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Volumn 58, Issue 2, 2013, Pages 91-97

Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia

Author keywords

biomarker; CpG island; epigenetics; first episode psychosis; gender difference

Indexed keywords

NUCLEOTIDE; TRANSCRIPTION FACTOR;

EID: 84875422528     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2012.140     Document Type: Article
Times cited : (86)

References (41)
  • 1
    • 79952722217 scopus 로고    scopus 로고
    • After GWAS: Searching for genetic risk for schizophrenia and bipolar disorder
    • Gershon, E. S., Alliey-Rodriguez, N. & Liu, C. After GWAS: searching for genetic risk for schizophrenia and bipolar disorder. Am. J. Psychiatry. 168, 253-256 (2011).
    • (2011) Am. J. Psychiatry. , vol.168 , pp. 253-256
    • Gershon, E.S.1    Alliey-Rodriguez, N.2    Liu, C.3
  • 3
    • 50449100461 scopus 로고    scopus 로고
    • Identification of loci associated with schizophrenia by genome-wide association and follow-up
    • O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V. et al. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet. 40, 1053-1055 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 1053-1055
    • O'Donovan, M.C.1    Craddock, N.2    Norton, N.3    Williams, H.4    Peirce, T.5    Moskvina, V.6
  • 5
    • 36849063138 scopus 로고    scopus 로고
    • Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection
    • Sharma, R. P., Grayson, D. R. & Gavin, D. P. Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection. Schizophr. Res. 98, 111-117 (2008).
    • (2008) Schizophr. Res. , vol.98 , pp. 111-117
    • Sharma, R.P.1    Grayson, D.R.2    Gavin, D.P.3
  • 8
    • 33750244045 scopus 로고    scopus 로고
    • Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    • Abdolmaleky, H. M., Cheng, K. H., Faraone, S. V., Wilcox, M., Glatt, S. J., Gao, F. et al. Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum. Mol. Genet. 15, 3132-3145 (2006).
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 3132-3145
    • Abdolmaleky, H.M.1    Cheng, K.H.2    Faraone, S.V.3    Wilcox, M.4    Glatt, S.J.5    Gao, F.6
  • 9
    • 20044389866 scopus 로고    scopus 로고
    • DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia
    • Iwamoto, K., Bundo, M., Yamada, K., Takao, H., Iwayama-Shigeno, Y., Yoshikawa, T. et al. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J. Neurosci. 25, 5376-5381 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 5376-5381
    • Iwamoto, K.1    Bundo, M.2    Yamada, K.3    Takao, H.4    Iwayama-Shigeno, Y.5    Yoshikawa, T.6
  • 10
  • 11
    • 79955480276 scopus 로고    scopus 로고
    • Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor beta(2) subunit
    • Pun, F. W., Zhao, C., Lo, W. S., Ng, S. K., Tsang, S. Y., Nimgaonkar, V. et al. Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor beta(2) subunit. Mol. Psychiatry. 16, 557-568 (2011).
    • (2011) Mol. Psychiatry. , vol.16 , pp. 557-568
    • Pun, F.W.1    Zhao, C.2    Lo, W.S.3    Ng, S.K.4    Tsang, S.Y.5    Nimgaonkar, V.6
  • 12
    • 79958009147 scopus 로고    scopus 로고
    • Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
    • Abdolmaleky, H. M., Yaqubi, S., Papageorgis, P., Lambert, A. W., Ozturk, S., Sivaraman, V. et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr. Res. 129, 183-190 (2011).
    • (2011) Schizophr. Res. , vol.129 , pp. 183-190
    • Abdolmaleky, H.M.1    Yaqubi, S.2    Papageorgis, P.3    Lambert, A.W.4    Ozturk, S.5    Sivaraman, V.6
  • 13
    • 33646247628 scopus 로고    scopus 로고
    • The quantification of COMT mRNA in post mortem cerebellum tissue: Diagnosis, genotype, methylation and expression
    • Dempster, E. L., Mill, J., Craig, I. W. & Collier, D. A. The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med. Genet. 7, 10 (2006).
    • (2006) BMC Med. Genet. , vol.7 , pp. 10
    • Dempster, E.L.1    Mill, J.2    Craig, I.W.3    Collier, D.A.4
  • 14
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    • Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L. et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am. J. Hum. Genet. 82, 696-711 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 696-711
    • Mill, J.1    Tang, T.2    Kaminsky, Z.3    Khare, T.4    Yazdanpanah, S.5    Bouchard, L.6
  • 15
    • 38949150121 scopus 로고    scopus 로고
    • Methylation status of the reelin promoter region in the brain of schizophrenic patients
    • Tochigi, M., Iwamoto, K., Bundo, M., Komori, A., Sasaki, T., Kato, N. et al. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol. Psychiatry. 63, 530-533 (2008).
    • (2008) Biol. Psychiatry. , vol.63 , pp. 530-533
