메뉴 건너뛰기




Volumn 17, Issue 7, 2014, Pages 1039-1052

The neurobiology of bipolar disorder: Identifying targets for specific agents and synergies for combination treatment

Author keywords

Bipolar disorder; cellular signalling; mitochondrial dysfunction and oxidative stress; neurobiology

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOLAMINE; CYCLIC AMP;

EID: 84901398313     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145713000096     Document Type: Review
Times cited : (62)

References (129)
  • 1
    • 0022899021 scopus 로고
    • Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients
    • Abdalla DS, Monteiro HP, Oliveira JA, Bechara EJ (1986) Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients. Clin Chem 32:805-807.
    • (1986) Clin Chem , vol.32 , pp. 805-807
    • Abdalla, D.S.1    Monteiro, H.P.2    Oliveira, J.A.3    Bechara, E.J.4
  • 7
    • 77950575478 scopus 로고    scopus 로고
    • Mitochondrial complex i activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder
    • Andreazza AC, Shao L, Wang JF, Young LT (2010) Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatry 67:360-368.
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 360-368
    • Andreazza, A.C.1    Shao, L.2    Wang, J.F.3    Young, L.T.4
  • 9
    • 84871803754 scopus 로고    scopus 로고
    • Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder
    • Arts B, Simons CJ, Os J (2013) Evidence for the impact of the CACNA1C risk allele rs1006737 on 2-year cognitive functioning in bipolar disorder. Psychiatr Genet 23:41-42.
    • (2013) Psychiatr Genet , vol.23 , pp. 41-42
    • Arts, B.1    Simons, C.J.2    Os, J.3
  • 12
    • 0032527572 scopus 로고    scopus 로고
    • A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
    • Benes FM, Kwok EW, Vincent SL, Todtenkopf MS (1998) A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 44:88-97.
    • (1998) Biol Psychiatry , vol.44 , pp. 88-97
    • Benes, F.M.1    Kwok, E.W.2    Vincent, S.L.3    Todtenkopf, M.S.4
  • 13
    • 33644622093 scopus 로고    scopus 로고
    • The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia
    • Benes FM, Matzilevich D, Burke RE, Walsh J (2006) The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia. Mol Psychiatry 11:241-251.
    • (2006) Mol Psychiatry , vol.11 , pp. 241-251
    • Benes, F.M.1    Matzilevich, D.2    Burke, R.E.3    Walsh, J.4
  • 14
    • 0034747123 scopus 로고    scopus 로고
    • GluR5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives
    • Benes FM, Todtenkopf MS, Kostoulakos P (2001a) GluR5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives. Hippocampus 11:482-491.
    • (2001) Hippocampus , vol.11 , pp. 482-491
    • Benes, F.M.1    Todtenkopf, M.S.2    Kostoulakos, P.3
  • 15
    • 0035884325 scopus 로고    scopus 로고
    • The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects
    • Benes FM, Vincent SL, Todtenkopf M (2001b) The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry 50:395-406.
    • (2001) Biol Psychiatry , vol.50 , pp. 395-406
    • Benes, F.M.1    Vincent, S.L.2    Todtenkopf, M.3
  • 18
    • 0036242537 scopus 로고    scopus 로고
    • The neurobiology of bipolar disorder: Focus on signal transduction pathways and the regulation of gene expression
    • Bezchlibnyk Y, Young LT (2002) The neurobiology of bipolar disorder: focus on signal transduction pathways and the regulation of gene expression. Can J Psychiatry 47:135-148.
    • (2002) Can J Psychiatry , vol.47 , pp. 135-148
    • Bezchlibnyk, Y.1    Young, L.T.2
  • 21
    • 0036753235 scopus 로고    scopus 로고
    • Low glial numbers in the amygdala in major depressive disorder
    • Bowley MP, Drevets WC, Ongür D, Price JL (2002) Low glial numbers in the amygdala in major depressive disorder. Biol Psychiatry 52:404-412.
