The effects of recombinant human bone morphogenetic protein-2, recombinant human bone morphogenetic protein-12, and adenoviral bone morphogenetic protein-12 on matrix synthesis in human annulus fibrosis and nucleus pulposus cells

Spine Journal

Volumn 8, Issue 3, 2008, Pages 449-456

  Gilbertson, Lars ^a   Ahn, Sang Ho ^b   Teng, Pang Ning ^a   Studer, Rebecca K ^c   Niyibizi, Christopher ^d   Kang, James D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Yeungnam University   (South Korea)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Annulus fibrosis cells; BMP 12; BMP 2; Gene therapy; Human intervertebral disc; Matrix protein synthesis; Nucleus pulposus cells

Indexed keywords

ADENOVIRUS VECTOR; COLLAGEN; GROWTH FACTOR; MATRIX PROTEIN; PROTEOGLYCAN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 12; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT CYTOKINE;

ANNULUS FIBROSUS; CELL CULTURE; CELL ISOLATION; COLLAGEN SYNTHESIS; DNA CONTENT; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; INCUBATION TIME; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; EXTRACELLULAR MATRIX PROTEINS; GENE THERAPY; GENETIC VECTORS; HUMANS; INTERVERTEBRAL DISK; RECOMBINANT PROTEINS; TRANSDUCTION, GENETIC;

EID: 42949126727     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spinee.2006.11.006     Document Type: Review

References (43)

