Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease

Spine Journal

Volumn 14, Issue 6, 2014, Pages 1017-1028

  Than, Khoi D ^a   Rahman, Shayan U ^a   Wang, Lin ^a   Khan, Adam ^a   Kyere, Kwaku A ^a   Than, Tracey T ^a   Miyata, Yoshinari ^a   Park, Yoon Shin ^b   La Marca, Frank ^a   Kim, Hyungjin M ^b   Zhang, Huina ^a   Park, Paul ^a   Lin, Chia Ying ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Back pain; BMP 2; Degenerative disc disease; Discogenic back pain; Rodent model; Simvastatin

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 2; SIMVASTATIN; SODIUM CHLORIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKACHE; BONE REGENERATION; CONSERVATIVE TREATMENT; CONTROLLED STUDY; DISCOGENIC PAIN; GENETIC ANALYSIS; HISTOLOGY; HYDROGEL; INTERVERTEBRAL DISK DEGENERATION; INTRADISCAL DRUG ADMINISTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINE RADIOGRAPHY; SPINE SURGERY; ANIMAL; DISEASE MODEL; DRUG EFFECTS; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENETICS; INTERVERTEBRAL DISC DEGENERATION; INTERVERTEBRAL DISK; INTRASPINAL DRUG ADMINISTRATION; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REGENERATION; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; GENE EXPRESSION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INJECTIONS, SPINAL; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; SIMVASTATIN; UP-REGULATION;

EID: 84901355324     PISSN: 15299430     EISSN: 18781632     Source Type: Journal    
DOI: 10.1016/j.spinee.2013.11.034     Document Type: Article

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