    • (2002) Biol Psychiatry , vol.52 , pp. 404-412
    • Bowley, M.P.1    Drevets, W.C.2    Ongür, D.3    Price, J.L.4
  • 22
    • 84870064101 scopus 로고    scopus 로고
    • Modeling psychiatric disorders at the cellular and network levels
    • Brennand KJ, Simone A, Tran N, Gage FH (2012) Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry 17:1239-1253.
    • (2012) Mol Psychiatry , vol.17 , pp. 1239-1253
    • Brennand, K.J.1    Simone, A.2    Tran, N.3    Gage, F.H.4
  • 24
    • 79960364274 scopus 로고    scopus 로고
    • Strategies to identify genes for complex disorders: A focus on bipolar disorder and chromosome 16p
    • Byerley W, Badner JA (2011) Strategies to identify genes for complex disorders: a focus on bipolar disorder and chromosome 16p. Psychiatr Genet 21:173-182.
    • (2011) Psychiatr Genet , vol.21 , pp. 173-182
    • Byerley, W.1    Badner, J.A.2
  • 27
    • 79960815278 scopus 로고    scopus 로고
    • Neuroprotective action of lithium in disorders of the central nervous system
    • Chiu CT, Chuang DM (2011) Neuroprotective action of lithium in disorders of the central nervous system. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36:461-476.
    • (2011) Zhong Nan da Xue Xue Bao Yi Xue Ban , vol.36 , pp. 461-476
    • Chiu, C.T.1    Chuang, D.M.2
  • 28
    • 78650144627 scopus 로고    scopus 로고
    • Olanzapine in the long-term treatment of bipolar disorder: A systematic review and meta-analysis
    • Cipriani A, Rendell J, Geddes JR (2011) Olanzapine in the long-term treatment of bipolar disorder: a systematic review and meta-analysis. J Psychopharmacol 24:1729-1738.
    • (2011) J Psychopharmacol , vol.24 , pp. 1729-1738
    • Cipriani, A.1    Rendell, J.2    Geddes, J.R.3
  • 29
    • 79952959359 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
    • Clay HB, Sillivan S, Konradi C (2010) Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int J Dev Neurosci 29:311-324.
    • (2010) Int J Dev Neurosci , vol.29 , pp. 311-324
    • Clay, H.B.1    Sillivan, S.2    Konradi, C.3
  • 30
    • 0037688084 scopus 로고    scopus 로고
    • Finding the intracellular signaling pathways affected by mood disorder treatments
    • Coyle JT, Duman RS (2003) Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 38:157-160.
    • (2003) Neuron , vol.38 , pp. 157-160
    • Coyle, J.T.1    Duman, R.S.2
  • 31
    • 0029795275 scopus 로고    scopus 로고
    • Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3′,5′- cyclic monophosphatedependent protein kinase
    • De Jongh KS, Murphy BJ, Colvin AA, Hell JW, Takahashi M, Catterall WA (1996) Specific phosphorylation of a site in the full-length form of the alpha 1 subunit of the cardiac L-type calcium channel by adenosine 3′,5′- cyclic monophosphatedependent protein kinase. Biochemistry 35:10392-10402.
    • (1996) Biochemistry , vol.35 , pp. 10392-10402
    • De Jongh, K.S.1    Murphy, B.J.2    Colvin, A.A.3    Hell, J.W.4    Takahashi, M.5    Catterall, W.A.6
  • 34
    • 74049110540 scopus 로고    scopus 로고
    • Genes, cognition and brain through a COMT lens
    • Dickinson D, Elvevåg B (2009) Genes, cognition and brain through a COMT lens. Neuroscience 164:72-87.
    • (2009) Neuroscience , vol.164 , pp. 72-87
    • Dickinson, D.1    Elvevåg, B.2
  • 35
    • 0028281236 scopus 로고
    • Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder
    • Dubovsky SL, Thomas M, Hijazi A, Murphy J (1994) Intracellular calcium signalling in peripheral cells of patients with bipolar affective disorder. Eur Arch Psychiatry Clin Neurosci 243:229-234.
