32244306)
31. Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169-172 (Pubitemid 28453294)