    • Tochigi, M.1    Iwamoto, K.2    Bundo, M.3    Komori, A.4    Sasaki, T.5    Kato, N.6
  • 16
    • 79960332723 scopus 로고    scopus 로고
    • Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder
    • Carrard, A., Salzmann, A., Malafosse, A. & Karege, F. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J. Affect. Disord. 132, 450-453 (2011).
    • (2011) J. Affect. Disord. , vol.132 , pp. 450-453
    • Carrard, A.1    Salzmann, A.2    Malafosse, A.3    Karege, F.4
  • 17
    • 79958714505 scopus 로고    scopus 로고
    • Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder
    • Ghadirivasfi, M., Nohesara, S., Ahmadkhaniha, H. R., Eskandari, M. R., Mostafavi, S., Thiagalingam, S. et al. Hypomethylation of the serotonin receptor type-2A Gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 156, 536-545 (2011).
    • (2011) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.156 , pp. 536-545
    • Ghadirivasfi, M.1    Nohesara, S.2    Ahmadkhaniha, H.R.3    Eskandari, M.R.4    Mostafavi, S.5    Thiagalingam, S.6
  • 19
    • 84861775810 scopus 로고    scopus 로고
    • Epigenetic aberrations in leukocytes of patients with schizophrenia: Association of global DNA methylation with antipsychotic drug treatment and disease onset
    • Melas, P. A., Rogdaki, M., Osby, U., Schalling, M., Lavebratt, C. & Ekstrom, T. J. Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset. FA S E B J. 26, 2712-2718 (2012).
    • (2012) FA S e B J. , vol.26 , pp. 2712-2718
    • Melas, P.A.1    Rogdaki, M.2    Osby, U.3    Schalling, M.4    Lavebratt, C.5    Ekstrom, T.J.6
  • 20
    • 81855183787 scopus 로고    scopus 로고
    • Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
    • Dempster, E. L., Pidsley, R., Schalkwyk, L. C., Owens, S., Georgiades, A., Kane, F. et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum. Mol. Genet. 20, 4786-4796 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4786-4796
    • Dempster, E.L.1    Pidsley, R.2    Schalkwyk, L.C.3    Owens, S.4    Georgiades, A.5    Kane, F.6
  • 21
    • 12944249385 scopus 로고    scopus 로고
    • Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia
    • Murphy, B. C., O'Reilly, R. L. & Singh, S. M. Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 133B, 37-42 (2005).
    • (2005) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.133 B , pp. 37-42
    • Murphy, B.C.1    O'Reilly, R.L.2    Singh, S.M.3
  • 22
    • 79960828534 scopus 로고    scopus 로고
    • Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins
    • Sugawara, H., Iwamoto, K., Bundo, M., Ueda, J., Miyauchi, T., Komori, A. et al. Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. Transl. Psychiatry. 1, e24 (2011).
    • (2011) Transl. Psychiatry. , vol.1
    • Sugawara, H.1    Iwamoto, K.2    Bundo, M.3    Ueda, J.4    Miyauchi, T.5    Komori, A.6
  • 23
    • 84862776228 scopus 로고    scopus 로고
    • A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder
    • Kaminsky, Z., Tochigi, M., Jia, P., Pal, M., Mill, J., Kwan, A. et al. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Mol. Psychiatry. 17, 728-740 (2012).
    • (2012) Mol. Psychiatry. , vol.17 , pp. 728-740
    • Kaminsky, Z.1    Tochigi, M.2    Jia, P.3    Pal, M.4    Mill, J.5    Kwan, A.6
  • 26
    • 57749093704 scopus 로고    scopus 로고
    • Using amap and ctc packages for huge clustering
    • Lucas, A. & Jasson, S. Using amap and ctc packages for huge clustering. R News. 6, 58-60 (2006).
    • (2006) R News. , vol.6 , pp. 58-60
    • Lucas, A.1    Jasson, S.2
  • 27
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher, V. G., Tibshirani, R. & Chu, G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl Acad. Sci. USA. 98, 5116-5121 (2001).
    • (2001) Proc. Natl Acad. Sci. USA. , vol.98 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 28
    • 0035992248 scopus 로고    scopus 로고
    • Empirical bayes methods and false discovery rates for microarrays
    • Efron, B. & Tibshirani, R. Empirical bayes methods and false discovery rates for microarrays. Genet. Epidemiol. 23, 70-86 (2002).
    • (2002) Genet. Epidemiol. , vol.23 , pp. 70-86
    • Efron, B.1    Tibshirani, R.2
  • 29
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da, W., Sherman, B. T. & Lempicki, R. A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37, 1-13 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 30
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44-57 (2009).
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang Da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 31
    • 0028955465 scopus 로고
    • Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients
    • Szymanski, S., Lieberman, J. A., Alvir, J. M., Mayerhoff, D., Loebel, A., Geisler, S. et al. Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients. Am. J. Psychiatry. 152, 698-703 (1995).
    • (1995) Am. J. Psychiatry. , vol.152 , pp. 698-703
    • Szymanski, S.1    Lieberman, J.A.2    Alvir, J.M.3    Mayerhoff, D.4    Loebel, A.5    Geisler, S.6
  • 32
    • 34548130797 scopus 로고    scopus 로고
    • Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
    • Shimabukuro, M., Sasaki, T., Imamura, A., Tsujita, T., Fuke, C., Umekage, T. et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J. Psychiatr. Res. 41, 1042-1046 (2007).
    • (2007) J. Psychiatr. Res. , vol.41 , pp. 1042-1046
    • Shimabukuro, M.1    Sasaki, T.2    Imamura, A.3    Tsujita, T.4    Fuke, C.5    Umekage, T.6
  • 33
    • 43049104493 scopus 로고    scopus 로고
    • No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients
    • Bromberg, A., Levine, J., Nemetz, B., Belmaker, R. H. & Agam, G. No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients. Schizophr. Res. 101, 50-57 (2008).
    • (2008) Schizophr. Res. , vol.101 , pp. 50-57
    • Bromberg, A.1    Levine, J.2    Nemetz, B.3    Belmaker, R.H.4    Agam, G.5
  • 34
    • 80052273655 scopus 로고    scopus 로고
    • Exome sequencing supports a de novo mutational paradigm for schizophrenia
    • Xu, B., Roos, J. L., Dexheimer, P., Boone, B., Plummer, B., Levy, S. et al. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat. Genet. 43, 864-868 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 864-868
    • Xu, B.1    Roos, J.L.2    Dexheimer, P.3    Boone, B.4    Plummer, B.5    Levy, S.6
  • 35
    • 84877760159 scopus 로고    scopus 로고
    • DNA methylation signatures of peripheral leukocytes in schizophrenia
    • e-pub ahead of print 9 September 2012; doi:10.1007/s12017-12012-18198- 12016
    • Kinoshita, M., Numata, S., Tajima, A., Shimodera, S., Ono, S., Imamura, A. et al. DNA methylation signatures of peripheral leukocytes in schizophrenia. Neuromol. Med. (e-pub ahead of print 9 September 2012; doi:10.1007/s12017-12012- 18198-12016).
    • Neuromol. Med
    • Kinoshita, M.1    Numata, S.2    Tajima, A.3    Shimodera, S.4    Ono, S.5    Imamura, A.6
  • 36
    • 0004883390 scopus 로고    scopus 로고
    • Human dopamine transporter gene: Coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyper-activity disorder populations
    • Vandenbergh, D. J., Thompson, M. D., Cook, E. H., Bendahhou, E., Nguyen, T., Krasowski, M. D. et al. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyper-activity disorder populations. Mol. Psychiatry. 5, 283-292 (2000).
    • (2000) Mol. Psychiatry. , vol.5 , pp. 283-292
    • Vandenbergh, D.J.1    Thompson, M.D.2    Cook, E.H.3    Bendahhou, E.4    Nguyen, T.5    Krasowski, M.D.6
  • 37
    • 26844528903 scopus 로고    scopus 로고
    • The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning
    • Lin, C. H., Hansen, S., Wang, Z., Storm, D. R., Tapscott, S. J. & Olson, J. M. The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning. Proc. Natl Acad. Sci. USA. 102, 14877-14882 (2005).
    • (2005) Proc. Natl Acad. Sci. USA. , vol.102 , pp. 14877-14882
    • Lin, C.H.1    Hansen, S.2    Wang, Z.3    Storm, D.R.4    Tapscott, S.J.5    Olson, J.M.6
  • 38
    • 70349554036 scopus 로고    scopus 로고
    • AP2gamma regulates basal progenitor fate in a region-and layer-specific manner in the developing cortex
    • Pinto, L., Drechsel, D., Schmid, M. T., Ninkovic, J., Irmler, M., Brill, M. S. et al. AP2gamma regulates basal progenitor fate in a region-and layer-specific manner in the developing cortex. Nat. Neurosci. 12, 1229-1237 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 1229-1237
    • Pinto, L.1    Drechsel, D.2    Schmid, M.T.3    Ninkovic, J.4    Irmler, M.5    Brill, M.S.6
  • 39
    • 79960120705 scopus 로고    scopus 로고
    • Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas
    • Banister, C. E., Koestler, D. C., Maccani, M. A., Padbury, J. F., Houseman, E. A. & Marsit, C. J. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics. 6, 920-927 (2011).
    • (2011) Epigenetics. , vol.6 , pp. 920-927
    • Banister, C.E.1    Koestler, D.C.2    MacCani, M.A.3    Padbury, J.F.4    Houseman, E.A.5    Marsit, C.J.6
  • 41
    • 24344441586 scopus 로고    scopus 로고
    • Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: A systematic review
    • Marshall, M., Lewis, S., Lockwood, A., Drake, R., Jones, P. & Croudace, T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch. Gen. Psychiatry. 62, 975-983 (2005).
    • (2005) Arch. Gen. Psychiatry. , vol.62 , pp. 975-983
    • Marshall, M.1    Lewis, S.2    Lockwood, A.3    Drake, R.4    Jones, P.5    Croudace, T.6


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