    • (1994) Eur Arch Psychiatry Clin Neurosci , vol.243 , pp. 229-234
    • Dubovsky, S.L.1    Thomas, M.2    Hijazi, A.3    Murphy, J.4
  • 36
    • 77951856813 scopus 로고    scopus 로고
    • Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder
    • Eastwood SL, Harrison PJ (2010) Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. Biol Psychiatry 67:1010-1016.
    • (2010) Biol Psychiatry , vol.67 , pp. 1010-1016
    • Eastwood, S.L.1    Harrison, P.J.2
  • 38
    • 0034307232 scopus 로고    scopus 로고
    • Associated disturbances in calcium homeostasis and G protein-mediated cAMP signaling in bipolar i disorder
    • Emamghoreishi M, Li PP, Schlichter L, Parikh SV, Cooke R, Warsh JJ (2000) Associated disturbances in calcium homeostasis and G protein-mediated cAMP signaling in bipolar I disorder. Biol Psychiatry 48:665-673.
    • (2000) Biol Psychiatry , vol.48 , pp. 665-673
    • Emamghoreishi, M.1    Li, P.P.2    Schlichter, L.3    Parikh, S.V.4    Cooke, R.5    Warsh, J.J.6
  • 39
    • 17844382678 scopus 로고    scopus 로고
    • Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein
    • Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ (2005) Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry 44:6513-6525.
    • (2005) Biochemistry , vol.44 , pp. 6513-6525
    • Farris, W.1    Leissring, M.A.2    Hemming, M.L.3    Chang, A.Y.4    Selkoe, D.J.5
  • 40
    • 33947668415 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase gene regulation in rat frontal cortex
    • Fatemi SH, Folsom TD (2007) Catechol-O-methyltransferase gene regulation in rat frontal cortex. Mol Psychiatry 12:322-323.
    • (2007) Mol Psychiatry , vol.12 , pp. 322-323
    • Fatemi, S.H.1    Folsom, T.D.2
  • 42
    • 50449089356 scopus 로고    scopus 로고
    • Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
    • Ferreira MA et al. (2008) Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40:1056-1058.
    • (2008) Nat Genet , vol.40 , pp. 1056-1058
    • Ferreira, M.A.1
  • 43
    • 84856702223 scopus 로고    scopus 로고
    • Inhibition of GSK3 by lithium, from single molecules to signaling networks
    • Freland L, Beaulieu JM (2012) Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front Mol Neurosci 5:14.
    • (2012) Front Mol Neurosci , vol.5 , pp. 14
    • Freland, L.1    Beaulieu, J.M.2
  • 46
    • 84855565338 scopus 로고    scopus 로고
    • Expression profiling in neuropsychiatric disorders: Emphasis on glutamate receptors in bipolar disorder
    • Ginsberg SD, Hemby SE, Smiley JF (2012) Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder. Pharmacol Biochem Behav 100:705-711.
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 705-711
    • Ginsberg, S.D.1    Hemby, S.E.2    Smiley, J.F.3
  • 47
    • 68749094080 scopus 로고    scopus 로고
    • Cardiovascular disease and hypertension among adults with bipolar i disorder in the United States
    • Goldstein BI, Fagiolini A, Houck P, Kupfer DJ (2009a) Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States. Bipolar Disord 11:657-662.
    • (2009) Bipolar Disord , vol.11 , pp. 657-662
    • Goldstein, B.I.1    Fagiolini, A.2    Houck, P.3    Kupfer, D.J.4
  • 48
    • 70349562518 scopus 로고    scopus 로고
    • Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: A systematic review of the literature
    • Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS (2009b) Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 70:1078-1090.