1. Diwan A.D., Parvataneni H.K., Khan S.N., Sandhu S.H., Girardi F.P., and Cammisa Jr. F.P. Current concepts in intervertebral disc restoration. Orthop Clin North Am 31 (2000) 453-464
2. Guiot B.H., and Fessler R.G. Molecular biology of degenerative disc disease. Neurosurgery 47 (2000) 1034-1040
3. Buckwalter J.A. Aging and degeneration of the human intervertebral disc. Spine 20 (1995) 1307-1314
4. Gruber H.E., and Hanley Jr. E.N. Observations on morphologic changes in the aging and degenerating human disc: secondary collagen alterations. BMC Musculoskelet Disord 3 (2002) 9 Epub 2002 Mar 21
5. Roughley P.J. Biology of Intervertebral disc aging and degeneration: Involvement of the extracellular matrix. Spine 29 (2004) 2691-2699
6. Omlor G.W., Lorenz H., Engelleiter K., et al. Changes in gene expression and protein distribution at different stages of mechanically induced disc degeneration-an in vivo study on the New Zealand white rabbit. J Orthop Res 24 (2006) 385-392
7. Moon S.H., Gilbertson L.G., Nishida K., et al. Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders. Spine 25 (2000) 2573-2579
8. Nishida K., Kang J.D., Gilbertson L.G., et al. Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. Spine 24 (1999) 2419-2425
9. Osada R., Ohshima H., Ishihara H., et al. Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs. J Orthop Res 14 (1996) 690-699
10. Thompson J.P., Oegema Jr. T.R., and Bradford D.S. Stimulation of mature canine intervertebral disc by growth factors. Spine 16 (1991) 253-260
11. Masuda K., Takegama K., An H., et al. Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J Orthop Res 21 (2003) 922-930
12. Takegami K., Thonar E.J., An H.S., et al. Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1. Spine 27 (2002) 1318-1325
13. Nagano T., Yonenobu K., Miyamoto S., Miyamoto S., Tohyama M., and Ono K. Distribution of the basic fibroblast growth factor and its receptor gene expression in normal and degenerated rat intervertebral discs. Spine 20 (1995) 1972-1978
14. Kim D.-J., Moon S.-H., Kim H., et al. Bone morphogenetic potein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine 28 (2003) 2679-2684
15. Yoon T.S., Su Kim K., Li J., et al. The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine 28 (2003) 1773-1780
16. Chen D., Zhao M., and Mundy G.R. Bone morphogenetic proteins. Growth Factors 22 (2004) 233-241
17. Sakou T. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone 22 (1998) 591-603
18. Wozney J.M., and Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop 346 (1998) 26-37
19. Wallach C.J., Sobajima S., Watanabe Y., et al. Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs. Spine 28 (2003) 2331-2337
20. Zhang Y, An HS, Thonar EJ-MA, Chubinskaya S, He JC, Phillips FM. Comparative effects of bone morphogenetic proteins and SOX9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells.
21. Furuya K., Nifuji A., Rosen V., and Noda M. Effects of GDF7/BMP12 on proliferation and alkaline phosphatase expression in rat osteoblastic osteosarcoma ROS 17/2.8 cells. J Cell Biochem 72 (1999) 177-180
22. Chuen F.S., Chuk C.Y., Ping W.Y., Nar W.W., Kim H.L., and Ming C.K. Immunohistochemical characterization of cells in adult human patellar tendons. J Histochem Cytochem 52 (2004) 1151-1157
23. Fu S.C., Wong Y.P., Chan B.P., et al. The roles of bone morphogenetic protein (BMP) 12 in stimulating the proliferation and matrix production of human patellar tendon fibroblasts. Life Sci 72 (2003) 2965-2974
24. Lou J., Tu Y., Ludwig F.J., Zhang J., and Manske P.R. Effect of bone morphogenetic protein-12 gene transfer on mesenchymal progenitor cells. Clin Orthop Relat Res 369 (1999) 333-339
25. Lou J., Tu Y., Burns M., Matthew J.S., and Manske P. BMP-12 gene transfer augmentation of lacerated tendon repair. J Orthop Res 19 (2001) 1199-1202
26. Wikesjo U.M., Sorensen R.G., Kinoshita A., Jian L.X., and Wozney J.M. Periodontal repair in dogs: effect of recombinant human bone morphogenetic protein-12 (rhBMP-12) on regeneration of alveolar bone and periodontal attachment. J Clin Periodontol 31 (2004) 662-670
27. Wolfman N.M., Hattersley G., Cox K., et al. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J Clin Invest 100 (1997) 321-330
28. An H.S., Takegami K., Kamada H., et al. Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine 30 (2004) 25-32
29. Masuda M.K., Imai Y., Okuma M., et al. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine 31 (2006) 742-754
30. Gelse K., von der Mark K., Aigner T., Park J., and Schneider H. Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum 48 (2003) 430-441
31. Shimer A.L., Chadderdon R.C., Gilbertson L.G., and Kang J.D. Gene therapy approaches for intervertebral disc degeneration. Spine 29 (2004) 2770-2778
32. Sobajima S., Kim J.S., Gilbertson L.G., and Kang J.D. Gene therapy for degenerative disc disease. Gene Therapy 11 (2004) 390-401
33. Horner H.A., Roberts S., Bielby R.C., et al. Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype. Spine 27 (2002) 1018-1028
34. Melrose J., Ghosh P., Taylor T.K., et al. A longitudinal study of the matrix changes induced in the intervertebral disc by surgical damage to the annulus fibrosus. J Orthop Res 10 (1992) 665-676
35. Sobajima S., Kompel J.F., Kim J.S., et al. A slowly progressive and reproducible animal model of intervertebral disc degeneration characterized by MRI, X-ray, and histology. Spine 30 (2005) 15-24
36. Nishida K., Kang J.D., Suh J.K., Robbins P.D., Evans C.H., and Giobertson L.G. Adenovirus-mediated gene transfer to nucleus pulposus cells. Implications for the treatment of intervertebral disc degeneration. Spine 23 (1998) 2437-2443
37. Thompson J.P., Pearce R.H., Schechter M.T., Adams M.E., Tsang I.K.Y., and Bishop P.B. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine 15 (1990) 411-415
38. Chelberg M.K., Banks G.M., Geiger D.F., and Ogema Jr. T.R. Identification of heterogeneous cell populations in normal human intervertebral disc. J Anat 186 (1995) 43-53
39. Robbins P.D., and Ghivizzani S.C. Viral vectors for gene therapy. Pharmacol Ther 80 (1998) 35-47
40. Suzuki K., Oyama M., Faulcon L., Robbins P.D., and Niyibizi C. In vivo expression of human growth hormone by genetically modified murine bone marrow stromal cells and its effect on the cells in vitro. Cell Transplant 9 (2000) 319-327
41. Li J., Yoon S.T., and Hutton W.C. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J Spinal Disord Tech 17 (2004) 423-428
42. Lee J.U., Hall R., Pelinkovic D., et al. New use of a three-dimensional pellet culture system for human intervertebral disc cells. Spine 26 (2001) 2316-2322
43. Yea L.C., and Lee J.C. Identification of an osteogenic protein-1 responsive element in the aggrecan promoter. Biochem Biophys Res Commun 323 (2004) 223-228