    • (2009) J Clin Psychiatry , vol.70 , pp. 1078-1090
    • Goldstein, B.I.1    Kemp, D.E.2    Soczynska, J.K.3    McIntyre, R.S.4
  • 49
    • 33745466922 scopus 로고    scopus 로고
    • Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications
    • Gould TD (2006) Targeting glycogen synthase kinase-3 as an approach to develop novel mood-stabilising medications. Expert Opin Ther Targets 10:377-392.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 377-392
    • Gould, T.D.1
  • 50
    • 4243196940 scopus 로고    scopus 로고
    • Emerging experimental therapeutics for bipolar disorder: Insights from the molecular and cellular actions of current mood stabilizers
    • Gould TD, Quiroz JA, Singh J, Zarate CA, Manji HK (2004) Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Mol Psychiatry 9:734-755.
    • (2004) Mol Psychiatry , vol.9 , pp. 734-755
    • Gould, T.D.1    Quiroz, J.A.2    Singh, J.3    Zarate, C.A.4    Manji, H.K.5
  • 53
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Group PGCBDW
    • Group PGCBDW (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 43:977-983.
    • (2011) Nat Genet , vol.43 , pp. 977-983
  • 55
    • 0019796721 scopus 로고
    • Possible involvement of endorphin withdrawal or imbalance in specific premenstrual syndromes and postpartum depression
    • Halbreich U, Endicott J (1981) Possible involvement of endorphin withdrawal or imbalance in specific premenstrual syndromes and postpartum depression. Med Hypotheses 7:1045-1058.
    • (1981) Med Hypotheses , vol.7 , pp. 1045-1058
    • Halbreich, U.1    Endicott, J.2
  • 57
    • 12744278205 scopus 로고    scopus 로고
    • Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis
    • Iwamoto K, Bundo M, Kato T (2005) Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 14:241-253.
    • (2005) Hum Mol Genet , vol.14 , pp. 241-253
    • Iwamoto, K.1    Bundo, M.2    Kato, T.3
  • 58
    • 0015524797 scopus 로고
    • On the catecholamine innervation of the hypothalamus, with special reference to the median eminence
    • Jonsson G, Fuxe K, Hokfelt T (1972) On the catecholamine innervation of the hypothalamus, with special reference to the median eminence. Brain Res 40:271-281.
    • (1972) Brain Res , vol.40 , pp. 271-281
    • Jonsson, G.1    Fuxe, K.2    Hokfelt, T.3
  • 59
    • 33750866196 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions
    • Jope RS, Roh MS (2006) Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr Drug Targets 7:1421-1434.
    • (2006) Curr Drug Targets , vol.7 , pp. 1421-1434
    • Jope, R.S.1    Roh, M.S.2
  • 61
    • 80051618423 scopus 로고    scopus 로고
    • Sleep and circadian rhythm disturbances in bipolar disorder: An urgent need for objective assessment and systematic follow-up
    • Kapczinski F, Frey BN, Vieta E (2011) Sleep and circadian rhythm disturbances in bipolar disorder: an urgent need for objective assessment and systematic follow-up. J Clin Psychiatry 72:724.
    • (2011) J Clin Psychiatry , vol.72 , pp. 724
    • Kapczinski, F.1    Frey, B.N.2    Vieta, E.3
  • 62
    • 52049115624 scopus 로고    scopus 로고
    • Molecular neurobiology of bipolar disorder: A disease of 'mood-stabilizing neurons'?
    • Kato T (2008) Molecular neurobiology of bipolar disorder: a disease of 'mood-stabilizing neurons'? Trends Neurosci 31:495-503.
    • (2008) Trends Neurosci , vol.31 , pp. 495-503
    • Kato, T.1
  • 63
    • 73249149898 scopus 로고    scopus 로고
    • Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals
    • Kempton MJ, Ruberto G, Vassos E, Tatarelli R, Girardi P, Collier D, Frangou S (2009) Effects of the CACNA1C risk allele for bipolar disorder on cerebral gray matter volume in healthy individuals. Am J Psychiatry 166:1413-1414.
    • (2009) Am J Psychiatry , vol.166 , pp. 1413-1414
    • Kempton, M.J.1    Ruberto, G.2    Vassos, E.3    Tatarelli, R.4    Girardi, P.5    Collier, D.6    Frangou, S.7
  • 64
    • 75949107129 scopus 로고    scopus 로고
    • Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients
    • Kim HW, Rapoport SI, Rao JS (2010) Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis 37:596-603.
    • (2010) Neurobiol Dis , vol.37 , pp. 596-603
    • Kim, H.W.1    Rapoport, S.I.2    Rao, J.S.3
  • 65
    • 17844403720 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress
    • King TD, Jope RS (2005) Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress. Neuroreport 16:597-601.
    • (2005) Neuroreport , vol.16 , pp. 597-601
    • King, T.D.1    Jope, R.S.2
  • 67
    • 81955161265 scopus 로고    scopus 로고
    • Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple sclerosis
    • Konradi C, Sillivan SE, Clay HB (2012) Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis. Neurobiol Dis 45:37-47.
    • (2012) Neurobiol Dis , vol.45 , pp. 37-47
    • Konradi, C.1    Sillivan, S.E.2    Clay, H.B.3
  • 68
    • 0035669463 scopus 로고    scopus 로고
    • Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: Psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists
    • Krupitsky EM, Burakov AM, Romanova TN, Grinenko NI, Grinenko AY, Fletcher J, Petrakis IL, Krystal JH (2001) Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Neuropsychopharmacology 25:936-947.
    • (2001) Neuropsychopharmacology , vol.25 , pp. 936-947
    • Krupitsky, E.M.1    Burakov, A.M.2    Romanova, T.N.3    Grinenko, N.I.4    Grinenko, A.Y.5    Fletcher, J.6    Petrakis, I.L.7    Krystal, J.H.8
  • 69
    • 0036096195 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
    • Kuloglu M, Ustundag B, Atmaca M, Canatan H, Tezcan AE, Cinkilinc N (2002) Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochem Funct 20:171-175.
    • (2002) Cell Biochem Funct , vol.20 , pp. 171-175
    • Kuloglu, M.1    Ustundag, B.2    Atmaca, M.3    Canatan, H.4    Tezcan, A.E.5    Cinkilinc, N.6
  • 72
    • 33646863671 scopus 로고    scopus 로고
    • Cytoprotection by lithium and valproate varies between cell types and cellular stresses
    • Lai JS, Zhao C, Warsh JJ, Li PP (2006) Cytoprotection by lithium and valproate varies between cell types and cellular stresses. Eur J Pharmacol 539:18-26.
    • (2006) Eur J Pharmacol , vol.539 , pp. 18-26
    • Lai, J.S.1    Zhao, C.2    Warsh, J.J.3    Li, P.P.4
  • 73
    • 69249217791 scopus 로고    scopus 로고
    • Neurobiological trait abnormalities in bipolar disorder
    • Langan C, McDonald C (2009) Neurobiological trait abnormalities in bipolar disorder. Mol Psychiatry 14:833-846.
    • (2009) Mol Psychiatry , vol.14 , pp. 833-846
    • Langan, C.1    McDonald, C.2
  • 77
    • 79958695642 scopus 로고    scopus 로고
    • The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives
    • Lelli-Chiesa G, Kempton MJ, Jogia J, Tatarelli R, Girardi P, Powell J, Collier DA, Frangou S (2011) The impact of the Val158Met catechol-O- methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives. Psychol Med 41:779-788.
    • (2011) Psychol Med , vol.41 , pp. 779-788
    • Lelli-Chiesa, G.1    Kempton, M.J.2    Jogia, J.3    Tatarelli, R.4    Girardi, P.5    Powell, J.6    Collier Frangou, D.A.S.7
  • 78
    • 39649094726 scopus 로고    scopus 로고
    • Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling
    • Liang MH, Wendland JR, Chuang DM (2008) Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol Cell Neurosci 37:440-453.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 440-453
    • Liang, M.H.1    Wendland, J.R.2    Chuang, D.M.3
  • 79
    • 78650510203 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder
    • Liu Y et al. (2011) Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry 16:2-4.
    • (2011) Mol Psychiatry , vol.16 , pp. 2-4
    • Liu, Y.1
  • 85
    • 56349172190 scopus 로고    scopus 로고
    • Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: Preliminary findings and a discussion of therapeutic mechanisms
    • Mallinger AG, Thase ME, Haskett R, Buttenfield J, Luckenbaugh DA, Frank E, Kupfer DJ, Manji HK (2008) Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. Bipolar Disord 10:856-866.
    • (2008) Bipolar Disord , vol.10 , pp. 856-866
    • Mallinger, A.G.1    Thase, M.E.2    Haskett, R.3    Buttenfield, J.4    Luckenbaugh, D.A.5    Frank, E.6    Kupfer, D.J.7    Manji, H.K.8
  • 87
    • 15244344775 scopus 로고    scopus 로고
    • Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder
    • Manaye KF, Lei DL, Tizabi Y, Dávila-García MI, Mouton PR, Kelly PH (2005) Selective neuron loss in the paraventricular nucleus of hypothalamus in patients suffering from major depression and bipolar disorder. J Neuropathol Exp Neurol 64:224-229.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 224-229
    • Manaye, K.F.1    Lei, D.L.2    Tizabi, Y.3    Dávila-García, M.I.4    Mouton, P.R.5    Kelly, P.H.6
  • 89
    • 0141510019 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial complex i due to peroxynitrite: Identification of reactive tyrosines by mass spectrometry
    • Murray J, Taylor SW, Zhang B, Ghosh SS, Capaldi RA (2003) Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry. J Biol Chem 278:37223-37230.
    • (2003) J Biol Chem , vol.278 , pp. 37223-37230
    • Murray, J.1    Taylor, S.W.2    Zhang, B.3    Ghosh, S.S.4    Capaldi, R.A.5
  • 90
    • 0028914437 scopus 로고
    • Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine
    • Napolitano A, Crescenzi O, Pezzella A, Prota G (1995) Generation of the neurotoxin 6-hydroxydopamine by peroxidase/H2O2 oxidation of dopamine. J Med Chem 38:917-922.
    • (1995) J Med Chem , vol.38 , pp. 917-922
    • Napolitano, A.1    Crescenzi, O.2    Pezzella, A.3    Prota, G.4
  • 91
    • 84875422528 scopus 로고    scopus 로고
    • Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia
    • Advance online publication. doi:10.1038/jhg.2012.140
    • Nishioka M, Bundo M, Koike S, Takizawa R, Kakiuchi C, Araki T, Kasai K, Iwamoto K (2012) Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia. J Hum Genet. Advance online publication. doi:10.1038/jhg.2012.140.
    • (2012) J Hum Genet
    • Nishioka, M.1    Bundo, M.2    Koike, S.3    Takizawa, R.4    Kakiuchi, C.5    Araki, T.6    Kasai, K.7    Iwamoto, K.8
  • 94
    • 0032573166 scopus 로고    scopus 로고
    • Glial reduction in the subgenual prefrontal cortex in mood disorders
    • Ongur D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95:13290-13295.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13290-13295
    • Ongur, D.1    Drevets, W.C.2    Price, J.L.3
  • 96
    • 34547499702 scopus 로고    scopus 로고
    • Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
    • Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T (2007) Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90:397-406.
    • (2007) Genomics , vol.90 , pp. 397-406
    • Pruunsild, P.1    Kazantseva, A.2    Aid, T.3    Palm, K.4    Timmusk, T.5
  • 97
    • 0042808739 scopus 로고    scopus 로고
    • Depression: What we can learn from postmortem studies
    • Rajkowska G (2003) Depression: what we can learn from postmortem studies. Neuroscientist 9:273-284.
    • (2003) Neuroscientist , vol.9 , pp. 273-284
    • Rajkowska, G.1
  • 98
    • 0035336748 scopus 로고    scopus 로고
    • Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
    • Rajkowska G, Halaris A, Selemon LD (2001) Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol Psychiatry 49:741-752.
    • (2001) Biol Psychiatry , vol.49 , pp. 741-752
    • Rajkowska, G.1    Halaris, A.2    Selemon, L.D.3
  • 100
    • 34548012115 scopus 로고    scopus 로고
    • GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder
    • Rowe MK, Wiest C, Chuang DM (2007) GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder. Neurosci Biobehav Rev 31:920-931.
    • (2007) Neurosci Biobehav Rev , vol.31 , pp. 920-931
    • Rowe, M.K.1    Wiest, C.2    Chuang, D.M.3
  • 101
    • 79960784301 scopus 로고    scopus 로고
    • Lithium in neuropsychiatry: A 2010 update
    • Rybakowski JK (2011) Lithium in neuropsychiatry: a 2010 update. World J Biol Psychiatry 12:340-348.
    • (2011) World J Biol Psychiatry , vol.12 , pp. 340-348
    • Rybakowski, J.K.1
  • 106
    • 77049125519 scopus 로고    scopus 로고
    • Genetic research into bipolar disorder: The need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization
    • Schulze TG (2010) Genetic research into bipolar disorder: the need for a research framework that integrates sophisticated molecular biology and clinically informed phenotype characterization. Psychiatr Clin North Am 33:67-82.
    • (2010) Psychiatr Clin North Am , vol.33 , pp. 67-82
    • Schulze, T.G.1
  • 108
    • 66149092770 scopus 로고    scopus 로고
    • Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
    • Scott LJ et al. (2009) Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA 106:7501-7506.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7501-7506
    • Scott, L.J.1
  • 109
    • 81255129681 scopus 로고    scopus 로고
    • Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene
    • Sears C, Markie D, Olds R, Fitches A (2011) Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene. Bipolar Disord 13:630-637.
    • (2011) Bipolar Disord , vol.13 , pp. 630-637
    • Sears, C.1    Markie, D.2    Olds, R.3    Fitches, A.4
  • 110
    • 39649109917 scopus 로고    scopus 로고
    • The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode
    • Selek S, Savas HA, Gergerlioglu HS, Bulbul F, Uz E, YumruM (2008) The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode. J Affect Disord 107:89-94.
    • (2008) J Affect Disord , vol.107 , pp. 89-94
    • Selek, S.1    Savas, H.A.2    Gergerlioglu, H.S.3    Bulbul, F.4    Uz, E.5    Yumru, M.6
  • 112
    • 0020570380 scopus 로고
    • Examining the dopamine hypotheses of schizophrenia and of mania using the prolactin response to antipsychotic drugs
    • Silverstone T, Cookson J (1983) Examining the dopamine hypotheses of schizophrenia and of mania using the prolactin response to antipsychotic drugs. Neuropharmacology 22:539-541.
    • (1983) Neuropharmacology , vol.22 , pp. 539-541
    • Silverstone, T.1    Cookson, J.2
  • 113
    • 43949118134 scopus 로고    scopus 로고
    • Whole-genome association study of bipolar disorder
    • Sklar P et al. (2008) Whole-genome association study of bipolar disorder. Mol Psychiatry 13:558-569.
    • (2008) Mol Psychiatry , vol.13 , pp. 558-569
    • Sklar, P.1
  • 114
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Sklar P et al. (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 43:977-983.
    • (2011) Nat Genet , vol.43 , pp. 977-983
    • Sklar, P.1
  • 115
    • 67651158803 scopus 로고    scopus 로고
    • Genome-wide association study of bipolar disorder in European American and African American individuals
    • Smith EN et al. (2009) Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 14:755-763.
    • (2009) Mol Psychiatry , vol.14 , pp. 755-763
    • Smith, E.N.1
  • 117
    • 33745463205 scopus 로고    scopus 로고
    • Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder
    • Sun X, Wang JF, Tseng M, Young LT (2006) Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J Psychiatry Neurosci 31:189-196.
    • (2006) J Psychiatry Neurosci , vol.31 , pp. 189-196
    • Sun, X.1    Wang, J.F.2    Tseng, M.3    Young, L.T.4
  • 118
    • 77955532269 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor in euthymic bipolar patients on prophylactic lithium therapy
    • Suwalska A, Sobieska M, Rybakowski JK (2010) Serum brain-derived neurotrophic factor in euthymic bipolar patients on prophylactic lithium therapy. Neuropsychobiology 62:229-234.
    • (2010) Neuropsychobiology , vol.62 , pp. 229-234
    • Suwalska, A.1    Sobieska, M.2    Rybakowski, J.K.3
  • 119
    • 84858987404 scopus 로고    scopus 로고
    • Gene-expression studies in understanding the mechanism of action of lithium
    • Toker L, Belmaker RH, Agam G (2012) Gene-expression studies in understanding the mechanism of action of lithium. Expert Rev Neurother 12:93-97.
    • (2012) Expert Rev Neurother , vol.12 , pp. 93-97
    • Toker, L.1    Belmaker, R.H.2    Agam, G.3
  • 120
    • 79951498943 scopus 로고    scopus 로고
    • Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar i disorder
    • Uemura T, Green M, Corson TW, Perova T, Li PP, Warsh JJ (2011) Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder. Bipolar Disord 13:41-51.
    • (2011) Bipolar Disord , vol.13 , pp. 41-51
    • Uemura, T.1    Green, M.2    Corson, T.W.3    Perova, T.4    Li, P.P.5    Warsh, J.J.6
  • 123
    • 37749029999 scopus 로고    scopus 로고
    • Defects of mitochondrial electron transport chain in bipolar disorder: Implications for mood-stabilizing treatment
    • Wang JF (2007) Defects of mitochondrial electron transport chain in bipolar disorder: implications for mood-stabilizing treatment. Can J Psychiatry 52:753-762.
    • (2007) Can J Psychiatry , vol.52 , pp. 753-762
    • Wang, J.F.1
  • 124
    • 67749122382 scopus 로고    scopus 로고
    • Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia
    • Wang JF, Shao L, Sun X, Young LT (2009) Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. Bipolar Disord 11:523-529.
    • (2009) Bipolar Disord , vol.11 , pp. 523-529
    • Wang, J.F.1    Shao, L.2    Sun, X.3    Young, L.T.4
  • 125
    • 0032921854 scopus 로고    scopus 로고
    • Methylation pharmacogenetics: Catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
    • Weinshilboum RM, Otterness DM, Szumlanski CL (1999) Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol 39:19-52.
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 19-52
    • Weinshilboum, R.M.1    Otterness, D.M.2    Szumlanski, C.L.3
  • 126
    • 84863960346 scopus 로고    scopus 로고
    • Free radical oxidation of cardiolipin: Chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases
    • Yin H, Zhu M (2012) Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases. Free Radic Res 46:959-974.
    • (2012) Free Radic Res , vol.46 , pp. 959-974
    • Yin, H.1    Zhu, M.2
  • 127
    • 55449130742 scopus 로고    scopus 로고
    • Bipolar disorder: Candidate drug targets
    • Zarate CA, Manji HK (2008) Bipolar disorder: candidate drug targets. Mt Sinai J Med 75:226-247.
    • (2008) Mt Sinai J Med , vol.75 , pp. 226-247
    • Zarate, C.A.1    Manji, H.K.2
  • 128
    • 62849092230 scopus 로고    scopus 로고
    • Singleton deletions throughout the genome increase risk of bipolar disorder
    • Zhang D et al. (2009) Singleton deletions throughout the genome increase risk of bipolar disorder. Mol Psychiatry 14:376-380.
    • (2009) Mol Psychiatry , vol.14 , pp. 376-380
    • Zhang, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.